Peptide/protein–polymer bioconjugates have attracted increasing interest as they have numerous potential applications in biotherapeutics, biotechnology, and nanotechnology. In their paper, Liu and co-workers employed reversible addition–fragmentation chain transfer radical (RAFT) polymerization to design poly(2-(2,3,4,6-tetra-O-acetyl-b-D-glucosyloxy)ethyl
methacrylate) (PAcGlcEMA) polymers end-functionalized with the tripeptide reduced glutathione (GSH). The resulting PGlcEMA-GSH bioconjugate exhibited high affinity for Concanavalin A and significant antioxidant activity.
The specific recognition of targeting glucose moieties and antioxidant ability of GSH make peptide–glycopolymer bioconjugate PGlcEMA-GSH a suitable candidate for antioxidant delivery systems, biomimetics and biodetection.
Glycopolymer–peptide bioconjugates with antioxidant activity via RAFT polymerization by Haiting Shi, Li Liu, Xiaobei Wang and Jingyi Li Polym. Chem., 2012, 3, 1182-1188.
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