Yong-Qiang Tu: ChemComm Editor’s Choice

Yong-Qiang TuMeet our Associate Editor in Organic Chemistry: Yong-Qiang Tu

Professor Yong-Qiang Tu (Lanzhou University, China) handles submissions to Chemical Communications (ChemComm) in organic chemistry.

Yong-Qiang’s research interests centre on tandem rearrangement reactions and their application to the total syntheses of bioactive alkaloids, synthetic studies of biologically active natural products, and the construction of C-C and C-N bonds via C-H functionalisations. We invite you to submit your urgent research to his editorial office.

Read Yong-Qiang’s Editor’s Choice selection of ChemComm articles by clicking on the links below – all articles are FREE for a limited period!

ChemComm is the home of urgent high quality communications from across the chemical sciences. With a world-renowned reputation for quality and fast times to publication (average of 40 days), ChemComm is the ideal place to publish your research.


Yong-Qiang Tu’s Editor’s Choice:

Enantioselective total synthesis of (+)-brazilin, (−)-brazilein and (+)-brazilide A
Xuequan Wang, Hongbin Zhang, Xiaodong Yang, Jingfeng Zhao and Chengxue Pan  
DOI: 10.1039/C3CC42385A

Domino Rh-catalyzed hydroformylation–double cyclization of o-amino cinnamyl derivatives: applications to the formal total syntheses of physostigmine and physovenine
Wen-Hua Chiou, Chien-Lun Kao, Jui-Chi Tsai and Yun-Man Chang  
DOI: 10.1039/C3CC43257B

An organocatalytic asymmetric sequential allylic alkylation–cyclization of Morita–Baylis–Hillman carbonates and 3-hydroxyoxindoles
Qi-Lin Wang, Lin Peng, Fei-Ying Wang, Ming-Liang Zhang, Li-Na Jia, Fang Tian, Xiao-Ying Xu and Li-Xin Wang   
DOI: 10.1039/C3CC45139A

A modular total synthesis of (±)-trigonoliimine C
B. Narendraprasad Reddy and Chepuri V. Ramana  
DOI: 10.1039/C3CC45512B

Synthetic modification of salinomycin: selective O-acylation and biological evaluation
Björn Borgström, Xiaoli Huang, Martin Pošta, Cecilia Hegardt, Stina Oredsson and Daniel Strand  
DOI: 10.1039/C3CC45983G

Highly enantioselective synthesis of chiral 7-ring O- and N-heterocycles by a one-pot nitro-Michael–cyclization tandem reaction
Renate Rohlmann, Constantin-Gabriel Daniliuc and Olga García Mancheño  
DOI: 10.1039/C3CC47397J

A new versatile approach to synthesise enantioenriched 3-hydroxyoxindoles, 1,3-dihydroisobenzofuran and 3-isochromanone derivatives by a rhodium-catalyzed asymmetric arylation–cyclization sequence
Yi Li, Dong-Xing Zhu and Ming-Hua Xu  
DOI: 10.1039/C3CC47927G

Enantioselective total synthesis of virosaine A and bubbialidine
Hideki Miyatake-Ondozabal, Linda M. Bannwarta and Karl Gademann
DOI: 10.1039/C3CC38783F

A catalytic multicomponent coupling reaction for the enantioselective synthesis of spiroacetals  
Lara Cala, Abraham Mendoza, Francisco J. Fañanás and Félix Rodríguez  
DOI: 10.1039/C3CC00118K

An easy access to fluoroalkanes by deoxygenative hydrofluorination of carbonyl compounds via their tosylhydrazones
Arvind K. Yadav, Vishnu P. Srivastava and Lal Dhar S. Yadav
DOI: 10.1039/C3CC00122A


You might also be interested in these ChemComm Themed Collections:

Organocatalysis
Guest edited by Keiji Maruoka, Hisashi Yamamoto, Liu-Zhu Gong and Benjamin List

Nucleic acids: new life, new materials
Guest edited by Mike Gait, Makoto Komiyama, David Liu, Jason Micklefield, Ned Seeman and Oliver Seitz

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Metal-organic frameworks (MOFs): ChemComm web-themed issue

We would like to celebrate with our authors and the community our web themed collection entitled “Metal-organic frameworks” recently published in ChemComm.

The issue was Guest Edited by Neil Champness (University of Nottingham, UK), Christian Serre (University of Versailles, France) and Seth Cohen (University of California, San Diego, USA), and contains an impressive collection of articles, including:

Feature Articles:

MOFs for CO2 capture and separation from flue gas mixtures: the effect of multifunctional sites on their adsorption capacity and selectivity
Zhijuan Zhang, Yonggang Zhao, Qihan Gong, Zhong Li and Jing Li
Chem. Commun., 2013, 49, 653-661, DOI: 10.1039/C2CC35561B

Commercial metal–organic frameworks as heterogeneous catalysts
Amarajothi Dhakshinamoorthy, Mercedes Alvaro and Hermenegildo Garcia
Chem. Commun., 2012, 48, 11275-11288, DOI: 10.1039/C2CC34329K

Communications:

Understanding excess uptake maxima for hydrogen adsorption isotherms in frameworks with rht topology
David Fairen-Jimenez, Yamil J. Colón, Omar K. Farha, Youn-Sang Bae, Joseph T. Hupp and Randall Q. Snurr
Chem. Commun., 2012, 48, 10496-10498, DOI: 10.1039/C2CC35711A

Targeted functionalisation of a hierarchically-structured porous coordination polymer crystal enhances its entire function
Kenji Hirai, Shuhei Furukawa, Mio Kondo, Mikhail Meilikhov, Yoko Sakata, Osami Sakata and Susumu Kitagawa
Chem. Commun., 2012, 48, 6472-6474, DOI: 10.1039/C2CC31421E

Take a look at the excellent work published in this themed collection: http://rsc.li/cc-mofs

We encourage you to share the link to this collection with your colleagues.

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Crystal structure highlights buckycatcher’s flexibility

Jessica Cocker writes about a hot ChemComm article for Chemistry World

The molecule will readily adjust the size of its opening to accommodate its guest

Chemists in the US have successfully isolated the first anion of a distinctive type of pincer molecule, known as a buckycatcher, and confirmed the extraordinary flexibility it has for encapsulating guest molecules.

The buckycatcher in this study (C60H28) consists of a tetrabenzocyclooctaraene tether that links two corannulene (the smallest and most studied buckybowl) pincers. In previous attempts to isolate this molecule, researchers have had difficulties with solvate formation, as solvents fill the large empty cleft that the buckycatcher uses to encapsulate guest molecules. However, Marina Petrukhina, and co-workers at the University at Albany, State University of New York, have finally managed to elucidate the structure of this rather interesting molecule by developing and carrying out a rather arduous solvent-free method that involved growing the crystals in a vacuum over several months.

The buckycatcher’s flexibiliy has been suggested before, but Petrukhina‘s team provide the first experimental evidence for the adjustability of the tetrabenzocyclooctaraene tether that connects its coranulene pincers and allows them to move closer or further apart to catch guest species.


Read the full article in Chemistry World»

Read the original journal article in ChemComm:
An unsolvated buckycatcher and its first dianion
Alexander V. Zabula, Yulia V. Sevryugina, Sarah N. Spisak, Lesya Kobryn, Renata Sygula, Andrzej Sygula and Marina A. Petrukhina  
Chem. Commun., 2014, Advance Article, DOI: 10.1039/C3CC49451A, Communication

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One minute synthesis for microporous materials

Michael Parkin writes about a hot ChemComm article for Chemistry World

Researchers in Japan have developed the fastest known synthetic route for preparing crystalline microporous solids. The method is currently being scaled-up to meet the increasing demand for these versatile materials in industrial applications.

AlPO4-5 has been commercialised as a vapour adsorbent for refrigerators

Crystalline microporous solids are an important class of inorganic material that impact our everyday lives. Their ordered structures contain arrays of channels and voids several nanometres across, enabling them to selectively and reversibly absorb molecules based on their shapes and sizes. This has led to their widespread use as catalysts, molecular sieves and gas sensors. Research into their potential use as hydrogen storage materials for mobile energy applications is also ongoing.

However, microporous solids often crystallise slowly and typically require several hours to several weeks of hydrothermal treatment to achieve satisfactory yields, limiting their applications on industrial scales. Now, a collaborative effort from the University of Tokyo and the Mitsubishi Chemical Group has led to an ultra-fast method for preparing the aluminophosphate AlPO4-5. A combination of rapid heating and crystal seeding completes the synthesis within one minute.


Read the full article in Chemistry World»

Read the original journal article in ChemComm:
One-minute synthesis of crystalline microporous aluminophosphate (AlPO4-5) by combining fast heating with a seed-assisted method
Zhendong Liu, Toru Wakihara, Daisuke Nishioka, Kazunori Oshima, Takahiko Takewaki and Tatsuya Okubo  
Chem. Commun., 2014, Advance Article, DOI: 10.1039/C3CC49548E, Communication

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Designer esters for complex carbohydrates

Eleanor Merritt writes about a HOT ChemComm article for Chemistry World

Scientists based in the US have developed a new strategy to simplify the chemical synthesis of complex carbohydrates.

TFA simultaneously cleaves all protecting groups from the precursors to form the desired oligosaccharides in quantitative yields

Oligosaccharides are polymeric carbohydrates consisting of a small number of monosaccharide monomers. They are essential to all cellular organisms, playing vital roles in cell recognition and signalling.

Automated methods are routinely used to prepare biomacromolecules such as peptides and nucleic acids, but similar strategies in oligosaccharide synthesis are far less developed. Oligosaccharides contain a large number of hydroxyl groups which normally have to be protected orthogonally, i.e. in such a way that they can be unmasked independently of one another. This poses a great challenge to chemists and has hindered progress towards automated carbohydrate synthesis.

Classical protecting groups for hydroxyl groups include benzyl ethers, which are generally removed via hydrogenolysis or dissolving metal reduction, and acetate, benzoate or pivaloate esters, which are cleaved using base-catalysed hydrolysis. While these reactions are well established, a high level of training in practical organic chemistry is required to carry them out, in contrast to deprotection in automated peptide synthesis, which can be as simple as shaking the protected molecule with an acidic or basic solution.

Xinyu Liu and Yao Li at the University of Pittsburgh have developed a series of acid-cleavable PMB- and NAP-capped 4-hydroxybutanoic acid and 2-(hydroxymethyl)benzoic acid ester-type protecting groups that act as surrogates of acetate and benzoate. Trifluoroacetic acid (TFA) in toluene can simultaneously cleave all of these groups during the final stage of an oligosaccharide assembly to emulate the synthetic efficiency traditionally reserved for peptide chemistry.


Read the full article in Chemistry World»

Read the original journal article in ChemComm:
Tunable Acid-Sensitive Ester Protecting Groups in Oligosaccharide Synthesis
Yao Li and Xinyu Liu  
Chem. Commun., 2013, Accepted Manuscript, DOI: 10.1039/C3CC49205B, Communication

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HOT ChemComm articles for December

Here are this month’s referee-recommended HOT ChemComm articles – download them for FREE for a limited time!

A modular LHC built on the DNA three-way junction
Markus Probst, Simon M. Langenegger and Robert Häner
Chem. Commun., 2014, 50, 159-161
DOI: 10.1039/C3CC47490A, Communication

Free to access until 19th January 2014


One pot synthesis of cyclohexanone oxime from nitrobenzene using a bifunctional catalyst
Paula Rubio-Marqués, Juan Carlos Hernández-Garrido, Antonio Leyva-Pérez and Avelino Corma
Chem. Commun., 2014, Advance Article
DOI: 10.1039/C3CC47693F, Communication

Free to access until 19th January 2014


Recent advances in cooperative bimetallic asymmetric catalysis: dinuclear Schiff base complexes
Shigeki Matsunaga and Masakatsu Shibasaki
Chem. Commun., 2014, Advance Article
DOI: 10.1039/C3CC47587E, Feature Article

Free to access until 19th January 2014


From assembled metal–organic framework nanoparticles to hierarchically porous carbon for electrochemical energy storage
Arlin Jose Amali, Jian-Ke Sun and Qiang Xu
Chem. Commun., 2014, Advance Article
DOI: 10.1039/C3CC48112C, Communication

Free to access until 19th January 2014


Nitrogenase: a general hydrogenator of small molecules
Ian Dance
Chem. Commun., 2013, 49, 10893-10907
DOI: 10.1039/C3CC46864J, Feature Article

Free to access until 19th January 2014


In situ atomic imaging of coalescence of Au nanoparticles on graphene: rotation and grain boundary migration
Jong Min Yuk, Myoungho Jeong, Sang Yun Kim, Hyeon Kook Seo, Jihyun Kim and Jeong Yong Lee
Chem. Commun., 2013, 49, 11479-11481
DOI: 10.1039/C3CC46545D, Communication
From themed collection Structure and chemistry of materials from in-situ electron microscopy

Free to access until 19th January 2014

THAT’S NOT ALL! Click here for more free HOT ChemComm articles for December!!

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Kiss-and-run drug delivery

Jeanne Therese Andres writes about a HOT ChemComm article for Chemistry World

Carriers that release hydrophobic substances at cell membranes but do not enter the cells themselves could be the foundation for a new way to deliver drugs into cells, according to a team of scientists in Germany.

  
 The carrier touches the cell membrane for around 100ms to release its cargo which ends up inside lipid droplets (LD) in the cell

Many drugs are not water- or blood-soluble, so nanocarriers are typically used to encapsulate and transport drugs through the bloodstream to target sites where they are then taken inside the cell before releasing their drug cargo. Previous efforts focussed on ensuring successful nanocarrier uptake, as this was assumed to be the best way to deliver drugs into cells. ‘But now, with our new “kiss-and-run” mechanism, we no longer need to worry about whether the carrier can enter the cell,’ says team leader Volker Mailänder from the Max Planck Institute for Polymer Research, ‘only the drug itself needs to do that.’

Mailänder and his team tested their approach using biodegradable poly-L-lactide nanoparticles that fleetingly touch the cell’s phospholipid layer for around 100ms to release their cargo, in this case a hydrophobic dye that was left to stain the cell membrane, before quickly detaching from the cell – hence the term ‘kiss-and-run.’ They later found that the dye, representing water-insoluble drug cargo, was ultimately stored as lipid droplets within the cell.


Read the full article in Chemistry World»

Read the original journal article in ChemComm:
Drug delivery without nanoparticle uptake: delivery by a kiss-and-run mechanism on the cell membrane
Daniel Hofmann, Claudia Messerschmidt, Markus B. Bannwarth, Katharina Landfester and Volker Mailänder  
Chem. Commun., 2014, Advance Article, DOI: 10.1039/C3CC48130A

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Chem Sci, ChemComm and Chem Soc Rev poster prizes awarded at J400 chemonostics symposium

Congratulations to our Chemical Science, ChemComm and Chem Soc Rev poster prize winners at Chemonostics: Chemical receptors in the development of simple diagnostic devices, a one-day symposium held in Bath, UK on 28 November 2013.  The event, organised by Professor Tony James from the University of Bath, was held to celebrate 400 years of Japan-British relations.  Our Editor Dr Robert Eagling was on hand to award the prizes.

J400 at Bath - Chemonostics

(Left to right) Giles Prentice, Rama Byravan, Robert Eagling, Xiaolong Sun

The RSC poster prizes were awarded to:

Giles Prentice (Bath) – Chem Soc Rev poster prize
Rama Byravan (Birmingham) – Chemical Science poster prize
Xiaolong Sun (Bath) – ChemComm poster prize

Once again, our warmest congratulations to all our winners!

Read J400: our cross-journal online collection celebrating the 400th anniversary of Japan-British relations

You may also be interested in our web collection dedicated to Professor Seiji Shinkai on the occasion of his 70th birthday

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Steering cells towards biocomputers

Carla Pegararo writes about a HOT ChemComm article for Chemistry World

Bacterial toxins that undergo unique cell interactions have been used to perform logic functions by researchers in Germany. In a similar way to how we store letters and words on computer disks, these proteins provide a new approach to storing information within whole cells.

The three components of the enterotoxin must bind to the cell membrane in a specific order to activate the logic gate

Synthetic biologists have already modified the genetic code of cells to create biocircuits capable of performing specific Boolean logic functions, for example AND gates and OR gates, for sensing, diagnostics and therapeutics. These genetic logic gates require sophisticated and extensive modifications of the cell DNA. Now, Erwin Märtlbauer and his team at the University of Munich have developed a comparably simple approach where proteins interact with the membrane of whole cells to produce a variety of combinatorial and sequential logic operators.

A unique enterotoxin protein made up of three components that must individually bind in a specific order to the cell membrane to cause cell death is central to Märtlbauer’s system. By using this sequential binding as the input of the logic gate and cell death as the output the team have created a logic operator with memory that is similar to a keypad lock, where unless the right key is pressed in the right order nothing will happen.


Read the full article in Chemistry World»

Read the original journal article in ChemComm:
Ordered self-assembly of proteins for computation in mammalian cells
Kui Zhu, Jianzhong Shen, Richard Dietrich, Andrea Didier, Xingyu Jiang and Erwin Märtlbauer  
Chem. Commun., 2014, Advance Article, DOI: 10.1039/C3CC48100J

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Nominate a colleague this week: ChemComm Emerging Investigator Lectureships 2014

This week is your last chance to nominate a colleague for the ChemComm Emerging Investigator Lectureships 2014.

Nominate by Friday 6th December 2013

The lectureships recognise emerging scientists in the early stages of their independent academic career. 2014 marks the 50th volume of ChemComm and in celebration of this very special anniversary we will be awarding three ChemComm Emerging Investigator Lectureships next year. So nominate a colleague today! 

To qualify
To be eligible for the ChemComm Emerging Investigator Lectureship, the candidate should have completed their PhD on or after 4th September 2005. The candidate should also have published at least one article in ChemComm during the course of their independent career.  

Award details
The recipient of the award will be invited to present a lecture at three different locations over a 12 month period. It is expected that at least one of the locations will be a conference. The recipient will receive a contribution of £1500 towards travel and accommodation costs. S/he will also be presented with a certificate and be asked to contribute a ChemComm Feature Article. 

Nominations
Those wishing to make a nomination should send the following details to the ChemComm Editorial Office by Friday 6th December 2013:  

  • Recommendation letter, including the name, contact details and website URL of the nominee.  
  • A one page CV for the nominee, including their date of birth, summary of education and career, list of up to five independent publications, total numbers of publications and patents and other indicators of esteem and evidence of independence.
  • A copy of the candidate’s best publication to date (as judged by the nominator).
  • Two supporting letters of recommendation from two independent referees. These should not be someone from the same institution or the candidate’s post doc or PhD supervisor.

The nominator and independent referees are requested to comment on the candidate’s presenting skills.  

Please note that self nomination is not permitted. 

Selection procedure
The ChemComm Editorial Board will draw up a short-list of candidates based on the information provided by the referees and nominator. Short-listed candidates will be asked to provide a supporting statement justifying why they deserve the award. The recipients of the award will then be selected and endorsed by the ChemComm Editorial Board, and will be announced in Spring 2014. 

Previous winners

2013    Professor Louise A. Berben (University of California Davis, USA) for synthetic and physical inorganic chemistry, who will give a plenary lecture at ISACS 13 in Dublin.
2013    Dr Marina Kuimova (Imperial College London, UK) for biophysical chemistry who will give her Lectureship in 2014.
2012 Professor Hiromitsu Maeda (Ritsumeikan University, Japan) – he was presented with his lecture certificate at ICPOC 21.
2011   Dr Scott Dalgarno (Heriot-Watt University, Edinburgh, UK) – Find out about his Emerging Investigator Lecture tour in China.
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