A simple yet powerful computational method of generating models that link microscopic or molecular properties of polymers to their biological effects has been reported by Winkler and co-workers.
At present the synthesis and characterisation of novel materials for tissue engineering is a time-consuming and costly process. In this hot paper, the adhesion of human embryonic stem cell embryoid bodies (hEB) to a large library of polymers is studied. Using a mathematical description of the molecular properties of the polymers, a novel method was employed to predict experimental hEB adhesion of the polymer library. This method was found to produce models that could accurately describe stem cell hEB adhesion on polymeric surfaces. The method could be used to predict polymers with improved properties for tissue engineering and other biomedical areas.
Modelling human embryoid body cell adhesion to a combinatorial library of polymer surfaces
J. Mater. Chem., 2012, 22, 20902
DOI: 10.1039/c2jm34782b (free to read for a short time)
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