A strategy for encoding & decoding DNA based on DNA–Au nanoparticle conjugates has been developed by South Korean scientists. The system uses amphiphilic polymer-protected DNA–Au nanoparticles. The DNA-encoded probes can be readily decoded using DNA–AuNP hybridization and dark-fieldbased AuNP scattering on microarrayed surface. Jwa-Min Nam and co-workers at Seoul National University say that the particles are stable in a wide range of salt concentrations, pH and temperatures and sustain their stability even after the addition of D,L-dithiothreitol. These particles could eventually find be used in artificial coding systems such forgery protection, forensics and multiplexing bioprobes.
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