Paper of the week: Fluorescent PEGylation agent by a thiolactone-based one-pot reaction

One pot preparation of fluorescent PEGylated proteins by a thiolactone reaction to be used in theranostic applications has been reported by Zhao et al.

Theranostic combinations usually contain an imaging, a therapeutic and a cloaking component to simultaneously fulfil diagnostic and therapeutic functions. Using upgraded PEGylation technology, a straightforward one-pot strategy based on thiolactone ring-opening has been developed to facilely synthesize a multifunctional PEGylation agent, fluorescent protein-reactive poly(ethylene glycol) (PEG), which can subsequently react with a model therapeutic protein to form a fluorescent PEGylated protein as a model of sophisticated theranostic combinations.

Fluorescent PEGylation agent by a thiolactone-based one-pot reaction: a new strategy for theranostic combinations by Yuan Zhao, Bin Yang, Yaling Zhang, Shiqi Wang, Changkui Fu, Yen Wei and   Lei Tao Polym. Chem., 2014,5, 6656-6661

Remzi Becer is a web-writer and advisory board member for Polymer Chemistry. He is currently a Senior Lecturer in Materials Science and the director of the Polymer Science and Nanotechnology masters programme at Queen Mary, University of London. Visit for more information.

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One Response to “Paper of the week: Fluorescent PEGylation agent by a thiolactone-based one-pot reaction”

  1. This is the way it should be worked and can not be doing this way. It is cool and this is best Snapchat Trophies

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