Author of the Month: Prof. Feihe Huang

Feihe Huang was born in Shaodong, Hunan, China in 1973. He obtained his Bachelor of Polymer Materials Science and Engineering degree from Hefei University of Technology in July 1996 and a Masters in Polymer Chemistry and Physics from the University of Science and Technology of China in July 1999. After a year of studying at the University of Washington, he transferred to Virginia Polytechnic Institute and State University (VT) where he joined Prof. Harry W. Gibson’s group in August 2000. He earned the degree of Master of Science in Chemistry in August 2003. He finished his coursework and research for his PhD in Chemistry during the spring of 2005 with the aid and guidance of Prof. Harry W. Gibson. He joined Prof. Peter J. Stang’s group at the University of Utah as a postdoctoral fellow in March 2005. In December 2005, he became a professor of chemistry at the Department of Chemistry, Zhejiang University. In March 2008, he became a Qiushi Chair Professor of Zhejiang University. His current research interests are supramolecular polymers and pillar[n]arene supramolecular chemistry.

Awards and honours he has received to date include the William Preston Award for a MS Thesis from VT, a 2004 Chinese Government Award for Outstanding Self-Financed Students Abroad, The Sigma Xi Research Award for Ph.D. Degree Candidates from the VT Chapter of Sigma Xi Research Society, Outstanding Ph.D. Dissertation Award from VT, the Thieme Chemistry Journals Award, the Outstanding Recent Graduate Alumnus Award from VT, a Humboldt Fellowship for Experienced Researchers from the Humboldt Foundation, The National Science Fund for Distinguished Young Winner (China), Fellow of the Royal Society of Chemistry, and the Chinese Chemical Society AkzoNobel Chemical Sciences Award. He has published more than 160 supramolecular chemistry papers in journals such as PNAS (2), J. Am. Chem. Soc. (18), Angew. Chem., Int. Ed. (5), Adv. Mater. (5), Chem. Soc. Rev. (5), Acc. Chem. Res. (5), Prog. Polym. Sci. (1). His publications have been cited more than 7700 times and he has a h-index of 49. He has served as a guest editor for Chem. Soc. Rev.Acc. Chem. Res.Chem. Rev.and Chem. Commun. He currently sits on the Advisory Boards of Chemical Society ReviewsChemical Communications, Acta Chim. SinicaMacromoleculesACS Macro Letters and Polymer Chemistry.

For more information about Feihe Huang’s research group visit the website

What was your inspiration in becoming a chemist?

I wanted to make new materials for us to have better lives and a greener world.

What was the motivation to write your Polymer Chemistry article?

Supramolecular crosslinked polymer gels have tremendous potential as smart materials because they offer a special combination of the elastic behaviour of solids and the microviscous properties of fluids. From many published reports related to supramolecular crosslinked polymer gels, one can reach two general conclusions: 1) there are many kinds of non-convalent interactions that can be used to crosslink polymeric chains to yield supramolecular gels and 2) usually these supramolecular gels contain only one kind of noncovalent crosslink. The consequence of using a single type of supramolecular crosslink is that above some level of external stimulation, sufficient cross-links are broken and subsequently a gel to sol transition usually occurs. This transition, which can occur across a narrow stimulus window, can limit applications in several ways. In order to solve this problem, we are interested in the fabrication of supramolecular crosslinked polymer gels containing two types of physical crosslinks based on two orthogonal supramolecular interactions. In such a system, one supramolecular crosslink can be used to maintain the gel state and the other to change the crosslinking density of the gel under external stimuli, thereby giving rise to the macroscale expansion-contraction behaviour of the gel without the gel-sol transition. The roles of the two networks can be reversed, allowing for a multi-responsive, expansion-contraction system that will be more adaptive. Finally, addition of both stimuli will allow breakdown of the gel. In this Polymer Chemistry article, we report that exactly such a double supramolecular crosslinked polymer gel based on hydrogen bonding and a macrocycle threading process achieves these properties.

Why did you choose Polymer Chemistry to publish your work?

Firstly, Polymer Chemistry is a very good journal and it is great to publish my work in it. Secondly, I am an Advisory Board member for Polymer Chemistry and I want to contribute to the development of this journal.

In which upcoming conferences may our readers meet you?

I am attending the First Artificial Molecular Switches and Motors Gordon Research Conference which will be held at Stonehill College, Easton, MA (USA) on 7th-12th June 2015. Follow the link for more information about this conference.

How do you spend your spare time?

Playing with my son, reading, listen to music, and travelling.

Which profession would you choose if you were not a scientist?

I would be a high-school teacher because I want to work with and help young people.



A double supramolecular crosslinked polymer gel exhibiting macroscale expansion and contraction behavior and multistimuli responsiveness

Xiaofan Ji, Kecheng Jie, Steve Zimmerman and Feihe Huang

Supramolecular crosslinked polymer gels show special properties largely as a result of the combined mechanical properties contributed by the covalently linked polymer chains and the reversible, stimuli-responsive supramolecular crosslinks. Most supramolecular crosslinked polymer gels contain only one kind of physical cross-link. Herein we report a novel supramolecular polymer gel containing two types of physical crosslinks based on two kinds of non-covalent interactions that are orthogonal: DAN-DeUG quadruply hydrogen-bonding interactions and benzo-21-crown-7/dialkylammonium salt host-guest interactions. One of the crosslinked networks is used to maintain the gel state while the other modulates the crosslink density through an external stimuli, thereby causing a volume change of the gel. This double supramolecular crosslinked polymer gel shows macroscale expansion and contraction behaviour and multistimuli responsiveness. Therefore, we successfully demonstrate that the macroscopic property changes of supramolecular systems can be induced by controlled self-assembly on the molecular scale.


Cyrille Boyer is a guest web-writer for Polymer Chemistry. He is currently an Associate Professor and an ARC-Future Fellow in the School of Chemical Engineering, University of New South Wales (Australia) and deputy director of the Australian Centre for NanoMedicine.


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Paper of the week: Dynamic intracellular delivery of antibiotics via pH-responsive polymersomes

Lane et al. report the intracellular delivery of antibiotics via pH-responsive polymersomes.

Reversible addition-fragmentation chain transfer (RAFT) polymerisation was employed to prepare a series of copolymers consisting of 2-hydroxyethyl methacrylate (HEMA) and poly(ethylene glycol) methyl ether methacrylate (FWavg [similar] 950 Da) (O950) with variable comonomer compositions and molecular weights for use as polymeric scaffolds. Reactivity ratios for the monomer pair were determined to be 1.37 and 0.290 respectively. To these scaffolds, trithiocarbonate-based RAFT chain transfer agents (CTAs) were grafted using carbodiimide chemistry. The resultant graft chain transfer agents (gCTA) were subsequently employed to polymerise dimethylaminoethyl methacrylate (DMAEMA) and N-(2-hydroxypropyl)methacrylamide (HPMA) between degrees of polymerisation (DP) of 25 and 200. Kinetic analysis for the polymerisation of DMAEMA targeting a DP of 100 from a 34 arm graft gCTA show linear Mn conversion and pseudo first order rate plots with narrow molecular weight distributions that move toward lower elution volumes with monomer conversion. Đ values for these polymerisations remain low at around 1.20 at monomer conversions as high as 70%. pH-responsive endosomalytic brushes capable of spontaneously self-assembling into polymersomes were synthesised and a combination of dynamic light scattering (DLS), cryoTEM, and red blood cell haemolysis were employed to evaluate the aqueous solution properties of the polymeric brush as a function of pH. Successful encapsulation of ceftazidime and pH-dependent drug release properties were confirmed by HPLC. Intracellular antibiotic activity of the drug-loaded polymersomes was confirmed in a macrophage coculture model of infection with B. thailandensis and RAW 264.7 cells.

Dynamic intracellular delivery of antibiotics via pH-responsive polymersomes by D. D. Lane, F. Y. Su, D. Y. Chiu, S. Srinivasan, J. T. Wilson, D. M. Ratner, P. S. Stayton and A. J. Convertine, Polym. Chem., 2015,6, 1255-1266.

Remzi Becer is a web-writer and Advisory Board member for Polymer Chemistry. He is currently a Senior Lecturer in Materials Science and the director of the Polymer Science and Nanotechnology masters programme at Queen Mary, University of London. Visit www.becergroup.com for more information.

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IP’15 – International Symposium on Ionic Polymerization

IP’15 - International Symposium on Ionic Polymerization

The 11th International Symposium on Ionic Polymerization (IP’15) will be held at Bordeaux University in the South West of France from 5th – 10th July 2015, organized and hosted by the Polymer Institute.

IP’15 will be the latest in a series of successful meetings, the most recent of which were held in Awaji (Japan, 2013), Akron (USA, 2011), Krakow (Poland, 2009), Kloster Banz (Germany, 2007), Goa (India, 2005), Boston (USA, 2003), Crete (2001, Greece).

IP’15 has roots from the series of international symposia on Cationic, Anionic, and Ring-Opening Polymerizations, which were merged as International Symposium on Ionic Polymerization in 1995, held in Istanbul (Turkey). Decision of the merger was made in the 11th International Symposium on Cationic Polymerization and Related Processes, held in Borovetz, Bulgaria, in 1993, with the recognition of closer relationship and interplay among these polymerization methods, in view of precise control of polymer structures and macromolecular architectures. Thus this symposium on Ionic Polymerization will be the 22nd symposium as the Cationic series as well as the 11th one named “Ionic Polymerization“.

Topics will cover academic and applied research in the areas of anionic, cationic, and related polymerization mechanisms. Contributions related to other methods of living/controlled polymerization (catalytic, controlled free-radical, and step-growth polymerizations) are welcome, as well as industrial applications and processes of these well-controlled polymerizations. For further details about the conference visit the website or email the organising committee.

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Paper of the week: Efficient microencapsulation of a liquid isocyanate with in situ shell functionalization

Nguyen et al. outline the efficient microencapsulation of a liquid isocyanate with in situ shell functionalization.

Nguyen et al. report on a one-pot, facile approach for the encapsulation of the liquid hexamethylene diisocyanate isocyanurate trimer in polyurea microcapsules formed via the oil-in-water interfacial reaction of an uretonimine-modified diphenyl methane diisocyanate trimer with triaminopyrimidine; with in situ shell functionalization/modification using different types of hydrophobic agents. Remarkably, the use of hexamethylenedisilazane resulted in microcapsules of about 70 μm in diameter, with a smooth outer surface and a high isocyanate core content up to 85 wt% as determined by quantitative online FT-IR analysis of the extracted core. On the other hand, the use of an alkylamine, fluorinated aromatic amine and/or perfluoride amine provided microcapsules of approximately 100 to 150 μm in diameter containing around 65–75 wt% of the isocyanate core content, with the outer shell surface bearing pendant hydrophobic groups as confirmed by SEM-EDX. The effects of the functionalizing compound on the microcapsule properties such as shell morphology, size distribution and stability were assessed. After one day immersion in water, the initial isocyanate content of the microcapsules with a non-functionalized shell dropped rapidly from 49 to 15 wt%, whereas the ones with the modified shell structure maintained their core content, suggesting a significantly enhanced microcapsule stability.

Efficient microencapsulation of a liquid isocyanate with in situ shell functionalization by Le-Thu T. Nguyen, Xander K. D. Hillewaere, Roberto F. A. Teixeira, Otto van den Berg and Filip E. Du Prez, Polym. Chem., 2015, 6, 1159-1170.

Remzi Becer is a web-writer and Advisory Board member for Polymer Chemistry. He is currently a Senior Lecturer in Materials Science and the director of the Polymer Science and Nanotechnology masters programme at Queen Mary, University of London. Visit www.becergroup.com for more information.

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Author of the Month: Prof. Jacques Lalevée

Prof. Jacques Lalevée was born in Remiremont (France) in 1976. After studying Physical Chemistry at the University of Nancy (now University of Lorraine), he received his Ph.D. degree in Materials Chemistry under the supervision of Prof. Jean Pierre Fouassier from Mulhouse in 2002. After approximately one-year of postdoctoral research with Prof. Gerd Kothe (Germany), he joined the “Ecole Nationale Supérieure de Chimie de Mulhouse (ENSCMu)” in September, 2004. He was promoted to full professor in September, 2009. Since 2011, Jacques has been a Professor at the “Institut Universitaire de France (IUF-Paris)”. His current research interests encompass free radical chemistry, the design of new (photo)polymerisation initiating systems and new polymers, as well as mechanistic elucidation in polymer chemistry. He has published nearly 200 peer-reviewed papers with an H-index of 29.

He was awarded the Guy Ourisson 2013 Prize as well as the national prize of the French polymer group (GFP) in 2014.

What was your inspiration in becoming a chemist?

I became really interested in chemistry at high school. I was fascinated by chemical reactions and the possibility of understanding events at this molecular scale. I have always been interested in free radical chemistry as many different reaction pathways can be expected from these chemical species. The “positive” use of free radicals in polymerisation processes was always a challenge for me; particularly the possibility of triggering processes by light for perfect time and spatial controls.

What was the motivation to write your Polymer Chemistry article?

Light-induced polymerisation technique is a promising approach for the fabrication of various polymeric materials due to its environmental, economic and production benefits. This technique is mainly based on the photochemically generated reactive species (e.g. radicals or cations, produced from the photochemical reactions of photoinitiating systems after the absorption of light) to rapidly transform the specially formulated reactive liquids to solids (3D polymeric networks for various materials) at room temperature. Recently, light-emitting diodes (LEDs) have attracted increased attention as potential irradiation sources for photopolymerisation processes substituting traditional mercury UV lamps; their advantages include being more environmentally friendly, having better light output, higher operating efficiency and lower cost and energy consumption.

Recently, the use of metal based complexes as photoredox catalysts in polymer science has generated lots of interest and is actually a huge challenge. In the present paper, we propose a new iridium complex (Ir(btp)2(tmd)) as a novel photoredox catalyst with enhanced efficiency under visible lights (laser diodes, LEDs and household halogen lamp) for i) cationic polymerisation, ii) free radical polymerisation, iii) controlled/living radical polymerisation and iv) polymer surface modification, including micropatterning by laser direct writing.

Why did you choose Polymer Chemistry to publish your work?

The Royal Society of Chemistry is clearly one of the leading societies and accordingly its polymer journal “Polymer Chemistry” has rapidly emerged as a leader journal in Polymer Science. The wide international readership, the quick submission and review system are also particularly interesting.

In which upcoming conferences may our readers meet you?

The European Polymer Congress (Dresden, Germany in June 2015) or 11th International Symposium on Ionic Polymerization (Bordeaux – France July 2015).

How do you spend your spare time?

Obviously, I am willing to spend more time with my family. I like cycling, and would like to dedicate more time to it.

Which profession would you choose if you were not a scientist?

I would become a teacher in middle school, it was my original idea, but I met excellent professors in the University and they have opened my mind to research.


Photoredox catalysis using a new iridium complex as an efficient toolbox for radical, cationic and controlled polymerizations under soft blue to green lights

Sofia Telitel, Frederic Dumur, Siham Telitel, Olivier Soppera, Marc Lepeltier, Yohann Guillaneuf, Julien Poly, Fabrice Morlet-Savary, Philippe Fioux, Jean-Pierre Fouassier, Didier Gigmes and Jacques Lalevée

A new iridium complex (nIr) was designed and investigated as a photoinitiator catalyst for radical and cationic polymerization upon very soft irradiations (lights ranging from 457 to 532 nm). A ring-opening polymerization (ROP) of an epoxy monomer was easily promoted through the interaction between nIr and an iodonium salt (Iod) upon light. In radical polymerization, nIr can be efficient in combination with phenacyl bromide (PBr) and optionally an amine. These photoinitiating systems work according to an original oxidative cycle and a regeneration of nIr is observed. A control of the methyl methacrylate polymerization (conducted under a 462 nm light) with 1.2–1.6 polydispersity indexes was displayed. Surface modifications by direct laser write was also easily carried out for the first time through surface re-initiation experiments, i.e. the dormant species being reactivated by light in the presence of nIr; the polymer surfaces were analyzed by XPS. The chemical mechanisms were examined through laser flash photolysis, NMR, ESR and size exclusion chromatography experiments.


Cyrille Boyer is a guest web-writer for Polymer Chemistry. He is currently an Associate Professor and an ARC-Future Fellow in the School of Chemical Engineering, University of New South Wales (Australia).


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Paper of the week: Highly regioselective Pd/C-catalyzed direct arylation toward thiophene-based π-conjugated polymers

Hayashi et al. have successfully developed a highly regioselective Pd/C-catalysed direct arylation toward thiophene-based π-conjugated polymers.

Pd/C heterogeneous catalysts were used in the direct arylation polycondensation of thiophenes. The efficient and highly regioselective polycondensation of thiophene monomers was achieved under phosphine-free conditions to give linear π-conjugated alternating copolymers with high molecular weight in high yield.

Highly regioselective Pd/C-catalyzed direct arylation toward thiophene-based π-conjugated polymers by Shotaro Hayashi, Yoshihisa Kojima and Toshio Koizumi Polym. Chem., 2015,6, 881-885.

Remzi Becer is a web-writer and Advisory Board member for Polymer Chemistry. He is currently a Senior Lecturer in Materials Science and the director of the Polymer Science and Nanotechnology masters programme at Queen Mary, University of London. Visit www.becergroup.com for more information.

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European Polymer Federation Congress 2015 (epf 2015)

The European Polymer Federation Congress 2015 (epf 2015) will be held this year in Dresden, Germany. The congress will run from 21st – 26th June 2015 at the International Congress Centre Dresden.

Dates and Deadlines:

Early registration closes on 20th April 2015.

The congress is broken down into six topics which cover a wide array of polymer research, so check out the topics and submit your poster abstracts now! Last minute poster abstracts will be accepted up until 31st March 2015Click here to find out more information about abstract submission.

Browse the programme:

Distinguished speakers have been announced for the congress, so why not take a look at the full list of contributors. Keynote speakers include: Polymer Chemistry’s Editor-in-Chief David Haddleton (University of Warwick, UK), Associate Editor Ben Zhong Tang (The Hong Kong University of Science and Technology) and Advisory Board Member Rachel O’Reilly (University of Warwick, UK). Along with a fantastic speaker line up, an exciting social programme is also planned; so don’t miss out, register today!

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‘Celebrating the Five-Year Anniversary of Polymer Chemistry’ Symposium

This year, Polymer Chemistry celebrates its fifth anniversary. To mark the occasion Editor-in-Chief Dave Haddleton and Associate Editors, Brent Sumerlin and Wei You, have organised a symposium entitled ‘Celebrating the Five-Year Anniversary of Polymer Chemistry‘ which will be held during the 249th ACS National Meeting & Exposition, in Denver, CO, USA.

Symposium Details:

The symposium will take place on 22nd March 2015 at Governor’s Square 14, Sheraton Denver Downtown Hotel between 8:30am – 4:50pm. We hope you can attend!

Symposium speakers:

The stimulating symposium talks will be delivered by distinguished speakers:

Nikolaos Hadjichristidis

Christopher Barner-Kowollik

Jean-François Lutz

Sebastien Perrier

Cyrille Boyer

Andrew Lowe

Virgil Percec

Heather Maynard

Xi Zhang

Hong Chen

Shiyong Liu

Todd Emrick

‘Celebrating the Five-Year Anniversary of Polymer Chemistry‘ Web Collection:

To accompany the symposium we have produced a web themed collection of recent papers published by the symposium speakers. We hope you enjoy reading these articles.

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Paper of the week: Novel polymer synthesis methodologies using combinations of thermally- and photochemically-induced nitroxide mediated polymerization

Guillaneuf and Gigmes and co-workers discuss novel polymer synthesis methodologies using combinations of thermally- and photochemically-induced nitroxide mediated polymerization

The combination of thermally- and photochemically-induced polymerization using light-sensitive alkoxyamines was investigated. The thermally driven polymerizations were performed via the cleavage of the alkoxyamine functionality, whereas the photochemically-induced polymerizations were carried out either by nitroxide mediated photo-polymerization (NMP2) or by a classical type II mechanism, depending on the structure of the light-sensitive alkoxyamine employed. Once the potential of the various structures as initiators of thermally- and photo-induced polymerizations was established, their use in combination for block copolymer syntheses was investigated. With each alkoxyamine investigated, block copolymers were successfully obtained and the system was applied to the post-modification of polymer coatings for application in patterning and photografting.

Novel polymer synthesis methodologies using combinations of thermally- and photochemically-induced nitroxide mediated polymerization by Jason Morris, Sofia Telitel, Kathryn E. Fairfull-Smith, Steven E. Bottle, Jacques Lalevée, Jean-Louis Clément, Yohann Guillaneuf and Didier Gigmes Polym. Chem., 2015,6, 754-763

Remzi Becer is a web-writer and Advisory Board member for Polymer Chemistry. He is currently a Senior Lecturer in Materials Science and the director of the Polymer Science and Nanotechnology masters programme at Queen Mary, University of London. Visit www.becergroup.com for more information.

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Author of the Month: Prof. Anthony Convertine

Anthony studied Chemistry at Edison College in Southwest Florida before transferring to the University of Southern Mississippi where he obtained his BS and PhD in Polymer Science and Engineering.  Under the supervision of his advisor, Professor Charles McCormick, he worked on preparing water-soluble polymers by RAFT polymerization.  Following the completion of his PhD studies he moved to Seattle Washington to do a postdoc with Professor Patrick Stayton and Allan Hoffman.  During his postdoc he worked on applying RAFT synthetic methodology to develop polymeric materials for delivering biologic drugs.  Following his postdoc, he took a position as a research assistant professor in the department of BioEngineering at the University of Washington.  To date Anthony has publish almost 60 research articles and patents and developed technology that has led to the establishment of a local area start up company.

His research is focused primarily on the application of controlled free radical polymerization and thiol-ene/Michael chemistry to develop powerful new delivery technologies that will enable the realization of therapies based on intracellularly active biologic drugs. These agents have the potential to revolutionize the treatment of serious diseases such as cancer and antibiotic resistant bacteria while minimizing harmful side effects.

What was your inspiration in becoming a chemist?

I think that I have always wanted to become a chemist.  From a very early age I enjoyed mixing whatever chemicals I could find to see what would happen. When I first started college I was required to take several chemistry classes as part of the pre-pharmacy curriculum. Along the way my organic chemistry instructor, Professor Scott, really inspired me to change my major to chemistry. His lab courses were fascinating and I was really intrigued by the idea that complex organic molecules could be made to react in deliberate ways. Soon after that I took a polymer chemistry course by Professor McCormick, who would later become my PhD advisor, which really sparked my imagination and cemented my desire to be a chemist.

What was the motivation to write your Polymer Chemistry article ?

The starting point for writing this article was the desire to create a new class of drug delivery system that could combine the high drug loading capacity and well defined structure of polymer-drug conjugates with the long circulation times of nanoparticle-based systems. Controlled radical polymerization methodologies, including the versatile reversible addition–fragmentation chain transfer (RAFT) polymerization process, are rapidly moving to the forefront in construction of drug delivery vehicles. The use of RAFT polymerization from multifunctional scaffolds provided a scientifically interesting approach for preparing these materials with spatially defined biofunctional segments.

Why did you choose Polymer Chemistry to publish your work?

Polymer chemistry is quickly becoming the premier journal for publishing cutting edge polymer science research across a range of polymer-related disciplines. The editors at Polymer Chemistry do a great job of making the manuscript figures and layouts look really sharp.  We are really excited about this work and felt that Polymer Chemistry would give our manuscripts excellent visibility. The work detailed in this manuscript was conducted along side a second closely related study so it made a lot of sense to publish them together.

In which upcoming conferences may our readers meet you?

We recently presented this work at the 2014 Zing Polymer Chemistry Conference in Cancun Mexico.  We are planning to attend the 2015 BMES meeting in Tampa, Florida.

How do you spend your spare time?

The Pacific Northwest is just amazing! There are so many natural wonders here that there is always a new hike to go on or a spectacular coastline to explore. I am also an aspiring surfer and take every opportunity to head down to the California coast to catch some waves. In the summer I like to head back to my hometown in Southwest Florida to fish for redfish with my cousin.  The mangrove shorelines and grassy flats have some of the best fishing in the world and are uniquely beautiful.  During football season you can usually find me at the local pub rooting for the Seattle Seahawks.

Which profession would you choose if you were not a chemist?

Pharmacist. Medicinal compounds and their affect on the human body have always fascinated me.


Well-defined single polymer nanoparticles for the antibody-targeted delivery of chemotherapeutic agents

D. D. Lane,   D. Y. Chiu,  F. Y. Su,   S. Srinivasan,   H. B. Kern,   O. W. Press,   P. S. Stayton and   A. J. Convertine

Aqueous reversible addition-fragmentation chain transfer (RAFT) polymerization was employed to prepare a series of linear copolymers of N,N-dimethylacrylamide (DMA) and 2-hydroxyethylacrylamide (HEAm) with narrow Đ values over a molecular weight range spanning three orders of magnitude (103 to 106 Da). Trithiocarbonate-based RAFT chain transfer agents (CTAs) were grafted onto these scaffolds using carbodiimide chemistry catalyzed with DMAP. The resultant graft chain transfer agent (gCTA) was subsequently employed to synthesize polymeric brushes with a number of important vinyl monomer classes including acrylamido, methacrylamido, and methacrylate. Brush polymerization kinetics were evaluated for the aqueous RAFT polymerization of DMA from a 10 arm gCTA. Polymeric brushes containing hydroxyl functionality were further functionalized in order to prepare 2nd generation gCTAs which were subsequently employed to prepare polymers with a brushed-brush architecture with molecular weights in excess of 106 Da. The resultant single particle nanoparticles (SNPs) were employed as drug delivery vehicles for the anthracycline-based drug doxorubicin via copolymerization of DMA with a protected carbazate monomer (bocSMA). Cell-specific targeting functionality was also introduced via copolymerization with a biotin-functional monomer (bioHEMA). Drug release of the hydrazone linked doxorubicin was evaluated as function of pH and serum and chemotherapeutic activity was evaluated in SKOV3 ovarian cancer cells.


Cyrille Boyer is a guest web-writer for Polymer Chemistry. He is currently an associate professor and an ARC-Future Fellow in the School of Chemical Engineering, University of New South Wales (Australia), deputy director of the Australian Centre for NanoMedicine and member of Centre for Advanced Macromolecular Design.


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