2018 Polymer Chemistry Lectureship awarded to Cyrille Boyer

It is with great pleasure that we announce Prof Cyrille Boyer (University of New South Wales) as the recipient of the 2018 Polymer Chemistry Lectureship.

This award, now in its fourth year, honours an early-career researcher who has made significant contribution to the polymer chemistry field. The recipient is selected by the Polymer Chemistry Editorial Board from a list of candidates nominated by the community.

Read on to find out more about Cyrille…
Professor Cyrille Boyer
Cyrille received his PhD in polymer chemistry from the University of Montpellier II (Ecole Nationale Superieure de Chimie de Montpellier) and he is currently Professor at the School of Chemical Engineering, University of New South Wales (UNSW), co-Director of Australian Centre for NanoMedicine and a member of the Centre for Advanced Macromolecular Design (CAMD).

He has received a number of awards such as the Malcolm McIntosh Prize for Physical Scientist of the year 2015, the 2016 LeFevre Memorial Prize, 2016 ACS Biomacromolecules/Macromolecules Award, the 2016 Journal of Polymer Science Innovation Award and the 2018 Polymer International – IUPAC Award.

Cyrille has published over 200 articles and his research interests mainly cover the use of photoredox catalysts to perform controlled/living radical polymerization and polymer post-modification, the synthesis of polymeric nanoparticles for drug delivery (antimicrobial polymers) and hybrid organic–inorganic nanoparticles for imaging and energy storage. In the last few years, his team has pioneered photoinduced electron/energy transfer reversible addition fragmentation chain transfer polymerization (PET-RAFT) for the synthesis of functional polymers.

To learn more about Cyrille’s research have a look at some of his publications in Polymer Chemistry

The effects of polymer topology and chain length on the antimicrobial activity and hemocompatibility of amphiphilic ternary copolymers
Rashin Namivandi-Zangeneh, Rebecca J Kwan, Thuy-Khanh Nguyen, Jonathan Yeow, Frances L Byrne, Stefan H Oehlers, Edgar HH Wong, Cyrille Boyer
Polym. Chem., 2018, Advance Article
DOI: 10.1039/C7PY01069A

Temperature programed photo-induced RAFT polymerization of stereo-block copolymers of poly(vinyl acetate)
Na Li,  Dongdong Ding,  Xiangqiang Pan,  Zhengbiao Zhang,  Jian Zhu,  Cyrille Boyer  and  Xiulin Zhu
Polym. Chem., 2017,8, 6024-6027
DOI: 10.1039/C7PY01531C

Oxygen tolerant photopolymerization for ultralow volumes
Jonathan Yeow,  Robert Chapman,  Jiangtao Xua  and  Cyrille Boyer
Polym. Chem., 2017,8, 5012-5022
DOI: 10.1039/C7PY00007C

RAFT-mediated, visible light-initiated single unit monomer insertion and its application in the synthesis of sequence-defined polymers
Changkui Fu,   Zixuan Huang,   Craig J. Hawker,   Graeme Moad,   Jiangtao Xu  and   Cyrille Boyer
Polym. Chem., 2017,8, 4637-4643
DOI: 10.1039/C7PY00713B

Application of oxygen tolerant PET-RAFT to polymerization-induced self-assembly
Gervase Ng,   Jonathan Yeow,   Jiangtao Xu   and Cyrille Boyer
Polym. Chem., 2017,8, 2841-2851
DOI: 10.1039/C7PY00442G

We would like to thank everybody who nominated a candidate for the 2018 Polymer Chemistry Lectureship. The Editorial Board had a very difficult task in choosing a winner from the many excellent and worthy candidates.

Please join us in congratulating Cyrille on winning this award!

 

 

 

 

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Paper of the month: Surface-attached poly(phosphoester)-hydrogels with benzophenone groups

Becker et al. report surface-attached poly(phosphoester) which form surface-attached polymer networks and hydrogels.

The undesired adsorption of bacteria, proteins and other biomolecules on surfaces of biomedical devices often triggers the formation of biofilms causing severe systemic infections. In order to circumvent this, functional polymeric coatings with antifouling and/or antimicrobial properties are typically used. Towards this direction, Wurm, Lienkamp and co-workers developed photo-reactive poly(phosphoester)s (PPEs) which form surface-attached polymer networks and hydrogels. To achieve this, a benzophenone-functionalized cyclic phosphate monomer was synthesized and subsequently copolymerized with ethylene ethyl phosphate (EEP) yielding hydrophilic functional polymers. Upon terpolymerization with additional comonomers polymeric materials with pentyl (PEP), furfuryl (FEP) or butenyl (BuEP) pendants groups were obtained. Importantly, all polymerizations were well-controlled with good agreement between theoretical and experimental molecular weights and low dispersity values. The copolymerization kinetics were carefully monitored via real-time 31P nuclear magnetic resonance spectroscopy indicating a gradient-like structure. The cross-linked surface attached PPE networks were then formed by spin-coating these polymers onto pre-functionalized substrates followed by UV irradiation. Importantly, the layer thickness could be varied between 56 and 263 nm and was dependant on the applied polymer and the hydrophilicity of the substrates. Atomic force microscopy was also employed to further characterize these materials showing a homogeneous and smooth morphology with static contact angles of 20-26° (for specific networks) and revealing hydrophilic surfaces. Given the biocompatible nature of PPEs, these networks can potentially be promising anti-fouling coatings candidates for biomedical devices such as implants or catheters. In addition, initial functionalization of the substrates using furane-containing PPE-coatings demonstrated that additional modifications can be performed therefore paving the way for more complex surface architectures.

Surface-attached poly(phosphoester)-hydrogels with benzophenone groups

Tips/comments directly from the authors:  

  1. Synthesis of PPEs must be conducted under strict exclusion of moisture.
  2. The resulting copolymers are extremely hydrophilic. Thus, care must be taken to immediately cross-link them after spin-coating, or else they will de-wet from the surface.

Surface-attached poly(phosphoester)-hydrogels with benzophenone groups, Polym. Chem., 2018, 9, 315-326, DOI: 10.1039/c7py01777d

 

About the webwriter
Athina
Dr. Athina Anastasaki is a Web Writer for Polymer Chemistry. She is currently a Global Marie Curie Fellow working alongside Professor Craig Hawker at the University of California, Santa Barbara (UCSB). Please, visit this site for more information.

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Paper of the month: The power of the ring: a pH-responsive hydrophobic epoxide monomer for superior micelle stability

Song et al. report a novel hydrophobic pH-responsive epoxide monomer that exhibits enhanced micelle stability.

Paper of the month DecemberPolymeric amphiphiles can find use in a wide range of applications including detergents, catalysts and drug delivery vehicles. However, new polymeric biocompatible micelles with increased stability, loading efficiency and degradability are still required to address related challenges in the drug delivery field. To this end, Kim and co-workers designed and synthesized a novel epoxide monomer namely tetrahydropyranyl glycidyl ether (TGE). A series of amphiphilic diblock co-polymers were subsequently synthesized with PTGE consisting of a hydrophobic pH-responsive block with poly ethylene glycol (PEG) being the hydrophilic part. These PEG-b-PTGE diblock copolymers showed superior stability in biological media, higher loading capacity, tunable release and controllable degradation when compared to the acrylic analogue 1-ethoxyethyl glycidyl ether (EEGE). The enhanced stability and tunability of the PTGE block were attributed to the increased hydrophophicity and the tight association between the chair conformations of the cyclic TGE side chains. All diblock copolymers exhibited low dispersity values and controlled molecular weights. The high stability of these micelles in combination with their high biocompatibility highlight their potential to be used in drug delivery. In summary, the developed new class of monomers and polymers will contribute to the advanced of polyethers as promising candidates for biomedical applications and beyond.

Tips/comments directly from the authors:  

  1. The synthesis of the TGE monomer is a very simple, one-step procedure, but the moisture should be strictly controlled during the synthesis. The residual water can result in byproduct, thus lowering the yield after purification.

  2. The polymerization using organic superbase t-BuP4 is a very simple and reliable method; however, the t-BuP4 must be handled and stored carefully by removing the moisture. Otherwise, it may cause a lower degree of polymerization than targeted one and self-initiation process. Thus, any source for moisture should be carefully removed in solvent, initiator and monomer.

The power of the ring: a pH-responsive hydrophobic epoxide monomer for superior micelle stability, Polym. Chem., 2017, 8, 7119-7132, DOI: 10.1039/c7py01613a

About the webwriter
Athina

Dr. Athina Anastasaki is a Web Writer for Polymer Chemistry. She is currently a Global Marie Curie Fellow working alongside Professor Craig Hawker at the University of California, Santa Barbara (UCSB). Please visit this site for more information.

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Paper of the month: Dual stimuli responsive self-healing and malleable materials based on dynamic thiol-Michael chemistry

Chakma et al. exploit dynamic thiol-Michael chemistry to prepare dual responsive self-healing and malleable materials.

Dynamically crosslinked polymeric materials have received significant attention owing to their unique characteristics including the introduction of mechanical properties and the possibility to extend a material’s lifetime. These materials can typically find use in a wide range of applications such as coatings and elastomers. Konkolewicz and co-workers significantly contributed towards this direction by developing a facile synthesis of dynamic materials with thiol-maleimide based adducts. Maleimides are of particular importance as they consist of a highly reactive vinyl group for thiol-Michael addition reactions and typically demonstrate very high yields under mild conditions. To synthesize such materials, a thiol-maleimide cross linker (2-((1-(2-(acryloyloxy)ethyl)-2,5-dioxopyrrolidin-3-yl)thio)ethylacrylate) was initially synthesized and subsequently incorporated into a polymer matrix of hydroxyethyl acrylate. The properties of the elastomeric materials were then carefully evaluated by tensile testing, creep recovery, swelling studies, differential scanning calorimetry and rheological experiments. It was found that these polymeric materials showed dynamic behaviours like self-healing and malleability at elevated pH values and temperatures. In addition, these materials possess significant healing properties and are mechanically stable towards creep deformation at room temperature and pressure. Their stimuli responsive self-healing, elastic, malleable and mechanically stable nature in combination with the facile nature of the synthesis paves the way for potential utilization in different applications that require enhanced properties and functions.

Dual stimuli responsive self-healing and malleable materials based on dynamic thiol-Michael chemistry

Tips/comments directly from the authors:

1. The synthetic techniques used to make the thiol-Michael based crosslinker (TMMDA) are very simple, but extra care should be given to store the crosslinker in the refrigerator or freezer. Storing the crosslinker at room temperature may result in background polymerization and eventually lead to loss of the crosslinker.

2. Although conventional free radical polymerization was used as a tool for polymerization, other polymerization techniques can be used as well. Although, reactivity of the thiol moiety has to be considered in that case.

3. Self-healing polymers are commonly responsive to single stimulus (e.g. temperature responsive Diels-Alder based polymer or light responsive disulfide polymer). TMMDA crosslinked materials developed in this paper have self-healing properties with both temperature and pH stimulus, giving them enhanced functionality and responsive character.

4. Dynamic materials synthesized in this article, based on the thiol-Michael reaction, showed malleability or reshape ability in response to both elevated temperature and pH. As a result, materials can be re-shaped into new configurations upon application of stimuli.

5. The thiol-Michael adducts are essentially static in the absence of thermal and pH stimulus, making the materials mechanically stable and creep resistant under ambient conditions.

 

Dual stimuli responsive self-healing and malleable materials based on dynamic thiol-Michael chemistry, Polym. Chem., 2017, 8, 6534-6543, DOI: 10.1039/C7PY01356F

 

About the webwriter

Dr. Athina Anastasaki is a Web Writer for Polymer Chemistry. She is currently a Global Marie Curie Fellow working alongside Professor Craig Hawker at the University of California, Santa Barbara (UCSB). Please, visit this link for more information.
Athina

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2018 Polymer Chemistry Lectureship is now open for nominations!

Do you know an early-career researcher who deserves recognition for their contribution to the polymer chemistry field?

Now is your chance to put them forward for the accolade they deserve.

Polymer Chemistry is pleased to announce that nominations are now being accepted for its 2018 Lectureship award. This annual award was established in 2015 to honour an early-stage career scientist who has made a significant contribution to the polymer chemistry field.

Previous winners

2017 – Julien Nicolas, Université Paris Sud, France

2016 – Feihe HuangZhejiang University, China

2015 – Richard HoogenboomGhent University, Belgium

Qualification

To be eligible for the Polymer Chemistry Lectureship, the candidate should be in the earlier stages of their scientific career, typically within 15 years of attaining their doctorate or equivalent degree, and will have made a significant contribution to the field.

Description

The recipient of the award will be asked to present a lecture at the Macro18 World Polymer Congress in Cairns, Australia, where they will also be presented with the award. The Polymer Chemistry Editorial Office will provide financial support to the recipient for travel and accommodation costs.

The recipient will also be asked to contribute a lead article to the journal and will have their work showcased free of charge on the front cover of the issue in which their article is published.

Selection

The recipient of the award will be selected and endorsed by the Polymer Chemistry Editorial Board.

Nominations

Those wishing to make a nomination should send details of the nominee, including a brief C.V. and a letter supporting the nomination, to the Polymer Chemistry Editorial Office by 15thJanuary 2018. Self-nomination is not permitted.

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Paper of the month: Polymer synthesis by mimicking nature’s strategy: the combination of ultra-fast RAFT and the Biginelli reaction

Wu et al. report the combination of ultra-fast RAFT and Biginelli reaction to prepare a large polymer library.

Nature is capable of synthesizing an unlimited number of biomacromolecules (e.g. proteins) with remarkable structures and functions by simply starting from only 20 amino acids. This process lies in the precise sequence-controlled polymerization of amino acids to control the primary structures of polypeptide precursors, followed by a highly efficient post-translation modification in order to define these structures.

Polymer synthesis by mimicking nature’s strategy

Inspired by nature’s strategy to synthesize proteins, Tao and co-workers developed a two-stage method to synthesize a large number of polymers with precisely controlled structures, different functionalities and various molecular diversities. Key to their strategy is the combination of controlled radical polymerization and post-polymerization modification. Specifically, reversible addition-fragmentation chain transfer (RAFT) polymerization was utilized to synthesize the polymer precursors starting from only 3 acrylamide monomers. By repeating the polymerization with different monomer sequences, 6 triblock copolymers with controlled chain ends, molecular weights and molar mass distributions were obtained. The different polarity of all synthesized precursors was then confirmed by reverse-phase high performance liquid chromatography (HPLC). The triblock copolymers were subsequently modified via the Biginelli reaction to rapidly generate 60 derivatives in a high-throughput (HPT) manner. HTP analyses was also conducted as an efficient and quick way to verify specific functionalities (e.g. radical scavengers, metal chelating agents, etc.).

In summary, the authors presented an efficient strategy to prepare and characterize large libraries of polymers with diverse structures and functions.

Tips/comments directly from the authors:

1. For the Biginelli reaction, acetic acid/MgCl2 is an efficient solvent/catalyst system to smoothly get the targeted compounds. However, this system is not as efficient for aliphatic aldehydes. Fortunately, the Biginelli reaction has been studied for more than 100 years and as such, many other solvent/catalyst systems have been established in this time. Thus, people can choose different conditions to perform the Biginelli reaction for the post-polymerization modification depending on the specific requirements and applications.

2. For the high throughput analysis of radical scavengers, the oxygen in the air might also quench the radical, and the radical colour was found to fade faster in summer than in winter. Thus, the use of fresh reagents and careful recording of the temperature is recommended.

3. The ultra-fast RAFT was used in the present work as a model polymerization to prepare copolymers. The authors believe other advanced controlled radical polymerization techniques (SET-ATRP, photo-induced CRPs, sulfur-free RAFT, etc.) can also be used to prepare multiblock copolymers, especially when thermo-sensitive monomers are used.

Polymer synthesis by mimicking nature’s strategy: the combination of ultra-fast RAFT and the Biginelli reaction, Polym. Chem., 2017, 8, 5679-5687, DOI: 10.1039/c7py01313b

 

About the webwriter
Athina

Dr. Athina Anastasaki is a Web Writer for Polymer Chemistry. She is currently a Global Marie Curie Fellow working alongside Professor Craig Hawker at the University of California, Santa Barbara (UCSB). Please visit this link for more information.

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Paper of the month: Sequence-coded ATRP macroinitiators

Telitel et al. report the synthesis of sequence-coded ATRP macroinitiators followed by a controlled polymerization

The development of strategies that allow the translation of the precise monomer sequence control achieved in nature over macromolecular structure (e.g. DNA) to whole synthetic systems is an exciting field in current polymer science. In particular, the fabrication of sequence-defined polymers paves the way for a diverse range of applications. For example, these macromolecules can be used to store monomer-coded information. Lutz and his team has pioneered this field and recently described the synthesis of digitally-encoded polyurethanes using an orthogonal solid-phase iterative approach. This class of materials is particularly interesting thanks to their unique physicochemical properties and straightforward sequencing by tandem mass spectrometry.

Sequence-coded ATRP macroinitiators

In the current contribution, Lutz and co-workers expand the application pool of these materials by covalently linking sequence-coded oligomers to other synthetic polymers. Sequence-coded oligourethanes were initially synthesized by orthogonal solid phase iterative chemistry on a modified Wang resin. While still attached to the solid support, the ω-OH-termini of the oligourethanes were transformed into atom transfer radical polymerization (ATRP) initiators by esterification with α-bromoisobutyryl bromide. Then, the oligomers were detached from the solid support and their cleaved α -COOH-termini were esterified with ethanol yielding monodisperse ATRP macro initiators. Upon polymerization of styrene from these precise oligomers, well-defined blocky architectures were obtained containing sequence-coded oligourethane segments. The polymerization was well-controlled, yielding materials with narrow molecular mass distributions and good agreement between theoretical and experimental molecular weights. Importantly, for a given macroinitiator length, the coded sequence of oligourethane had no influence on the ATRP process. Overall, these exciting results open up interesting perspectives for the development of plastic materials containing sequence-coded traceability barcodes.

Tips/comments directly from the authors:

  1. Sequence-coded oligourethanes have an interesting tendency to crystallize, which is currently under investigation. Consequently, these oligomers are usually relatively easy to characterize in solution directly after their synthesis but may become less soluble in standard solvents with time and storage.
  2. As mentioned in the communication, the tendency toward self-organization of the oligourethanes might influence their macroinitiator behavior. The preliminary results shown in this communication indicate that a controlled radical polymerization behavior is attainable with these macroinitiators. However, a deeper understanding of the initiation step is probably mandatory.
  3. The atom transfer radical polymerization of styrene was chosen as a simple polymerization model in the present work. Nevertheless, other controlled radical polymerization techniques might, of course, be considered for preparing such materials.

Sequence-coded ATRP macroinitiators Polym. Chem., 2017, 8, 4988-4991, DOI: 10.1039/C7PY00496F

 

About the webwriter

Athina Anastasaki

Dr. Athina Anastasaki is a Web Writer for Polymer Chemistry. She is currently a Global Marie Curie Fellow working alongside Professor Craig Hawker at the University of California, Santa Barbara (UCSB). Please, visit this link for more information.

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Photopolymerization Fundamentals 2017 Poster Prize Winner

Congratulations to Abishek Shete, who was awarded the Polymer Chemistry Best Poster Award at Photopolymerization Fundamentals 2017, in Boulder, Colorado, USA. Abishek is currently carrying out research in the CJK Polymer Research group at the University of Delaware.

In addition, due to the high number of exellent poster presentations, three candidates were given honourable mentions;

  • Dillon Love, University of Colorado,
  • Hanns Houck, Karlsruhe Institute of Technology, Ghent University, Queensland University of Technology,
  • Camila Uzcategui, University of Colorado.

Congratulations to all winners!

 

Polymer Chemistry Poster Prize Winners Photopolymerization Fundamentals 2017

Left to right: Christopher Barner-Kowollik (Editor in Chief of Polymer Chemistry), Abishek Shete, (Main Poster Prize Winner) Dillon Love, (Honorable Mention) Hanns Houck, (Honorable Mention) Camila Uzcategui, (Honorable Mention) Christopher Bowman (Chair of the 2017 Photopolymerization Fundamentals Conference)

 

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Paper of the month: Block co-polyMOFs: assembly of polymer-polyMOF hybrids via iterative exponential growth and “click” chemistry

MacLeod and Johnson report the synthesis of block co-polyMOFs via a combination of iterative exponential growth and copper “click” chemistry

Block copolymer (BCP) assemblies are derived from covalently linked polymer chains and can undergo phase separation and thus find use in a wide range of applications including micropatterning, battery and electronic technologies. Metal-organic frameworks (MOFs) are another class of self-assembled matter consisting of crystalline networks with angstrom-scale order and permanent porosity. Owing to these advantageous properties, they can enable functions such as gas, energy storage, catalysis and selective-separation.

 

In the Johnson group, impressive efforts have been made to merge amorphous polymer networks with multi-component supramolecular assembly to generate soft materials with novel properties. In their current contribution, the group expands these types of hybrid materials by reporting a novel BCP where one block is a uniform benzene dicarboxylate (BDC)-based oligomer synthesized by iterative exponential growth (IEG), and the other is polystyrene (PS) prepared by atom transfer radical polymerization (ATRP). In order to achieve this, the authors initially synthesized the BDC-based oligomer with a defined end-functionality bearing an alkyne group that would allow for further diversification. This alkyne group was subsequently used to couple to azide-terminated polystyrene. In the presence of Zn ions, this BCP forms a “block co-polyMOF” (BCPMOF) material comprised of polyMOF domains embedded in a PS matrix.

The presented work is the first demonstration that it is possible to generate a crystalline polyMOF-amorphous polymer hybrid material from a single diblock copolymer. As such, BCPMOFs represent a new composite material that possesses the processability of the polymers while exhibiting enhanced stability towards ambient conditions when compared to the isolated MOFs. The ultimate goal of the group is to obtain BCPMOFs with robust mechanical properties, high surface areas, and tunable, well-defined domain sizes.

 

Tips/comments directly from the authors:

  1. In the synthesis of the mono benzylated diethyl 2,5-dihydroxyterephthalate, A, UV absorbance can readily distinguish the starting material from the product. The starting material elutes before the product and can be isolated for reuse.
  2. As noted in the supporting information, side products can occur during the coupling reaction to form L1. It is critical that ethanol is used to maintain the ethyl ester.
  3. The coupling reactions tend to require longer reaction times as the molecular weight of the reactants grows. Upon scaling up of the reactions, do not be temped to increase the concentration too much as it can lead to side product formation.
  4. The same synthetic protocols were used to form polyMOFs and block co-polyMOFs: 2.5 eq Zn(II) per BDC unit in Ln, was combined with Ln(PS) in DMF, heated at 100°C for 24h, followed by DMF washings to remove excess Zn(II) and unreacted ligand. Unlike the purification and isolation of L2 and L4, special care was taken for L4PS-Zn to use minimal organic solvent due to the solubility imparted by polystyrene.

 

Block co-polyMOFs: assembly of polymer-polyMOF hybrids via iterative exponential growth and “click” chemistry
Polym. Chem., 2017, 8, 4488-4493, DOI: 10.1039/c7py00922d

 

About the web writer


Dr. Athina Anastasaki is a web writer for Polymer Chemistry. She is currently a Global Marie Curie Fellow working alongside Professor Craig Hawker at the University of California, Santa Barbara (UCSB). Please visit this website for more information.

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Focus on: Antimicrobial polymers

Antimicrobial agents kill or inhibit the growth of microorganisms, and can be sub-divided into several classes depending on the type of microorganism they target. Sub-divisions include, antibacterial, antifungal, antiviral and antiparasitic agents. In particular, antibacterial agents are incredibly important worldwide, with the emergence of multi-drug resistant bacteria. Antibiotic-resistant infections are becoming an increased health and economic burden on society. As such the development of new antibacterials continues to be paramount to limiting the spread of multi-drug resistant bacteria.

This month we focus on three articles published in Polymer Chemistry which have reported the use of antimicrobial polymers. In each case the polymers reported have antibacterial properties, and in one article polymers were also investigated for their antifungal properties.

 

 

1. Cationic peptidopolysaccharides synthesized by ‘click’ chemistry with enhanced broad-spectrum antimicrobial activities
Yajuan Su, Liang Tian, Meng Yu, Qiang Gao, Dehui Wang, Yuewei Xi, Peng Yang, Bo Lei, Peter X. Ma, Peng Li
Polym. Chem., 2017, 8, 3788-3800; DOI: 10.1039/C7PY00528H

Cationic peptidopolysaccharides were prepared through the grafting of ε-poly-L-lysine (EPL) to a chitosan (CS) backbone by thiol-ene “click” chemistry. The resulting CS-g-EPL polymers were assessed for their antimicrobial activity against Gram negative bacteria, Gram positive bacteria and fungi, which showed broad-spectrum antimicrobial activity. In addition the hemolytic activity of the polymers was determined, and the lead candidate was further investigated for it’s biocompatability.

2. Astaxanthin-based polymers as new antimicrobial compounds
S. Weintraub, T. Shpigel, L. G. Harris, R. Schuster, E. C. Lewis, D. Y. Lewitus
Polym. Chem., 2017, 8, 4182-4189; DOI: 10.1039/C7PY00663B

Astaxanthin (ATX) is an organic pigment produced by fungi and algae, possessing various therapeutic properties. Polyesters were prepared using carbodiimide-mediated coupling of ATX, which is a diol, with alkyl- and PEG-diacids. The diacid used influenced the resulting physico–chemical–mechanical properties of the polymers. Antibacterial activity was observed against three strains of bacteria, including MRSA, and the materials were found to be non-toxic in an in vivo wound healing model.

3. Bio-inspired peptide decorated dendrimers for a robust antibacterial coating on hydroxyapatite
Yaping Gou, Xiao Yang, Libang He, Xinyuan Xu, Yanpeng Liu, Yuebo Liu, Yuan Gao, Qin Huang, Kunneng Liang, Chunmei Ding, Jiyao Li, Changsheng Zhao, Jianshu Li
Polym. Chem., 2017, 8, 4264-4279; DOI: 10.1039/C7PY00811B

The authors report the use of a salivary statherin protein inspired dendrimer, for use as an antibacterial coating for implanted biomaterials. A peptide sequence was coupled to the surface of a G4 PAMAM dendrimer, by Michael addition. The materials showed adsorption to hydroxyapatite surfaces with sufficient binding strength to survive washing. The adsorbed dendrimers endowed antimicrobial properties observed by an inhibition of biofilm formation and through in vivo experiments.

 

Read these articles for free until September 10th


About the webwriterFiona Hatton

Dr. Fiona Hatton is a web writer for Polymer Chemistry. She is currently a postdoctoral researcher in the Armes group at the University of Sheffield, UK. Find her on Twitter: @fi_hat

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