Enzymatic cascade reactions in biosynthesis on the cover of NPR issue 3, 2012

Welcome to NPR issue 3, 2012!

This month’s cover features the work of Kurt Faber et al. at the University of Graz, Austria, with a review on the enzyme-initiated cascade reactions for the ring formation of cyclic terpenoids and polyethers. The authors provide a mechanistic analysis of enzymatic cascade reactions leading to biomimetic strategies for natural product synthesis. 

Also in the issue, read Clay C. C. Wang‘s review article on the  impact of whole genome sequencing on Aspergillus secondary metabolite research:

Pedro N. Leão and coworkers provide insights into the chemical ecology of cyanobacteria, highlighting both evolutionary and chemotaxonomical studies:

Qingsong Liu et al. review the history of several classes of natural products as kinase inhibitors, analyzing their structural binding information and highlighting their therapeutic development potential:

Why not also read on the didemnin family of marine depsipeptides in this review article by Madeleine M. Joullié et al..  The authors highlight the long-standing study of didemnins and its critical application towards the understanding of the molecular mechanism of action of tamandarins and their potential use as therapeutic agents:

 We hope that you enjoy this issue!

View the issue

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Natural Products in OBC

Read the latest Natural Product chemistry published in our sister journal OBC…

Organic & Biomolecular Chemistry, our sister journal, publishes many articles that cover natural product chemistry.

We will try to keep you updated, although the safest bet is for you to sign up to OBC’s e-alert (free service) and receive the table of content directly in your inbox every time an issue is published.

The latest natural products’ related articles from OBC issue 9 have been collated here:

Studies of the H–D exchange mechanism of malonganenone B
Peter G. K. Clark, Matthias Lein and Robert A. Keyzers

Unexpected enzyme-catalyzed regioselective acylation of flavonoid aglycones and rapid product screening
Eleni Kyriakou, Alexandra Primikyri, Pantelis Charisiadis, Maria Katsoura, Ioannis P. Gerothanassis, Haralambos Stamatis and Andreas G. Tzakos

Total synthesis of a cuticular hydrocarbon from the cane beetle Antitrogus parvulus: confirmation of the relative stereochemistry
Norazah B. Basar, Hao Liu, Devendra Negi, Hasnah M. Sirat, Gareth A. Morris and Eric J. Thomas

An iterative Shimizu non-aldol approach for the stereoselective synthesis of C13-C22 fragment of callystatin A
Sandip A. Pujari and Krishna P. Kaliappan

Organocatalytic stereoselective synthesis of passifloricin A
Pradeep Kumar, Menaka Pandey, Priti Gupta and Dilip D. Dhavale

Stereocontrolled asymmetric synthesis of syn-E-1,4-diol-2-enes using allyl boronates and its application in the total synthesis of solandelactone F
Anna Robinson and Varinder K. Aggarwal

Enantioselective synthesis of the carbocyclic nucleoside (−)-abacavir
Grant A. Boyle, Christopher D. Edlin, Yongfeng Li, Dennis C. Liotta, Garreth L. Morgans and Chitalu C. Musonda


 

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Building a nation of scientists

Goverdhan MehtaGoverdhan Mehta talks to Sheena Elliott and Elinor Richards about the progress of science in India and the challenges scientists face

Goverdhan Mehta is a researcher, specialising in organic synthesis. He has helped to build institutions in India – the Indian Institute of Technology, Kanpur, the University of Hyderabad, and the Indian Institute of Science, Bangalore. He was director of the Indian Institute of Science (1998-2005) and vice chancellor of the University of Hyderabad (1994-1998).

Your research is focused on organic chemistry. What attracted you to that field?

There is something intrinsically fascinating about organic chemistry. In my early high school years, when I was exposed to interesting chemical structures, I was attracted to them. I had a sense of appreciation for art and organic molecules to me provided a wonderful expression of art at a molecular level.

What are your main achievements in the field?

I have worked in many areas of organic chemistry, but it’s synthesis that’s given me the greatest pleasure. As organic chemistry advanced, different contemporary challenges came to my attention. The main driver for me to pursue those challenges was the intricacy of the target structure synthesis. There was also an element of expectation that perhaps our research might become useful to society. We continue to need new drugs for a variety of disorders, so we synthesised a large number of natural products; many of them are biologically active and it is quite possible that some of them can provide leads for new drug discovery.

Over the last few years, I have become interested in how to address a problem that the ageing population is facing – neurodegeneration. It has been shown that some natural products can slow down neurodegeneration. In some cases, there is also an indication that they can help restore lost cognitive function. So I have been working on the synthesis of such lead molecules. As I’m getting older, I recognise the need for doing something in that area!

You’ve won numerous awards. Which achievements are you most proud of?

I don’t think that awards and recognition have necessarily brought me a great sense of joy. They do bring a sense of satisfaction because your peers have recognised your work. But I don’t think any serious researcher works for awards. It is the sheer joy of research that keeps people going. Recognition has come my way, but don’t think that I can equate that with the joy of doing research.

What are the challenges facing scientists in India and how could these be overcome?

Scientists all over the world are facing challenges on two fronts. The first problem is that scientists are not being supported by society as much as they should and some governments are not always forthcoming in terms of providing budgetary support. The second problem is that scientists, and science in general, have become isolated both in terms of discipline and, to some extent, in terms of geographical location. This is being redressed now with increasing international collaborations, so in the geographical sense, the isolation is being reduced. But I think disciplinary isolation vis a vis other knowledge streams and fragmentation of science is still a serious challenge.

It is a good time for scientists in India because the government is very supportive of science. Funding is no longer as serious a problem as it is in other parts of the world. Recently, our prime minister said that the budget for science will be almost doubled over the next few years. But I’m not too sure that we as a scientific community are steering science in India in the direction that it ought to be heading. I believe that the government and the scientific community must set a goal that in the next 10 years, India will be among the world’s leading scientific countries.

What is your opinion on the perception that Indian science and research is falling behind the rest of the world, following recent comments by Prime Minister Manmohan Singh?

Prime Minister Singh’s statement referred mainly to China. China has made more progress in science and technology than India. Scientific productivity in India has increased, but not as much as in China. Since we are behind, to simply say that we are walking and walking well is not enough. We should be galloping to catch up. My judgement is that our progress is not commensurate with the support that the government is providing, and not commensurate with the capacity, capability, enthusiasm and the vibrancy that our youth have. We can achieve much more.

How do the different industries compare (the pharmaceutical industry in particular or the more general chemical industry)?

It is only over the last 10 or 12 years, since the economic reforms, that industry in India has grown at such a rate so as to be in a position to invest in research and development. I expect that investment by industry is going to rise; however, the current level of investment is not in an acceptable range. There are certain sectors – pharma, for example – and some other chemical industries, where I think India’s potential is immense, but there are some challenges with the policies that are being pursued. We have to devise a well thought out strategy.

The prime minister’s Science Advisory Council reported that there is an absence of any Indian universities among the world’s best. What is your opinion on the quality of universities in India?

I’m not a great believer in the ranking systems being followed, but the fact is that no Indian university features among the top few hundred universities. However, if we were to look at undergraduate teaching, India has institutions that produce graduates through excellent teaching and training. The graduates are probably as good as they are anywhere else in the world. If you were to grade an institution on the quality of undergraduates, I would say that the Indian Institutes of Technology rank among the top 10 institutions in the world. But, if you bring in research and other elements, they will not feature anywhere near the top. So the quality of research is a serious problem. I think it is high time that the scientific community and scientific leadership in our country sort out an effective, implementable strategy to make a major shift.

You experienced difficulty obtaining a visa to travel to the US in 2006, when you were invited to give a lecture at the University of Florida. At the time, a report from the National Academy of Sciences in the US said that at least 3000 scientists had faced a similar problem. Have things improved since then or do you believe that the visa problem is hampering scientific progress and career development for scientists?

It was ironic that I and a leading scientist from the US, Jane Lubchenco (who at that time was president of the International Council for Science before I succeeded her), wrote an editorial about the principle of universatility of science and the visa regime in Science a few months before this happened. We wrote that it was important for the international growth of science that scientists were able to travel. Little did I realise that soon I would be a victim of this! I think the situation has improved, but a lot more needs to be done. While the US National Academy of Sciences is playing a very positive role towards this end, the academies can only do the advocacy. Eventually, it is the government and the state department of security staff that makes the final judgement.

If you have any spare time, how do you fill it?

For most scientists, and I’m no exception, your research is a hobby. What other profession can give you that pleasure and privilege? In a previous interview, I was asked what I would wish for. I said we Indians believe in rebirth and so the only wish I have is that if I were to be born again, I would be a scientist. I would like to be a chemist, hopefully a better one.

Read the original article and see Professor Mehta’s recent RSC published papers at Chemistry World

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Natural Products in OBC

Read the latest Natural Product chemistry published in our sister journal OBC…

Organic & Biomolecular Chemistry, our sister journal, publishes many articles that cover natural product chemistry.

We will try to keep you updated, although the safest bet is for you to sign up to OBC’s e-alert (free service) and receive the table of content directly in your inbox every time an issue is published.

The latest natural products’ related articles have been collated here:

  • Limonoids

Kv1.2 potassium channel inhibitors from Chukrasia tabularis
Hong-Bing Liu, Hua Zhang, Ping Li, Yan Wu, Zhao-Bing Gao and Jian-Min Yue
Org. Biomol. Chem., 2012, 10, 1448-1458
DOI: 10.1039/C1OB06666H, Paper

  • Fungal glycolipid

Fusaroside, a unique glycolipid from Fusarium sp., an endophytic fungus isolated from Melia azedarach
Sheng-Xiang Yang, Hong-Peng Wang, Jin-Ming Gao, Qiang Zhang, Hartmut Laatsch and Yi Kuang
Org. Biomol. Chem., 2012, 10, 819-824
DOI: 10.1039/C1OB06426F

  • Pancratistatin analogues

A formal [3+3]-annulation-based approach to pancratistatins: total synthesis of (±)-7-deoxy-pancratistatin and its 2-epi and 2,4-diepi analogues
Olaia Nieto-García, Hugo Lago-Santomé, Fernando Cagide-Fagín, Juan Carlos Ortiz-Lara and Ricardo Alonso
Org. Biomol. Chem., 2012, 10, 825-834
DOI: 10.1039/C1OB06374J, Paper

  •  Bromotyrosine natural products

Syntheses of pseudoceramines A–D and a new synthesis of spermatinamine, bromotyrosine natural products from marine sponges J. Mikael Hillgren, Christopher T. Öberg and Mikael Elofsson
Org. Biomol. Chem., 2012, 10, 1246-1254
DOI: 10.1039/C1OB06722B, Paper

  • Alkaloids synthesis

One-pot reductive coupling of N-acylcarbamates with activated alkenes: application to the asymmetric synthesis of pyrrolo[1,2-a]azepin-5-one ring system and (−)-xenovenine Xue-Kui Liu, Xiao Zheng, Yuan-Ping Ruan, Jie Ma and Pei-Qiang Huang
Org. Biomol. Chem., 2012, 10, 1275-1284
DOI: 10.1039/C1OB06697H, Paper

Want to see your natural products article featured on this blog? Submit it online here

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Top ten most accessed articles in November

This month sees the following articles in Natural Product Reports that are in the top ten most accessed:

Hot off the press
Robert A. Hill and Andrew Sutherland
Nat. Prod. Rep., 2011, 28, 1879-1882
DOI: 10.1039/C1NP90043A

Pathways for degradation of lignin in bacteria and fungi
Timothy D. H. Bugg, Mark Ahmad, Elizabeth M. Hardiman and Rahman Rahmanpour
Nat. Prod. Rep., 2011, 28, 1883-1896
DOI: 10.1039/C1NP00042J

Aminobenzoates as building blocks for natural product assembly lines
Christopher T. Walsh, Stuart W. Haynes and Brian D. Ames
Nat. Prod. Rep., 2012, 29, 37-59
DOI: 10.1039/C1NP00072A

Marine natural products
John W. Blunt, Brent R. Copp, Murray H. G. Munro, Peter T. Northcote and Michèle R. Prinsep
Nat. Prod. Rep., 2011, 28, 196-268
DOI: 10.1039/C005001F

Natural products and Pharma 2011: Strategic changes spur new opportunities
Guy T. Carter
Nat. Prod. Rep., 2011, 28, 1783-1789
DOI: 10.1039/C1NP00033K

Isoprenoids in three-dimensional space: the stereochemistry of terpene biosynthesis
Jeroen S. Dickschat
Nat. Prod. Rep., 2011, 28, 1917-1936
DOI: 10.1039/C1NP00063B

Sesquiterpene synthases: Passive catalysts or active players?
David J. Miller and Rudolf K. Allemann
Nat. Prod. Rep., 2012, 29, 60-71
DOI: 10.1039/C1NP00060H

The diazofluorene antitumor antibiotics: Structural elucidation, biosynthetic, synthetic, and chemical biological studies
Seth B. Herzon and Christina M. Woo
Nat. Prod. Rep., 2012, 29, 87-118
DOI: 10.1039/C1NP00052G

Multitargeting by curcumin as revealed by molecular interaction studies
Subash C. Gupta, Sahdeo Prasad, Ji Hye Kim, Sridevi Patchva, Lauren J. Webb, Indira K. Priyadarsini and Bharat B. Aggarwal
Nat. Prod. Rep., 2011, 28, 1937-1955
DOI: 10.1039/C1NP00051A

Influenza neuraminidase: A druggable target for natural products
Ulrike Grienke, Michaela Schmidtke, Susanne von Grafenstein, Johannes Kirchmair, Klaus R. Liedl and Judith M. Rollinger
Nat. Prod. Rep., 2012, 29, 11-36
DOI: 10.1039/C1NP00053E

Why not take a look at the articles today and blog your thoughts and comments below.

Fancy submitting an article to Natural Product Reports? Then why not submit to us today or alternatively email us your suggestions.

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Dean Tantillo wins 2012 NPR Lecture Award

Dean TantilloWe are delighted to announce that Professor Dean Tantillo from the University of California, Davis (USA) is the winner of the 2011 NPR Lecture Award. Professor Tantillo was selected for his work in the field of enzymology.

“It is an honor to be chosen as the 2012 NPR lecturer,” Professor Tantillo commented on receiving the award. “My students at UC Davis have worked hard to show how theoretical chemistry can contribute to natural products research and I am delighted that a fantastic journal like NPR supports this growing part of the natural products community. Thanks!”

The conference at which the lecture will be delivered will be announced in due course.

The NPR Lecture Award is awarded to a researcher who has made a significant contribution to the field of natural products and who has also had some involvement with the journal. You can view Professor Tantillo’s recent article for NPR below:

Biosynthesis via carbocations: Theoretical studies on terpene formation
Dean J. Tantillo
Nat. Prod. Rep., 2011, 28, 1035-1053
DOI: 10.1039/C1NP00006C

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New additions to the macrocyclic bisbibenzyl family on the cover of NPR issue 2

Issue 2 of NPR is now online, including our regular Hot off the Press feature from Robert A. Hill and Andrew Sutherland and the latest marine natural products review from John Blunt et al.

The interesting cover article is from David Harrowven and Sarah Kostiuk, highlighting their review on the synthesis and stereochemistry of newly discovered macrocyclic bisbenzyl natural products, a group commonly, but not exclusively, found in the bryophyte plant family. The review provides at timely update to that by G. M. Keserű and M. Nógrádi in 1995.

The issue also includes a Highlight article from Paris Hamilton and Dev Arya on natural product DNA major groove binders, and reviews on the biosynthesis of 3-amino-5-hydroxybenzoic acid-derived NPs and angucyclines.

View the issue

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Meet the NPR team

The NPR team will be attending a number of conferences in 2012 and we would be delighted to meet you.

Dr Marie Cote, Deputy Editor

Dr Richard Kelly, Managing Editor


Here are just some of the conferences where you can meet us in the coming months:

Please let us know if you are planning on attending any of these meetings, as it would be lovely to meet you there!

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Influenza Neuroaminidase on the cover of NPR Issue 1, 2012

Welcome to NPR Issue 1, 2012

Looking back on 2011, we’d like to thank all our authors, readers and referees for what has been another very successful year for Natural Product Reports. A big thanks also goes to the NPR Editorial Board for their great support and enthusiasm.

Read the 2012 Editorial by NPR Chair Professor Bradley Moore and Editor Dr Richard Kelly reflecting on this year’s many highlights and catch a glimpse of what to look ahead to for a bright 2012!



On the cover of this first Issue is the work of Judith M. Rollinger et al., reviewing the increasing research efforts of the past decade on neuroaminidase (NA) for lead discovery strategies from nature, focusing on the structure, function and druggability of influenza NA, and its inhibition by natural products. This review will be free to access for the next 6 weeks.

Influenza neuraminidase: A druggable target for natural products
Ulrike Grienke, Michaela Schmidtke, Susanne von Grafenstein, Johannes Kirchmair, Klaus R. Liedl and Judith M. Rollinger
DOI: 10.1039/C1NP00053E

Also in this Issue, read:

     

    We hope you enjoy reading our first issue for this new volume of NPR and we wish you all the warmest Season’s Greetings.

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    Natural Products in OBC

    Read the latest Natural Product chemistry published in our sister journal OBC…

    Organic & Biomolecular Chemistry publishes many articles that cover natural product chemistry. We will try to keep you updated, although the safest bet is for you to sign up to OBC’s e-alert (free service) and receive the table of content directly in your inbox every time an issue is published.

    In OBC Issue 1, 2012 , you will find:

     

     

     

     

    Want to see your natural products article featured on this blog? Submit it online here.

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