Archive for the ‘Board News’ Category

Welcoming Dr Cassandra Quave to the NPR Editorial Board

Natural Product Reports is delighted to welcome Dr Cassandra L. Quave to the Editorial Board.

About Cassandra:

Dr Cassandra Quave is Curator of the Herbarium and Associate Professor of Dermatology and Human Health at Emory University, USA, where she leads natural product drug discovery research initiatives and teaches courses on medicinal plants, microbiology, and pharmacology. She obtained a B.Sc. in Biology and Anthropology (Emory University, 2000) and a Ph.D. in Biology (Florida International University, 2008).

Dr. Quave’s research is supported by the NIH, industry contracts, and philanthropy. She is a Fellow of the Explorers Club, a past President of the Society for Economic Botany, a recipient of the Emory Williams Teaching Award and Charles Heiser, Jr. Mentor Award. She is the host of Foodie Pharmacology, a podcast dedicated to exploring the links between food and medicine. Dr Quave has authored more than 100 scientific publications, two edited books, and seven patents. Her research has been the subject of feature profiles in the New York Times Magazine, BBC Science Focus, National Geographic Magazine, Brigitte Magazin, NPR, PBS, and the National Geographic Channel. She is the author of a science memoir entitled The Plant Hunter: One Scientist’s Quest for Nature’s Next Medicines.

As a medical ethnobotanist, Cassandra’s work focuses on the documentation and pharmacological evaluation of plants used in traditional medicine. Find out more about about Cassandra’s research on her webpage.

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Welcoming Prof. Heike Brötz-Oesterhelt to the NPR Editorial Board

Prof. Heike Brötz-Oesterhelt

Prof. Heike Brötz-Oesterhelt

Natural Product Reports is delighted to welcome Professor Heike Brötz-Oesterhelt to the Editorial Board.

Heike Brötz-Oesterhelt holds a degree in Microbiology from the University of Bonn. After her PhD in 1997, she joined the Anti-Infectives Research Department of Bayer HealthCare, leading hit and lead discovery teams for 8 years. In 2004, she co-founded the anti-infective biotech company AiCuris, Wuppertal, Germany. She returned to academia as a professor for Pharmaceutical Biology at the University of Duesseldorf in 2010, and four years later became Chair of the Department of Microbial Bioactive Compounds at the University of Tuebingen. She is speaker of the Transregional Collaborative Research Centre TRR261 ‘Cellular Mechanisms of Antibiotic Action and Production’ and co-speaker of the Cluster of Excellence “Controlling Microbes to Fight Infection”.

Heike is particularly interested in the molecular mechanisms of new antibacterial natural products and the operation modes of novel antibiotic targets. Find out more about Heike’s research on her webpage, or by reading her Open Access NPR article below:

Conformational control of the bacterial Clp protease by natural product antibiotics

Nat. Prod. Rep., 2017,34, 815-831
Graphical abstract: Conformational control of the bacterial Clp protease by natural product antibiotics
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New Editorial Board Members – Natural Product Reports

We are delighted to warmly welcome three new Editorial Board Members to our Natural Product ReportsProfessor Dong-Chan Oh (Seoul National University, South Korea), and Professor Eriko Takano (University of Manchester, UK), and Professor Changsheng Zhang (South China Sea Institute of Oceanology, China Academy of Sciences, China).

Dong-Chan Oh studied oceanography and chemistry at Seoul National University, Republic of Korea. He obtained Ph. D. in marine natural products chemistry at Scripps Institution of Oceanography in 2006. After graduation, he joined Harvard Medical School as a postdoctoral research fellow and later worked as an instructor. In 2009, he started his independent academic career at Natural Products Research Institute, College of Pharmacy, Seoul National University in Korea. He conducted his research as a Howard Hughes Medical Institute International Early Career Scientist from 2012 to 2017. Dong-Chan Oh is currently a full professor of College of Pharmacy and the director of Natural Products Research Institute at Seoul National University.

His research focuses on the discovery, the structure elucidation, and the stereochemical determination of new bioactive natural products from microbes.

Eriko Takano is the Professor of Synthetic Biology in the Manchester Institute of Biotechnology, Department of Chemistry, School of Natural Sciences, Faculty of Science and Engineering, at the University of Manchester since 2012. In 2014, she was appointed as one of the three directors for the EPSRC/BBSRC-funded Manchester Synthetic Biology Research Centre, SYNBIOCHEM and in 2018, she was appointed as the deputy head of department of Chemistry. Eriko graduated from Kitasato University in Japan and did her undergraduate project with Prof Satoshi Omura (2015 Nobel Prize in Physiology and Medicine), before working at a R&D facility for a company, Meiji Seika Kaisha, for several years. After leaving industry, she obtained her PhD at the John Innes Institute, Norwich, UK, in 1994 on the regulation of antibiotic production in Streptomyces coelicolor. Before her arrival in Manchester, she had been Associate Professor at the University of Groningen, The Netherlands, and Assistant Professor (C1) at the Department of Microbiology / Biotechnology, University of Tübingen, in Germany.

Eriko is internationally recognized as a pioneer in the synthetic biology of microbes for antibiotic production. Her interests are in bioinformatics software development for designing natural products producers; untargeted metabolomics for chassis engineering in Streptomyces; secondary metabolite biosynthesis pathway assembly; and regulatory circuit engineering through signalling molecules and non-coding RNAs. Eriko has published 103 peer-reviewed papers and 4 book chapters and holds 5 patents. She is the Fellow of the Royal Society of Biology and has served as an expert advisor for the European Commission Scientific Committee on Emerging and Newly Identified Health Risks on synthetic biology, where she contributed to a series of three official Opinions with major impact on the development of the field.

Changsheng Zhang obtained a BSc. in Biology (Shanghai Jiaotong University, China, 1994) and an MSc. in Biotechnolgy (East China University of Science and Technology, 1997). In 2002, he obtained his Ph.D in Chemical Microbiology (Bergische University of Wuppertal, Germany) with Prof. Dr. W. Piepersberg. He carried out postdoctoral research on natural product glycosylation studies with J. S. Thorson at University of Wisconsin, Madison (2003-2008). In 2008, he joined the South China Sea Institute of Oceanology, China Academy of Sciences.

His research interest focuses on marine polycyclic natural product discovery and biosynthesis

You can find some of their most recent RSC publications below:


Bioinformatics for the synthetic biology of natural products: integrating across the Design–Build–Test cycle
Pablo Carbonell, Andrew Currin, Adrian J. Jervis, Nicholas J. W. Rattray, Neil Swainston, Cunyu Yan, Eriko Takano and Rainer Breitling
Nat. Prod. Rep., 2016, 33, 925-932, DOI: 10.1039/C6NP00018E, Highlight

Switchable foldamer ion channels with antibacterial activity
Anna D. Peters, Stefan Borsley, Flavio della Sala, Dominic F. Cairns-Gibson, Marios Leonidou, Jonathan Clayden, George F. S. Whitehead, Iñigo J. Vitórica-Yrezábal, Eriko Takano, John Burthem, Scott L. Cockroft and Simon J. Webb
Chem. Sci., 2020, Advance Article, DOI: 10.1039/D0SC02393K, Edge Article

Functional characterization of the halogenase SpmH and discovery of new deschloro-tryptophan dimers
Zhiwen Liu, Liang Ma, Liping Zhang, Wenjun Zhang, Yiguang Zhu, Yuchan Chen, Weimin Zhang and Changsheng Zhang
Org. Biomol. Chem., 2019, 17, 1053-1057, DOI: 10.1039/C8OB02775G, Communication

Heterologous expression of the trichostatin gene cluster and functional characterization of N-methyltransferase TsnB8
Wei Liu, Vinay Gopal Jannu, Zhiwen Liu, Qingbo Zhang, Xiaodong Jiang, Liang Ma, Wenjun Zhang, Changsheng Zhang and Yiguang Zhu
Org. Biomol. Chem., 2020, 18, 3649-3653, DOI: 10.1039/D0OB00617C, Communication

Activation and characterization of a cryptic gene cluster reveals a cyclization cascade for polycyclic tetramate macrolactams
Subhasish Saha, Wenjun Zhang, Guangtao Zhang, Yiguang Zhu, Yuchan Chen, Wei Liu, Chengshan Yuan, Qingbo Zhang, Haibo Zhang, Liping Zhang, Weimin Zhang and Changsheng Zhang
Chem. Sci., 2017, 8, 1607-1612, DOI: 10.1039/C6SC03875A, Edge Article

Identification and bioactivity evaluation of secondary metabolites from Antarctic-derived Penicillium chrysogenum CCTCC M 2020019
Imran Khan, Haibo Zhang, Wei Liu, Liping Zhang, Fang Peng, Yuchan Chen, Qingbo Zhang, Guangtao Zhang, Weimin Zhang and Changsheng Zhang
RSC Adv., 2020, 10, 20738-20744, DOI: 10.1039/D0RA03529G, Paper

Characterization of the flavoenzyme XiaK as an N-hydroxylase and implications in indolosesquiterpene diversification
Qingbo Zhang, Huixian Li, Lu Yu, Yu Sun, Yiguang Zhu, Hanning Zhu, Liping Zhang, Shu-Ming Li, Yuemao Shen, Changlin Tian, Ang Li, Hung-wen Liu and Changsheng Zhang
Chem. Sci., 2017, 8, 5067-5077, DOI: 10.1039/C7SC01182B

Flavoenzyme CrmK-mediated substrate recycling in caerulomycin biosynthesis
Yiguang Zhu, Marie-Ève Picard, Qingbo Zhang, Julie Barma, Xavier Murphy Després, Xiangui Mei, Liping Zhang, Jean-Baptiste Duvignaud, Manon Couture, Weiming Zhu, Rong Shi and Changsheng Zhang
Chem. Sci., 2016, 7, 4867-4874, DOI: 10.1039/C6SC00771F, Edge Article

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Tobias Gulder – NPR’s new Chair of the Editorial Board

We are delighted to announce that Professor Tobias A. M. Gulder is the new Chair of the Natural Product Reports Editorial Board.

“Natural Product Reports has been my favorite journal for critical reviews in natural product chemistry since entering the field as a graduate student. I became a member of the Editorial Board of NPR in 2017 and have since enjoyed working with the Royal Society of Chemistry Editorial Team and the Board Members to further develop the journal. I feel honored to succeed Brad Moore as the Chair of the journal and look forward to continue his successful work for the natural product community.”

We are very grateful to Professor Bradley Moore for all of his contributions to the journal during his years with us as an Editorial Board member and then as Chair.

As we wish Professor Moore well with his future endeavours we warmly welcome Professor Gulder to his new position, leading the journal to continued success.

About Tobias

Tobias A. M. Gulder holds degrees in Chemistry from the University of Würzburg (Diploma 2004, PhD 2008). After postdoctoral training at the Scripps Institution of Oceanography with Bradley Moore (2008-2010) he started his independent work as a Liebig and Emmy Noether fellow at the University of Bonn (2011-2014). In 2014 he accepted to offer to join the Technical University of Munich as Professor of Biosystems Chemistry at the Department of Chemistry and the Center for Integrated Protein Science Munich (CIPSM). In 2019 he became the Chair of Technical Biochemistry at the Technical University of Dresden.

Professor Gulder’s research interests focus on the structure, biosynthesis and synthesis of bacterial natural products. This includes the elucidation of new biosynthetic transformations and their application to the biocatalytic synthesis of natural products as well as the manipulation of biosynthetic pathways to generate new molecular structures.

 

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New Editorial Board Members

We are delighted to welcome two new Editorial Board Members to Natural Product Reports. Professor Hendrik Luesch (University of Florida, USA) and Dr Marnix Medema (Wageningen University, Netherlands).

Professor Hendrik Luesch leads a multidisciplinary marine natural products research program that integrates isolation, synthesis, pharmacology, mechanism of action and early development studies. Find out more on his lab’s webpage.

Hendrik obtained his PhD at University of Hawaii with Richard E. Moore in 2002. He undertook three years of postdoctoral studies  as an Irving S. Sigal Fellow at The Scripps Research Institute with Peter G. Schultz. Since 2005 he has been faculty at the University of Florida (UF) and is currently Professor and Chair of the Department of Medicinal Chemistry.

 

 

 


Dr Marnix Medema’s group currently develops and applies computational tools to understand bacterial, fungal and plant natural product biosynthesis from a genomic perspective. Find out more on his webpage.

Marnix completed his PhD in 2013 in the groups of Eriko Takano and Rainer Breitling at the University of Groningen. In 2015, following a postdoctoral fellowship in the group of Frank Oliver Glöckner (Max Planck Institute for Marine Microbiology in Bremen, Germany), he joined Wageningen University.

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New Editorial Board Members

We are very pleased to welcome two new members to our Natural Product Reports Editorial Board. Professor Janet Smith (University of Michigan, USA) and Dr Olga Genilloud (Fundación MEDINA, Spain).

Professor Janet Smith obtained her PhD in Biochemistry from the University of Wisconsin-Madison in 1978. After postdoctoral studies at the Naval Research Laboratory, she was an associate research scientist at Columbia University.  Professor Smith moved to Purdue University and established a research program in structural biology in 1987, where she remained as Professor of Biological Sciences until moving to the Life Science Institute, University of Michigan, in 2005. She is currently Margaret J. Hunter Collegiate Professor in the Life Sciences, Professor of Biological Chemistry and Director of the Centre for Structural Biology at University of Michigan.

Her research focuses on:

  • Understanding protein structure and function using X-ray crystallography as a structural tool
  • Examining the structures of proteins from infectious pathogens including the RNA viruses that cause West Nile disease, yellow fever, and dengue hemorrhagic fever
  • Understanding the operation of biosynthetic assembly lines for natural products and the activity and selectivity of enzymes that catalyse unusual reactions in natural product biosynthesis

Dr Olga Genilloud obtained her PhD in Biochemistry and Molecular Genetics from the Universidad Complutense de Madrid in 1988. Following this she joined the Drug Discovery Research Center at Merck Sharp and Dohme in Spain were she led the bacterial natural products program. In 2009 she was appointed Scientific Director at Fundación MEDINA and Head of the Microbiology department.

Her main research interests are focused on:

  • The production of novel microbial natural products
  • The exploration of novel microbial diversity to deliver novel chemistry
  • The development of molecular and chemical tools to support natural products drug discovery and the identification of potential new therapeutics

Find out more about the other members of our Editorial and Advisory Boards here.

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Editorial Board Changes

As the new year gets underway we would like to share some changes to our Editorial Board.

Editorial Board Retirements

After 6 years with Natural Product Reports we are very sorry to see Professors David L. Jakeman and Stefan Schulz step down from their roles on the Editorial Board. We would like to take this opportunity to thank both David and Stefan for all of their time and effort over the past 6 years, helping to make the journal the success it is today. Thank you!

However, we are pleased to say that although David and Stefan may be leaving the Editorial Board they will not be leaving us entirely. Both are now members of the Advisory Board for the journal and we look forward to continue working with them in the future in this new role.

Prof. David L. Jakeman

Prof. Stefan Schulz


New Editorial Board Members

We would also like to take this opportunity to welcome some new faces to the Natural Product Reports family.

Prof. Giovanni Appendino

Professor Giovanni Appendino, Universita del Piemonte Orientale, Italy.

Professor Giovanni Appendino did his Laurea Degree at the University of Torino (Italy) in 1979. He did Post-Laurea work at the Laboratory of Organic Synthesis, University of Gent (Belgium) with Prof. Pierre De Clercq. He has been a Full Professor of Organic Chemistry at the Università del Piemonte Orientale, Department of Pharmaceutical Sciences, Novara (Italy), since 2000.

Research activity in his laboratories takes inspiration from plant natural products to address problems in various realms of biomedical investigation, from pharmacology and nutrition (new drug leads and health-promoting dietary ingredients) to organic/medicinal chemistry (new synthetic methodologies and optimization of natural product drug leads) and cell biology (novel mechanisms of activity).



Prof. Mark Brönstrup

Professor Mark Brönstrup, Helmholtz Centre for Infection Research, Germany

Mark Brönstrup studied Chemistry at the Philipps-Universität Marburg and at the Imperial College in London. In 1999 he received his doctorate from the Technical University Berlin in Organic Chemistry. After his graduation, he worked from 2000 to 2004 as a laboratory head for Mass Spectrometry at Aventis, complemented by a research sabbatical in 2003 at Harvard Medical School. From 2005 to 2010 he led the Natural Product Sciences section at Sanofi-Aventis in Frankfurt with the goal of discovering leads from natural sources and optimising them to clinical candidates. He dealt with translational research projects from 2010 to 2013 as a section head for Biomarkers & Diagnostics in the Diabetes Division, and a domain head for Biomarkers, Bioimaging & Biological Assays at Sanofi. Since December 2013, he heads the department Chemical Biology at the Helmholtz Centre for Infection Research; additionally, he holds a Professorship (W3) at the Leibniz Universität Hannover.

Mark Brönstrup’s research uses chemical biology tools to understand mechanisms for the treatment of infectious diseases.



Professors Appendino and Brönstrup began their roles as Editorial Board members from January 2015, and we look forward to working closely with them over the coming months and years.

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New Editorial Board Members for Natural Product Reports

We are very pleased to welcome two new members to our Editorial Board this month: Professor Julia Kubanek (Georgia Institute of Technology, USA) and Professor Wen Liu (Shanghai Institute of Organic Chemistry, China).


Professor Julia Kubanek

Prof. Kubanek received her Ph.D. in Organic Chemistry in 1998 from the University of British Columbia. Following this she held postdoctoral positions at the Scripps Institution of Oceanography, University California San Diego (1998–2000) and the University of North Carolina at Wilmington (2000–2001). In 2001 she joined the Georgia Institute of Technology becoming a Professor in 2011.

Her current areas of interest include:

Aquatic chemical ecology; Chemical signaling; Chemical communication; Marine natural products chemistry; Chemical biology; Secondary metabolism; Drug discovery; Plankton ecology; Metabolomics

I’ve been reading Natural Product Reports since I was a graduate student in the early 1990’s. I’m pleased to join the NPR family as a member of the Editorial Board and looking forward to working with authors to bring important research to the attention of the natural products chemistry community.” Prof. Julia Kubanek



Professor Wen Liu

Prof. Wen Liu obtained his Ph.D. degree from the Chinese Academy of Medical Sciences (Peking Union Medical School) in 2000. After postdoctoral studies at the Department of Chemistry, University of California, Davis (2000-2001), and the School of Pharmacy, University of Wisconsin-Madison (2001-2003), he joined the Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences in 2003.

His research interests focus on:
1) natural product biosynthesis (genetics, biochemistry and chemistry)
2) combinatorial biosynthesis for production improvement and structural diversity
3) genome and/or transcriptome mining for discovery of novel microbial natural products

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NPR welcomes Professor Greg Challis to its Editorial Board

Natural Product Reports is delighted to announce Professor Greg Challis (University of Warwick, UK) as a new Editorial Board member. 

Greg Challis graduated with a BSc in Chemistry (1994) from Imperial College London and a DPhil in Organic Chemistry (1998) from the University of Oxford. He was a postdoctoral research fellow in the Department of Chemistry at Johns Hopkins University, USA (1998-2000) and in the Department of Genetics at the John Innes Centre, UK (2000-2001). In 2001 he was appointed to a lectureship in Chemical Biology in the Department of Chemistry at the University of Warwick and in 2006 he was promoted to his present position of Professor of Chemical Biology.

Challis’s research interests encompass diverse aspects of the chemistry and biology of natural products, including genomics-driven discovery of new bioactive metabolites, elucidation of novel pathways for natural product biosynthesis, mechanistic enzymology of unusual biosynthetic enzymes, biosynthetic engineering approaches to the production of novel natural product derivatives, elucidation of the biological functions of natural products, and natural product total synthesis. His research achievements have been recognised by numerous honours and awards, most recently the Gabor Medal (2009).

Why not read some of Greg Challis’s latest NPR contributions to NPR:

New natural product biosynthetic chemistry discovered by genome mining
Nat. Prod. Rep., 2009,26, 977-986

Ribosomally synthesized and post-translationally modified peptide natural products: overview and recommendations for a universal nomenclature
Nat. Prod. Rep., 2013,30, 108-160 (bottromycins section)

NPR benefits from the expertise of exceptional scientists guiding the development of the journal.
 Find out more on our Editorial and Advisory Board members!

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Welcome to Professor Daniel Romo who joins the NPR Editorial Board

We are delighted to announce the appointment of Professor Daniel Romo to the Editorial Board of Natural Products Reports, as of January 2013. 

Daniel Romo received his B.A. in chemistry/biology from Texas A&M and a PhD in Chemistry from Colorado State University as a NSF Minority Graduate Fellow under the tutelage of the late Prof. Albert I. Meyers. Following postdoctoral studies at Harvard as an American Cancer Society Fellow, with Prof. Stuart L. Schreiber, he began his independent career at TexasA&M in 1993 and is currently Professor of Chemistry and Director of the Natural Products LINCPHIN Laboratory (TAMU).

Research interests in the Romo Group are at the interface of chemistry and biology focused on total synthesis and biomechanistic studies of natural products and the asymmetric synthesis and application of beta-lactones in organic synthesis and as potential drug candidates. This search led Romo to examine marine specimens –  many recent bioactive molecules have been discovered in marine species that are now making their way to the clinic.
Romo sees natural products as playgrounds for developing new synthetic strategies and making related compounds with potentially important therapeutic applications. Natural products are keys to cell biology, and he is working to build the bridge between synthesis and biology.

‘If I couldn’t be dreaming up ways to make natural products, I would want to be diving to isolate those natural products and fishing from the deck on my off time!’ says Daniel.

Why not read Daniel Romo’s latest NPR review article:

Biosynthesis, asymmetric synthesis, and pharmacology, including cellular targets, of the pyrrole-2-aminoimidazole marine alkaloids
Ali Al-Mourabit, Manuel A. Zancanella, Supriya Tilvi and Daniel Romo
DOI: 10.1039/C0NP00013B

 
NPR benefits from the expertise of exceptional scientists guiding the development of the journal. Do you know who they are? Find out more on our Editorial and Advisory Board members.
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