Natural Products Blog

The articles below are some of the most read Natural Product Reports articles in April, May and June 2016.


Marine natural products
John W. Blunt, Brent R. Copp, Robert A. Keyzers, Murray H. G. Munro and Michèle R. Prinsep
DOI: 10.1039/C5NP00156K, Review Article

Natural product isolation – how to get from biological material to pure compounds
Franz Bucar, Abraham Wube and Martin Schmid
DOI: 10.1039/C3NP20106F, Review Article

Marine natural products
John W. Blunt, Brent R. Copp, Robert A. Keyzers, Murray H. G. Munro and Michèle R. Prinsep
DOI: 10.1039/C3NP70117D, Review Article

Marine natural products
John W. Blunt, Brent R. Copp, Robert A. Keyzers, Murray H. G. Munro and Michèle R. Prinsep
DOI: 10.1039/C4NP00144C, Review Article

Recent advances in engineering nonribosomal peptide assembly lines
M. Winn, J. K. Fyans, Y. Zhuo and J. Micklefield
DOI: 10.1039/C5NP00099H, Review Article
From themed collection Biosynthetic Assembly Lines

Fragmentation reactions using electrospray ionization mass spectrometry: an important tool for the structural elucidation and characterization of synthetic and natural products
Daniel P. Demarque, Antonio E. M. Crotti, Ricardo Vessecchi, João L. C. Lopes and Norberto P. Lopes
DOI: 10.1039/C5NP00073D, Review Article

Ester coupling reactions – an enduring challenge in the chemical synthesis of bioactive natural products
Michail Tsakos, Eva S. Schaffert, Lise L. Clement, Nikolaj L. Villadsen and Thomas B. Poulsen
DOI: 10.1039/C4NP00106K, Review Article

Synthetic approaches towards alkaloids bearing α-tertiary amines
Anastasia Hager, Nina Vrielink, Dominik Hager, Julien Lefranc and Dirk Trauner
DOI: 10.1039/C5NP00096C, Review Article

Defensive symbioses of animals with prokaryotic and eukaryotic microorganisms
Laura V. Flórez, Peter H. W. Biedermann, Tobias Engl and Martin Kaltenpoth
DOI: 10.1039/C5NP00010F, Review Article
From themed collection Chemical Ecology


Have you read our most recent themed issues yet:

• Methods in Molecular Structure Elucidation

• Strategies for Cellular Target Identification of Natural Products

Keep up-to-date with the latest issues of Natural Product Reports by joining our e-alerts.

The articles below are some of the most read Natural Product Reports articles in January, February and March 2016.

Marine natural products
John W. Blunt, Brent R. Copp, Robert A. Keyzers, Murray H. G. Munro and Michèle R. Prinsep
DOI: 10.1039/C5NP00156K, Review Article

Metabolomics in chemical ecology
Constanze Kuhlisch and Georg Pohnert
DOI: 10.1039/C5NP00003C, Review Article

Defensive symbioses of animals with prokaryotic and eukaryotic microorganisms
Laura V. Flórez, Peter H. W. Biedermann, Tobias Engl and Martin Kaltenpoth
DOI: 10.1039/C5NP00010F, Review Article

Biosynthesis of fungal meroterpenoids
Yudai Matsuda and Ikuro Abe
DOI: 10.1039/C5NP00090D, Review Article

Marine natural products
John W. Blunt, Brent R. Copp, Robert A. Keyzers, Murray H. G. Munro and Michèle R. Prinsep
DOI: 10.1039/C4NP00144C, Review Article

Prospecting for new bacterial metabolites: a glossary of approaches for inducing, activating and upregulating the biosynthesis of bacterial cryptic or silent natural products
Joseph Scott Zarins-Tutt, Tania Triscari Barberi, Hong Gao, Andrew Mearns-Spragg, Lixin Zhang, David J. Newman and Rebecca Jane Miriam Goss
DOI: 10.1039/C5NP00111K, Review Article

Recent advances in engineering nonribosomal peptide assembly lines
M. Winn, J. K. Fyans, Y. Zhuo and J. Micklefield
DOI: 10.1039/C5NP00099H, Review Article

Mass spectrometry imaging of plant metabolites – principles and possibilities
Nanna Bjarnholt, Bin Li, Janina D’Alvise and Christian Janfelt
DOI: 10.1039/C3NP70100J, Review Article

Ester coupling reactions – an enduring challenge in the chemical synthesis of bioactive natural products
Michail Tsakos, Eva S. Schaffert, Lise L. Clement, Nikolaj L. Villadsen and Thomas B. Poulsen
DOI: 10.1039/C4NP00106K, Review Article

Bacterial terpene cyclases
Jeroen S. Dickschat
DOI: 10.1039/C5NP00102A, Review Article

Natural product and natural product derived drugs in clinical trials
Mark S. Butler, Avril A. B. Robertson and Matthew A. Cooper
DOI: 10.1039/C4NP00064A, Review Article

Don’t forget to take a look at our recent themed issues on:
Biosynthetic Assembly Lines
Strategies for Cellular Target Identification of Natural Products

Keep up-to-date with the latest issues of Natural Product Reports with our E-alerts

The articles below are the most read Natural Product Reports articles in July, August and September 2015.

Natural product isolation – how to get from biological material to pure compounds
Franz Bucar, Abraham Wube and Martin Schmid
DOI: 10.1039/C3NP20106F, Review Article

Natural products and Pharma 2011: Strategic changes spur new opportunities
Guy T. Carter
DOI: 10.1039/C1NP00033K, Highlight

Marine natural products
John W. Blunt, Brent R. Copp, Robert A. Keyzers, Murray H. G. Munro and Michèle R. Prinsep
DOI: 10.1039/C4NP00144C, Review Article

Defensive symbioses of animals with prokaryotic and eukaryotic microorganisms
Laura V. Flórez, Peter H. W. Biedermann, Tobias Engl and Martin Kaltenpoth
DOI: 10.1039/C5NP00010F, Review Article

Metabolomics in chemical ecology
Constanze Kuhlisch and Georg Pohnert
DOI: 10.1039/C5NP00003C, Review Article

Hot off the press
Robert A. Hill and Andrew Sutherland
DOI: 10.1039/C5NP90032H, Hot off the Press Article

Natural product and natural product derived drugs in clinical trials
Mark S. Butler, Avril A. B. Robertson and Matthew A. Cooper
DOI: 10.1039/C4NP00064A, Review Article

Mass spectrometry imaging of plant metabolites – principles and possibilities
Nanna Bjarnholt, Bin Li, Janina D’Alvise and Christian Janfelt
DOI: 10.1039/C3NP70100J, Review Article

Triterpenoids
Robert A. Hill and Joseph D. Connolly
DOI: 10.1039/C4NP00101J, Review Article

The chemistry and biological activity of the Hyacinthaceae
Dulcie A. Mulholland, Sianne L. Schwikkard and Neil R. Crouch
DOI: 10.1039/C3NP70008A, Review Article

The articles below were the most read Natural Product Reports articles in July, August and September 2014.

Discovering the secondary metabolite potential encoded within entomopathogenic fungi
Donna M. Gibson, Bruno G. G. Donzelli, Stuart B. Krasnoff and Nemat O. Keyhanic  
DOI: 10.1039/C4NP00054D

Explorations of fungal biosynthesis of reduced polyketides – a personal viewpoint
John C. Vederas 
DOI: 10.1039/C4NP00091A

Microbial biosynthesis of medicinally important plant secondary metabolites
Myoung Chong Song, Eun Ji Kim, Eunji Kim, Kris Rathwell, Sang-Jip Nam and Yeo Joon Yoon 
DOI: 10.1039/C4NP00057A

The phosphopantetheinyl transferases: catalysis of a post-translational modification crucial for life
Joris Beld, Eva C. Sonnenschein, Christopher R. Vickery, Joseph P. Noel and Michael D. Burkart
DOI: 10.1039/C3NP70054B

Xanthone dimers: a compound family which is both common and privileged
Tim Wezeman, Stefan Bräse and Kye-Simeon Masters 
DOI: 10.1039/ C4NP00050A

Marine natural products
John W. Blunt, Brent R. Copp, Robert A. Keyzers, Murray H. G. Munro and Michèle R. Prinsep 
DOI: 10.1039/C3NP70117D

Fungal polyketide biosynthesis – a personal perspective
Thomas J. Simpson 
DOI: 10.1039/C4NP00065J

Natural product isolation – how to get from biological material to pure compounds
Franz Bucar, Abraham Wube and Martin Schmid 
DOI: 10.1039/C3NP20106F

Natural product and natural product derived drugs in clinical trials
Mark S. Butler, Avril A. B. Robertson and Matthew A. Cooper 
DOI: 10.1039/C4NP00064A

Natural products containing ‘decalin’ motif in microorganisms
Gang Li, Souvik Kusari and Michael Spiteller 
DOI: 10.1039/C4NP00031E

During the months April – June 2014, the most downloaded Natural Product Reports articles were:

Explorations of fungal biosynthesis of reduced polyketides – a personal viewpoint
John C. Vederas
DOI: 10.1039/C4NP00091A

Microbial biosynthesis of medicinally important plant secondary metabolites
Myoung Chong Song, Eun Ji Kim, Eunji Kim, Kris Rathwell, Sang-Jip Nam and Yeo Joon Yoon
DOI: 10.1039/C4NP00057A

Marine natural products
John W. Blunt, Brent R. Copp, Robert A. Keyzers, Murray H. G. Munro and Michèle R. Prinsep
DOI: 10.1039/C3NP70117D

Natural product isolation – how to get from biological material to pure compounds
Franz Bucar, Abraham Wube and Martin Schmid
DOI: 10.1039/C3NP20106F

Fungal polyketide biosynthesis – a personal perspective
Thomas J. Simpson
DOI: 10.1039/C4NP00065J

Natural product synthesis in the age of scalability
Christian A. Kuttruff, Martin D. Eastgate and Phil S. Baran
DOI: 10.1039/C3NP70090A

Recreational drug discovery: natural products as lead structures for the synthesis of smart drugs
Giovanni Appendino, Alberto Minassi and Orazio Taglialatela-Scafati
DOI: 10.1039/C4NP00010B

Thinking big about small beings – the (yet) underdeveloped microbial natural products chemistry in Brazil
Laura P. Ióca, Pierre-Marie Allard and Roberto G. S. Berlinck
DOI: 10.1039/C3NP70112C

Recent advances in deep-sea natural products
Danielle Skropeta and Liangqian Wei
DOI: 10.1039/C3NP70118B

Ribosomally synthesized and post-translationally modified peptide natural products: overview and recommendations for a universal nomenclature
Wilfred A. van der Donk et al.
DOI: 10.1039/C2NP20085F

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During January, February and March this year, the following articles were the Top Ten most accessed:

Marine natural products
John W. Blunt, Brent R. Copp, Robert A. Keyzers, Murray H. G. Munro and Michèle R. Prinsep  
Nat. Prod. Rep., 2014,31, 160-258
DOI: 10.1039/c3np70117d

Natural product synthesis in the age of scalability
Christian A. Kuttruff, Martin D. Eastgate and Phil S. Baran
Nat. Prod. Rep., 2014,31, 419-432
DOI: 10.1039/c3np70090a

Trying to rationalize total synthesis
Johann Mulzer  
Nat. Prod. Rep., 2014,31, 595-603
DOI: 10.1039/c3np70105k

Natural product isolation – how to get from biological material to pure compounds
Franz Bucar, Abraham Wube and Martin Schmid  
Nat. Prod. Rep., 2013,30, 525-545
DOI: 10.1039/c3np20106f

Industrial natural product chemistry for drug discovery and development
Armin Bauer and Mark Brönstrup
Nat. Prod. Rep., 2014,31, 35-60
DOI: 10.1039/c3np70058e

Diversity, abundance and natural products of marine sponge-associated actinomycetes
Usama Ramadan Abdelmohsen, Kristina Bayer and Ute Hentschel  
Nat. Prod. Rep., 2014,31, 381-399
DOI: 10.1039/c3np70111e

Fungal metabolites with anticancer activity
Antonio Evidente, Alexander Kornienko, Alessio Cimmino, Anna Andolfi, Florence Lefranc, Véronique Mathieu and Robert Kiss  
Nat. Prod. Rep., 2014,31, 617-627
DOI: 10.1039/c3np70078j

Mass spectrometry imaging of plant metabolites – principles and possibilities
Nanna Bjarnholt, Bin Li, Janina D’Alvise and Christian Janfelt  
Nat. Prod. Rep., 2014, Advance Article
DOI: 10.1039/c3np70100j

Ribosomally synthesized and post-translationally modified peptide natural products: overview and recommendations for a universal nomenclature
Wilfred A. van der Donk et al.
Nat. Prod. Rep., 2013,30, 108-160
DOI: 10.1039/c2np20085f

Recent progress in neuroactive marine natural products
Ryuichi Sakai and Geoffrey T. Swanson  
Nat. Prod. Rep., 2014,31, 273-309
DOI: 10.1039/c3np70083f

If you have any comments on any of these articles, why not leave these in the comment box below?

Do you have an article you would like to submit to NPR? If so, email us your suggestions today!

During October, November and December, the following articles were the Top Ten most accessed:

Industrial natural product chemistry for drug discovery and development
Armin Bauer and Mark Brönstrup  
Nat. Prod. Rep., 2014,31, 35-60
DOI: 10.1039/c3np70058e

Marine natural products
John W. Blunt, Brent R. Copp, Robert A. Keyzers, Murray H. G. Munro and Michèle R. Prinsep  
Nat. Prod. Rep., 2013,30, 237-323
DOI: 10.1039/c2np20112g

Natural product isolation – how to get from biological material to pure compounds
Franz Bucar, Abraham Wube and Martin Schmid  
Nat. Prod. Rep., 2013,30, 525-545
DOI: 10.1039/c3np20106f

Natural products as starting points for the synthesis of complex and diverse compounds
Karen C. Morrison and Paul J. Hergenrother  
Nat. Prod. Rep., 2014,31, 6-14
DOI: 10.1039/c3np70063a

Natural product synthesis in the age of scalability
Christian A. Kuttruff, Martin D. Eastgate and Phil S. Baran  
Nat. Prod. Rep., 2014,31, 419-432
DOI: 10.1039/c3np70090a

Natural compounds with anti-ageing activity
Aikaterini Argyropoulou, Nektarios Aligiannis, Ioannis P. Trougakos and Alexios-Leandros Skaltsounis  
Nat. Prod. Rep., 2013,30, 1412-1437
DOI: 10.1039/c3np70031c

Ribosomally synthesized and post-translationally modified peptide natural products: overview and recommendations for a universal nomenclature
Paul G. Arnison, Mervyn J. Bibb, Gabriele Bierbaum, Albert A. Bowers, Tim S. Bugni, Grzegorz Bulaj, Julio A. Camarero, Dominic J. Campopiano, Gregory L. Challis, Jon Clardy et al.
Nat. Prod. Rep., 2013,30, 108-160
DOI: 10.1039/c2np20085f

Hot off the press
Robert A. Hill and Andrew Sutherland  
Nat. Prod. Rep., 2013,30, 1462-1466
DOI: 10.1039/c3np90036c

Impact of copper-catalyzed cross-coupling reactions in natural product synthesis: the emergence of new retrosynthetic paradigms
Gwilherm Evano, Cédric Theunissen and Alexandre Pradal  
Nat. Prod. Rep., 2013,30, 1467-1489
DOI: 10.1039/c3np70071b

Blue flower color development by anthocyanins: from chemical structure to cell physiology
Kumi Yoshida, Mihoko Mori and Tadao Kondo  
Nat. Prod. Rep., 2009,26, 884-915
DOI: 10.1039/b800165k

If you have any comments or thoughts on any of these articles, please leave these in the comment box below.

Do you have an article you would like to submit to Natural Product Reports? Why not submit to us here today or alternatively email us your suggestions!

These are the Top ten most accessed articles between the months for July to September 2013

Marine natural products
John W. Blunt, Brent R. Copp, Robert A. Keyzers, Murray H. G. Munro and Michèle R. Prinsep
Nat. Prod. Rep., 2013,30, 237-323
DOI: 10.1039/c2np20112g

Natural product isolation – how to get from biological material to pure compounds
Franz Bucar, Abraham Wube and Martin Schmid  
Nat. Prod. Rep., 2013,30, 525-545
DOI: 10.1039/c3np20106f

Recent advances in the heterologous expression of microbial natural product biosynthetic pathways
Sarah E. Ongley, Xiaoying Bian, Brett A. Neilan and Rolf Müller
Nat. Prod. Rep., 2013,30, 1121-1138
DOI: 10.1039/c3np70034h

Hot off the Press
Robert A. Hill and Andrew Sutherland  
Nat. Prod. Rep., 2013,30, 1074-1078
DOI: 10.1039/c3np90022c

Natural sesquiterpenoids
Braulio M. Fraga  
Nat. Prod. Rep., 2013,30, 1226-1264
DOI: 10.1039/c3np70047j

Ribosomally synthesized and post-translationally modified peptide natural products: overview and recommendations for a universal nomenclature
Paul G. Arnison et al.
Nat. Prod. Rep., 2013,30, 108-160
DOI: 10.1039/c2np20085f

The chemistry and biological activity of the Hyacinthaceae
Dulcie A. Mulholland, Sianne L. Schwikkard and Neil R. Crouch  
Nat. Prod. Rep., 2013,30, 1165-1210
DOI: 10.1039/C3NP70008A 

Natural compounds with anti-ageing activity
Aikaterini Argyropoulou, Nektarios Aligiannis, Ioannis P. Trougakos and Alexios-Leandros Skaltsounis  
Nat. Prod. Rep., 2013,30, 1412-1437
DOI: 10.1039/C3NP70031C

Yeast-based genome mining, production and mechanistic studies of the biosynthesis of fungal polyketide and peptide natural products
Yuta Tsunematsu, Kan’ichiro Ishiuchi, Kinya Hotta and Kenji Watanabe
Nat. Prod. Rep., 2013,30, 1139-1149
DOI: 10.1039/c3np70037b

From micrograms to grams: scale-up synthesis of eribulin mesylate
Melvin J. Yu, Wanjun Zheng and Boris M. Seletsky  
Nat. Prod. Rep., 2013,30, 1158-1164
DOI: 10.1039/C3NP70051H

If you have any comments or thoughts, why not leave these in the comment box below!

Do you have an article you would like to submit to Natural Product Reports? Why not submit to us here today or alternatively email us your suggestions!

Please take a look at the top 10 most accessed Natural Product Reports articles for the second quarter of 2013:

Natural product isolation – how to get from biological material to pure compounds  
Franz Bucar, Abraham Wube and Martin Schmid  
Nat. Prod. Rep., 2013, 30, 525-545  
DOI: 10.1039/C3NP20106F 

Marine natural products  
John W. Blunt, Brent R. Copp, Robert A. Keyzers, Murray H. G. Munro and Michèle R. Prinsep   
Nat. Prod. Rep., 2013, 30, 237-323  
DOI: 10.1039/C2NP20112G 

Ribosomally synthesized and post-translationally modified peptide natural products: overview and recommendations for a universal nomenclature  
Wilfred A. van der Donk, et al.
Nat. Prod. Rep., 2013, 30, 108-160    
DOI: 10.1039/C2NP20085F

Marine natural products: synthetic aspects 
Jonathan C. Morris   
Nat. Prod. Rep., 2013, 30, 783-805  
DOI: 10.1039/C3NP20116C 

Hot off the press  
Robert A. Hill and Andrew Sutherland 
Nat. Prod. Rep., 2013, 30, 760-764  
DOI: 10.1039/C3NP90015K  

The antibody-drug conjugate: an enabling modality for natural product-based cancer therapeutics  
Hans-Peter Gerber, Frank E. Koehn and Robert T. Abraham   
Nat. Prod. Rep., 2013, 30, 625-639  
DOI: 10.1039/C3NP20113A 

The enzymes of β-lactam biosynthesis 
Refaat B. Hamed, J. Ruben Gomez-Castellanos, Luc Henry, Christian Ducho, Michael A. McDonough and Christopher J. Schofield 
Nat. Prod. Rep., 2013, 30, 21-107  
DOI: 10.1039/C2NP20065A 

Simple indole alkaloids and those with a non-rearranged monoterpenoid unit  
Minoru Ishikura, Takumi Abe, Tominari Choshi and Satoshi Hibino  
Nat. Prod. Rep., 2013, 30, 694-752  
DOI: 10.1039/C3NP20118J 

Using NMR to identify and characterize natural products  
Rosemary C. Breton and William F. Reynolds   
Nat. Prod. Rep., 2013, 30, 501-524  
DOI: 10.1039/C2NP20104F 

Perspectives on natural product epigenetic modulators in chemical biology and medicine  
Fanny L. Cherblanc, Robert W. M. Davidson, Paolo Di Fruscia, Nitipol Srimongkolpithak and Matthew J. Fuchter 
Nat. Prod. Rep., 2013, 30, 605-624  
DOI: 10.1039/C3NP20097C 

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