Natural Products Blog

Cytotoxic and antioxidant marine natural products on the cover of NPR issue 5

12 Apr 2012

Welcome to NPR issue 5, 2012

This month’s striking subaquatic cover features the work of Suthananda N. Sunassee and Michael T. Davies-Coleman at Rhodes University, Grahamstown, South Africa, with a review on Cytotoxic and antioxidant marine prenylated quinones and hydroquinones.
Focusing on 159 prenylated quinones, hydroquinones and naphthoquinones with reported cytotoxic and/or antioxidant properties isolated from various marine organisms over the past 40 years, the authors highlight trends in the structural distribution of these cytotoxic compounds within the different marine phyla.

Cytotoxic and antioxidant marine prenylated quinones and hydroquinones
Suthananda N. Sunassee and Michael T. Davies-Coleman
Nat. Prod. Rep., 2012, 29, 513-535
DOI: 10.1039/C2NP00086E

Also in this May issue, why not read:

NMR in natural products: understanding conformation, configuration and receptor interactions
Teresa Carlomagno
Nat. Prod. Rep., 2012, 29, 536-554

Cytisine: a natural product lead for the development of drugs acting at nicotinic acetylcholine receptors
Edwin G. Pérez, Carolina Méndez-Gálvez and Bruce K. Cassels
Nat. Prod. Rep., 2012, 29, 555-567

Peptidoglycan as Nod1 ligand; fragment structures in the environment, chemical synthesis, and their innate immunostimulation
Yukari Fujimoto, Ambara Rachmat Pradipta, Naohiro Inohara and Koichi Fukase
Nat. Prod. Rep., 2012, 29, 568-579

Recent discovery of plant-derived anti-diabetic natural products
Hsin-Yi Hung, Keduo Qian, Susan L. Morris-Natschke, Chau-Shin Hsu and Kuo-Hsiung Lee
Nat. Prod. Rep., 2012, 29, 580-606

Access the full issue

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Natural Products in OBC

04 Apr 2012

By Marie Cote, Deputy Editor.

Our latest selection of Natural Products research works from our sister journal OBC…

Organic & Biomolecular Chemistry, our sister journal, publishes many articles that cover natural product chemistry.

We will try to keep you updated, although the safest bet is for you to sign up to OBC’s e-alert (free service) and receive the table of content directly in your inbox every time an issue is published.

The latest natural products’ related articles from OBC have been collated here:

Apocarotenoids in the sexual interaction of Phycomyces blakesleeanus
Silvia Polaino, Jose A. Gonzalez-Delgado, Pilar Arteaga, M. Mar Herrador, Alejandro F. Barrero and Enrique Cerdá-Olmedo

Heteroatom-directed Wacker oxidations. A protection-free synthesis of (−)-heliophenanthrone

Parag Mukherjee and Tarun K. Sarkar

Investigation of the electrophilic reactivity of the cytotoxic marine alkaloid discorhabdin B
Cary F. C. Lam, Tanja Grkovic, A. Norrie Pearce and Brent R. Copp

Organocatalytic enantioselective Michael addition of a kojic acid derivative to nitro olefins
Jiyu Wang, Qing Zhang, Hui Zhang, Yujun Feng, Weicheng Yuan and Xiaomei Zhang

Biotransformation of clovane derivatives. Whole cell fungi mediated domino synthesis of rumphellclovane A
Giovanni Gontijo de Souza, Thays Silva Oliveira, Jacqueline Aparecida Takahashi, Isidro González Collado, Antonio José Macías-Sánchez and Rosario Hernández-Galán

Biomimetic synthesis, antibacterial activity and structure–activity properties of the pyroglutamate core of oxazolomycin
Plamen Angelov, Yui Kwan Sonia Chau, Paul J. Fryer, Mark G. Moloney, Amber L. Thompson and Paul C. Trippier

Ketosulfonyl indoles in the regiodefined synthesis of tryptophols and related indole derivatives
Alessandro Palmieri and Marino Petrini

Also of Interest:

MedChemComm’s themed issue on Natural Products is growing – have you had a look yet? View all the articles here

Want to see your natural products article featured on this blog? Submit online here

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There is still time to join ICPOC21!

30 Mar 2012

By James Anson.

Good news!

There’s still a chance to submit your oral abstract to ICPOC21: 21st IUPAC International Conference on Physical Organic Chemistry organised by the Organic Division of the RSC on behalf of IUPAC, to be held 9 – 13 September 2012 at Durham University.

The Scientific Committee is currently reviewing all submissions, and has agreed to accept contributions up to Friday 13 April to allow for the Easter holiday break.

Why join ICPOC21?

Professor Dean Tantillo, University of California, Davis (USA) is the winner of the 2011 NPR Lecture Award. and will be delivering his lecture at ICPOC 21.

The NPR Lecture Award is awarded to a researcher who has made a significant contribution to the field of natural products and who has been involved with the journal. Professor Tantillo was selected for his work in the field of enzymology.

In addition to the outstanding plenary sessions, there will be three parallel sessions over the five days comprising invited lectures and contributed talks, as well as poster sessions.

A broad range of scientists from across the whole community who share a quantitative perspective on chemistry will be there, providing an opportunity to discuss and celebrate the current status, development, and the future of physical organic chemistry.

Make sure you are one of them! Don’t miss the oral abstract submission deadline – 13 April.

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Latest Natural Product Research in OBC

15 Mar 2012

By Marie Cote, Deputy Editor.

Organic & Biomolecular Chemistry, our sister journal, publishes many articles that cover natural product chemistry.

The latest natural products’ related articles from OBC have been collated here:

Synthesis and biological investigation of the β-thiolactone and β-lactam analogs of tetrahydrolipstatin
Sylvain Aubry, Geneviève Aubert, Thierry Cresteil and David Crich

Total synthesis of (+)-anamarine
Krishnammagari Suresh Kumar and Cirandur Suresh Reddy

A search for BACE inhibitors reveals new biosynthetically related pyrrolidones, furanones and pyrroles from a southern Australian marine sponge, Ianthella sp.
Hua Zhang, Melissa M. Conte, Xiao-Cong Huang, Zeinab Khalil and Robert J. Capon

Aza-Claisen rearrangement of 2-C-hydroxymethyl glycals as a versatile strategy towards synthesis of isofagomine and related biologically important azasugarsY. Suman Reddy, Pavan K. Kancharla, Rashmi Roy, Yashwant D. Vankar

Chemoenzymatic formal synthesis of (−)- and (+)-epibatidine
Derek R. Boyd, Narain D. Sharma, Magdalena Kaik, Peter B. A. M^cIntyre, Paul J. Stevenson, Christopher C. R. Allen

Silver-promoted Friedel–Crafts reaction: concise total synthesis of (−)-ardeemin, (−)-acetylardeemin and (−)-formylardeemin
Y. Wang, C. Kong, Y. Du, H. Song, D. Zhang, Y. Qin

Also of Interest:
The first articles from MedChemComm’s themed issue on Natural Products are available, including contributions from Professors Craig Townsend and Margaret Brimble
Want to see your natural products article featured on this blog? Submit online here

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Vibsane-type diterpenoids on the cover of NPR issue 4

15 Mar 2012

By Marie Cote, Deputy Editor.

Welcome to NPR issue 4, 2012!

This month’s cover features the work of Jeffrey Y. W. Mak and Craig M. Williams who highlight the key accomplishments in the total synthesis of visbanins, which are rare, structurally dense diterpenes occuring exclusively in the Viburnum species.

Key achievements in the total synthesis of vibsane-type diterpenoids
Jeffrey Y. W. Mak and Craig M. Williams
Nat. Prod. Rep., 2012, 29, 440-448
DOI: 10.1039/C2NP00067A

Also in the issue, read the latest Hot Of The Press article by Robert A. Hill and Andrew Sutherland,

A Highlight by Jiyong Hong and Hendrik Luesch on Largazole, a potent inhibitor of histone deacetylases (HDACs) which has attracted considerable interest from the scientific community. This Highlight summarizes recent advances to date in the characterization of this marine natural product:

Largazole: From discovery to broad-spectrum therapy
Jiyong Hong and Hendrik Luesch
Nat. Prod. Rep., 2012, 29, 449-456
DOI: 10.1039/C2NP00066K

A review article by Yuan-Chao Li and Ze-Hong Miao et al. focusing on thunder god vine’s (Tripterygium wilfordii Hook F) principal bioactive ingredient triptolide:

Triptolide: structural modifications, structure–activity relationships, bioactivities, clinical development and mechanisms
Zhao-Li Zhou, Ya-Xi Yang, Jian Ding, Yuan-Chao Li and Ze-Hong Miao

Richard Robins and Guillaume Tcherkez et al. ‘s review discussing biochemical and physiological factors underlying the site-specific, non-random distribution of 13C/12C isotope ratios within plant metabolites, which can be determined by isotopic 13C NMR spectrometry:

Biochemical and physiological determinants of intramolecular isotope patterns in sucrose from C3, C4 and CAM plants accessed by isotopic 13C NMR spectrometry: a viewpoint
Alexis Gilbert, Virginie Silvestre, Richard J. Robins, Gérald S. Remaud and Guillaume Tcherkez

R. Kiss and coworkers present both natural and synthetic phenazines with a critical focus on in vitro, in vivo and available clinical anti-cancer activities of these compounds, covering the literature published since 2000:

Phenazines and cancer
A. Cimmino, A. Evidente, V. Mathieu, A. Andolfi, F. Lefranc, A. Kornienko and R. Kiss

View the issue

Also of Interest:
The first articles from MedChemComm’s themed issue on Natural Products are available, including contributions from Professors Craig Townsend and Margaret Brimble

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Natural Products in OBC and MedChemComm

06 Mar 2012

By Marie Cote, Deputy Editor.

Our selection of the latest Natural Product chemistry published in our sister journal OBC…

Organic & Biomolecular Chemistry and MedChemComm, our sister journals, publish many articles that cover natural product chemistry.

We will try to keep you updated, although the safest bet is for you to sign up to OBC’s and MedChemComm‘s e-alerts (free service), and receive their tables of content directly in your inbox every time an issue is published.

The latest natural products’ related articles have been collated here:

The microbial cell factory
Cormac D. Murphy
Org. Biomol. Chem., 2012, 10, 1949-1957
DOI: 10.1039/C2OB06903B, Perspective

Fungal biofilm inhibitors from a human oral microbiome-derived bacterium
Xiaoru Wang, Lin Du, Jianlan You, Jarrod B. King and Robert H. Cichewicz
Org. Biomol. Chem., 2012, 10, 2044-2050
DOI: 10.1039/C2OB06856G, Paper

Pyrazine alkaloids via dimerization of amino acid-derived α-amino aldehydes: biomimetic synthesis of 2,5-diisopropylpyrazine, 2,5-bis(3-indolylmethyl)pyrazine and actinopolymorphol C
Sandhya Badrinarayanan and Jonathan Sperry
Org. Biomol. Chem., 2012, 10, 2126-2132
DOI: 10.1039/C2OB06935K, Paper

Novel, unifying mechanism for amphotericin B and other polyene drugs: electron affinity, radicals, electron transfer, autoxidation, toxicity, and antifungal action
Peter Kovacic and Andrew Cooksy
Med. Chem. Commun., 2012, 3, 274-280
DOI: 10.1039/C2MD00267A, Review

Intramolecular proton transfer impact on antibacterial properties of ansamycin antibiotic rifampicin and its new amino analogues
Krystian Pyta, Piotr Przybylski, Barbara Wicher, Maria Gdaniec and Joanna Stefańska
Org. Biomol. Chem., 2012, 10, 2385-2388
DOI: 10.1039/C2OB00008C, Communication

Efficient syntheses of 2,3-disubstituted natural quinazolinones via iridium catalysis
Jie Fang and Jianguang Zhou
Org. Biomol. Chem., 2012, 10, 2389-2391
DOI: 10.1039/C2OB07178A, Communication

View the first articles from MedChemComm’s themed issue on Natural Products, including contributions from Professors Craig Townsend and Margaret Brimble

Want to see your natural products article featured on this blog? Submit online here

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NPR poster prizes awarded at Zing Natural Products conference

27 Feb 2012

By Marie Cote, Deputy Editor.

Congratulations to Ramona Riclea (TU Braunschweig, Germany) and Khomaizon Kadir (University of Bristol, UK) who each won a Natural Product Reports poster prize at the Zing Natural Products conference held on 10-13 February in Lanzarote.

Ramona, currently studying for her PhD in the group of Dr. Jeroen S. Dickschat, presented her winning work entitled

‘Synthesis and biosynthesis of novel bioactive secondary metabolites from Streptomycetes’

while Khomaizon, PhD student working with Drs Andy Bailey and Colin M Lazarus, was rewarded for her winning poster presenting her research on:

‘Efficient expression system for production of natural products in Aspergillus orizae’

Both awardees receive a prize certificate and a one-year subscription to Natural Product Reports. Congratulations!

From left to right, Dr Jeroen Dickschat and poster prize winners Ramona Riclea and Khomaizon Kadir receiving their award certificate from Dr Marie Cote, NPR deputy editor.

The meeting was co-Chaired by NPR Advisory Board member and former NPR Chair David O’Hagan (University of St Andrews, UK) and NPR Advisory Board member Margaret Brimble (University of Auckland, New Zealand) and brilliantly covered the breadth of natural products research: from isolation and structural studies to biosynthesis to synthesis of molecules. Included in the line up of speakers were NPR Editorial Board members Andreas Kirschning (Leibniz University of Hannover, Germany) Stefan Schulz (TU Braunschweig, Germany), Dirk Trauner (Ludwig-Maximilians-Universität München), former NPR Chair Tom Simpson (University of Bristol, UK) and former Lecture Award winner Jason Micklefield (University of Manchester, UK).

The conference was a perfect opportunity to not only see some of the latest cutting edge natural products research but also to meet authors and readers of the journal – all this in very enjoyable surroundings!

For critical and though-provoking reviews across a broad range of areas of natural products research, you can turn to Natural Product Reports…

But did you know?

– Our sister journal Organic & Biomolecular Chemistry regularly publishes natural products related works: See them all here.

– Why not also view the very first articles from MedChemComm’s themed issue on Natural Products?

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Natural Products Blog

Cytotoxic and antioxidant marine natural products on the cover of NPR issue 5

Natural Products in OBC

There is still time to join ICPOC21!

Top ten most accessed articles in February

Latest Natural Product Research in OBC

Vibsane-type diterpenoids on the cover of NPR issue 4

Top ten most accessed articles in January

Natural Products in OBC and MedChemComm

NPR poster prizes awarded at Zing Natural Products conference

Top ten most accessed articles in December

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