Archive for the ‘Hot articles’ Category

Cystic fibrosis treatment clears the way

Stabilising a mucus attacking enzyme with cross-links could allow it to be delivered orally to fight infections in cystic fibrosis patients.

Pseudomonas aeruginosa is one of the commonest opportunistic pathogens in cystic fibrosis. The bacterium produces alginate, a polysaccharide which causes significant mucus build-up in the lungs and intestine. In addition to affecting patients’ quality of life, this also significantly obstructs the delivery of antibiotics, requiring increased dosages which can lead to antibiotic resistance and an increased chance of side-effects.

Guillermo Castro at the National University of La Plata in Argentina, and his team, investigate the delivery of drugs with significant administrative problems’…

Interested? If so, read the full article at Chemistry World here.

Cross-linking alginate lyase in the presence of BSA stabilises the enzyme but leaves the active site intact
Please click on the below title to access the original article which is free to access until 7th April 2014 :

Development of novel alginate lyase cross-linked aggregates for the oral treatment of cystic fibrosis
G. A. Islan, Y. N. Martinez, A. Illanes and G. R. Castro
RSC Adv., 2014, 4, 11758-11765
DOI: 10.1039/C3RA47850E

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‘HOT’ articles!

Our referees have spoken once again and chosen the below ‘HOT’ articles. Please have a gander and let us know what you think in the comments section below:

Mn2+/graphene oxide nanocomposite efficiently catalyzes the epoxidation of alkenes with H2O2
Weiguo Zheng, Rong Tan, Lili Zhao, Yaju Chen, Chuanwu Xiong and Donghong Yin
RSC Adv., 2014, 4, 11732-11739
DOI: 10.1039/C3RA47183G

GA

Enzymatic oxidation as a potential new route to produce polysaccharide aerogels
Kirsi S. Mikkonen, Kirsti Parikka, Jussi-Petteri Suuronen, Abdul Ghafar, Ritva Serimaa and Maija Tenkanen
RSC Adv., 2014, 4, 11884-11892
DOI: 10.1039/C3RA47440B 

GA

Sensitive and regenerable organochalcogen probes for the colorimetric detection of thiols
Shah Jaimin Balkrishna, Ananda S. Hodage, Shailesh Kumar, Piyush Panini and   Sangit Kumar
RSC Adv., 2014, 4, 11535-11538
DOI: 10.1039/C4RA00381K

GA

And remember – these articles are free to access for 4 weeks!

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Turmeric – potential ingredient to anti-cancer therapies

Turmeric, a spice commonly used in curries, contains a natural polyphenol called curcumin, which has been revealed as a promising anti-cancer therapeutic.

Tautomeric forms of curcumin and nanoparticle drug delivery systems

The undesirable properties and side effects of current anti-cancer therapeutics have inspired scientists to search for a natural remedy which may be better tolerated.  Curcumin has been demonstrated to inhibit cancer cell survival and to induce apoptosis without promoting the development of side effects.

Studies comparing the incidences of cancer in India and the West revealed that there was a lower risk of cancer in India. It is proposed that a major contribution to these statistics could be the increased intake of plant derivatives, such as curcumin, into the diet. In Asia, turmeric has been used for its medicinal properties for more than two thousand years!

In the 1800s scientists were able to isolate the curcumin molecule, but the structure wasn’t elucidated until 1910 – it is the structure which is responsible for its unique physiochemical and biological properties:

  • Often used as a dye due to its vibrant colour.
  • Increases the thermal stability of collagen, used for dermal wound healing.
  • Stability is maintained at room temperature allowing it to be used for medicinal purposes.

Traditional medicine has used curcumin to treat several conditions including inflammation, respiratory infections and blood clotting, but there is a rapidly growing interest in its effects on cancer.

Curcumin has yet to be licenced as a drug, possibly due to its susceptibility to rapid degradation in a wide range of environments and its sensitivity to pH and light. Under certain conditions curcumin becomes unstable and degrades, yielding other compounds. As many drug delivery systems tend to stabilize curcumin it needs to be determined whether it is curcumin itself or its degradation products that provided the biological activities observed.

To find out more about the chemical properties, bioactivity and approaches to cancer cell delivery of curcumin, read the full review by clicking the link.

Curcumin, a promising anti-cancer therapeutic: a review of its chemical properties, bioactivity and approaches to cancer cell delivery
Melessa Salem, Sohrab Rohani and Elizabeth Gillies
DOI: 10.1039/C3RA46396F

Access is free* until the 28.03.14 for registered users

*Access is free for 4 weeks through a registered RSC account – click here to register

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‘HOT’ articles – take a look!

Our referees have selected the below ‘HOT’ articles for this month. Please have a read and let us know your thoughts below!

Utilization of the photophysical and photochemical properties of phosphorescent transition metal complexes in the development of photofunctional cellular sensors, imaging reagents, and cytotoxic agents
Kenneth Kam-Wing Lo, Steve Po-Yam Lia
RSC Adv., 2014, 4, 10560-10585
DOI: 10.1039/C3RA47611A

GA

Carbon-based quantum dots for fluorescence imaging of cells and tissues
Pengju G. Luo, Fan Yang, Sheng-Tao Yang, Sumit K. Sonkar, Liju Yang, Jessica J. Broglie, Yun Liu and Ya-Ping Sun
RSC Adv., 2014, 4, 10791-10807
DOI: 10.1039/C3RA47683A 

GA

Automated system for extraction and instantaneous analysis of millimeter-sized samples
Jie-Bi Hu, Ssu-Ying Chen, June-Tai Wu, Yu-Chie Chen and Pawel L. Urban
RSC Adv., 2014, 4, 10693-10701
DOI: 10.1039/C3RA48023B 

GA

These articles are free to access for 4 weeks!

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Reclaiming spilt oil

The ability to recover oil from land-based spills should reduce the cost of decontamination

© Shutterstock

Scientists in Canada have shown they can recover oil from contaminated sand using surfactants whose emulsion stabilising ability is deactivated by carbon dioxide.

Land-based oil spills can be remedied by taking the sand (or soil away) for washing. The sand is heated and mixed with a surfactant solution, before the oil containing emulsion is removed to leave clean sand. However, the entire emulsion must be disposed of as hazardous waste.

Switchable surfactants could offer a less wasteful solution. Unlike normal surfactants, switchable surfactants can be switched off by an external trigger, allowing the oil and water phases to separate, by destabilising the emulsion.

The negative surface charges on sand particles mean that surfactants for cleaning oil contaminated sand need to be anionic. Cationic switchable surfactants were pioneered by Philip Jessop and his colleagues at Queens University, Kingston, Ontario, in 2006, and now the team have created an anionic version.

To release oil captured by Jessop’s carboxylate and phenolate anionic surfactants carbon dioxide is bubbled through the emulsion, acidifying the aqueous phase. This switches the surfactant structure from anionic to neutral, disrupting the emulsion by removing its ability to stabilise the oil/water interface. The oil separates and can be decanted for reuse and sale. Decarbonising the solution will switch the surfactants back on.

Read the rest of the story by Emily Skinner in Chemistry World!

Read the original research paper in RSC Advances:

Switchable anionic surfactants for the remediation of oil-contaminated sand by soil washing
Elize Ceschia, Jitendra R. Harjani, Chen Liang, Zahra Ghoshouni, Tamer Andrea, R. Stephen Brown and Philip G. Jessop
RSC Adv., 2014, 4, 4638-4645
DOI: 10.1039/C3RA47158F, Paper

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HOT papers in RSC Advances

Here are the latest HOT papers published in RSC Advances:

Size-adjustable annular ring-functionalized mesoporous silica as effective and selective adsorbents for heavy metal ions
Fa-Kuen Shieh, Chia-Teng Hsiao, Hsien-Ming Kao, Yu-Chein Sue, Kuan-Wei Lin, Chang-Cheng Wu, Xi-Hong Chen, Lei Wan, Ming-Hua Hsu, Jih Ru Hwu, Chia-Kuang Tsung and Kevin C.-W. Wu  
RSC Adv., 2013, 3, 25686-25689
DOI: 10.1039/C3RA45016C

GA

A quantitative assessment of the production of ˙OH and additional oxidants in the dark Fenton reaction: Fenton degradation of aromatic amines
Claudio Minero, Mirco Lucchiari, Valter Maurino and Davide Vione  
RSC Adv., 2013, 3, 26443-26450
DOI: 10.1039/C3RA44585B

GA 

Synthesis of dibenzyl carbonate: towards a sustainable catalytic approach
Giulia Fiorani and Maurizio Selva  
RSC Adv., 2014, 4, 1929-1937
DOI: 10.1039/C3RA42904K

GA

All the papers listed above are free to access for the next 4 weeks!

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HOT papers in RSC Advances

Here are the latest HOT papers published in RSC Advances:

Synthesis of [18F]4-(4-fluorophenyl)-1,2,4-triazole-3,5-dione: an agent for specific radiolabelling of tyrosine
Flagothier Jessica, Warnier Corentin, Dammicco Sylvestre, Lemaire Christian and Luxen André
RSC Adv., 2013, 3, 24936-24940
DOI: 10.1039/C3RA44666B

GA

Novel environmentally friendly (Bi, Ca, Zn, La)VO4 inorganic yellow pigments
Wendusu, Taihei Honda, Toshiyuki Masui and Nobuhito Imanaka  
RSC Adv., 2013, 3, 24941-24945
DOI: 10.1039/C3RA43978J

GA

Iron-catalysed alkene hydrogenation and reductive cross-coupling using a bench-stable iron(II) pre-catalyst
Dominik J. Frank, Léa Guiet, Alexander Käslin, Elliot Murphy and Stephen P. Thomas  
RSC Adv., 2013, 3, 25698-25701
DOI: 10.1039/C3RA44519D

GA

All the papers listed above are free to access for the next 4 weeks!

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HOT papers in RSC Advances

Here are the latest HOT papers published in RSC Advances:

Biobutanol: An outlook of an academist and industrialist
 Sandip B. Bankar, Shrikant A. Survase, Heikki Ojamo and Tom Granström, 
RSC Adv., 2013, 3, 24734-24757, DOI: 10.1039/C3RA43011A

GA

A cationic water-soluble pillar[6]arene: synthesis, host–guest properties, and self-assembly with amphiphilic guests in water
Yingjie Ma, Jie Yang, Jinying Li, Xiaodong Chi and Min Xue,
RSC Adv., 2013, 3, 23953-23956, DOI: 10.1039/C3RA44727H

GA

Multifunctional graphene quantum dots-conjugated titanate nanoflowers for fluorescence-trackable targeted drug delivery
Xin Ting Zheng, Hui Ling He and Chang Ming Li,
RSC Adv., 2013, 3, 24853-24857, DOI: 10.1039/C3RA44125C

GA

All the papers listed above are free to access for the next 4 weeks!

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Iridium complexes for solid state lighting

Sara Coles is a guest web-writer for RSC Advances. She currently works for Johnson Matthey in Royston, UK.


 

Interesting research is being done on solid state lighting, organic light emitting diodes (OLEDs), light emitting electrochemical cells (LEECs) and dye sensitised solar cells (DSSCs). Eli Zysman-Colman’s group, which recently moved from Université de Sherbrooke in Canada to University of St Andrews in the UK, works on precious metals complexes for light-emitting applications.

The group has a wealth of publications in the field, among the latest are this paper in RSC Advances which correlates the structures of heteroleptic cationic iridium complexes with their electrochemiluminescence behaviour to gain insight into tuning their emission wavelength and intensity. The aim, of course, is to generate efficient complexes that could one day find use in various lighting applications, display screens and devices.

Find out about the Zysman-Colman group’s fundamental research in RSC Advances. Free to access for 4 weeks.

Correlating electronic structures to electrochemiluminescence of cationic Ir complexes
Kalen N. Swanick, Sébastien Ladouceur, Eli Zysman-Colman and Zhifeng Ding 
RSC Adv., 2013, 3, 19961–19964, DOI: 10.1039/C3RA43134G

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The private lives of plants

Scientists in Japan have designed a microdevice to monitor the effect that chemicals have on the growth of pollen tubes.

  

In higher plants, the male and female gametes are located in separate tissues within the plant. The male gamete is produced inside a pollen grain and for pollination to occur it must be carried to the female part of the plant by a growing pollen tube. Chemical signals from the female part of the plant attract the pollen tube towards it and only compatible pollen tubes make it all the way.

While these events are happening around us every day, they happen on the microscale, making them very difficult to study. Previous research into plant reproduction has suggested that the direction of pollen tube growth is controlled by a gradient of attractant molecules. However, most assays spot chemoattractant onto a medium then allow it to spread, which makes it difficult to determine the exact concentration of attractant molecule at the head of the pollen tube.

Now, Noritada Kaji and colleagues at Nagoya University have created a microfluidic assay that can more accurately investigate pollen tube growth. ‘Lab-on-a-chip technologies have found a new partner in plant physiology research,’ says Kaji. ‘Our simple microfluidic platform provides precisely defined concentration gradients of chemoattractants over an extended time period to enable the digital discrimination of chemoattractant effects on directional pollen tube growth.’

Read the rest of the story in Chemistry World!

Read the original research paper in RSC Advances:

M Horade et al, RSC Adv., 2013, DOI: 10.1039/c3ra42804d

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