Analytical Methods Blog

Yu et al., Anal. Methods, 2013, Advance Article

Mutation, apoptosis and cancer can develop from damaged DNA, however the cell produces proteins capable of repairing DNA to prevent these dangerous effects. One of these proteins produced by cells, 8-oxoG DNA glycosylase/AP lyase (hOGG1), targets DNA lesions caused by reactive oxygen species. Typically studying this glycosylase requires large instrumentation, such as HPLC, or radioactive labeling. Ru-Qin Yu and coworkers at Hunan University developed a system, where the hOGG1 cleaves at the mismatch site on a DNA strand, and releases a DNAzyme mimetic, which produces a colored signal. This rapid and sensitive colorimetric assay measured the activity of hOGG1 for a range of concentrations, with an affordable DNA probe, and user-friendly instrumentation.

This paper will be free to read until Nov 30th.

A novel DNAzyme-based colorimetric assay for the detection of hOGG1 activity with lambda exonuclease cleavage
Shu-Cheng Liu, Hui-Wang Wu, Jian-hui Jiang, Guo-Li Shen and Ru-Qin Yu
Anal. Methods, 2013, Advance Article
DOI: 10.1039/C2AY26018B

Take a look below at some wonderful HOT articles we’ve recently published this month in Analytical Methods. There are papers covering a large variety of fields, including the analysis of cosmetics, semivolatiles in drinking water, microarrays, and refrigerant systems. These HOT papers will be free to read until November 19th.

Preparation of aligned porous silica monolithic capillary columns and their evaluation for HPLC
Adham Ahmed, Peter Myers and Haifei Zhang
Anal. Methods, 2012, Advance Article
DOI: 10.1039/C2AY25671A

Fabricating three-dimensional hydrogel oligonucleotide microarrays to detect single nucleotide polymorphisms
Xia Liu, Tao Li, Dianjun Liu and Zhenxin Wang
Anal. Methods, 2012, Advance Article
DOI: 10.1039/C2AY25904D

Measurement of iodide and caffeine content in cellulite reduction cosmetic products sold in the European market
Emilia Marchei, Daniela De Orsi, Carmine Guarino, Stefano Dorato, Roberta Pacifici and Simona Pichini
Anal. Methods, 2012, Advance Article
DOI: 10.1039/C2AY25761K

A novel outlook on detecting microbial contamination in cosmetic products: analysis of biomarker volatile compounds by solid-phase microextraction gas chromatography-mass spectrometry
Gerardo Alvarez-Rivera, Trinidad De Miguel, Maria Llompart, Carmen Garcia-Jares, Tomas Gonzalez Villa and Marta Lores
Anal. Methods, 2012, Advance Article
DOI: 10.1039/C2AY25833A

Development of EPA Method 525.3 for the analysis of semivolatiles in drinking water
Paul E. Grimmett and Jean W. Munch
Anal. Methods, 2013, Advance Article
DOI: 10.1039/C2AY25880C

Determination of the Raman depolarization ratio in optically active samples
Johannes Kiefer and Malte Kaspereit
Anal. Methods, 2012, Advance Article
DOI: 10.1039/C2AY25987G

A compact comprehensive two-dimensional gas chromatography (GC×GC) approach for the analysis of biogenic VOCs
Samuel J. Edwards, Alastair C. Lewis, Stephen J. Andrews, Richard T. Lidster, Jacqueline F. Hamilton and Christopher N. Rhodes
Anal. Methods, 2012, Advance Article
DOI: 10.1039/C2AY25710F

A sensor probe for the continuous in situ monitoring of ammonia leakage in secondary refrigerant systems
Raman Subramanian, Karl Crowley, Aoife Morrin and Anthony J. Killard
Anal. Methods, 2012, Advance Article
DOI: 10.1039/C2AY25688F

We have a bumper crop of HOT articles in this issue of Analytical Methods. Take a look at some of the hot science that we have published in this month’s issue. These papers will be free to read until Nov 9th.

XPS investigation of a Si-diode in operation
Sefik Suzer
Anal. Methods, 2012, 4, 3527-3530
DOI: 10.1039/C2AY25901J

Using gallic acid-modified gold nanoassemblies to detect the Pb²⁺ of tea
Caiyun Jiang, Meihua Ma and Yuping Wang
Anal. Methods, 2012, 4, 3570-3574
DOI: 10.1039/C2AY25648G

Reagentless amperometric immunosensor for α-1-fetoprotein based on assembly of nano-Au@SiO₂ composite
Xiaomei Huang, Xiang Deng and Di Wu
Anal. Methods, 2012, 4, 3575-3579
DOI: 10.1039/C2AY25778E

Electrochemical sensing platform based on Schiff-base cobalt(II)/single-walled carbon nanohorns complexes system
Baoping Lu, Zhe Zhang, Jinhui Hao, Guobao Xu, Bailin Zhang and Jilin Tang
Anal. Methods, 2012, 4, 3580-3585
DOI: 10.1039/C2AY25940K

Simultaneous determination of Pb(II) and Cd(II) using an electrode modified with electropolymerized thiadiazole film
Changzhi Zhao, Hui Liu and Li Wang
Anal. Methods, 2012, 4, 3586-3592
DOI: 10.1039/C2AY25525A

The preparation and use of synthetic isotope mixtures for testing the accuracy of the PTIMS method for ¹⁰B/¹¹B isotope ratio determination using boron mannitol complex and NaCl for the formation of Na₂BO₂⁺
Radhika M. Rao, Ankush R. Parab and Suresh Kumar Aggarwal
Anal. Methods, 2012, 4, 3593-3599
DOI: 10.1039/C2AY25439E

A new matrix of MALDI-TOF MS for the analysis of thiolate-protected gold clusters
Haruki Kouchi, Hideya Kawasaki and Ryuichi Arakawa
Anal. Methods, 2012, 4, 3600-3603
DOI: 10.1039/C2AY26013A

Take a look below at some wonderful HOT articles we’ve recently published this month in Analytical Methods. There are papers covering a large variety of methods including XPS, MALDI-TOF MS, Raman spectroscopy and much more. These papers will be free to read until Oct 26th.

The preparation and use of synthetic isotope mixtures for testing the accuracy of the PTIMS method for ¹⁰B/¹¹B isotope ratio determination using boron mannitol complex and NaCl for the formation of Na₂BO₂⁺
Radhika M. Rao, Ankush R. Parab and Suresh Kumar Aggarwal
Anal. Methods, 2012, Advance Article
DOI: 10.1039/C2AY25439E

Diagnostic segregation of human brain tumours using Fourier-transform infrared and/or Raman spectroscopy coupled with discriminant analysis
Ketan Gajjar, Lara D. Heppenstall, Weiyi Pang, Katherine M. Ashton, Júlio Trevisan, Imran I. Patel, Valon Llabjani, Helen F. Stringfellow, Pierre L. Martin-Hirsch, Timothy Dawson and Francis L. Martin
Anal. Methods, 2012, Advance Article
DOI: 10.1039/C2AY25544H

Electrochemical sensing platform based on Schiff-base cobalt(II)/single-walled carbon nanohorns complexes system
Baoping Lu, Zhe Zhang, Jinhui Hao, Guobao Xu, Bailin Zhang and Jilin Tang
Anal. Methods, 2012, Advance Article
DOI: 10.1039/C2AY25940K

Determination of carbonate ion contents in layered double hydroxides by FTIR spectrometry
Toshiyuki Tanaka, Yoshikazu Kameshima, Shunsuke Nishimoto and Michihiro Miyake
Anal. Methods, 2012, Advance Article
DOI: 10.1039/C2AY25850A

A new matrix of MALDI-TOF MS for the analysis of thiolate-protected gold clusters
Haruki Kouchi, Hideya Kawasaki and Ryuichi Arakawa
Anal. Methods, 2012, Advance Article
DOI: 10.1039/C2AY26013A

XPS investigation of a Si-diode in operation
Sefik Suzer
Anal. Methods, 2012, Advance Article
DOI: 10.1039/C2AY25901J

Laura Ruvuna, Web Writer

D'Auria et al., Anal. Methods, 2012, Advance Article

Researchers in Italy have developed a new technique for detecting an amphetamine and methamphetamine precursor, 1-phenyl-2-propanone, also known as benzyl methyl ketone (BMK). Catching the precursors in shipment reduces the manufacturing and availability of these dangerous drugs, but it can be difficult as the density is similar to water. Common techniques such as gas chromatography and HPLC, while effective, require large instrumentation with testing performed in the laboratory. Alternatively, Stefano Di Giovanni, Sabato D’Auria and coworkers synthesized a BMK derivative, with the goal of growing antibodies and detecting the resulting fluorescent signal from binding with BMK. Using this system, they have managed to detect down to 100 nM and, are transitioning from large laboratory equipment towards a smaller, portable optical detection device. This article will be free to read until Oct 19th.