Archive for the ‘Hot Articles 2012’ Category

HOT Article: improved brain tumour diagnosis

Diagnostic segregation of human brain tumours using FT-IR and Raman

Gajjar et al., Anal. Methods, 2012, Advance Article

Scientists at Lancaster University and Lancashire Teaching Hospitals NHS Trust have used infrared and Raman spectroscopy for brain tumour diagnosis.

Professor Frank Martin and colleagues used the techniques combined with statistical analysis to discriminate between normal brain tissue and three different tumour types based on the unique spectral fingerprints of their biochemical composition.

Current diagnostic approaches lack the spatial resolution required by surgeons, and delineating the excision border is important in making sure the tumour is completely removed. Vibrational spectroscopy has potential for analysing brain tissue, and Raman in particular can be performed in vivo within seconds or minutes. The information obtained by this method can be combined with conventional methods, for example immunohistochemistry, to diagnose and grade brain tumours to allow for more accurate planning and execution of surgery and/or radiation therapy. This offers more potential for individualised treatment and better long-term survival.

Professor Martin says, “These are really exciting developments which could lead to significant improvements for individual patients diagnosed with brain tumours.  We and other research teams are now working towards a sensor which can be used during brain surgery to give surgeons precise information about the tumour and tissue type that they are operating on.”

Read the article in full using the link below – it will be free to access until 8 October.

Diagnostic segregation of human brain tumours using Fourier-transform infrared and/or Raman spectroscopy coupled with discriminant analysis
Ketan Gajjar, Lara D. Heppenstall, Weiyi Pang, Katherine M. Ashton, Júlio Trevisan, Imran I. Patel, Valon Llabjani, Helen F. Stringfellow, Pierre L. Martin-Hirsch, Timothy Dawson and Francis L. Martin
Anal. Methods, 2012, Advance Article
DOI: 10.1039/C2AY25544H

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HOT articles in Analytical Methods

Ghourchian et al., Anal. Methods, 2012, Advance Article

A cholesterol biosensor

From the University of Tehran, Iran, Hedayatollah Ghourchian and colleagues have developed an electrochemical biosensor that was able to determine cholesterol levels in serum samples. Cholesterol levels in blood is a good indicator of diseases such as Alzheimer’s disease, and coronary heart disease.

A nanocomposite based biosensor for cholesterol determination
Somayeh Karimi, Hedayatollah Ghourchian, Parvaneh Rahimi and Hossain-Ali Rafiee-Pour
Anal. Methods, 2012, Advance Article
DOI: 10.1039/C2AY25826A

Extracting and quantifying the ingredients of Prozac®.

Thurbide et al., Anal. Methods, 2012, Advance Article

A team from Canada and the US have optimized a method for extracting the active pharmaceutical ingredient from Prozac® capsules. Kevin. B Thurbide, from Calgary University, and colleagues worked on a method using enhanced fluidity liquid extraction. Read more by clicking on the link below.

Characterization of sample preparation of Prozac® capsules using enhanced fluidity liquid extraction
Fadi L. Alkhateeb, Kevin B. Thurbide, Gordon Lambertus and Eric Jensen
Anal. Methods, 2012, Advance Article
DOI: 10.1039/C2AY25737H

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HOT article: Improving the stationary phase for HPLC

Liang et al., Anal. Methods, Advance Article

Silica-based stationary phases are very commonly used for high performance liquid chromatography but in most cases cannot be used above pH of 8. There have been a number of approaches used, mainly including post-synthesis grafting and direct synthesis, to improve the high pH stability of silica-based stationary phases. In this paper, Xinmiao Liang and colleagues from Dalian Institute of Chemical Physics have used porous spherical silicon oxynitride (sph-SiON) material as a stationary phase for HPLC. Read more about their work below.

Silicon oxynitride microspheres as stationary phase for high performance liquid chromatography
Huihui Wan, Xingya Xue, Yuguang Du and Xinmiao Liang
Anal. Methods, 2012, Advance Article
DOI: 10.1039/C2AY25783A

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HOT Article: New Development for Amphetamine Drug Detection

By Pui Sai Lau, Web Writer

Mashayekhi et al., Anal. Methods, 2012, Advance Article

With the prevalent misuse of amphetamine and its derivatives, drug testing is routinely performed in clinical and forensic laboratories. Effective testing requires high efficiency and reproducibility for analysis of complex, real samples. Hossein Ali Mashayekhi and colleagues from Islamic Azad University, Iran, have created a novel strategy to detect amphetamine and its related compounds in human urine by using ultrasound-assisted emulsification microextraction and gas chromatography. Find out more details by accessing the link below.

Simultaneous determination of amphetamine and related compounds in human urine using ultrasound-assisted emulsification microextraction and gas chromatography
Mohammad Rezaee, Hossein Ali Mashayekhi and Shirin Sadeghi Garmaroudi
Anal. Methods, 2012, Advance Article
DOI: 10.1039/C2AY25461A

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HOT articles in Analytical Methods this August!

It’s been a busy month with so many great papers, so here are some HOT articles from Analytical Methods that you might have missed this August! Included is a contribution from our Advisory Board member Craig E. Banks. The range of topics covered include screen printed electrodes, bioanalytical analysis, fluorescent probes, and water analysis.

Why not take a look, they will be free to read for 2 weeks.

Electroanalytical properties of screen printed shallow recessed electrodes
Jonathan P. Metters, Fang Tan, Rashid O. Kadara and Craig E. Banks
Anal. Methods, 2012, Advance Article
DOI: 10.1039/C2AY25512J

A solid-phase extraction liquid chromatography-tandem mass spectrometry method for the percutaneous absorption assessment of 3-(4′-methylbenzylidene)camphor via human urine analysis
Zacarías León-González, Alberto Chisvert, Isabel Fernández and Amparo Salvador
Anal. Methods, 2012, Advance Article
DOI: 10.1039/C2AY25490E

Chisvert et al, Anal. Methods, 2012, Advance Article

Selective solid-phase extraction using molecularly imprinted polymers for the analysis of norfloxacin in fish
Baixin Zhang, Jingchan Zhao, Bijing Sha and Miao Xian
Anal. Methods, 2012, Advance Article
DOI: 10.1039/C2AY25707F

Anthracene appended coumarin derivative as a Cr(III) selective turn-on fluorescent probe for living cell imaging: a green approach towards speciation studies
Subarna Guha, Sisir Lohar, Arnab Banerjee, Animesh Sahana, Subhra Kanti Mukhopadhyay, Jesús Sanmartín Matalobos and Debasis Das
Anal. Methods, 2012, Advance Article
DOI: 10.1039/C2AY25693B

Hu et al., Anal. Methods, 2012, Advance Article

Novel magnetic ion imprinted polymer as a highly selective sorbent for extraction of gold ions in aqueous samples
Homeira Ebrahimzadeh, Elahe Moazzen, Mostafa M. Amini and Omid Sadeghi
Anal. Methods, 2012, Advance Article
DOI: 10.1039/C2AY25407G

Well-defined surface ion-imprinted magnetic microspheres for facile onsite monitoring of lead ions at trace level in water
Yang Cui, Jia-Qi Liu, Zhang-Jun Hu, Xia-Wei Xu and Hong-Wen Gao
Anal. Methods, 2012, Advance Article
DOI: 10.1039/C2AY25656H

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What’s HOT in Issue 9?

Rapid and sensitive chromatograpHOT article: Rapid and sensitive chromatographic determination of free sialic acid in complex bio-pharma sampleshic determination of free sialic acid in complex bio-pharma samples

Alwael et al., Anal. Methods, 2012,4, 2668-2673

There are plenty of HOT articles to take a look at in our latest issue, including one from our Editor-in-Chief, Brett Paull. His paper, with co-authors Hassan Alwael and Damian Connolly, describes a rapid, sensitive and reproducible liquid chromatographic method specifically for the quantitative determination of total free sialic acid, employing thiobarbituric acid as pre-column tagging agent, following the oxidation of sialic acid with periodic acid.

Rapid and sensitive chromatographic determination of free sialic acid in complex bio-pharma fermentation media samples
Hassan Alwael, Damian Connolly and Brett Paull
Anal. Methods, 2012,4, 2668-2673
DOI: 10.1039/C2AY25299F

Take a look at the rest of this issue’s HOT articles below – they will all be free to access until 7 September.

(more…)

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Latest Track on the Detection Playlist: Diagnosis of Influenza using DVD Reader Technology

Maquieira et al., Anal. Methods, 2012, Advance Article

By Pui Sai Lau, Web Writer

Many people loathe the aches and pains attributed to influenza (or flu) infection, which is especially prevalent during the winter months. However, depending on the aggressiveness of the pathogen subtype, more severe health complications including mortality can occur, particularly in infants and the elderly. While several detection methods are available for influenza diagnosis, limitations still exist such as long-analysis time, requirement of intensive labor and high cost. To tackle some of these issues, Ángel Maquieira and colleagues from Valencia, Spain have developed a sandwich immunoassay on commercial DVDs that makes use of a standard DVD reader for quantification. Check out their discovery by accessing the link below!

Influenza A virus infection diagnosis based on DVD reader technology
María-José Bañuls, María-Victoria González-Pedro, Rosa Puchades and Ángel Maquieira
Anal. Methods, 2012, Advance Article
DOI: 10.1039/C2AY25493J

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HOT articles in Analytical Methods

Take a look below at some wonderful HOT articles we’ve recently published in Analytical Methods. There are papers covering a large variety of fields, including stationary phases for HPLC, water analysis, glucose sensing and profiling fats and meats. These papers will be free to read for two weeks.

A protocol for the validation of qualitative methods of detection
Roy Macarthur and Christoph von Holst
Anal. Methods, 2012, Advance Article
DOI: 10.1039/C2AY05719K

Porous silica microspheres obtained by grinding monolithic columns as stationary phase for high performance liquid chromatography
Qishu Qu,  Qian Gu,  Lihua Shi,  Zuli Gu and Xiaoya Hu
Anal. Methods, 2012, Advance Article
DOI: 10.1039/C2AY25330E

Development of solution, film and membrane based fluorescent sensor for the detection of fluoride anions from water
Gunin Saikia,  Atul K. Dwivedi and Parameswar K. Iyer
Anal. Methods, 2012, Advance Article
DOI: 10.1039/C2AY25565K

Mesoporous CuO: Alternative enzyme-free glucose sensing structure with excellent kinetics of electrode process
Mei-Fang Wang,  Qin-An Huang,  Xiang-Zi Li and Yan Wei
Anal. Methods, 2012, Advance Article
DOI: 10.1039/C2AY25501D

Study on the electrochemical properties of maltol at a carbon paste electrode and its analytical application
Jing Zhou,  Kai Zhang,  Yamin Li,  Kunjing Li and Baoxian Ye
Anal. Methods, 2012, Advance Article
DOI: 10.1039/C2AY25514F

Intact triacylglycerol profiles of fats and meats via thermal imprinting easy ambient sonic-spray ionization mass spectrometry
Andréia M. Porcari,  Nicolas V. Schwab,  Rosana M. Alberici,  Elaine C. Cabral,  Damila R. de Moraes,  Paula F. Montanher,  Christina R. Ferreira,  Marcos N. Eberlin and Jesuí V. Visentainer
Anal. Methods, 2012, Advance Article
DOI: 10.1039/C2AY25550B


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HOT Article: Determining free sialic acid levels in bio-pharma samples

Paull et al., Anal. Methods, 2012, Advance Article

This month we have a HOT article from Brett Paull, the Editor in Chief of Analytical Methods. Sialic acids have many biological roles. The importance of sialic acids to a glycoprotein’s half-life means that there is a strong need to determine the sialic acid content of a glycoprotein when examining its function and activity as a potential therapeutic. A team from Ireland and Australia, have developed a very rapid and analytically robust method that can quantitatively determine total free sialic acid, based upon monolithic reversed-phase chromatography. This method has been developed and specifically applied to process a range of very complex samples from the biopharmaceutical industry. This article will be free to read for 2 weeks.

Rapid and sensitive chromatographic determination of free sialic acid in complex bio-pharma fermentation media samples
Hassan Alwael, Damian Connolly and Brett Paull
Anal. Methods, 2012, Advance Article
DOI: 10.1039/C2AY25299F

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HOT Article: Colorimetric detection of lysine using gold nanoparticles

Xu et al, Anal. Methods, 2012, Advance Article

By Laura Ruvuna, Web Writer

Sensors don’t always require expensive equipment or complex attachment chemistries, and when possible a visual color change is enough. In this HOT article, Maotian Xu and colleagues from Shangqiu Normal University, China, have detected lysine effectively and cheaply using the colorimetric properties of gold nanoparticles during aggregation. The lysine content in food is important for growth and development, and using this assay it was detected in three different commercial food sources. In addition to the visual change, the UV-Vis spectra scaled linearly with lysine concentration. See more about this simple but sensitivity system below, it will be free to read for 2 weeks.

Colorimetric detection of lysine using gold nanoparticles aggregation
Yanli Zhou,  Zhichong Yang and Maotian Xu
Anal. Methods, 2012, Advance Article
DOI: 10.1039/C2AY25475A

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