OBC Inside Cover Issue 18: “Double-click” chemistry

Isao Kii, Takamitsu Hosoya and colleagues modify an azido-biomolecule by a new method that conjugates three molecules spontaneously in a catalyst-free strain-promoted “double-click” (SPDC) reaction.

If you find “click chemistry” interesting, this will double your enjoyment!

Discover this facile method to prepare various functional biomolecules by “clicking” here.

Strain-promoted double-click reaction for chemical modification of azido-biomolecules
Isao Kii, Akira Shiraishi, Toshiyuki Hiramatsu, Takeshi Matsushita, Hidehiro Uekusa, Suguru Yoshida, Makoto Yamamoto, Akira Kudo, Masatoshi Hagiwara and Takamitsu Hosoya
Org. Biomol. Chem., 2010, 8, 4051-4055
DOI: 10.1039/C0OB00003E , Communication

Free to access until early October!

What do you think?

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Tom Driver-OBC cover Issue 17-Free to access now

Tom Driver, from University of Illinois at Chicago, tells us about efficient ways to  construct new C-N and S-N bonds from azides using Transition metal-catalyzed N-atom transfer reactions.

This is the inside cover article of OBC Issue 17 and therefore is free to access for 6 weeks!

A simple, colourful and direct cover for a comprehensible, didactic and clear perspective.

Read it here and feel free to comment on it.

Recent advances in transition metal-catalyzed N-atom transfer reactions of azides
Tom G. Driver
Org. Biomol. Chem., 2010, 8, 3831-3846

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Synthesis of oxindole-OBC Issue 17 cover

Jian Zhou and colleagues at East China Normal University in Shanghai find a very straightforward method for the synthesis of oxindole, a very important subunit in many bioactive natural products and drugs.

OBC cover of Issue 17 shows the direct road that leads to the synthesis of this very useful product. It is free to access for 6 weeks from publication of the issue.

Do you want to know more? Read it here and let us know what you think!

A facile method for the synthesis of oxindole based quaternary α-aminonitriles via the Strecker reaction
Yun-Lin Liu, Feng Zhou, Jun-Jie Cao, Cong-Bin Ji, Miao Ding and Jian Zhou
Org. Biomol. Chem., 2010, 8, 3847-3850

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OBC Accepted Manuscripts

In a fast moving subject field, you need your research results to be available to the community as soon as possible.

At Organic & Biomolecular Chemistry (OBC), you can now have the unedited and unformatted version of your article published shortly after acceptance as an Accepted Manuscript. This new, free service from RSC Publishing allows you to make your results available to the community, in citable form, before publication of the edited article.

Of course, each OBC article will continue to receive the current high quality editing and formatting service from a professional technical editor, and the Accepted Manuscript version of an article will become unavailable when the fully edited and formatted Advance Article version is published.
 
More information about Accepted Manuscripts can be found below.

What are Accepted Manuscripts?
Accepted Manuscripts are articles which have been published prior to technical editing, formatting and proof reading. All Accepted Manuscripts have been through the RSC Publishing peer review process and have been accepted for publication.

In what format does my Accepted Manuscript appear?
Accepted Manuscripts appear online as a PDF file. An Accepted Manuscript is published in the format in which it is received from you. Any supplementary material will be available as a separate file(s).

How does my Accepted Manuscript appear in the online article listing?
Accepted Manuscripts are listed in the Advance Article tab on the RSC Publishing Platform. The authors’ names in this listing will appear in the form and the order that they were entered into OBC’s online submission system by the corresponding author. Once the Advance Article version is published, the names in the listing will appear as given in the manuscript.

What files do I need to supply before acceptance?
Information about the required file formats will be supplied to you at the same time as you receive the referees’ comments on your manuscript. Submission using the RSC’s article template is encouraged but not required. Where text and image files are received separately they will be collated for publication by an RSC Publishing Editor.

What happens to my article once it has been published as an Accepted Manuscript?
Once an article has been published as an Accepted Manuscript it will be edited and formatted by a professional team of Technical Editors. The proof will then be sent to you for checking. The Accepted Manuscript will be replaced by the fully edited, formatted and proof-read Advance Article as soon as this is available.

Are Accepted Manuscripts the final scientific article of record?
No. The articles published as Accepted Manuscripts are not the final scientific version of record. The Advance Article version of the article represents the final scientific article of record.

How do I cite an Accepted Manuscript?
Accepted Manuscripts can be cited using the Digital Object Identifier (DOI®), which is printed in the left-hand margin of each page of the manuscript. The DOI for each manuscript will be retained once the fully edited Advance Article is published, so that any citations to the Accepted Manuscript will link to the final version.

Does my article have to be published as an Accepted Manuscript?
No. You have the opportunity to opt out of having your manuscript published as an Accepted Manuscript before it is accepted. Therefore not all OBC articles will be published as an Accepted Manuscript version.

When is the official publication date of my manuscript?
The official publication date of your article will be the date when the Accepted Manuscript version is published.

Can my Accepted Manuscript be published before the RSC’s “Licence to Publish” is completed?
No. A completed “Licence to Publish” must be received before your article can be published.

For further information about Accepted Manuscripts please contact the Editorial office.

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OBC HOT article- Hans Joachim Knolker

Knölker and co-workers  describe an efficient total synthesis of the sesquiterpenes (±)-β-isocomene and (±)-isocomene using a Lewis acid-promoted [3 + 2] cycloaddition of allyl-tert-butyldiphenylsilane as the key-step.

This is an OBC HOT article (as rated by the referees and the Editorial Office) and it will be free to access for 4 weeks.

You can download it here and comment on this blog.

Organosilicon-mediated total synthesis of the triquinane sesquiterpenes (±)-β-isocomene and (±)-isocomene
Arndt W. Schmidt, Thomas Olpp, Elke Baum, Tina Stiffel and Hans-Joachim Knölker
Org. Biomol. Chem., 2010, Advance Article

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OBC attended BOSS XII

‘The BOSS-conference is a unique international symposium’– this is written on the BOSS XII web page and after having been there I concur!

The 12th Belgian Organic Synthesis Symposium was held in Namur (Belgium). This is a biennial meeting that attracts researchers, mostly graduate students and post-docs, from all over the globe, especially Europe.

Young rising stars and established organic chemists, a brilliant lecture delivered by Eric Jacobsen(Harvard University), the recipient of the “Janssen Pharmaceutica Prize for Creativity in Organic Synthesis”, and a fantastic one-day course by Professor David MacMillan (Princeton University), Editor-in-chief of Chemical Science, were the ingredients of the perfect cocktail of this summer.

OBC sponsored a poster prize which was awarded to Kurt Hoogewijs, University of Ghent. Congratulations! We hope you enjoy your prize: a RSC book entitled ‘Eco-Friendly Synthesis of Fine Chemicals’ edited by Roberto Ballini.

I’d also like to congratulate Prof. Manfred T. Reetz (Max Planck, MULHEIM / Ruhr, Germany) and Prof. Stéphane Vincent (FUNDP Namur, Belgium), Chairman and host of BOSS XII,  for organising such a superb conference.

Take a look at some recently published papers by some of the speakers of this meeting.

Micro-scale process development of transaminase catalysed reactions
Matthew D. Truppo and Nicholas J. Turner
Org. Biomol. Chem., 2010, 8, 1280-1283

Biosynthesis of the mitochondrial adenine nucleotide translocase (ATPase) inhibitor bongkrekic acid in Burkholderia gladioli
Barbara Rohm, Kirstin Scherlach and Christian Hertweck
Org. Biomol. Chem., 2010, 8, 1520-1522

Towards the synthesis of a Yersinia pestiscell wallpolysaccharide: enantioselective synthesis of an L-glycero-D-manno-heptose building block
Takafumi Ohara, Alexander Adibekian, Davide Esposito, Pierre Stallforth and Peter H. Seeberger
Chem. Commun., 2010, 46, 4106-4108

Ring-opening reaction of Bus- and SES-protected aziridines using lithiated dithianes
Ken Sakakibara and Kyoko Nozaki
Org. Biomol. Chem., 2009, 7, 502-507

Synthesis, photophysical, electrochemical, and electrochemiluminescent properties of 5,15-bis(9-anthracenyl)porphyrin derivatives
Chloè Sooambar, Vincent Troiani, Carlo Bruno, Massimo Marcaccio, Francesco Paolucci, Andrea Listorti, Abdelhalim Belbakra, Nicola Armaroli, Alessandra Magistrato, Rita De Zorzi, Silvano Geremia and Davide Bonifazi
Org. Biomol. Chem., 2009, 7, 2402-2413

Silver-catalysed protodecarboxylation of carboxylic acids
Lukas J. Gooßen, Christophe Linder, Nuria Rodríguez, Paul P. Lange and Andreas Fromm
Chem. Commun., 2009, 7173-7175

Metal-catalyzed rearrangement of enantiomerically pure alkylidenecyclopropane derivatives as a new access to cyclobutenes possessing quaternary stereocenters
Ahmad Masarwa, Alois Fürstner and Ilan Marek
Chem. Commun., 2009, 5760-5762 

Stereoselective gold-catalyzed cycloaddition of functionalized ketoenynes: synthesis of (+)-orientalol F
Eloísa Jiménez-Núñez, Kian Molawi and Antonio M. Echavarren
Chem. Commun., 2009, 7327-7329

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GRC Bioorganic Chemistry: OBC was there

The 2010 Bioorganic Chemistry Gordon Research Conference was held in Proctor Academy, Andover (Newhampshire) last June.

 

The meeting was attended by over 150 people. The broad scope of the meeting together with the mixture of young and experienced researchers and its international audience contributed to the success of this conference.

The quality of both the talks and the posters was outstanding and the friendly atmosphere encouraged many interesting and fruitful discussions. I had the pleasure of meeting many people from industry and academia.
I would like to congratulate the organisers and Christine Chow and Arthur Hanel -Chairs of the meeting- for putting together such an inspirational conference.

Read some articles from some of the speakers here:

Cellular uptake and binding of guanidine-modified phthalocyanines to KRAS/HRAS G-quadruplexes
Alexandro Membrino, Manikandan Paramasivam, Susanna Cogoi, Jawad Alzeer, Nathan W. Luedtke and Luigi E. Xodo
Chem. Commun., 2010, 46, 625-627

Quantum mechanics/molecular mechanics investigation of the mechanism of phosphate transfer in human uridine-cytidine kinase 2
Adam J. T. Smith, Ying Li and K. N. Houk
Org. Biomol. Chem., 2009, 7, 2716-2724

The chemistry of marine furanocembranoids, pseudopteranes, gersolanes, and related natural products
Paul A. Roethle and Dirk Trauner
Nat. Prod. Rep., 2008, 25, 298-317

Radicals with a controlled lifestyle
JoAnne Stubbe
Chem. Commun., 2003, 2511-2513

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Aqueous aldol reactions from two different points of view

Carlos Barbas III and Nobuyuki Mase look at recent developments and applications of aldolase-type organocatalytic direct transformations in aqueous media in this new Perspective article. You will learn more about the role of water in organocatalysis, a field that is rapidly developing.

In water, on water, and by water: mimicking nature’s aldolases with organocatalysis and water
Nobuyuki Mase, Carlos F. Barbas and III, Org. Biomol. Chem., 2010
DOI: 10.1039/c004970k

On the same theme, take a look at Thomas Nugent and colleagues’ recent paper on diastereo- and enantioselective aqueous aldol reactions and discover a very promising organocatalyst template for this kind of reaction.

Picolylamine as an organocatalyst template for highly diastereo- and enantioselective aqueous aldol reactions
Thomas C. Nugent, M. Naveed Umar and Ahtaram Bibi, Org. Biomol. Chem., 2010
DOI: 10.1039/c0ob00049c

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Organic & Biomolecular Chemistry achieves its highest ever impact factor

The latest citation data released by Thomson ISI on 17 June 2010 reveal that Organic & Biomolecular Chemistry’s Impact Factor has risen to its highest ever value of 3.762.

OBC's impact factor growth

Organic & Biomolecular Chemistry’s Impact Factor growth over the last 5 years

‘Another highest-ever figure for the fifth successive year, maintaining its position as one of the leading journals for publishing high quality and widely-read organic research’ says Richard Kelly, the Editor of Organic & Biomolecular Chemistry.

Be part of this success and submit now to OBC!

OBC’s broad scope means that we publish great research across the entire spectrum of organic and biomolecular chemistry, including emerging areas. We welcome all types of manuscripts: communications, full papers and reviews. We have a very international authorship and readership that is continously growing (like our impact factor!).

Thank you to all our authors, readers and referees who are the architects of this success.

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Follow Organic & Biomolecular Chemistry with Twitter

Organic & Biomolecular Chemistry has joined the Twitter community! Keep up to date with the latest Hot Articles and news by becoming a follower of our Twitter feed.

Follow us here

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Twitter is a social networking tool that allows for real-time updates of short messages. If you tweet, follow the Organic & Biomolecular Chemistry feed to keep up to date with the latest Hot Articles, published issues, themed issues and latest news.

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