Isao Kii, Takamitsu Hosoya and colleagues modify an azido-biomolecule by a new method that conjugates three molecules spontaneously in a catalyst-free strain-promoted “double-click” (SPDC) reaction.
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Discover this facile method to prepare various functional biomolecules by “clicking” here.
Strain-promoted double-click reaction for chemical modification of azido-biomolecules
Isao Kii, Akira Shiraishi, Toshiyuki Hiramatsu, Takeshi Matsushita, Hidehiro Uekusa, Suguru Yoshida, Makoto Yamamoto, Akira Kudo, Masatoshi Hagiwara and Takamitsu Hosoya
Org. Biomol. Chem., 2010, 8, 4051-4055
DOI: 10.1039/C0OB00003E , Communication
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