Efficient Biodiesel Conversion

Aaron Socha and Jason Sello at Brown University, USA, describe an efficient method to convert both virgin and waste vegetable oils into biodiesel in a single reaction vessel by using scandium and bismuth triflates as catalysts.

Some of the advantages of this new environmentally friendly method are:

  • The lack of corrosive chemicals
  • The high efficiency: conversion in 6 times faster
  • The simplicity: one step reaction in one vessel
  • The use of environmentally friendly and recoverable catalysts

Not surprisingly, this paper has been highlighted in many different outlets. These are just some of them:

You can now read this article for free until the 4th November:

Efficient conversion of triacylglycerols and fatty acids to biodiesel in a microwave reactor using metal triflate catalysts
Aaron M. Socha and Jason K. Sello
Org. Biomol. Chem., 2010, 8, 4753-4756
DOI: 10.1039/C0OB00014K, Paper

From the Organic & Biomolecular Chemistry editorial office we wanted to congratulate the authors of this paper and encourage them to carry on developing their meaningful research.

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Nobel Prize to Organic Chemistry

Congratulations to  Richard Heck (University of Delaware, USA), Ei-ichi Negishi (Purdue University, USA) and Akira Suzuki (Hokkaido University, Japan), the recipients of the 2010 Nobel Prize in Chemistry.

These three chemists have been working independently on palladium-catalysed cross coupling reactions to make C-C bonds to design new organic molecules. Their chemical methods are widely used by the chemical communities  to develop new compounds and molecules with applications in pharmaceuticals, agriculture and the electronic industry.

I was listening to Professor Negishi this morning on his first interview live from Stockholm and he was absolutely delighted with the news. He was awoken by a phone call that told him he was one of the Chemistry Nobel Prize winners – what a great way of waking up in the morning!

Negishi said that he was ‘extremely happy – this means a lot’.   ‘I have been dreaming about this prize for half a century, since I came to America and encountered several Nobel laureates, when I realised it was not a story – it was a reality which in principle could happen to anyone, including myself.’ 
Professor Negishi, 2010 was your turn! Congratulations.

Neghisi, Suzuki and Heck will go to Stockohlm next December to receive this very well deserved prestigious prize. From Organic & Biomolecular Chemistry we wanted to send our most sincere appreciation and admiration to these three pioneers of organic chemistry.

Read more from Chemistry World here.

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OBC Accepted Manuscripts: publishing your research even faster

In a fast moving subject field, you need your research to be available to the community as soon as possible.

At Organic & Biomolecular Chemistry (OBC) we are working with our authors to make this happen. That’s why you can now choose to have the unedited and unformatted version of your article published shortly after acceptance as an Accepted Manuscript.

This new, free service from RSC Publishing allows you to make your results available, in citable form, before publication of the edited article. Published on the website as a downloadable pdf file, your Accepted Manuscript is readily accessible to the people you want to read it.

Of course, all OBC articles will continue to receive the current high quality editing and formatting service from RSC Publishing’s professional team of technical editors. Once the fully edited and formatted Advance Article is published the Accepted Manuscript version of your article will become unavailable.

Check out these examples of recent Accepted Manuscripts free:

Microwave and flow syntheses of Pseudomonas quinolone signal (PQS) and analogues
James Hodgkinson, Warren Galloway, Shreya Saraf, Ian R Baxendale, Steven V Ley, Mark Ladlow, Martin Welch      
and David Spring
Org. Biomol. Chem., 2010, DOI: 10.1039/C0OB00652A

A ferrocene functionalized rotaxane host system capable of the electrochemical recognition of chloride
Nicholas Henley Evans and P D Beer
Org. Biomol. Chem., 2010, DOI: 10.1039/C0OB00458H

More information about OBC Accepted Manuscripts can be found on our blog.

Wouldn’t it be great to have your research read by your peers almost as soon as you know your manuscript has been accepted? Go online to submit your next article  to OBC now: we look forward to receiving your work.

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HOT: 4 steps to (+)-pestalazine B

Carlos Perez-Balado and Angel R. de Lera at University of Vigo have designed a convergent and versatile synthetic route to the preparation on this heterodimeric diketopiperazine alkaloid in just 4 steps.

This versatile methodology allows the synthesis of several diastereomers.

The paper is a nice trip through the unexpected paths of organic chemistry that lead you to the right compound.  Discover all of this and much more in this HOT paper. We loved it, the referees loved it and I’m sure you will love it too!

Free to access until the end of October

Concise total synthesis and structural revision of (+)-pestalazine B
Carlos Pérez-Balado and Ángel R. de Lera
Org. Biomol. Chem., 2010, Advance Article
DOI: 10.1039/C0OB00531B , Paper

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HOT Mycolactone core: Two synthetic approaches

Kwang-Seuk Ko,  Matthew D. Alexander, Michael D. Burkart and colleagues at University of California at San Diego, give us two different synthetic routes to make one product: the macrolide core of the mycolactone polyketides.

As you can see, organic synthesis is a matter of choice!

Read about the story of these new synthetic methods, the authors’ different approaches to their findings and how they succeded with the synthesis of their targeted molecule.

Free to access until the end of October

Synthetic studies on the mycolactone core
Kwang-Seuk Ko, Matthew D. Alexander, Shaun D. Fontaine, James E. Biggs-Houck, James J. La Clair and Michael D. Burkart
Org. Biomol. Chem., 2010, Advance Article
DOI: 10.1039/C0OB00540A, Paper

Read Michael Burkart’s story of this paper on the comments!

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HOT: Proctolin structure revealed

Judith Howard, Olga Chetina and colleagues at University of Durham ellucidate the crystal structure of Proctolin [Arg-Tyr-Leu-Pro-Thr], a much studied insect neuropeptide.

This is a very important step towards the design of the ideal insecticide, highly selective, environmentally friendly, safe and of course effective.  It becomes even more relevant when we think about malaria and mosquitoes resistance to insecticides as one of the main problems to control the spread of the disease.

‘We have revealed the structure of Proctolin [Arg-Tyr-Leu-Pro-Thr]. The molecular association is very unusual for small peptides and it is hoped that the structure elucidation will enable the design of new insecticides towards the effective control of malaria’ say the authors of the paper.

I certainly hope so and I also think research like this one takes us a step closer!

Read the full paper that will be free to access until the end of October.

Crystal structure of the insect neuropeptide proctolin.
Judith A. K. Howard, Dmitry S. Yufit, Olga V. Chetina, Simon J. Teat, Silvia C. Capelli and Philip Pattison
Org. Biomol. Chem., 2010, Advance Article
DOI: 10.1039/C0OB00345J, Paper

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Inside Cover Issue 20: Silicon is the link

Hans-Joachim Knölkner and colleagues reveal the link between this beautiful church in Dresden and β-isocomene: silicon

Find out more about this curious conection in this article and read about the total synthesis of the sesquiterpenes (±)-β-isocomene and (±)-isocomene via a Lewis acid promoted [3 + 2] cycloaddition of allyl-tert-butyldiphenylsilane.

This article will be free to access until 10th November

Organosilicon-mediated total synthesis of the triquinane sesquiterpenes (±)-β-isocomene and (±)-isocomene
Arndt W. Schmidt, Thomas Olpp, Elke Baum, Tina Stiffel and Hans-Joachim Knölker
Org. Biomol. Chem., 2010, 8, 4562-4568
DOI: 10.1039/C0OB00051E

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Front Cover Issue 20: Proton as the electrophile

This colourful and arty cover by Chunling Fu, Shengming Ma and colleagues shows the mechanism of a highly regio- and stereo- selective hydration of 1,2-allenylic sulfoxides.

In this reaction, the proton acts as the electrophile and water coming from the solvent attacks the sulfinyl group.
Not convinced yet?  There are even crystal structures to prove it!

Download the article for free until 10th November

Studies on highly regio- and stereoselective hydration of 1,2-allenylic sulfoxides
Zhao Fang, Chao Zhou, Chunling Fu and Shengming Ma
Org. Biomol. Chem., 2010, 8, 4554-4561
DOI: 10.1039/C0OB00007H

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Top ten most accessed articles in August

This month sees the following articles in Organic & Biomolecular Chemistry that are in the top ten most accessed:-

Recent advances in transition metal-catalyzed N-atom transfer reactions of azides
Tom G. Driver
Org. Biomol. Chem., 2010, 8, 3831 – 3846, DOI: 10.1039/c005219c, Perspective

Sequential combination of Michael and acetalization reactions: direct catalytic asymmetric synthesis of functionalized 4-nitromethyl-chromans as drug intermediates
Dhevalapally B. Ramachary and Rajasekar Sakthidevi
Org. Biomol. Chem., 2010, 8, 4259 – 4265, DOI: 10.1039/c0ob00189a, Communication

Strain-promoted double-click reaction for chemical modification of azido-biomolecules
Isao Kii, Akira Shiraishi, Toshiyuki Hiramatsu, Takeshi Matsushita, Hidehiro Uekusa, Suguru Yoshida, Makoto Yamamoto, Akira Kudo, Masatoshi Hagiwara and Takamitsu Hosoya
Org. Biomol. Chem., 2010, 8, 4051 – 4055, DOI: 10.1039/c0ob00003e, Communication

Recent advances in stereoselective glycosylation through intramolecular aglycon delivery
Akihiro Ishiwata, Yong Joo Lee and Yukishige Ito
Org. Biomol. Chem., 2010, 8, 3596 – 3608, DOI: 10.1039/c004281a, Perspective

A facile method for the synthesis of oxindole based quaternary a-aminonitriles via the Strecker reaction
Yun-Lin Liu, Feng Zhou, Jun-Jie Cao, Cong-Bin Ji, Miao Ding and Jian Zhou
Org. Biomol. Chem., 2010, 8, 3847 – 3850, DOI: 10.1039/c0ob00174k, Communication

High-throughput synthesis of azide libraries suitable for direct “click” chemistry and in situ screening
Rajavel Srinivasan, Lay Pheng Tan, Hao Wu, Peng-Yu Yang, Karunakaran A. Kalesh and Shao Q. Yao
Org. Biomol. Chem., 2009, 7, 1821 – 1828, DOI: 10.1039/b902338k

In water, on water, and by water: mimicking nature’s aldolases with organocatalysis and water
Nobuyuki Mase, Carlos F. Barbas III
Org. Biomol. Chem., 2010, 8, 4043 – 4050, DOI: 10.1039/c004970k, Perspective

Organosilicon-mediated total synthesis of the triquinane sesquiterpenes (±)-beta-isocomene and (±)-isocomene
Arndt W. Schmidt, Thomas Olpp, Elke Baum, Tina Stiffel and Hans-Joachim Knölker
Org. Biomol. Chem., 2010, DOI: 10.1039/c0ob00051e

Intramolecular cycloaddition in 6,6-spiroepoxycyclohexa-2,4-dienone: simple aromatics to (±)-Platencin
Vishwakarma Singh, Bharat Chandra Sahu, Varsha Bansal and Shaikh M. Mobin
Org. Biomol. Chem., 2010, 8, 4472 – 4481, DOI: 10.1039/c004316h

Radical stability and its role in synthesis and catalysis
Johnny Hioe and Hendrik Zipse
Org. Biomol. Chem., 2010, 8, 3609 – 3617, DOI: 10.1039/c004166a, Perspective

Why not take a look at the articles today and blog your thoughts and comments below.

Fancy submitting an article to Organic & Biomolecular Chemistry? Then why not submit to us today or alternatively email us your suggestions.

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Nominations for the 2011 Prizes and Awards are now open

The RSC currently presents around 60 prestigious Prizes and Awards annually to scientists in all the main chemical science disciplines allowing for the greatest range of scientists to be recognised for their work; individuals, teams and organisations working across the globe.

There are nine categories of awards including specific categories for Industry and Education so whether you work in business, industry, research or education recognition is open to everyone.

Our Prizes and Awards represent the dedication and outstanding achievements in the chemicals sciences and are a platform to showcase inspiring science to gain the recognition deserved.

Do you know someone who has made a significant contribution to advancing the chemical sciences? View our full list of Prizes and Awards and use the online system to nominate yourself or colleagues.

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