Organic & Biomolecular Chemistry Blog

Tanabe, Nishimoto and co-workers at Kyoto University, propose a mechanism for the intramolecular cyclization of modified oligodeoxynucleotides bearing a pair of disulfides.

This colourful cover represents how X-Ray irradiation of an aqueous solution of modified oligodeoxynucleotides with a pair of disulfides at both ends causes efficient cyclization via an
intramolecular exchange reaction.

The article is free to access until the end of November.

Radiolytic cyclization of stem-and-loop structured oligodeoxynucleotide with neighboring arrangement of α,ω-bis-disulfides
Kazuhito Tanabe, Eiji Matsumoto, Takeo Ito and Sei-ichi Nishimoto
Org. Biomol. Chem., 2010, 8, 4837-4842
DOI: 10.1039/C0OB00275E

Congratulations to  Richard Heck (University of Delaware, USA), Ei-ichi Negishi (Purdue University, USA) and Akira Suzuki (Hokkaido University, Japan), the recipients of the 2010 Nobel Prize in Chemistry.

These three chemists have been working independently on palladium-catalysed cross coupling reactions to make C-C bonds to design new organic molecules. Their chemical methods are widely used by the chemical communities  to develop new compounds and molecules with applications in pharmaceuticals, agriculture and the electronic industry.

I was listening to Professor Negishi this morning on his first interview live from Stockholm and he was absolutely delighted with the news. He was awoken by a phone call that told him he was one of the Chemistry Nobel Prize winners – what a great way of waking up in the morning!

Negishi said that he was ‘extremely happy – this means a lot’.   ‘I have been dreaming about this prize for half a century, since I came to America and encountered several Nobel laureates, when I realised it was not a story – it was a reality which in principle could happen to anyone, including myself.’ 
Professor Negishi, 2010 was your turn! Congratulations.

Neghisi, Suzuki and Heck will go to Stockohlm next December to receive this very well deserved prestigious prize. From Organic & Biomolecular Chemistry we wanted to send our most sincere appreciation and admiration to these three pioneers of organic chemistry.

Read more from Chemistry World here.

In a fast moving subject field, you need your research to be available to the community as soon as possible.

At Organic & Biomolecular Chemistry (OBC) we are working with our authors to make this happen. That’s why you can now choose to have the unedited and unformatted version of your article published shortly after acceptance as an Accepted Manuscript.

This new, free service from RSC Publishing allows you to make your results available, in citable form, before publication of the edited article. Published on the website as a downloadable pdf file, your Accepted Manuscript is readily accessible to the people you want to read it.

Of course, all OBC articles will continue to receive the current high quality editing and formatting service from RSC Publishing’s professional team of technical editors. Once the fully edited and formatted Advance Article is published the Accepted Manuscript version of your article will become unavailable.

Check out these examples of recent Accepted Manuscripts free:

More information about OBC Accepted Manuscripts can be found on our blog.

Wouldn’t it be great to have your research read by your peers almost as soon as you know your manuscript has been accepted? Go online to submit your next article  to OBC now: we look forward to receiving your work.