Archive for the ‘Most read’ Category

What are your colleagues reading in Organic & Biomolecular Chemistry?

The articles below are some of the most read Organic & Biomolecular Chemistry articles in April, May and June 2017.

Review Articles:

Design and synthesis of analogues of natural products
Martin E. Maier
DOI: 10.1039/C5OB00169B

Transition-metal catalyzed valorization of lignin: the key to a sustainable carbon-neutral future
Markus D. Kärkäs, Bryan S. Matsuura, Timothy M. Monos, Gabriel Magallanes and Corey R. J. Stephenson
DOI: 10.1039/C5OB02212F

Selective chemical labeling of proteins
Xi Chen and Yao-Wen Wu
DOI: 10.1039/C6OB00126B

Site-selective incorporation and ligation of protein aldehydes
Richard J. Spears and Martin A. Fascione
DOI: 10.1039/C6OB00778C

1,3-Dipolar cycloadditions of azomethine imines
Carmen Nájera, José M. Sansano and Miguel Yus
DOI: 10.1039/C5OB01086A

Organocatalytic synthesis of axially chiral atropisomers
P. Renzi
DOI: 10.1039/C7OB00908A

The application of design of experiments (DoE) reaction optimisation and solvent selection in the development of new synthetic chemistry
Paul M. Murray, Fiona Bellany, Laure Benhamou, Dejan-Krešimir Bučar, Alethea B. Tabor and Tom D. Sheppard
DOI: 10.1039/C5OB01892G

Recent advances in the synthesis and application of fluorescent α-amino acids
Alexander H. Harkiss and Andrew Sutherland
DOI: 10.1039/C6OB01715K

Communications & Papers:

Amidation of unactivated ester derivatives mediated by trifluoroethanol
Christopher G. McPherson, Nicola Caldwell, Craig Jamieson, Iain Simpson and Allan J. B. Watson
DOI: 10.1039/C7OB00593H, Communication

A rapid and efficient one-pot method for the reduction of N-protected α-amino acids to chiral α-amino aldehydes using CDI/DIBAL-H
Jakov Ivkovic, Christian Lembacher-Fadum and Rolf Breinbauer D
OI
: 10.1039/C5OB01838B, Communication

A protocol for amide bond formation with electron deficient amines and sterically hindered substrates
Maria E. Due-Hansen, Sunil K. Pandey, Elisabeth Christiansen, Rikke Andersen, Steffen V. F. Hansen and Trond Ulven
DOI: 10.1039/C5OB02129D, Communication

A NHC-catalyzed 1,3-dipolar cycloaddition reaction of allyl ketones with azides: direct access to 1,4,5-trisubstituted 1,2,3-triazoles
Huijun Yuan, Lili Zhang, Zhantao Liu, Yang Liu, Jian Wang and Wenjun Li
DOI: 10.1039/C7OB00906B, Communication

A novel off–on fluorescent probe for sensitive imaging of mitochondria-specific nitroreductase activity in living tumor cells
Bo Huang, Wen Chen, Yong-Qing Kuang, Wei Liu, Xian-Jun Liu, Li-Juan Tang and Jian-Hui Jiang
DOI: 10.1039/C7OB00781G, Communication

FeCl3 catalysed 7-membered ring formation in a single pot: a new route to indole-fused oxepines/azepines and their cytotoxic activity
K. Shiva Kumar, Meesa Siddi Ramulu, Bandari Rajesham, N. Praveen Kumar, Vani Voora and Rama Krishna Kancha
DOI: 10.1039/C7OB00715A,Paper

Copper-catalyzed oxidative decarboxylative coupling of α-keto acids and sulfoximines
Chaleena Pimpasri, Ladawan Sumunnee and Sirilata Yotphan
DOI: 10.1039/C7OB00776K, Paper

Tf2NH-catalyzed formal [3 + 2] cycloaddition of oxadiazolones with ynamides: a simple access to aminoimidazoles
Yingying Zhao, Yancheng Hu, Xincheng Li and Boshun Wan
DOI: 10.1039/C7OB00701A, Communication

Cyclic dipeptide based cell-penetrating peptidomimetics for effective DNA delivery
Chilakapati Madhu, Chandrashekhar Voshavar, K. Rajasekhar and Thimmaiah Govindaraju
DOI: 10.1039/C7OB00167C, Communication

Synthesis, properties, and crystal structures of π-extended double [6]helicenes: contorted multi-dimensional stacking lattice
Takao Fujikawa, Nobuhiko Mitoma, Atsushi Wakamiya, Akinori Saeki, Yasutomo Segawa and Kenichiro Itami
DOI: 10.1039/C7OB00987A, Paper

Urotensin-II peptidomimetic incorporating a non-reducible 1,5-triazole disulfide bond reveals a pseudo-irreversible covalent binding mechanism to the urotensin G-protein coupled receptor
Salvatore Pacifico, Aidan Kerckhoffs, Andrew J. Fallow, Rachel E. Foreman, Remo Guerrini, John McDonald, David G. Lambert and Andrew G. Jamieson
DOI: 10.1039/C7OB00959C, Paper

Enantioselective total synthesis of (+)-arborescidine C and related tetracyclic indole alkaloids using organocatalysis
Vishal M. Sheth, Bor-Cherng Hong and Gene-Hsiang Lee
DOI: 10.1039/C7OB00473G, Communication

Asymmetric synthesis of CF3-containing tetrahydroquinoline via a thiourea-catalyzed cascade reaction
Yuanyuan Zhu, Boyu Li, Cui Wang, Zhenghao Dong, Xiaoling Zhong, Kairong Wang, Wenjin Yan and Rui Wang
DOI: 10.1039/C7OB01013C, Communication

Palladium-catalyzed Suzuki–Miyaura coupling of amides by carbon–nitrogen cleavage: general strategy for amide N–C bond activation
Guangrong Meng and Michal Szostak
DOI: 10.1039/C6OB00084C, Paper

Ru(II)-Catalyzed annulation of benzamidines and alkynes by C–H/N–H activation: a facile synthesis of 1-aminoisoquinolines
P. P. Kaishap, G. Duarah, D. Chetia and S. Gogoi
DOI: 10.1039/C7OB00389G, Paper

2,2,2-Trifluoroethanol as a solvent to control nucleophilic peptide arylation
Diana Gimenez, Anica Dose, Nicholas L. Robson, Graham Sandford, Steven L. Cobb and Christopher R. Coxon
DOI: 10.1039/C7OB00295E, Communication

Regioselective 6-endodig iodocyclization: an accessible approach for iodo-benzo[a]phenazines
Sonu Kumar, Mohammad Mujahid and Akhilesh K. Verma
DOI: 10.1039/C7OB00671C, Paper

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Most read articles in July – September 2016

The articles below are 10 of the most read Review articles and 10 of the most read Papers & Communications from Organic & Biomolecular Chemistry in July, August and September 2016.

Review Articles

Transition-metal catalyzed valorization of lignin: the key to a sustainable carbon-neutral future
Markus D. Kärkäs, Bryan S. Matsuura, Timothy M. Monos, Gabriel Magallanes and Corey R. J. Stephenson
DOI: 10.1039/C5OB02212F, Review Article

Selective chemical labeling of proteins
Xi Chen and Yao-Wen Wu
DOI: 10.1039/C6OB00126B, Review Article

Synthesis of substituted pyrenes by indirect methods
Juan M. Casas-Solvas, Joshua D. Howgego and Anthony P. Davis
DOI: 10.1039/C3OB41993B, Review Article

Modern advances in heterocyclic chemistry in drug discovery
Alexandria P. Taylor, Ralph P. Robinson, Yvette M. Fobian, David C. Blakemore, Lyn H. Jones and Olugbeminiyi Fadeyi
DOI: 10.1039/C6OB00936K, Review Article

Recent applications in natural product synthesis of dihydrofuran and -pyran formation by ring-closing alkene metathesis
Reece Jacques, Ritashree Pal, Nicholas A. Parker, Claire E. Sear, Peter W. Smith, Aubert Ribaucourt and David M. Hodgson
DOI: 10.1039/C6OB00593D, Review Article

Organic synthetic transformations using organic dyes as photoredox catalysts
Shunichi Fukuzumi and Kei Ohkubo
DOI: 10.1039/C4OB00843J, Review Article

Palladium catalysed meta-C–H functionalization reactions
Aniruddha Dey, Soumitra Agasti and Debabrata Maiti
DOI: 10.1039/C6OB00395H, Review Article

Design and synthesis of analogues of natural products
Martin E. Maier
DOI: 10.1039/C5OB00169B, Review Article

Biomineralization-inspired synthesis of functional organic/inorganic hybrid materials: organic molecular control of self-organization of hybrids
Atsushi Arakaki, Katsuhiko Shimizu, Mayumi Oda, Takeshi Sakamoto, Tatsuya Nishimura and Takashi Kato
DOI: 10.1039/C4OB01796J , Review Article

Synthesis of highly functionalized C60 fullerene derivatives and their applications in material and life sciences
Weibo Yan, Stefan M. Seifermann, Philippe Pierrat and Stefan Bräse
DOI: 10.1039/C4OB01663G, Review Article


Papers & Communications

A protocol for amide bond formation with electron deficient amines and sterically hindered substrates
Maria E. Due-Hansen, Sunil K. Pandey, Elisabeth Christiansen, Rikke Andersen, Steffen V. F. Hansen and Trond Ulven
DOI: 10.1039/C5OB02129D, Communication

5-Position-selective C–H trifluoromethylation of 8-aminoquinoline derivatives
Ben S. Pilgrim, Alice E. Gatland, Carlos H. A. Esteves, Charlie T. McTernan, Geraint R. Jones, Matthew R. Tatton, Panayiotis A. Procopiou and Timothy J. Donohoe
DOI: 10.1039/C6OB01325B, Paper

Enantioselective synthesis of 2,3-disubstituted trans-2,3-dihydrobenzofurans using a Brønsted base/thiourea bifunctional catalyst
Pan Gao, Li Liu, Zhuangzhi Shi and Yu Yuan
DOI: 10.1039/C6OB01326K, Paper

Iridium(III)-catalyzed regioselective direct arylation of sp2 C–H bonds with diaryliodonium salts
Estela Haldón, M. Carmen Nicasio and Pedro J. Pérez
DOI: 10.1039/C6OB01145D, Paper

Palladium-catalyzed enolate arylation as a key C–C bond-forming reaction for the synthesis of isoquinolines
Ben S. Pilgrim, Alice E. Gatland, Carlos H. A. Esteves, Charlie T. McTernan, Geraint R. Jones, Matthew R. Tatton, Panayiotis A. Procopiou and Timothy J. Donohoe
DOI: 10.1039/C5OB02320C, Paper

Facile one-pot synthesis of unsymmetrical ureas, carbamates, and thiocarbamates from Cbz-protected amines
Hee-Kwon Kim and Anna Lee
DOI: 10.1039/C6OB01290F, Paper

Insights into the catalytic mechanism of N-acetylglucosaminidase glycoside hydrolase from Bacillus subtilis: a QM/MM study
Hao Su, Xiang Sheng and Yongjun Liu
DOI: 10.1039/C6OB00320F, Paper

Scalable anti-Markovnikov hydrobromination of aliphatic and aromatic olefins
Marzia Galli, Catherine J. Fletcher, Marc del Pozo and Stephen M. Goldup
DOI: 10.1039/C6OB00692B, Communication

A rapid and efficient one-pot method for the reduction of N-protected α-amino acids to chiral α-amino aldehydes using CDI/DIBAL-H
Jakov Ivkovic, Christian Lembacher-Fadum and Rolf Breinbauer
DOI: 10.1039/C5OB01838B, Communication

Pd-catalyzed cascade allylic alkylation and dearomatization reactions of indoles with vinyloxirane
Run-Duo Gao, Qing-Long Xu, Li-Xin Dai and Shu-Li You
DOI: 10.1039/C6OB01523A, Communication

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What are your colleagues reading in Organic & Biomolecular Chemistry?

The articles below are some of the most read Organic & Biomolecular Chemistry articles in January, February and March 2016.

Development of a stable phosphoarginine analog for producing phosphoarginine antibodies
Han Ouyang, Chuan Fu, Songsen Fu, Zhe Ji, Ying Sun, Peiran Deng and Yufen Zhao
DOI: 10.1039/C5OB02603B, Communication

Bifunctional primary amine-thioureas in asymmetric organocatalysis
Olga V. Serdyuk, Christina M. Heckel and Svetlana B. Tsogoeva
DOI: 10.1039/C3OB41403E, Perspective

Transition-metal catalyzed valorization of lignin: the key to a sustainable carbon-neutral future
Markus D. Kärkäs, Bryan S. Matsuura, Timothy M. Monos, Gabriel Magallanes and Corey R. J. Stephenson
DOI: 10.1039/C5OB02212F, Review Article

Design and synthesis of analogues of natural products
Martin E. Maier
DOI: 10.1039/C5OB00169B, Review Article

Organic synthetic transformations using organic dyes as photoredox catalysts
Shunichi Fukuzumi and Kei Ohkubo
DOI: 10.1039/C4OB00843J, Review Article

Biomineralization-inspired synthesis of functional organic/inorganic hybrid materials: organic molecular control of self-organization of hybrids
Atsushi Arakaki, Katsuhiko Shimizu, Mayumi Oda, Takeshi Sakamoto, Tatsuya Nishimura and Takashi Kato
DOI: 10.1039/C4OB01796J, Review Article

Synthesis of substituted pyrenes by indirect methods
Juan M. Casas-Solvas, Joshua D. Howgego and Anthony P. Davis
DOI: 10.1039/C3OB41993B, Review Article

Recent synthetic additions to the visible light photoredox catalysis toolbox
Ricardo A. Angnes, Zhou Li, Carlos Roque D. Correia and Gerald B. Hammond
DOI: 10.1039/C5OB01349F, Review Article

A protocol for amide bond formation with electron deficient amines and sterically hindered substrates
Maria E. Due-Hansen, Sunil K. Pandey, Elisabeth Christiansen, Rikke Andersen, Steffen V. F. Hansen and Trond Ulven
DOI: 10.1039/C5OB02129D, Communication

Metal catalyzed defunctionalization reactions
Atanu Modak and Debabrata Maiti
DOI: 10.1039/C5OB01949D, Review Article

(more…)

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What are your colleagues reading in Organic & Biomolecular Chemistry?

The articles below are the most read Organic & Biomolecular Chemistry articles in July, August and September 2015.

Linear and star-shaped pyrazine-containing acene dicarboximides with high electron-affinity
Jinjun Shao, Jingjing Chang and Chunyan Chi
DOI: 10.1039/C2OB25680K, Paper

Recent synthetic additions to the visible light photoredox catalysis toolbox
Ricardo A. Angnes, Zhou Li, Carlos Roque D. Correia and Gerald B. Hammond
DOI: 10.1039/C5OB01349F, Review Article

Biomineralization-inspired synthesis of functional organic/inorganic hybrid materials: organic molecular control of self-organization of hybrids
Atsushi Arakaki, Katsuhiko Shimizu, Mayumi Oda, Takeshi Sakamoto, Tatsuya Nishimura and Takashi Kato
DOI: 10.1039/C4OB01796J, Review Article

Decarboxylative functionalization of cinnamic acids
Arun Jyoti Borah and Guobing Yan
DOI: 10.1039/C5OB00727E, Review Article

Design and synthesis of analogues of natural products
Martin E. Maier
DOI: 10.1039/C5OB00169B, Review Article

Anatomy of gold catalysts: facts and myths
Beatrice Ranieri, Imma Escofet and Antonio M. Echavarren
DOI: 10.1039/C5OB00736D, Review Article

Copper-catalyzed trifluoromethylation of alkenes: synthesis of trifluoromethylated benzoxazines
Sadhan Jana, Athira Ashokan, Shailesh Kumar, Ajay Verma and Sangit Kumar
DOI: 10.1039/C5OB01196E, Communication

Synthesis of substituted pyrenes by indirect methods
Juan M. Casas-Solvas, Joshua D. Howgego and Anthony P. Davis
DOI: 10.1039/C3OB41993B, Review Article

Enantioselective cooperative catalysis
Suleman M. Inamdar, Valmik S. Shinde and Nitin T. Patil
DOI: 10.1039/C5OB00986C, Review Article

Organic synthetic transformations using organic dyes as photoredox catalysts
Shunichi Fukuzumi and Kei Ohkubo
DOI: 10.1039/C4OB00843J, Review Article

(more…)

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What are your colleagues reading in Organic & Biomolecular Chemistry?

The articles below are the most read Organic & Biomolecular Chemistry articles in July, August and September 2014.

Marine natural products-inspired phenylmethylene hydantoins with potent in vitro and in vivo antitumor activities via suppression of Brk and FAK signaling
Asmaa A. Sallam, Mohamed M. Mohyeldin, Ahmed I. Foudah, Mohamed R. Akl, Sami Nazzal, Sharon A. Meyer, Yong-Yu Liu and Khalid A. El Sayed 
DOI: 10.1039/C4OB00553H

Watsonianone A–C, anti-plasmodial β-triketones from the Australian tree, Corymbia watsoniana
Anthony R. Carroll, Vicky M. Avery, Sandra Duffy, Paul I. Forster and Gordon P. Guymer 
DOI: 10.1039/C2OB26931G

Pyridostatin analogues promote telomere dysfunction and long-term growth inhibition in human cancer cells
Sebastian Müller, Deborah A. Sanders, Marco Di Antonio, Stephanos Matsis, Jean-François Riou, Raphaël Rodriguez and Shankar Balasubramanian 
DOI: 10.1039/C2OB25830G

Synthesis, characterization and biological evaluation of carboranylmethylbenzo[b]acridones as novel agents for boron neutron capture therapy
A. Filipa F. da Silva, Raquel S. G. R. Seixas, Artur M. S. Silva, Joana Coimbra, Ana C. Fernandes, Joana P. Santos, António Matos, José Rino, Isabel Santos and Fernanda Marques 
DOI: 10.1039/C4OB00644E

Organic synthetic transformations using organic dyes as photoredox catalysts
Shunichi Fukuzumi and Kei Ohkubo 
DOI: 10.1039/C4OB00843J

Copper-catalysed direct radical alkenylation of alkyl bromides
Xu Zhang, Hong Yi, Zhixiong Liao, Guoting Zhang, Chao Fan, Chu Qin, Jie Liu and Aiwen Lei 
DOI: 10.1039/C4OB00813H

Metal-free oxidative olefination of primary amines with benzylic C–H bonds through direct deamination and C–H bond activation
Liang Gong, Li-Juan Xing, Tong Xu, Xue-Ping Zhu, Wen Zhou, Ning Kang and Bin Wang 
DOI: 10.1039/C4OB01025F

Recent advances in trifluoromethylation of organic compounds using Umemoto’s reagents
Cai Zhang 
DOI: 10.1039/C4OB00671B

An efficient route to synthesize isatins by metal-free, iodine-catalyzed sequential C(sp3)–H oxidation and intramolecular C–N bond formation of 2′-aminoacetophenones
Venkatachalam Rajeshkumar, Selvaraj Chandrasekar and Govindasamy Sekar 
DOI: 10.1039/C4OB01564A

Amino acid chirons: a tool for asymmetric synthesis of heterocycles
Priyanka Singh, Krishnananda Samanta, Sanjit Kumar Das and Gautam Panda 
DOI: 10.1039/C4OB00943F

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Q2 Top Ten most accessed articles

During the months April – June 2014, the most downloaded Organic & Biomolecualr Chemistry articles were:

Design, synthesis, and application of tartaric acid derived N-spiro quaternary ammonium salts as chiral phase-transfer catalysts
Mario Waser, Katharina Gratzer, Richard Herchl and Norbert Müller
DOI: 10.1039/C1OB06573D

Far-red and near infrared BODIPY dyes: synthesis and applications for fluorescent pH probes and bio-imaging
Yong Ni and Jishan Wu
DOI: 10.1039/C3OB42554A

Direct acylation of N-benzyltriflamides from the alcohol oxidation level via palladium-catalyzed C–H bond activation
Jihye Park, Aejin Kim, Satyasheel Sharma, Minyoung Kim, Eonjeong Park, Yukyoung Jeon, Youngil Lee, Jong Hwan Kwak, Young Hoon Jung and In Su Kim
DOI: 10.1039/C3OB40140E

sp3 C–H oxidation by remote H-radical shift with oxygen- and nitrogen-radicals: a recent update
Shunsuke Chiba and Hui Chen
DOI: 10.1039/C4OB00469H

Watsonianone A–C, anti-plasmodial β-triketones from the Australian tree, Corymbia watsoniana
Anthony R. Carroll, Vicky M. Avery, Sandra Duffy, Paul I. Forster and Gordon P. Guymer
DOI: 10.1039/C2OB26931G

Recent advances in biocompatible nanocarriers for delivery of chemotherapeutic cargoes towards cancer therapy
Chung Yen Ang, Si Yu Tan and Yanli Zhao
DOI: 10.1039/C4OB00164H

Continuous flow chemistry: a discovery tool for new chemical reactivity patterns
Jan Hartwig, Jan B. Metternich, Nikzad Nikbin, Andreas Kirschning and Steven V. Ley
DOI: 10.1039/C4OB00662C

Bifunctional primary amine-thioureas in asymmetric organocatalysis
Olga V. Serdyuk, Christina M. Heckel and Svetlana B. Tsogoeva
DOI: 10.1039/C3OB41403E

Palladium-catalyzed three-component reaction of N-tosylhydrazone, norbornene and aryl halide
Fangdong Hu, Ying Xia, Zhenxing Liu, Chen Ma, Yan Zhang and Jianbo Wang
DOI: 10.1039/C4OB00590B

A coumarin-quinolinium-based fluorescent probe for ratiometric sensing of sulfite in living cells
Li Tan, Weiying Lin, Sasa Zhu, Lin Yuan and Kaibo Zheng
DOI: 10.1039/C4OB00132J

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Q1 Top Ten most accessed Organic & Biomolecular Chemistry articles

During January, February and March this year, the following articles were the Top Ten most accessed:

Rapid synthesis of Abelson tyrosine kinase inhibitors using click chemistry
Karunakaran A. Kalesh, Kai Liu and Shao Q. Yao  
Org. Biomol. Chem., 2009,7, 5129-5136
DOI: 10.1039/b913333j

Bifunctional primary amine-thioureas in asymmetric organocatalysis
Olga V. Serdyuk, Christina M. Heckel and Svetlana B. Tsogoeva  
Org. Biomol. Chem., 2013,11, 7051-7071
DOI: 10.1039/c3ob41403e

Copper-catalyzed highly efficient ester formation from carboxylic acids/esters and formates
Jun Liu, Changdong Shao, Yanghui Zhang, Guangfa Shi and Shulei Pan
Org. Biomol. Chem., 2014,12, 2637-2640
DOI: 10.1039/c4ob00193a

Synthetic applications of photoredox catalysis with visible light
Yumeng Xi, Hong Yi and Aiwen Lei  
Org. Biomol. Chem., 2013,11, 2387-2403
DOI: 10.1039/c3ob40137e

Recent progress towards transition metal-catalyzed synthesis of y-lactams
Long-Wu Ye, Chao Shu and Fabien Gagosz  
Org. Biomol. Chem., 2014,12, 1833-1845
DOI: 10.1039/c3ob42181c

Synthesis of substituted pyrenes by indirect methods
Juan M. Casas-Solvas, Joshua D. Howgego and Anthony P. Davis
Org. Biomol. Chem., 2014,12, 212-232
DOI: 10.1039/c3ob41993b

KI-catalyzed arylation of benzothiazoles from the coupling of aryl aldehydes with benzothiazoles in neat water
Yuyu Gao, Qiuling Song, Guolin Cheng and Xiuling Cui  
Org. Biomol. Chem., 2014,12, 1044-1047
DOI: 10.1039/c3ob42318b

A biocompatible, highly efficient click reaction and its applications
Yue Yuan and Gaolin Liang  
Org. Biomol. Chem., 2014,12, 865-871
DOI: 10.1039/c3ob41241e

“Frustrated Lewis pairs”: a concept for new reactivity and catalysis
Douglas W. Stephan  
Org. Biomol. Chem., 2008,6, 1535-1539
DOI: 10.1039/b802575b

Support of academic synthetic chemistry using separation technologies from the pharmaceutical industry
Erik L. Regalado, Marisa C. Kozlowski, John M. Curto, Tobias Ritter, Michael G. Campbell, Anthony R. Mazzotti, Bruce C. Hamper, Christopher D. Spilling, Michael P. Mannino, Li Wan, Jin-Quan Yu, Jinchu Liu and Christopher J. Welch  
Org. Biomol. Chem., 2014,12, 2161-2166
DOI: 10.1039/c3ob42195c

Please post your comments or thoughts on any of these articles in the comment box below.

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Q4 Top Ten most accessed Organic & Biomolecular Chemistry articles

During October, November and December, the following articles were the Top Ten most accessed:

A coumarin-based fluorescent probe for biological thiols and its application for living cell imaging
Lingliang Long, Liping Zhou, Lin Wang, Suci Meng, Aihua Gong, Fengyi Du and Chi Zhang
Org. Biomol. Chem., 2013,11, 8214-8220
DOI: 10.1039/c3ob41741g; Download PDF

Bifunctional primary amine-thioureas in asymmetric organocatalysis
Olga V. Serdyuk, Christina M. Heckel and Svetlana B. Tsogoeva
Org. Biomol. Chem., 2013,11, 7051-7071
DOI: 10.1039/c3ob41403e; Download PDF

To be or not to be metal-free: trends and advances in coupling chemistries
Rick Arneil D. Arancon, Carol Sze Ki Lin, Carolina Vargas and Rafael Luque
Org. Biomol. Chem., 2014,12, 10-35
DOI: 10.1039/c3ob41768a; Download PDF

Synthetic applications of arylboronic acid via an aryl radical transfer pathway
Guobing Yan, Minghua Yang and Xiangmei Wu
Org. Biomol. Chem., 2013,11, 7999-8008
DOI: 10.1039/c3ob41851k; Download PDF

Synthetic applications of photoredox catalysis with visible light
Yumeng Xi, Hong Yi and Aiwen Lei
Org. Biomol. Chem., 2013,11, 2387-2403
DOI: 10.1039/c3ob40137e; Download PDF

Analysis of the reactions used for the preparation of drug candidate molecules
John S. Carey, David Laffan, Colin Thomson and Mike T. Williams
Org. Biomol. Chem., 2006,4, 2337-2347
DOI: 10.1039/b602413k; Download PDF

N-heterocyclic carbene-catalyzed reactions of C–C unsaturated bonds
Xiang-Yu Chen and Song Ye
Org. Biomol. Chem., 2013,11, 7991-7998
DOI: 10.1039/c3ob41469h; Download PDF

Copper-catalyzed redox-neutral C–H amination with amidoximes
Hui Chen and Shunsuke Chiba
Org. Biomol. Chem., 2014,12, 42-46
DOI: 10.1039/c3ob41871e; Download PDF

Recent trends in Pd-catalyzed remote functionalization of carbonyl compounds
Ivan Franzoni and Clément Mazet
Org. Biomol. Chem., 2014,12, 233-241
DOI: 10.1039/c3ob42050g; Download PDF

Maximising multivalency effects in protein–carbohydrate interactions
Roland J. Pieters
Org. Biomol. Chem., 2009,7, 2013-2025
DOI: 10.1039/b901828j; Download PDF

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Q3 Top Ten most accessed Organic & Biomolecular Chemistry articles

During July, August and September, the following articles were the Top Ten most accessed:

Synthesis of azetidines and pyrrolidines via iodocyclisation of homoallyl amines and exploration of activity in a zebrafish embryo assay
Antonio Feula, Sundeep S. Dhillon, Rama Byravan, Mandeep Sangha, Ronald Ebanks, Mariwan A. Hama Salih, Neil Spencer, Louise Male, Istvan Magyary, Wei-Ping Deng, Ferenc Müller and John S. Fossey
Org. Biomol. Chem., 2013, 11, 5083-5093
DOI: 10.1039/c3ob41007b

Electrophilicity: the “dark-side” of indole chemistry
Marco Bandini
Org. Biomol. Chem., 2013, 11, 5206-5212
DOI: 10.1039/c3ob40735g

Transition-metal-catalyzed additions of C–H bonds to C–X (X = N, O) multiple bonds via C–H bond activation
Guobing Yan, Xiangmei Wu and Minghua Yang
Org. Biomol. Chem., 2013, 11, 5558-5578
DOI: 10.1039/c3ob40652k

Synthetic applications of photoredox catalysis with visible light
Yumeng Xi, Hong Yi and Aiwen Lei  
Org. Biomol. Chem., 2013,11, 2387-2403
DOI: 10.1039/C3OB40137E

Bioorthogonal labelling of biomolecules: new functional handles and ligation methods
Marjoke F. Debets, Jan C. M. van Hest and Floris P. J. T. Rutjes  
Org. Biomol. Chem., 2013,11, 6439-6455
DOI: 10.1039/C3OB41329B

DABCO-promoted synthesis of pyrazoles from tosylhydrazones and nitroalkenes
Meng Tang, Wen Zhang and Yuanfang Kong  
Org. Biomol. Chem., 2013,11, 6250-6254
DOI: 10.1039/C3OB41435C

Organocatalytic asymmetric synthesis of ß3-amino acid derivatives
Sun Min Kim and Jung Woon Yang
Org. Biomol. Chem., 2013, 11, 4737-4749
DOI: 10.1039/c3ob40917a

The first asymmetric total synthesis of (+)-coriandrone A and B
Wenjing Wang, Jijun Xue, Tian Tian, Yingdong Jiao and Ying Li  
Org. Biomol. Chem., 2013,11, 6686-6690
DOI: 10.1039/C3OB41497C

Design and biological characterization of hybrid compounds of curcumin and thalidomide for multiple myeloma
Kai Liu, Datong Zhang, Jeremy Chojnacki, Yuhong Du, Haian Fu, Steven Grant and Shijun Zhang  
Org. Biomol. Chem., 2013,11, 4757-4763
DOI: 10.1039/C3OB40595H

Pd(0)-catalyzed benzylic arylation–oxidation of 4-methylquinazolines via sp3 C–H activation under air conditions
Dan Zhao, Min-Xue Zhu, Yue Wang, Qi Shen and Jian-Xin Li  
Org. Biomol. Chem., 2013,11, 6246-6249
DOI: 10.1039/C3OB41488D

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Q2 Top 10 for Organic & Biomolecular Chemistry

Please take a look at the top 10 most accessed Organic & Biomolecular Chemistry articles for the second quarter of 2013:

Synthetic applications of photoredox catalysis with visible light  
Yumeng Xi, Hong Yi and Aiwen Lei  
Org. Biomol. Chem., 2013, 11, 2387-2403  
DOI: 10.1039/C3OB40137E 

Redesign of enzyme for improving catalytic activity and enantioselectivity toward poor substrates: manipulation of the transition state  
Tadashi Ema, Yasuko Nakano, Daiki Yoshida, Shusuke Kamata and Takashi Sakai  
Org. Biomol. Chem., 2012, 10, 6299-6308  
DOI: 10.1039/C2OB25614B 

Recent advances in the synthesis of aromatic nitro compounds  
Guobing Yan and Minghua Yang  
Org. Biomol. Chem., 2013, 11, 2554-2566  
DOI: 10.1039/C3OB27354G 

Expeditious synthesis of bacterial, rare sugar building blocks to access the prokaryotic glycome  
Madhu Emmadi and Suvarn S. Kulkarni  
Org. Biomol. Chem., 2013, 11, 3098-3102  
DOI: 10.1039/C3OB40615F 

Transition metal-catalyzed functionalization of pyrazines  
Nicolai I. Nikishkin, Jurriaan Huskens and Willem Verboom   
Org. Biomol. Chem., 2013, 11, 3583-3602  
DOI: 10.1039/C3OB40460A 

New trends in bismuth-catalyzed synthetic transformations  
Thierry Ollevier 
Org. Biomol. Chem., 2013, 11, 2740-2755  
DOI: 10.1039/C3OB26537D 

Synthesis and biological evaluation of new paclitaxel analogs and discovery of potent antitumor agents  
Kyriacos C. Nicolaou and Roman A. Valiulin 
Org. Biomol. Chem., 2013, 11, 4154-4163  
DOI: 10.1039/C3OB40654G 

Manipulating non-innocent π-spacers: the challenges of using 2,6-disubstituted BODIPY cores within donor–acceptor light-harvesting motifs  
Catherine Bonnier, Devin D. Machin, Omar Abdi and Bryan D. Koivisto 
Org. Biomol. Chem., 2013, 11, 3756-3760  
DOI: 10.1039/C3OB40213D 

Bu4NI-catalyzed decarboxylative acyloxylation of an sp3 C–H bond adjacent to a heteroatom with α-oxocarboxylic acids  
Shuai Zhang, Li-Na Guo, Hua Wang and Xin-Hua Duan 
Org. Biomol. Chem., 2013, 11, 4308-4311  
DOI: 10.1039/C3OB40748A 

Recent applications of arene diazonium salts in organic synthesis  
Fanyang Mo, Guangbin Dong, Yan Zhang and Jianbo Wang 
Org. Biomol. Chem., 2013, 11, 1582-1593  
DOI: 10.1039/C3OB27366K

We would very much welcome your thoughts and comments below.

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