While retinoids are essential in many biological processes such as vision or cell differentiation and can be found in many of our favorite cosmetic products, both phototoxicity and photocarcinogenicity have been reported for retinol. Professor Fukuzumi and Dr. El-Agamey at Ozaka University (Japan) are shedding light on the roles of retinol in phototoxicity and free radical initiated oxidative stress: using Laser Flash Photolysis, the scientists have successfully generated the retinol radical cation , which was found to be reactive towards bases and other carotinoids inducing pro-oxidant effects.
Wish to find out more? Why not read this OBC paper today!
Laser flash photolysis study on the retinol radical cation in polar solvents
Ali El-Agamey and Shunichi Fukuzumi
Org. Biomol. Chem.., 2011, Advance Article
DOI: 10.1039/C1OB05814B, Paper
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