Haifeng Du and colleagues from the Chinese Academy of Sciences and the Beijing University of Chemical Technology (Beijing, PR China) have used a simple one-step condensation of a α,β-unsaturated ketones and readily available (R)-tert-butanesulfinamide to synthesise a variety of chiral olefin/sulfinimide hybrid ligands. Highly efficient in rhodium-catalyzed asymmetric 1,4-additions, these novel ligands lead to high yields with excellent ee’s (up to 98%) , and could find wide application as a useful asymmetric synthetic methodology.
Interested in asymmetric 1,4-additions? Why not read this OBC communication now!
Chiral N-tert-butanesulfinyl α,β-unsaturated ketimine: a simple and highly effective olefin/sulfinimide hybrid ligand for asymmetric 1,4-additions
Xiangqing Feng, Beibei Wei, Jing Yang and Haifeng Du
Org. Biomol. Chem., 2011, 9, 5927-5929
DOI: 10.1039/C1OB05971H
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