Natural Products Blog

Natural Product Reports Issue 6 is published on line

25 May 2011

In this issue you will find some of our regular reviews on natural products:

– Robert Hill‘s review on triterpenoids updates their previous review published last year.

– Zhon Jin publishes his two regular reviews:

Amaryllidaceae and sceletium alkaloids. You can also see the previous one here.
Muscarine, imidazole and thiazole alkaloids. Download the previous one here.

Apart from those reviews, you can also find Robert Hill and Andrew Sutherland‘s hot of the press. This month, they look at various aspects of current developments in bioorganic chemistry and novel natural products, such as salvileucalin C from Salvia leucantha.

Dean Tantillo talks about theoretical studies on terpene formation and Tohru Dairi helps us understand how nature solves the problem in the biosynthesis of small molecules.

Finally, Jesus Jimemez Barbero uses NMR methods to study the interaction between natural products and their receptors.

I hope you enjoy reading this issue.

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Natural Products in OBC

16 May 2011

By Lorena Tomas Laudo.

Organic & Biomolecular Chemistry, our sister journal, publishes many articles that cover natural product chemistry. We will try to keep you updated, although the safest bet is for you to sign up to OBC’s e-alert (free service) and receive the table of content directly in your inbox every time an issue is published.

The latest natural products’ related articles in OBC Issue 11 (coming soon) have been collated here.

If you want to see your natural products article featured on this blog you can submit it here.

Cascade polycyclisations in natural product synthesis
Edward A. Anderson
Org. Biomol. Chem., 2011, Advance Article
DOI: 10.1039/C1OB05212H, Emerging Area

Intramolecular catalytic asymmetric carbon–hydrogen insertion reactions. Synthetic advantages in total synthesis in comparison with alternative approaches
Michael P. Doyle, Maxim Ratnikov and Yu Liu
Org. Biomol. Chem., 2011, Advance Article
DOI: 10.1039/C0OB00698J, Perspective

A family of multicyclic indolosesquiterpenes from a bacterial endophyte
Ling Ding, Armin Maier, Heinz-Herbert Fiebig, Wen-Han Lin and Christian Hertweck
Org. Biomol. Chem., 2011, Advance Article
DOI: 10.1039/C1OB05283G, Communication

Intermolecular radical addition to N-acylhydrazones as a stereocontrol strategy for alkaloid synthesis: formal synthesis of quinine
Gregory K. Friestad, An Ji, Chandra Sekhar Korapala and Jun Qin
Org. Biomol. Chem., 2011, Advance Article
DOI: 10.1039/C1OB05219E, Communication

Free radical 5-exo-dig cyclization as the key step in the synthesis of bis-butyrolactone natural products: experimental and theoretical studies
Gangavaram V. M. Sharma, Devoju Harinada Chary, Nagula Chandramouli, Florian Achrainer, Sateesh Patrudu and Hendrik Zipse
Org. Biomol. Chem., 2011, Advance Article
DOI: 10.1039/C1OB00019E, Paper

Efficient synthesis of esermethole and its analogues
Yongyun Zhou, Yuanhong Zhao, Xiaoyong Dai, Jianping Liu, Liang Li and Hongbin Zhang
Org. Biomol. Chem., 2011, Advance Article
DOI: 10.1039/C1OB05275F, Paper

New insights into ergot alkaloid biosynthesis in Claviceps purpurea: An agroclavine synthase EasG catalyses, via a non-enzymatic adduct with reduced glutathione, the conversion of chanoclavine-I aldehyde to agroclavine
Marco Matuschek, Christiane Wallwey, Xiulan Xie and Shu-Ming Li
Org. Biomol. Chem., 2011, Advance Article
DOI: 10.1039/C0OB01215G, Paper

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NPR Issue 5 is here

19 Apr 2011

By Lorena Tomas Laudo.

The 5th issue of NPR 2011 is now published on-line and it comes with 7 very interesting reviews and a beautiful cover!

Stephane Quideau and his team synthesise ellagitannin natural products. Bernd Nidetzky and colleagues tell us about the biosynthesis and applications of Glycosides as compatible solutes. Scott A. Snyder and co-workers look at different synthetic approaches to oligomeric natural products. Antonio Salatino‘s team talk about propolis, a honeybee product, composed mainly of wax and resins.
Vincent Ferrieres and his team review recent discoveries performed in the field of glycans and related glycoconjugates that have demonstrated immunomodulatory activities. Huimin Gao and coworkers describe bufadienolides and their antitumor activity and last but not least, Andrei V. Nikolaev and his team look at synthetic glycosylphosphatidylinositol (GPI) anchors.

Take a look at it and enjoy it!

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Natural Products in OBC

13 Apr 2011

By Lorena Tomas Laudo.

The latest natural products’ related articles in OBC Issue 9 have been collated here.

If you want to see your natural products article featured on this blog you can submit it here.

Structure elucidation and biosynthesis of lysine-rich cyclic peptides in Xenorhabdus nematophila
Sebastian W. Fuchs, Anna Proschak, Thorsten W. Jaskolla, Michael Karas and Helge B. Bode
Org. Biomol. Chem., 2011, 9, 3130-3132
DOI: 10.1039/C1OB05097D

Synthetic studies towards marmycins A and B: development of the vinylogous aldol–aza-Michael domino reaction
Emmanuel Bourcet, Manuel C. Bröhmer, Martin Nieger and Stefan Bräse
Org. Biomol. Chem., 2011, 9, 3136-3138
DOI: 10.1039/C1OB05124E

Synthesis of the reported structure of crassiflorone, a naturally occurring quinone isolated from the African ebony Diospyros crassiflora, and regioisomeric pentacyclic furocoumarin naphthoquinones
Jalindar Padwal, William Lewis and Christopher J. Moody
Org. Biomol. Chem., 2011, 9, 3484-3493
DOI: 10.1039/C0OB01231A, Paper

Hirsutosterols A–G, polyoxygenated steroids from a Formosan soft coral Cladiella hirsuta
Bo-Wei Chen, Shu-Ming Chang, Chiung-Yao Huang, Jui-Hsin Su, Zhi-Hong Wen, Yang-Chang Wu and Jyh-Horng Sheu
Org. Biomol. Chem., 2011, 9, 3272-3278
DOI: 10.1039/C1OB05106G, Paper

The mechanism of radical-trapping antioxidant activity of plant-derived thiosulfinates
Philip T. Lynett, Krista Butts, Vipraja Vaidya, Graham E. Garrett and Derek A. Pratt
Org. Biomol. Chem., 2011, 9, 3320-3330
DOI: 10.1039/C1OB05192J, Paper

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NPR Issue 4 is now published on-line

24 Mar 2011

By Lorena Tomas Laudo.

Welcome to our latest NPR Issue number 4!

This issue starts with a Hot off the Press article where Robert Hill cherry-picks 27 recent papers that cover different aspects of current developments in bioorganic chemistry and novel natural products such as dibelamcandal A from Belamcanda chinensis.

We then go to a review on carotenoids and their cleavage products where Michael Walter and Dieter Strack cover structural, molecular genetic and functional aspects of carotenoids and apocarotenoids alike.

Coran M. H. Watanabe and his colleagues tell us about the discovery and biological activity of the azinomycins, their mode of action, related synthetic analogs and biosynthesis, and finish with a discussion on the less studied metabolite, ficellomycin.

A very comprehensive review on the latest withanolide steroids reported until 2010 follows. Feng Qiu and co-workers discuss their diverse biological and pharmacological activities.

For those NPR readers who are more into pharmacology and medicinal chemistry, Grzegorz Bulaj‘s team talk about the advances toward developing systemically active and CNS-penetrant neuropeptide analogs. The provide an overview of structural and pharmacological properties and review the potential application of these natural products as drug leads for pain, epilepsy and other neurological diseases.

Gaelle Chouraqui and his research group focus on different methods to create simultaneously the spirolactone and the quaternary spiro stereocentre and their application to the synthesis of natural products.

Then a survey on the chemical, biological, and mycological literature dealing with the isolation, structural elucidation, biological activities, and synthesis of nitrogen-containing compounds by Ji-Kai Liu and colleagues.

Another one for our medchem readers. This one deals with natural products and Chagas’ disease. Take a look at Celso Vataru Nakamura‘s review.

And to finish off, Andrea Vasas and Judit Hohmann update us on naturally occurring xanthanes and xanthanolides.

That is all for Issue 4! We hope you enjoy it and find it interesting.

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Natural Products in OBC

15 Mar 2011

By Lorena Tomas Laudo.

The latest natural products’ related articles in OBC Issue 7 (coming soon) have been collated here.

If you want to see your natural products article featured on this blog you can submit it here.

Green oxidations of furans—initiated by molecular oxygen—that give key natural product motifs
Tamsyn Montagnon, Dimitris Noutsias, Ioanna Alexopoulou, Maria Tofi and Georgios Vassilikogiannakis
Org. Biomol. Chem., 2011,
DOI: 10.1039/C0OB00952K, Emerging Area

Efficient iron-mediated approach to pyrano[3,2-a]carbazole alkaloids—first total syntheses of O-methylmurrayamine A and 7-methoxymurrayacine, first asymmetric synthesis and assignment of the absolute configuration of (−)-trans-dihydroxygirinimbine Konstanze K. Gruner, Thomas Hopfmann, Kazuhiro Matsumoto, Anne Jäger, Tsutomu Katsuki and Hans-Joachim Knölker
Org. Biomol. Chem., 2011,
DOI: 10.1039/C0OB01088J, Communication

Chemical synthesis and biological evaluation of gallidermin-siderophore conjugates
Sabesan Yoganathan, Clarissa S. Sit and John C. Vederas
Org. Biomol. Chem., 2011,
DOI: 10.1039/C0OB00846J, Paper

Substrate specificity of Rv3378c, an enzyme from Mycobacterium tuberculosis, and the inhibitory activity of the bicyclic diterpenoids against macrophage phagocytosis
Tsutomu Hoshino, Chiaki Nakano, Takahiro Ootsuka, Yosuke Shinohara and Takashi Hara
Org. Biomol. Chem., 2011,
DOI: 10.1039/C0OB00884B, Paper

The design, synthesis and photochemical study of a biomimetic cyclodextrin model of Photoactive Yellow Protein (PYP)
Christina Loukou, Pascale Changenet-Barret, Marie-Noelle Rager, Pascal Plaza, Monique M. Martin and Jean-Maurice Mallet
Org. Biomol. Chem., 2011,
DOI: 10.1039/C0OB00646G, Paper

7-Deazapurine biosynthesis: NMR study of toyocamycin biosynthesis in Streptomyces rimosus using 2-13C-7-15N-adenine
Ugo Battaglia, Jed E. Long, Mark S. Searle and Christopher J. Moody
Org. Biomol. Chem., 2011
DOI: 10.1039/C0OB01054E, Paper

Aromatic A-ring analogues of orobanchol, new germination stimulants for seeds of parasitic weeds
Heetika Malik, Wouter Kohlen, Muhammad Jamil, Floris P. J. T. Rutjes and Binne Zwanenburg
Org. Biomol. Chem., 2011
DOI: 10.1039/C0OB00735H, Paper

A stereoselective, Sm(II)-mediated approach to decorated cis-hydrindanes: synthetic studies on faurinone and pleuromutilin
Thomas J. K. Findley, David Sucunza, Laura C. Miller, Matthew D. Helm, Madeleine Helliwell, David T. Davies and David J. Procter
Org. Biomol. Chem., 2011
DOI: 10.1039/C0OB01086C, Paper

Total synthesis of (−)-indolactam V
Zhengren Xu, Fengying Zhang, Lihe Zhang and Yanxing Jia
Org. Biomol. Chem., 2011
DOI: 10.1039/C0OB01115K, Paper

First total synthesis of Papilistatin
Meng Wu, Ling Li, An-Zheng Feng, Bo Su, De-min Liang, Yu-xiu Liu and Qing-min Wang
Org. Biomol. Chem., 2011
DOI: 10.1039/C0OB01214A, Paper

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Natural Products in OBC

07 Mar 2011

By Lorena Tomas Laudo.

The latest natural products’ related articles in OBC Issue 6 (coming soon) have been collated here.

If you want to see your natural products article featured on this blog you can submit it here.

Asymmetric synthesis of Pachastrissamine (Jaspine B) and its diastereomers via η3-allylpalladium intermediates
Mikko Passiniemi and Ari M. P. Koskinen
Org. Biomol. Chem., 2011, 9, 1774-1783
DOI: 10.1039/C0OB00643B

Studies towards the synthesis of the northern polyene of viridenomycin and synthesis of Z-double bond analogues
Jonathan P. Knowles, Victoria E. O′Connor and Andrew Whiting
Org. Biomol. Chem., 2011, 9, 1876-1886
DOI: 10.1039/C0OB00977F

Transannular dipolar cycloaddition as an approach towards the synthesis of the core ring system of the sarain alkaloids
Andrew I. Franklin, David Bensa, Harry Adams and Iain Coldham
Org. Biomol. Chem., 2011, 9, 1901-1907
DOI: 10.1039/C0OB01019G

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Natural Products Blog

Natural Product Reports Issue 6 is published on line

Top ten most accessed articles in April

Natural Products in OBC

Top ten most accessed articles in March

NPR Issue 5 is here

Natural Products in OBC

Top ten most accessed articles in February

NPR Issue 4 is now published on-line

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