Natural Products Blog

NPR Issue 3 published on line and it comes with a present

24 Feb 2011

After our successful themed issue on Marine Natural Products, NPR Issue 3 comes along!

This new issue brings you 8 fantastic articles in a wide variety of different topics.

If you are interested in β-glucans, we have the most up-to-date highlight for you.
If your topic is ergot alkaloids, here you will find a summary of the last ten years of this family of natural products. In case you miss some marine natural products literature we can offer you this review on marine derived 2-aminoimidazoles with oxidised benzyl groups. You can also find out more about transhinones as potential therapeutic agents or the clinical significance of pentacyclic triterpenes. Finally, two ‘natural’ reviews, one on disesquiterpenoids and one on glycoconjugates with antitumor activity.

Ups! I almost forgot! We are giving you this very interesting review on ginseng FREE to access! Take a look at it.

Enjoy NPR Issue 3.

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Natural Products in OBC

01 Feb 2011

By Lorena Tomas Laudo.

Organic & Biomolecular Chemistry, our sister journal, publishes many articles that cover natural product chemistry. We will try to keep you updated, although the safest bet is for you to sign up to OBC’s e-alert (free service) and receive the table of content directly in your inbox every time an issue is published.

The latest natural products’ related articles in OBC Issue 4 (coming soon) have been collated here.

If you want to see your natural products article featured on this blog you can submit it here.

Total synthesis of cyanolide A
Zhen Yang, Xingang Xie, Peng Jing, Gaoyuan Zhao, Jiyue Zheng, Changgui Zhao and Xuegong She
Org. Biomol. Chem., 2011, Advance Article
DOI: 10.1039/C0OB00971G, Communication

Synthesis of the (−)-TAN-2483B ring system via a D-mannose-derived cyclopropane
Russell J. Hewitt and Joanne E. Harvey
Org. Biomol. Chem., 2011, Advance Article
DOI: 10.1039/C0OB00851F, Communication

Efficient synthesis of the anticancer β-elemene and other bioactive elemanes from sustainable germacrone
Alejandro F. Barrero, M. Mar Herrador, José F. Quílez del Moral, Pilar Arteaga, Niklas Meine, M. Carmen Pérez-Morales and Julieta V. Catalán
Org. Biomol. Chem., 2011, Advance Article
DOI: 10.1039/C0OB00467G, Paper

New hedgehog/GLI-signaling inhibitors from Adenium obesum
Midori A. Arai, Chikashi Tateno, Takashi Koyano, Thaworn Kowithayakorn, Seiichiro Kawabe and Masami Ishibashi
Org. Biomol. Chem., 2011, Advance Article
DOI: 10.1039/C0OB00677G, Paper

Reveromycins Revealed: New polyketide spiroketals from Australian marine-derived and terrestrial Streptomyces spp. A case of natural products vs. artifacts
Leith Fremlin, Michelle Farrugia, Andrew M. Piggott, Zeinab Khalil, Ernest Lacey and Robert J. Capon
Org. Biomol. Chem., 2011, Advance Article
DOI: 10.1039/C0OB00654H, Paper

Rapid and practical synthesis of (−)-1-deoxyaltronojirimycin
Oskari K. Karjalainen and Ari M. P. Koskinen
Org. Biomol. Chem., 2011, Advance Article
DOI: 10.1039/C0OB00747A, Paper

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Christian Hertweck wins 2011 NPR Lecture Award

26 Jan 2011

By Richard Kelly.

We are delighted to announce that Professor Christian Hertweck from the Leibniz Institute for Natural Product Research in Jena, Germany, is the winner of the 2011 NPR Lecture Award. Professor Hertweck was selected for his contribution to the field of biosynthesis.

“I am honoured that I have been nominated and selected for the NPR lecture award and would like to use this opportunity to thank my colleagues and collaborators for great teamwork and support”, said Professor Hertweck on winning the award. ”Without them, I guess I would not have much to say during the lecture…

Also, reading NPR articles and reviews has always been an excellent way to keep up with the latest developments in natural product research – a constant source for inspiration. Thank you very much!”

The lecture will be delivered at the 52^nd annual meeting of the American Society of Pharmacognosy, to be held in San Diego, US between July 30^th and August 3^rd this year. Also speaking at the meeting will be NPR Board members Guy Carter, Sarah O’Connor and Joern Piel, and 2010 NPR Lecture Award winner Christopher Walsh. For general information about the meeting please visit the conference website at http://www.asp2011.com.

The NPR Lecture Award is awarded to a researcher who has made a significant contribution to the field of natural products and who has also had some involvement with the journal. Professor Hertweck has authored a number of articles for NPR and you can view his most recent articles below:

The chemistry and biology of cytochalasans
Kirstin Scherlach, Daniela Boettger, Nicole Remme and Christian Hertweck
Nat. Prod. Rep., 2010, 27, 869-886

Type II polyketide synthases: gaining a deeper insight into enzymatic teamwork
Christian Hertweck, Andriy Luzhetskyy, Yuri Rebets and Andreas Bechthold
Nat. Prod. Rep., 2007, 24, 162-190

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Marine Natural Products themed issue

25 Jan 2011

By Lorena Tomas Laudo.

Welcome to NPR Issue 2, one of the most exciting issues of Natural Product Reports: the Marine Natural Products themed issue.

This themed issue has been guest edited by four of our Editorial Board members: Marcel Jaspars, Bradley Moore, Joern Piel and Russell Cox.
Let me say thanks to all of them for their enthusiasm and hard work putting this very interesting issue together.

This issue covers a number of aspects of marine natural product chemistry. From their structural diversity and synthesis to their natural function and their ecological role. Discover everything this marine natural products themed issue offers and read it now.

If you want to take a look at the first Marine Natural themed issue published in 2004 you can do it here:
Marine Natural Products 2004
Enjoy it!

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HOT: Analysing ginseng

24 Jan 2011

By Lorena Tomas Laudo.

Ginseng is one of the world’s most widely used medicinal plants and it is one of the best selling natural products nowadays. Due to its medicinal effects, ginseng has always been an attractive natural product to study and understand.

However, one of the biggest challenges of ginseng research is the complexity of its chemical constituents and their analysis. Thus, a wide range of analytical methods need to be used to fully characterise these ‘magical components’.

In this very comprehensive review, Lian-Wen Qi, Chong-Zhi Wang and Chun-Su Yuan illustrate the recent advances in the isolation and analysis of ginseng and highlight its new applications, especially in species authentication, quality assessment and interaction with biological systems.

It is a HOT review because it received very positive comments from the referees and the editorial office.

This will be an excellent article for new-comers in the field as well as a refreshment course for old-timers

Download it now, it’s free to access and learn more about ginseng!

Isolation and analysis of ginseng: advances and challenges
Lian-Wen Qi, Chong-Zhi Wang and Chun-Su Yuan
Nat. Prod. Rep., 2011, Advance Article
DOI: 10.1039/C0NP00057D, Review

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Natural Products in OBC

17 Jan 2011

By Lorena Tomas Laudo.

The latest natural products’ related articles in OBC Issue 3 (coming soon) have been collated here.

If you want to see your natural products article featured on this blog you can submit it here.

New synthetic strategies towards psammaplin A, access to natural product analogues for biological evaluation
Matthias G. J. Baud, Thomas Leiser, Franz-Josef Meyer-Almes and Matthew J. Fuchter
Org. Biomol. Chem., 2011, Advance Article
DOI: 10.1039/C0OB00824A, Communication

Efficient total synthesis of (−)-stemoamide
Toshio Honda, Tomoha Matsukawa and Kazunori Takahashi
Org. Biomol. Chem., 2011, Advance Article
DOI: 10.1039/C0OB00850H, Communication

Stereoselective synthesis of the C15–C26 fragment of the antitumor agent (−)-dictyostatin
Leticia Ferreiro-Mederos, Silvia Vila-Gisbert, Antonio Urbano, M. Carmen Carreño and Françoise Colobert
Org. Biomol. Chem., 2011, Advance Article
DOI: 10.1039/C0OB00491J, Paper

Antimicrobial phenalenone derivatives from the marine-derived fungus Coniothyrium cereale
Mahmoud Fahmi Elsebai, Stefan Kehraus, Ulrike Lindequist, Florenz Sasse, Saad Shaaban, Michael Gütschow, Michaele Josten, Hans-Georg Sahl and Gabriele M. König
Org. Biomol. Chem., 2011, Advance Article
DOI: 10.1039/C0OB00625D, Paper

Klysimplexins I–T, eunicellin-based diterpenoids from the cultured soft coral Klyxum simplex
Bo-Wei Chen, Chih-Hua Chao, Jui-Hsin Su, Chung-Wei Tsai, Wei-Hsien Wang, Zhi-Hong Wen, Chiung-Yao Huang, Ping-Jyun Sung, Yang-Chang Wu and Jyh-Horng Sheu
Org. Biomol. Chem., 2011, Advance Article
DOI: 10.1039/C0OB00351D, Paper

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Natural Product Reports at the Zing Natural Products conference – February 2011

11 Jan 2011

By Richard Kelly.

2011 will again see the Natural Product Reports (NPR) Editorial team travelling to conferences around the world to meet researchers and to see some of the latest work being carried out. A full list of where you can find us this year can be found on the NPR blog.

The first meeting on our schedule for this year is the Zing Natural Products conference – 13th – 16th February – in Sharm-el-Sheikh, Egypt. This conference, sponsored by NPR, will be a great opportunity to not only see some of the latest cutting edge natural products research but also to meet authors and readers of the journal. Editor Richard Kelly will be attending on behalf of NPR.

The meeting will be co-Chaired by NPR Advisory Board member and former NPR Chair David O’Hagan (University of St Andrews, UK) and NPR Advisory Board member Margaret Brimble (University of Auckland, New Zealand) and looks set to cover the breadth of natural products research: from isolation and structural studies to biosynthesis to synthesis of molecules. Included in the line up of speakers are NPR Editorial Board members Andreas Kirschning (Leibniz University of Hannover, Germany) and Stefan Schulz (TU Braunschweig, Germany), former NPR Chair Tom Simpson (University of Bristol, UK) and former Lecture Award winner Jason Micklefield (University of Manchester, UK).

If you are travelling to this conference and would like to meet Richard Kelly, Editor of NPR, then please drop us an email to let us know.

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NPR Lecture Award presented at Pacifichem

10 Jan 2011

By Richard Kelly.

December saw the presentation of the 2010 NPR lecture award at the Pacifichem conference in Hawaii. Professor Chris Walsh, from Harvard Medical School in the US delivered his award lecture, entitled “Posttranslational approach to natural product biosynthesis” during the Natural Products Biosynthesis symposium at the meeting.

Professor Chris Walsh receives his award from NPR Chair Professor Brad Moore.

Professor Walsh was selected for the award in recognition of his work on natural product biosynthesis, in particular his work on investigating the structure and function of enzymes. He has written a number of articles for NPR, some of which you can view below:

Structural insights into nonribosomal peptide enzymatic assembly lines
Alexander Koglin, Christopher T. Walsh, Nat. Prod. Rep., 2009, (8),987-1000
DOI: 10.1039/b904543k

Total biosynthesis: in vitro reconstitution of polyketide and nonribosomal peptide pathways
Elizabeth S. Sattely, Michael A. Fischbach, Christopher T. Walsh, Nat. Prod. Rep., 2008, (4),757-793
DOI: 10.1039/b801747f

Biological formation of pyrroles: Nature’s logic and enzymatic machinery
Christopher T. Walsh, Sylvie Garneau-Tsodikova, Annaleise R. Howard-Jones, Nat. Prod. Rep., 2006, (4),517-531
DOI: 10.1039/b605245m

NPR sponsors a lecture each year at an international meeting. The recipient will have made a significant research contribution to natural products chemistry in its broadest sense, and will have published in or have had some affiliation to the journal. The award is open to anyone fitting these criteria.

The 2011 award winner will be announced in the next few weeks.

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Natural Products Blog

Top ten most accessed articles in January

NPR Issue 3 published on line and it comes with a present

Natural Products in OBC

Top ten most accessed articles in December

Christian Hertweck wins 2011 NPR Lecture Award

Marine Natural Products themed issue

HOT: Analysing ginseng

Natural Products in OBC

Natural Product Reports at the Zing Natural Products conference – February 2011

NPR Lecture Award presented at Pacifichem

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