Influenza Neuroaminidase on the cover of NPR Issue 1, 2012

Welcome to NPR Issue 1, 2012

Looking back on 2011, we’d like to thank all our authors, readers and referees for what has been another very successful year for Natural Product Reports. A big thanks also goes to the NPR Editorial Board for their great support and enthusiasm.

Read the 2012 Editorial by NPR Chair Professor Bradley Moore and Editor Dr Richard Kelly reflecting on this year’s many highlights and catch a glimpse of what to look ahead to for a bright 2012!



On the cover of this first Issue is the work of Judith M. Rollinger et al., reviewing the increasing research efforts of the past decade on neuroaminidase (NA) for lead discovery strategies from nature, focusing on the structure, function and druggability of influenza NA, and its inhibition by natural products. This review will be free to access for the next 6 weeks.

Influenza neuraminidase: A druggable target for natural products
Ulrike Grienke, Michaela Schmidtke, Susanne von Grafenstein, Johannes Kirchmair, Klaus R. Liedl and Judith M. Rollinger
DOI: 10.1039/C1NP00053E

Also in this Issue, read:

     

    We hope you enjoy reading our first issue for this new volume of NPR and we wish you all the warmest Season’s Greetings.

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    Natural Products in OBC

    Read the latest Natural Product chemistry published in our sister journal OBC…

    Organic & Biomolecular Chemistry publishes many articles that cover natural product chemistry. We will try to keep you updated, although the safest bet is for you to sign up to OBC’s e-alert (free service) and receive the table of content directly in your inbox every time an issue is published.

    In OBC Issue 1, 2012 , you will find:

     

     

     

     

    Want to see your natural products article featured on this blog? Submit it online here.

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    Nominations for the 2012 RSC Prizes and Awards now open

    Nominations for the 2012 RSC Prizes and Awards close on the 15 January 2012

    Our Prizes and Awards represent the dedication and outstanding achievements and are a platform to showcase inspiring science to gain the recognition deserved. Don’t forget to nominate colleagues who have made a significant contribution to advancing the chemical sciences.

    View our full list of Prizes and Awards and use the online system to nominate a colleague.

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    Top ten most accessed articles in October

    This month sees the following articles in Natural Product Reports that are in the top ten most accessed:

    Natural products and Pharma 2011: Strategic changes spur new opportunities
    Guy T. Carter
    Nat. Prod. Rep., 2011, 28, 1783-1789
    DOI: 10.1039/C1NP00033K

    Multitargeting by curcumin as revealed by molecular interaction studies
    Subash C. Gupta, Sahdeo Prasad, Ji Hye Kim, Sridevi Patchva, Lauren J. Webb, Indira K. Priyadarsini and Bharat B. Aggarwal
    Nat. Prod. Rep., 2011, 28, 1937-1955
    DOI: 10.1039/C1NP00051A

    Isoprenoids in three-dimensional space: the stereochemistry of terpene biosynthesis
    Jeroen S. Dickschat
    Nat. Prod. Rep., 2011, 28, 1917-1936
    DOI: 10.1039/C1NP00063B

    Marine natural products
    John W. Blunt, Brent R. Copp, Murray H. G. Munro, Peter T. Northcote and Michèle R. Prinsep
    Nat. Prod. Rep., 2011, 28, 196-268
    DOI: 10.1039/C005001F

    The sorbicillinoid family of natural products: Isolation, biosynthesis, and synthetic studies
    Andrew M. Harned and Kelly A. Volp
    Nat. Prod. Rep., 2011, 28, 1790-1810
    DOI: 10.1039/C1NP00039J

    Hot off the Press
    Robert A. Hill and Andrew Sutherland
    Nat. Prod. Rep., 2011, 28, 1621-1625
    DOI: 10.1039/C1NP90035H

    Hypervalent iodine reagents in the total synthesis of natural products
    Luiz F. Silva, Jr. and Berit Olofsson
    Nat. Prod. Rep., 2011, 28, 1722-1754
    DOI: 10.1039/C1NP00028D

    Combinatorial biosynthesis in plants: A (p)review on its potential and future exploitation
    Jacob Pollier, Tessa Moses and Alain Goossens
    Nat. Prod. Rep., 2011, 28, 1897-1916
    DOI: 10.1039/C1NP00049G

    Hot off the Press
    Robert A. Hill and Andrew Sutherland
    Nat. Prod. Rep., 2011, 28, 1879-1882
    DOI: 10.1039/C1NP90043A

    The regulation of the secondary metabolism of Streptomyces: new links and experimental advances
    Gilles P. van Wezel and Kenneth J. McDowall
    Nat. Prod. Rep., 2011, 28, 1311-1333
    DOI: 10.1039/C1NP00003A

    Why not take a look at the articles today and blog your thoughts and comments below.

    Fancy submitting an article to Natural Product Reports? Then why not submit to us today or alternatively email us your suggestions.

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    Challenges in Organic Chemistry and Chemical Biology symposium

    The first of the International Symposia on Advancing the Chemical Sciences (ISACS) series next year is to be Challenges in Organic Chemistry and Chemical Biology (ISACS7) on 12 – 15 June at the University of Edinburgh, UK.

    See the excellent list of confirmed speakers and details of the abstract submission process here.

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    New Editorial Board members for NPR

    We are delighted to announce the appointment of two new members to the Editorial Board of Natural Products Reports, Professors Ikuro Abe and Dirk Trauner who will be joining the Board in January 2012.

    Ikuro Abe received his PhD degree in 1989 from The University of Tokyo under the direction of Professor Yutaka Ebizuka, where he studied chemistry and biochemistry of natural products biosynthesis.  After two years postdoctoral research with Professor Guy Ourisson at the CNRS Institut de Chimie des Substances Naturelles, and mostly with Professor Michel Rohmer at the Ecole Nationale Supérieure de Chimie de Mulhouse, in France (1989-1991), he went to the USA to work with Professor Glenn D. Prestwich at the State University of New York at Stony Brook (1991-1996) and then at The University of Utah (1996-1998) as a Research Assistant Professor.  In 1998, he returned to Japan to the University of Shizuoka, School of Pharmaceutical Sciences (1998-2009).  In 2009, he moved back to The University of Tokyo, Graduate School of Pharmaceutical Sciences as Professor of Natural Products Chemistry.

    His main research interests focus on exploring and engineering natural products biosynthesis, see below for some examples of his work:

    Enzymatic synthesis of cyclic triterpenes
    Ikuro Abe
    DOI: 10.1039/B616857B

    Structure and function of the chalcone synthase superfamily of plant type III polyketide synthases
    Ikuro Abe and Hiroyuki Morita
    DOI: 10.1039/B909988N


    Dirk Trauner was born and grew up in Linz, Austria. After studying biology and then biochemistry at the University of Vienna, he joined Professor Johann Mulzerʼs group at the Free University of Berlin to pursue natural products synthesis. In the late 1990s, he was a postdoctoral fellow with Professor Samuel J. Danishefsky at the Memorial Sloan-Kettering Cancer Center in New York City. In 2000, Dirk joined the University of California, Berkeley, where he rose through the ranks to become an Associate Professor of Chemistry. In summer of 2008, he moved to the University of Munich, where he currently resides as a Professor for Chemical Biology and Genetics.

    His research interests range from organic synthesis and natural products to chemical neurobiology and optochemical genetics. View his contribution to our Synthesis themed issue below:

    The chemistry of marine furanocembranoids, pseudopteranes, gersolanes, and related natural products
    Paul A. Roethle and Dirk Trauner
    DOI: 10.1039/B705660P

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    New Advisory Board members for NPR

    The Editorial Office is pleased to announce the recent appointment of two new Advisory Board members for Natural Product Reports, Yeo Joon Yoon and Vanderlan da Silva Bolzani.

    Yeo Joon Yoon received his PhD in chemical and biological engineering from Seoul National University in 2000. He has worked with Prof Charles R. Hutchinson at the University of Wisconsin at Madison as a predoctoral researcher and also with Prof David H. Sherman at the University of Minnesota as a postdoctoral researcher. In 2002 he returned to Korea as Assistant Professor of Chemical Engineering and Bioengineering at the University of Ulsan and then moved to Ewha Womans University in 2004, where he is Associate Professor of Chemistry.

    His major scientific interests are the characterization of biosynthetic pathways for secondary metabolites, focusing on polyketides and aminoglycosides in actinomycetes, combinatorial biosynthesis of novel natural products, and the application of metabolic engineering and synthetic biology to the production of secondary metabolites.


    Vanderlan da Silva Bolzani is full professor at Sao Paulo State University (UNESP), and has published over 186 research publications, 5 patents and 4 book chapters. A Fellow of the Royal Society of Chemistry (UK) and a Science Productivity CNPq Fellow, she has received several awards, the most recent is the Distinguished Woman in Science Chemistry and Chemical Engineering award conceived by the ACS & IUPAC. Her PhD degree in Organic Chemistry was obtained under the guidance of Professor Otto Richard Gottlieb, University of São Paulo and after a post-doctorate at Virginia Polytechnic Institute (VPISU-USA) she joined the São Paulo State University (UNESP). Dr. Bolzani is currently is Vice-Director of the UNESP Innovation Agency (AUIN), was President of the Brazilian Chemical Society from 2008-2010, and is currently Counsellor. 

    Her field of interest is plant science, and she has been involved in the isolation, bioactivity and function of secondary metabolites and peptides from plants. Also she has studied biosynthesis of piperidine alkaloids, and recently has been involved in metabolomic studies of medicinal plants and sugar cane. She has strong work collaborations with national pharmaceutical and cosmetic industries looking for new drugs from plants species. 

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    Degradation of lignin in bacteria and fungi on the cover of NPR issue 12


    Natural Product Reports’ last issue of the year is now published on line.

    On the cover of this December issue is an article by Timothy Bugg et al. at the University of Warwick (UK), which highlights recent progress in the understanding of the microbial breakdown of lignin, and catabolic pathways for the breakdown of lignin components.

    Also check out our latest Hot of the Press article by Robert A. Hill and Andrew Sutherland, discover the potential of combinatorial biosynthesis in plants, read all about the stereochemical aspects of the biosynthetic pathways to terpenes, and learn on curcumin’s multitargeting powers.

    All of this in a very successful 2011 last issue. We hope you enjoy it!

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    Natural Products in OBC

    Organic & Biomolecular Chemistry, our sister journal, publishes many articles that cover natural product chemistry. We will try to keep you updated, although the safest bet is for you to sign up to OBC’s e-alert (free service) and receive the table of content directly in your inbox every time an issue is published.

    The latest natural products’ related articles in OBC Issue 23 have been collated here:

    Efficient approach to novel 1α-triazolyl-5α-androstane derivatives as potent antiproliferative agents
    Zalán Kádár, Ádám Baji, István Zupkó, Tibor Bartók, János Wölfling and Éva Frank
    Org. Biomol. Chem., 2011, 9, 8051-8057
    DOI: 10.1039/C1OB06086D, Paper


    Design and synthesis of trans-3-aminopyran-2-carboxylic acid (APyC) and α/β-peptides with 9/11-helix
    Gangavaram V. M. Sharma, Kodeti Srinivas Reddy, Shaik Jeelani Basha, Kondreddi Ravinder Reddy and Akella V. S. Sarma
    Org. Biomol. Chem., 2011, 9, 8102-8111
    DOI: 10.1039/C1OB06279D, Paper


    6,6-Spiroimine analogs of (−)-gymnodimine A: synthesis and biological evaluation on nicotinic acetylcholine receptors
    Leslie Duroure, Thierry Jousseaume, Rómulo Aráoz, Elvina Barré, Pascal Retailleau, Laurent Chabaud, Jordi Molgó and Catherine Guillou
    Org. Biomol. Chem., 2011, 9, 8112-8118
    DOI: 10.1039/C1OB06257C, Paper



    Want to see your natural products article featured on this blog? Submit it online here.

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    Top ten most accessed articles in September

    This month sees the following articles in Natural Product Reports that are in the top ten most accessed:

    Hot off the Press
    Robert A. Hill and Andrew Sutherland
    Nat. Prod. Rep., 2011, 28, 1621-1625
    DOI: 10.1039/C1NP90035H

    Natural products and Pharma 2011: Strategic changes spur new opportunities
    Guy T. Carter
    Nat. Prod. Rep., 2011, 28, 1783-1789
    DOI: 10.1039/C1NP00033K

    Hypervalent iodine reagents in the total synthesis of natural products
    Luiz F. Silva, Jr. and Berit Olofsson
    Nat. Prod. Rep., 2011, 28, 1722-1754
    DOI: 10.1039/C1NP00028D

    Flavonoids and their glycosides, including anthocyanins
    Nigel C. Veitch and Renée J. Grayer
    Nat. Prod. Rep., 2011, 28, 1626-1695
    DOI: 10.1039/C1NP00044F

    Diterpenoids of terrestrial origin
    James R. Hanson
    Nat. Prod. Rep., 2011, 28, 1755-1772
    DOI: 10.1039/C1NP90021H

    Pathways for degradation of lignin in bacteria and fungi
    Timothy D. H. Bugg, Mark Ahmad, Elizabeth M. Hardiman and Rahman Rahmanpour
    Nat. Prod. Rep., 2011, Advance Article
    DOI: 10.1039/C1NP00042J

    Natural products in anti-obesity therapy
    Ilze Vermaak, Alvaro M. Viljoen and Josias H. Hamman
    Nat. Prod. Rep., 2011, 28, 1493-1533
    DOI: 10.1039/c1np00035g

    Marine natural products
    John W. Blunt, Brent R. Copp, Murray H. G. Munro, Peter T. Northcote and Michèle R. Prinsep
    Nat. Prod. Rep., 2011, 28, 196-268
    DOI: 10.1039/C005001F

    Marine chemical ecology
    Valerie J. Paul, Melany P. Puglisi and Raphael Ritson-Williams
    Nat. Prod. Rep., 2006, 23, 153-180
    DOI: 10.1039/B404735B

    Natural sesquiterpenoids
    Braulio M. Fraga
    Nat. Prod. Rep., 2011, 28, 1580-1610
    DOI: 10.1039/C1NP00046B

    Why not take a look at the articles today and blog your thoughts and comments below.

    Fancy submitting an article to Natural Product Reports? Then why not submit to us today or alternatively email us your suggestions.

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