Natural Products Blog

Organic & Biomolecular Chemistry, our sister journal, publishes many articles that cover natural product chemistry. We will try to keep you updated, although the safest bet is for you to sign up to OBC’s e-alert (free service) and receive the table of content directly in your inbox every time an issue is published.

The latest natural products’ related articles in OBC Issue 11 (coming soon) have been collated here.

If you want to see your natural products article featured on this blog you can submit it here.

Cascade polycyclisations in natural product synthesis
Edward A. Anderson
Org. Biomol. Chem., 2011, Advance Article
DOI: 10.1039/C1OB05212H, Emerging Area

Intramolecular catalytic asymmetric carbon–hydrogen insertion reactions. Synthetic advantages in total synthesis in comparison with alternative approaches
Michael P. Doyle, Maxim Ratnikov and Yu Liu
Org. Biomol. Chem., 2011, Advance Article
DOI: 10.1039/C0OB00698J, Perspective

A family of multicyclic indolosesquiterpenes from a bacterial endophyte
Ling Ding, Armin Maier, Heinz-Herbert Fiebig, Wen-Han Lin and Christian Hertweck
Org. Biomol. Chem., 2011, Advance Article
DOI: 10.1039/C1OB05283G, Communication

Intermolecular radical addition to N-acylhydrazones as a stereocontrol strategy for alkaloid synthesis: formal synthesis of quinine
Gregory K. Friestad, An Ji, Chandra Sekhar Korapala and Jun Qin
Org. Biomol. Chem., 2011, Advance Article
DOI: 10.1039/C1OB05219E, Communication

Free radical 5-exo-dig cyclization as the key step in the synthesis of bis-butyrolactone natural products: experimental and theoretical studies
Gangavaram V. M. Sharma, Devoju Harinada Chary, Nagula Chandramouli, Florian Achrainer, Sateesh Patrudu and Hendrik Zipse
Org. Biomol. Chem., 2011, Advance Article
DOI: 10.1039/C1OB00019E, Paper

Efficient synthesis of esermethole and its analogues
Yongyun Zhou, Yuanhong Zhao, Xiaoyong Dai, Jianping Liu, Liang Li and Hongbin Zhang
Org. Biomol. Chem., 2011, Advance Article
DOI: 10.1039/C1OB05275F, Paper

New insights into ergot alkaloid biosynthesis in Claviceps purpurea: An agroclavine synthase EasG catalyses, via a non-enzymatic adduct with reduced glutathione, the conversion of chanoclavine-I aldehyde to agroclavine
Marco Matuschek, Christiane Wallwey, Xiulan Xie and Shu-Ming Li 
Org. Biomol. Chem., 2011, Advance Article
DOI: 10.1039/C0OB01215G, Paper

Organic & Biomolecular Chemistry, our sister journal, publishes many articles that cover natural product chemistry. We will try to keep you updated, although the safest bet is for you to sign up to OBC’s e-alert (free service) and receive the table of content directly in your inbox every time an issue is published.

The latest natural products’ related articles in OBC Issue 9 have been collated here.

If you want to see your natural products article featured on this blog you can submit it here.

Structure elucidation and biosynthesis of lysine-rich cyclic peptides in Xenorhabdus nematophila
Sebastian W. Fuchs, Anna Proschak, Thorsten W. Jaskolla, Michael Karas and Helge B. Bode
Org. Biomol. Chem., 2011, 9, 3130-3132
DOI: 10.1039/C1OB05097D

Synthetic studies towards marmycins A and B: development of the vinylogous aldol–aza-Michael domino reaction
Emmanuel Bourcet, Manuel C. Bröhmer, Martin Nieger and Stefan Bräse
Org. Biomol. Chem., 2011, 9, 3136-3138
DOI: 10.1039/C1OB05124E

Synthesis of the reported structure of crassiflorone, a naturally occurring quinone isolated from the African ebony Diospyros crassiflora, and regioisomeric pentacyclic furocoumarin naphthoquinones
Jalindar Padwal, William Lewis and Christopher J. Moody
Org. Biomol. Chem., 2011, 9, 3484-3493
DOI: 10.1039/C0OB01231A, Paper

Hirsutosterols A–G, polyoxygenated steroids from a Formosan soft coral Cladiella hirsuta
Bo-Wei Chen, Shu-Ming Chang, Chiung-Yao Huang, Jui-Hsin Su, Zhi-Hong Wen, Yang-Chang Wu and Jyh-Horng Sheu
Org. Biomol. Chem., 2011, 9, 3272-3278
DOI: 10.1039/C1OB05106G, Paper

The mechanism of radical-trapping antioxidant activity of plant-derived thiosulfinates
Philip T. Lynett, Krista Butts, Vipraja Vaidya, Graham E. Garrett and Derek A. Pratt
Org. Biomol. Chem., 2011, 9, 3320-3330
DOI: 10.1039/C1OB05192J, Paper

Organic & Biomolecular Chemistry, our sister journal, publishes many articles that cover natural product chemistry. We will try to keep you updated, although the safest bet is for you to sign up to OBC’s e-alert (free service) and receive the table of content directly in your inbox every time an issue is published.

The latest natural products’ related articles in OBC Issue 7 (coming soon) have been collated here.

If you want to see your natural products article featured on this blog you can submit it here.

Green oxidations of furans—initiated by molecular oxygen—that give key natural product motifs
Tamsyn Montagnon, Dimitris Noutsias, Ioanna Alexopoulou, Maria Tofi and Georgios Vassilikogiannakis
Org. Biomol. Chem., 2011,
DOI: 10.1039/C0OB00952K, Emerging Area

Efficient iron-mediated approach to pyrano[3,2-a]carbazole alkaloids—first total syntheses of O-methylmurrayamine A and 7-methoxymurrayacine, first asymmetric synthesis and assignment of the absolute configuration of (−)-trans-dihydroxygirinimbine Konstanze K. Gruner, Thomas Hopfmann, Kazuhiro Matsumoto, Anne Jäger, Tsutomu Katsuki and Hans-Joachim Knölker
Org. Biomol. Chem., 2011,
DOI: 10.1039/C0OB01088J, Communication

Chemical synthesis and biological evaluation of gallidermin-siderophore conjugates
Sabesan Yoganathan, Clarissa S. Sit and John C. Vederas
Org. Biomol. Chem., 2011,
DOI: 10.1039/C0OB00846J, Paper

Substrate specificity of Rv3378c, an enzyme from Mycobacterium tuberculosis, and the inhibitory activity of the bicyclic diterpenoids against macrophage phagocytosis
Tsutomu Hoshino, Chiaki Nakano, Takahiro Ootsuka, Yosuke Shinohara and Takashi Hara
Org. Biomol. Chem., 2011,
DOI: 10.1039/C0OB00884B, Paper

The design, synthesis and photochemical study of a biomimetic cyclodextrin model of Photoactive Yellow Protein (PYP)
Christina Loukou, Pascale Changenet-Barret, Marie-Noelle Rager, Pascal Plaza, Monique M. Martin and Jean-Maurice Mallet
Org. Biomol. Chem., 2011,
DOI: 10.1039/C0OB00646G, Paper

7-Deazapurine biosynthesis: NMR study of toyocamycin biosynthesis in Streptomyces rimosus using 2-13C-7-15N-adenine
Ugo Battaglia, Jed E. Long, Mark S. Searle and Christopher J. Moody
 Org. Biomol. Chem., 2011
DOI: 10.1039/C0OB01054E, Paper

Aromatic A-ring analogues of orobanchol, new germination stimulants for seeds of parasitic weeds
Heetika Malik, Wouter Kohlen, Muhammad Jamil, Floris P. J. T. Rutjes and Binne Zwanenburg
Org. Biomol. Chem., 2011
DOI: 10.1039/C0OB00735H, Paper

A stereoselective, Sm(II)-mediated approach to decorated cis-hydrindanes: synthetic studies on faurinone and pleuromutilin
Thomas J. K. Findley, David Sucunza, Laura C. Miller, Matthew D. Helm, Madeleine Helliwell, David T. Davies and David J. Procter
Org. Biomol. Chem., 2011
DOI: 10.1039/C0OB01086C, Paper

Total synthesis of (−)-indolactam V
Zhengren Xu, Fengying Zhang, Lihe Zhang and Yanxing Jia
Org. Biomol. Chem., 2011
DOI: 10.1039/C0OB01115K, Paper

First total synthesis of Papilistatin
Meng Wu, Ling Li, An-Zheng Feng, Bo Su, De-min Liang, Yu-xiu Liu and Qing-min Wang
Org. Biomol. Chem., 2011
DOI: 10.1039/C0OB01214A, Paper

Organic & Biomolecular Chemistry, our sister journal, publishes many articles that cover natural product chemistry. We will try to keep you updated, although the safest bet is for you to sign up to OBC’s e-alert (free service) and receive the table of content directly in your inbox every time an issue is published.

The latest natural products’ related articles in OBC Issue 4 (coming soon) have been collated here.

If you want to see your natural products article featured on this blog you can submit it here.

Total synthesis of cyanolide A
Zhen Yang, Xingang Xie, Peng Jing, Gaoyuan Zhao, Jiyue Zheng, Changgui Zhao and Xuegong She
Org. Biomol. Chem., 2011, Advance Article
DOI: 10.1039/C0OB00971G, Communication

Synthesis of the (−)-TAN-2483B ring system via a D-mannose-derived cyclopropane
Russell J. Hewitt and Joanne E. Harvey
Org. Biomol. Chem., 2011, Advance Article
DOI: 10.1039/C0OB00851F, Communication

Efficient synthesis of the anticancer β-elemene and other bioactive elemanes from sustainable germacrone
Alejandro F. Barrero, M. Mar Herrador, José F. Quílez del Moral, Pilar Arteaga, Niklas Meine, M. Carmen Pérez-Morales and Julieta V. Catalán
Org. Biomol. Chem., 2011, Advance Article
DOI: 10.1039/C0OB00467G, Paper

New hedgehog/GLI-signaling inhibitors from Adenium obesum
Midori A. Arai, Chikashi Tateno, Takashi Koyano, Thaworn Kowithayakorn, Seiichiro Kawabe and Masami Ishibashi
Org. Biomol. Chem., 2011, Advance Article
DOI: 10.1039/C0OB00677G, Paper

Reveromycins Revealed: New polyketide spiroketals from Australian marine-derived and terrestrial Streptomyces spp. A case of natural products vs. artifacts
Leith Fremlin, Michelle Farrugia, Andrew M. Piggott, Zeinab Khalil, Ernest Lacey and Robert J. Capon
Org. Biomol. Chem., 2011, Advance Article
DOI: 10.1039/C0OB00654H, Paper
 
Rapid and practical synthesis of (−)-1-deoxyaltronojirimycin
Oskari K. Karjalainen and Ari M. P. Koskinen
Org. Biomol. Chem., 2011, Advance Article
DOI: 10.1039/C0OB00747A, Paper

Organic & Biomolecular Chemistry, our sister journal, publishes many articles that cover natural product chemistry. We will try to keep you updated, although the safest bet is for you to sign up to OBC’s e-alert (free service) and receive the table of content directly in your inbox every time an issue is published.

The latest natural products’ related articles in OBC Issue 3 (coming soon) have been collated here.

If you want to see your natural products article featured on this blog you can submit it here.

New synthetic strategies towards psammaplin A, access to natural product analogues for biological evaluation
Matthias G. J. Baud, Thomas Leiser, Franz-Josef Meyer-Almes and Matthew J. Fuchter
 Org. Biomol. Chem., 2011, Advance Article
DOI: 10.1039/C0OB00824A, Communication

Efficient total synthesis of (−)-stemoamide
Toshio Honda, Tomoha Matsukawa and Kazunori Takahashi
 Org. Biomol. Chem., 2011, Advance Article
DOI: 10.1039/C0OB00850H, Communication

Stereoselective synthesis of the C15–C26 fragment of the antitumor agent (−)-dictyostatin
Leticia Ferreiro-Mederos, Silvia Vila-Gisbert, Antonio Urbano, M. Carmen Carreño and Françoise Colobert
 Org. Biomol. Chem., 2011, Advance Article
DOI: 10.1039/C0OB00491J, Paper

Antimicrobial phenalenone derivatives from the marine-derived fungus Coniothyrium cereale
Mahmoud Fahmi Elsebai, Stefan Kehraus, Ulrike Lindequist, Florenz Sasse, Saad Shaaban, Michael Gütschow, Michaele Josten, Hans-Georg Sahl and Gabriele M. König
 Org. Biomol. Chem., 2011, Advance Article
DOI: 10.1039/C0OB00625D, Paper

Klysimplexins I–T, eunicellin-based diterpenoids from the cultured soft coral Klyxum simplex
Bo-Wei Chen, Chih-Hua Chao, Jui-Hsin Su, Chung-Wei Tsai, Wei-Hsien Wang, Zhi-Hong Wen, Chiung-Yao Huang, Ping-Jyun Sung, Yang-Chang Wu and Jyh-Horng Sheu
 Org. Biomol. Chem., 2011, Advance Article
DOI: 10.1039/C0OB00351D, Paper

Organic & Biomolecular Chemistry, our sister journal, publishes many articles that cover natural product chemistry. We will try to keep you updated, although the safest bet is for you to sign up to OBC’s e-alert (free service) and receive the table of content directly in your inbox every time an issue is published.

The latest NP articles have been collated here.

If you want to see your natural products article featured on this blog you can submit it here.

Synthesis of (±)-desethylrhazinal using a tandem radical addition-cyclization process
Ehecatl Paleo, Yazmin M. Osornio and Luis D. Miranda
Org. Biomol. Chem., 2011, 9, 361-362
DOI: 10.1039/C0OB00572J, Communication

Intramolecular hydroalkoxylation in Brønsted acidic ionic liquids and its application to the synthesis of (±)-centrolobine
Yunkyung Jeong, Do-Young Kim, Yunsil Choi and Jae-Sang Ryu
Org. Biomol. Chem., 2011, 9, 374-378
DOI: 10.1039/C0OB00701C, Communication

(S)-Stereoisomer of telomestatin as a potent G-quadruplex binder and telomerase inhibitor
Takayuki Doi, Kazuaki Shibata, Masahito Yoshida, Motoki Takagi, Masayuki Tera, Kazuo Nagasawa, Kazuo Shin-ya and Takashi Takahashi
Org. Biomol. Chem., 2011, 9, 387-393
DOI: 10.1039/C0OB00513D, Paper

Anti-malarial, anti-algal, anti-tubercular, anti-bacterial, anti-photosynthetic, and anti-fouling activity of diterpene and diterpene isonitriles from the tropical marine sponge Cymbastela hooperi
Anthony D. Wright, Adam McCluskey, Mark J. Robertson, Kylie A. MacGregor, Christopher P. Gordon and Jana Guenther
Org. Biomol. Chem., 2011, 9, 400-407
DOI: 10.1039/C0OB00326C, Paper

Nucleotidylation of unsaturated carbasugar in validamycin biosynthesis
Jongtae Yang, Hui Xu, Yirong Zhang, Linquan Bai, Zixin Deng and Taifo Mahmud
Org. Biomol. Chem., 2011, 9, 438-449
DOI: 10.1039/C0OB00475H, Paper

Asymmetric total synthesis of (+)-swainsonine
Soontorn Chooprayoon, Chutima Kuhakarn, Patoomratana Tuchinda, Vichai Reutrakul and Manat Pohmakotr
Org. Biomol. Chem., 2011, 9, 531-537
DOI: 10.1039/C0OB00388C, Paper

Wilsoniamines A and B: novel alkaloids from the temperate Australian bryozoan, Amathia wilsoni
Anthony R. Carroll, Sandra Duffy, Melissa Sykes and Vicky M. Avery
Org. Biomol. Chem., 2011, 9, 604-609
DOI: 10.1039/C0OB00538J, Paper