Natural Products Blog

Organic & Biomolecular Chemistry, our sister journal, publishes many articles that cover a variety of natural product chemistry.

We try to keep you updated here, although your best bet is for you to sign up to OBC’s e-alert (free service), and receive the tables of content directly in your inbox every time an issue is published.

The latest natural products’ related articles have been collated here:

First total synthesis of (+)-indicanone
Yujiro Hayashi, Kumiko Ogawa, Fuyuhiko Inagaki and Chisato Mukai
Org. Biomol. Chem., 2012, 10, 4747-4751
DOI: 10.1039/C2OB25500F, Paper

Synthesis of the trans-hydrindane core of dictyoxetane
Benedicte Defaut, Thomas B. Parsons, Neil Spencer, Louise Male, Benson M. Kariuki and Richard S. Grainger
Org. Biomol. Chem., 2012, 10, 4926-4932
DOI: 10.1039/C2OB25384D, Paper

A novel C,D-spirolactone analogue of paclitaxel: autophagy instead of apoptosis as a previously unknown mechanism of cytotoxic action for taxoids
Milena V. Trmcic, Radomir V. Matovic, Gordana I. Tovilovic, Biljana Z. Ristic, Vladimir S. Trajkovic, Zorana B. Ferjancic and Radomir N. Saicic
Org. Biomol. Chem., 2012, 10, 4933-4942
DOI: 10.1039/C2OB25514F, Paper

Rubesanolides C–E: abietane diterpenoids isolated from Isodon rubescens and evaluation of their anti-biofilm activity
Juan Zou, Lutai Pan, Qiji Li, Jianxin Pu, Ping Yao, Min Zhu, Jeffrey A. Banas, Hongjie Zhang and Handong Sun
Org. Biomol. Chem., 2012, 10, 5039-5044
DOI: 10.1039/C2OB25192B, Paper

First total synthesis of the biscarbazole alkaloid oxydimurrayafoline
Carsten Börger, Micha P. Krahl, Margit Gruner, Olga Kataeva and Hans-Joachim Knölker
Org. Biomol. Chem., 2012, 10, 5189-5193
DOI: 10.1039/C2OB25842K, Communication

Total synthesis of indole-3-acetonitrile-4-methoxy-2-C-β-D-glucopyranoside. Proposal for structural revision of the natural product
Akop Yepremyan and Thomas G. Minehan
Org. Biomol. Chem., 2012, 10, 5194-5196
DOI: 10.1039/C2OB25821H, Communication

Asymmetric formal synthesis of schulzeines A and C
Jaebong Jang, Jong-Wha Jung, Jaeseung Ahn, Jaehoon Sim, Dong-Jo Chang, Dae-Duk Kim and Young-Ger Suh
Org. Biomol. Chem., 2012, 10, 5202-5204
DOI: 10.1039/C2OB25772F, Communication

First diastereoselective synthesis of methyl caffeoyl- and feruloyl-muco-quinates
Rakesh Jaiswal, Michael H. Dickman and Nikolai Kuhnert
Org. Biomol. Chem., 2012, 10, 5266-5277
DOI: 10.1039/C2OB25124H, Paper

Also of interest is the Natural Products themed issue from MedChemComm, and this OBC blog featuring 10 of the best, most highly cited papers covering natural products from the past 10 years.

Organic & Biomolecular Chemistry, our sister journal, publishes many articles that cover natural product chemistry.

We try to keep you updated here, although your best bet is for you to sign up to OBC’s e-alert (free service), and receive the tables of content directly in your inbox every time an issue is published.

The latest natural products’ related articles have been collated here:

Stereoselective synthesis and hormonal activity of novel dafachronic acids and naturally occurring steroids isolated from corals
Ratni Saini, Sebastian Boland, Olga Kataeva, Arndt W. Schmidt, Teymuras V. Kurzchalia and Hans-Joachim Knölker
Org. Biomol. Chem., 2012, 10, 4159-4163
DOI: 10.1039/C2OB25394A, Communication

Elucidation of post-PKS tailoring steps involved in landomycin biosynthesis
Madan K. Kharel, Pallab Pahari, Khaled A. Shaaban, Guojun Wang, Caleb Morris and Jürgen Rohr
Org. Biomol. Chem., 2012, 10, 4256-4265
DOI: 10.1039/C2OB07171A, Paper

Total synthesis of ent-calystegine B4 via nitro-Michael/aldol reaction
Akio Kamimura, Koichiro Miyazaki, Shuzo Suzuki, Shingo Ishikawa and Hidemitsu Uno
Org. Biomol. Chem., 2012, 10, 4362-4366
DOI: 10.1039/C2OB25386K, Paper

Asymmetric synthesis of 2-alkyl-substituted tetrahydroquinolines by an enantioselective aza-Michael reaction
Laura L. Taylor, Frederick W. Goldberg and King Kuok (Mimi) Hii
Org. Biomol. Chem., 2012, 10, 4424-4432
DOI: 10.1039/C2OB25122A, Paper

Stereoselective synthesis of (−)-1-epi-ventiloquinone L and (+)-ventiloquinone L, the monomeric unit of cardinalin 3
Rodney A. Fernandes, Arun B. Ingle and Vijay P. Chavan
Org. Biomol. Chem., 2012, 10, 4462-4466
DOI: 10.1039/C2OB25453K, Paper

Organic & Biomolecular Chemistry, our sister journal, publishes many articles that cover natural product chemistry.

We will try to keep you updated, although the safest bet is for you to sign up to OBC’s e-alert (free service), and receive the tables of content directly in your inbox every time an issue is published.

The latest natural products’ related articles have been collated here:

Synthesis of the anti-influenza agent (−)-oseltamivir free base and (−)-methyl 3-epi-shikimate
Varun Rawat, Soumen Dey and Arumugam Sudalai
Org. Biomol. Chem., 2012, 10, 3988-3990
DOI: 10.1039/C2OB25635E, Communication

Design and synthesis of screening libraries based on the muurolane natural product scaffold
Emma C. Barnes, Vanida Choomuenwai, Katherine T. Andrews, Ronald J. Quinn and Rohan A. Davis
Org. Biomol. Chem., 2012, 10, 4015-4023
DOI: 10.1039/C2OB00029F, Paper

Solar irradiation of the seed germination stimulant karrikinolide produces two novel head-to-head cage dimers
Adrian Scaffidi, Mark T. Waters, Brian W. Skelton, Charles S. Bond, Alexandre N. Sobolev, Rohan Bythell-Douglas, Allan J. McKinley, Kingsley W. Dixon, Emilio L. Ghisalberti, Steven M. Smith and Gavin R. Flematti
Org. Biomol. Chem., 2012, 10, 4069-4073
DOI: 10.1039/C2OB25090J, Paper

Construction of the biaryl-part of vancomycin aglycon via atropo-diastereoselective Suzuki–Miyaura coupling
Timo Leermann, Pierre-Emmanuel Broutin, Frédéric R. Leroux and Françoise Colobert
Org. Biomol. Chem., 2012, 10, 4095-4102
DOI: 10.1039/C2OB25373A, Paper

Stereoselective total synthesis of the acetylenic carotenoids alloxanthin and triophaxanthin
Yumiko Yamano, Mahankhali Venu Chary and Akimori Wada
Org. Biomol. Chem., 2012, 10, 4103-4108
DOI: 10.1039/C2OB25321F, Paper

Synthesis of the unique angular tricyclic chromone structure proposed for aspergillitine, and its relationship with alkaloid TMC-120B
Sebastián O. Simonetti, Enrique L. Larghi, Andrea B. J. Bracca and Teodoro S. Kaufman
Org. Biomol. Chem., 2012, 10, 4124-4134
DOI: 10.1039/C2OB25067E, Paper

Organic & Biomolecular Chemistry, our sister journal, publishes many articles that cover natural product chemistry.

We will try to keep you updated, although the safest bet is for you to sign up to OBC’s e-alert (free service) and receive the table of content directly in your inbox every time an issue is published.

The latest natural products’ related articles published in issue 18 and issue 19 have been collated here:

The first isocyanide of plant origin expands functional group diversity in cruciferous phytoalexins: synthesis, structure and bioactivity of isocyalexin A
M. Soledade C. Pedras and Estifanos E. Yaya
DOI: 10.1039/C2OB25492A

Synthesis of the macrolactone core of (+)-neopeltolide by transannular cyclization
Gangavaram V. M. Sharma, Sheri Venkat Reddy and Kallaganti V. S. Ramakrishna
DOI: 10.1039/C2OB25151E

A convenient biomimetic synthesis of optically active putative neurotoxic metabolites of MDMA (“ecstasy”) from R-(−)- and S-(+)-N-methyl-α-methyldopamine precursors
Claire-Marie Martinez, Anne Neudörffer and Martine Largeron
DOI: 10.1039/C2OB25245G

Flexible synthesis of montanine-like alkaloids: revisiting the structure of montabuphine
Yifu Guan, Hongbin Zhang, Chengxue Pan, Jia Wang, Rong Huang and Qilin Li
DOI: 10.1039/C2OB25374G, Communication

Stereoselective synthesis of functionalised carbocyclic amides: construction of the syn-(4aS,10bS)-phenanthridone skeleton
Sajjad Ahmad, Michael D. Swift, Louis J. Farrugia, Hans Martin Senn and Andrew Sutherland 
DOI: 10.1039/C2OB25334H, Paper

We hope you enjoy the selection! And why not also view MedChemComm‘s themed issue on Natural Products, still growing…

Organic & Biomolecular Chemistry, our sister journal, publishes many articles that cover natural product chemistry.

We will try to keep you updated, although the safest bet is for you to sign up to OBC’s e-alert (free service) and receive the table of content directly in your inbox every time an issue is published.

The latest natural products’ related articles have been collated here:

• Limonoids

Kv1.2 potassium channel inhibitors from Chukrasia tabularis
Hong-Bing Liu, Hua Zhang, Ping Li, Yan Wu, Zhao-Bing Gao and Jian-Min Yue
Org. Biomol. Chem., 2012, 10, 1448-1458
DOI: 10.1039/C1OB06666H, Paper

• Fungal glycolipid

Fusaroside, a unique glycolipid from Fusarium sp., an endophytic fungus isolated from Melia azedarach
Sheng-Xiang Yang, Hong-Peng Wang, Jin-Ming Gao, Qiang Zhang, Hartmut Laatsch and Yi Kuang
Org. Biomol. Chem., 2012, 10, 819-824
DOI: 10.1039/C1OB06426F

• Pancratistatin analogues

A formal [3+3]-annulation-based approach to pancratistatins: total synthesis of (±)-7-deoxy-pancratistatin and its 2-epi and 2,4-diepi analogues
Olaia Nieto-García, Hugo Lago-Santomé, Fernando Cagide-Fagín, Juan Carlos Ortiz-Lara and Ricardo Alonso
Org. Biomol. Chem., 2012, 10, 825-834
DOI: 10.1039/C1OB06374J, Paper

•  Bromotyrosine natural products

Syntheses of pseudoceramines A–D and a new synthesis of spermatinamine, bromotyrosine natural products from marine sponges J. Mikael Hillgren, Christopher T. Öberg and Mikael Elofsson
Org. Biomol. Chem., 2012, 10, 1246-1254
DOI: 10.1039/C1OB06722B, Paper

• Alkaloids synthesis

One-pot reductive coupling of N-acylcarbamates with activated alkenes: application to the asymmetric synthesis of pyrrolo[1,2-a]azepin-5-one ring system and (−)-xenovenine Xue-Kui Liu, Xiao Zheng, Yuan-Ping Ruan, Jie Ma and Pei-Qiang Huang
Org. Biomol. Chem., 2012, 10, 1275-1284
DOI: 10.1039/C1OB06697H, Paper

Want to see your natural products article featured on this blog? Submit it online here

Organic & Biomolecular Chemistry publishes many articles that cover natural product chemistry. We will try to keep you updated, although the safest bet is for you to sign up to OBC’s e-alert (free service) and receive the table of content directly in your inbox every time an issue is published.

In OBC Issue 1, 2012 , you will find:

• A concise asymmetric synthesis of (−)-rasfonin
  Yange Huang, Adriaan J. Minnaard and Ben L. Feringa
  Org. Biomol. Chem., 2012, 10, 29-31, DOI: 10.1039/C1OB06700A, Communication

• Combining two-directional synthesis and tandem reactions: a short formal synthesis of halichlorine
  Camille Gignoux, Annabella F. Newton, Alexandre Barthelme, William Lewis, Marie-Lyne Alcaraz and Robert A. Stockman
  Org. Biomol. Chem., 2012, 10, 67-69, DOI: 10.1039/C1OB06380D, Paper

• 3,4′-Linked bis(piperidines) related to the haliclonacyclamine class of marine alkaloids: synthesis using crossed-aldol chemistry and preliminary biological evaluations
  Martin G. Banwell, Mark J. Coster, Natasha L. Hungerford, Mary J. Garson, Stephen Su, Andrew C. Kotze and Murray H. G. Munro
  Org. Biomol. Chem., 2012, 10, 154-161, DOI: 10.1039/C1OB06418E, Paper

• Discovery of a potent and highly β1 specific proteasome inhibitor from a focused library of urea-containing peptide vinyl sulfones and peptide epoxyketones
  Wouter A. van der Linden, Lianne I. Willems, Tamer B. Shabaneh, Nan Li, Mark Ruben, Bogdan I. Florea, Gijs A. van der Marel, Markus Kaiser, Alexei F. Kisselev and Herman S. Overkleeft
  Org. Biomol. Chem., 2012, 10, 181-194, DOI: 10.1039/C1OB06554H, Paper

Want to see your natural products article featured on this blog? Submit it online here.