Author Archive

RSC US Roadshow 2012 – Week 4: North East

Natural Product Reports Editor Richard Kelly will be visiting several North East universities next week as part of the RSC US Roadshows 2012.

Week 4 sees the Royal Society of Chemistry visiting four universities in Pennsylvania and New York:

May 7th – University of Pittsburgh
May 8th – Pennsylvania State University
May 10th – University of Pennsylvania
May 11th – Columbia University

Read more about the US roadshows 2012:

Starting in mid April 2012, RSC Publishing has been touring the United States of America to share more than 170 years experience of publishing in the chemical sciences. Sixteen universities across the country are hosting these one-day events, which are open to all members of the hosting institute.

Attendees have the opportunity to explore RSC’s apps on mobile devices and meet informally with RSC editors. Lunchtime discussion groups explore reading habits and opportunities in the 21st century and an afternoon seminar give an insight into the world of scholarly publishing, with tips on how to get published in high impact journals. A demonstration of ChemSpider, and a guest lecture from an RSC associate editor or board member are available at many of the roadshows.

Follow the RSC Roadshows on Twitter – just look for #RSC2012.

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Natural Products in OBC

Organic & Biomolecular Chemistry, our sister journal, publishes many articles that cover natural product chemistry.

We will try to keep you updated, although the safest bet is for you to sign up to OBC’s e-alert (free service) and receive the table of content directly in your inbox every time an issue is published.

 

The latest natural products’ related articles published in issue 18 and issue 19 have been collated here:

The first isocyanide of plant origin expands functional group diversity in cruciferous phytoalexins: synthesis, structure and bioactivity of isocyalexin A
M. Soledade C. Pedras and Estifanos E. Yaya
DOI: 10.1039/C2OB25492A

Synthesis of the macrolactone core of (+)-neopeltolide by transannular cyclization
Gangavaram V. M. Sharma, Sheri Venkat Reddy and Kallaganti V. S. Ramakrishna
DOI: 10.1039/C2OB25151E

A convenient biomimetic synthesis of optically active putative neurotoxic metabolites of MDMA (“ecstasy”) from R-(−)- and S-(+)-N-methyl-α-methyldopamine precursors
Claire-Marie Martinez, Anne Neudörffer and Martine Largeron
DOI: 10.1039/C2OB25245G

Flexible synthesis of montanine-like alkaloids: revisiting the structure of montabuphine
Yifu Guan, Hongbin Zhang, Chengxue Pan, Jia Wang, Rong Huang and Qilin Li
DOI: 10.1039/C2OB25374G, Communication

Stereoselective synthesis of functionalised carbocyclic amides: construction of the syn-(4aS,10bS)-phenanthridone skeleton
Sajjad Ahmad, Michael D. Swift, Louis J. Farrugia, Hans Martin Senn and Andrew Sutherland 
DOI: 10.1039/C2OB25334H, Paper

 

We hope you enjoy the selection! And why not also view MedChemComm‘s themed issue on Natural Products, still growing…

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Cytotoxic and antioxidant marine natural products on the cover of NPR issue 5

Welcome to NPR issue 5, 2012

This month’s striking subaquatic cover features the work of Suthananda N. Sunassee and Michael T. Davies-Coleman at Rhodes University, Grahamstown, South Africa,  with a review on Cytotoxic and antioxidant marine prenylated quinones and hydroquinones.
Focusing on 159 prenylated quinones, hydroquinones and naphthoquinones with reported cytotoxic and/or antioxidant properties isolated from various marine organisms over the past 40 years, the authors highlight trends in the structural distribution of these cytotoxic compounds within the different marine phyla.

Cytotoxic and antioxidant marine prenylated quinones and hydroquinones
Suthananda N. Sunassee and Michael T. Davies-Coleman
Nat. Prod. Rep., 2012, 29, 513-535
DOI: 10.1039/C2NP00086E

Also in this May issue, why not read:

NMR in natural products: understanding conformation, configuration and receptor interactions
Teresa Carlomagno
Nat. Prod. Rep., 2012, 29, 536-554

Cytisine: a natural product lead for the development of drugs acting at nicotinic acetylcholine receptors
Edwin G. Pérez, Carolina Méndez-Gálvez and Bruce K. Cassels
Nat. Prod. Rep., 2012, 29, 555-567

Peptidoglycan as Nod1 ligand; fragment structures in the environment, chemical synthesis, and their innate immunostimulation
Yukari Fujimoto, Ambara Rachmat Pradipta, Naohiro Inohara and Koichi Fukase
Nat. Prod. Rep., 2012, 29, 568-579

Recent discovery of plant-derived anti-diabetic natural products
Hsin-Yi Hung, Keduo Qian, Susan L. Morris-Natschke, Chau-Shin Hsu and Kuo-Hsiung Lee
Nat. Prod. Rep., 2012, 29, 580-606

Access the full issue

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Natural Products in OBC

Organic & Biomolecular Chemistry, our sister journal, publishes many articles that cover natural product chemistry.

We will try to keep you updated, although the safest bet is for you to sign up to OBC’s e-alert (free service) and receive the table of content directly in your inbox every time an issue is published.

The latest natural products’ related articles from OBC have been collated here:

  • Apocarotenoids in the sexual interaction of Phycomyces blakesleeanus
    Silvia Polaino, Jose A. Gonzalez-Delgado, Pilar Arteaga, M. Mar Herrador, Alejandro F. Barrero and Enrique Cerdá-Olmedo
  • Heteroatom-directed Wacker oxidations. A protection-free synthesis of (−)-heliophenanthrone
    Parag Mukherjee and Tarun K. Sarkar
  • Investigation of the electrophilic reactivity of the cytotoxic marine alkaloid discorhabdin B
    Cary F. C. Lam, Tanja Grkovic, A. Norrie Pearce and Brent R. Copp
  • Organocatalytic enantioselective Michael addition of a kojic acid derivative to nitro olefins
    Jiyu Wang, Qing Zhang, Hui Zhang, Yujun Feng, Weicheng Yuan and Xiaomei Zhang
  • Biotransformation of clovane derivatives. Whole cell fungi mediated domino synthesis of rumphellclovane A
    Giovanni Gontijo de Souza, Thays Silva Oliveira, Jacqueline Aparecida Takahashi, Isidro González Collado, Antonio José Macías-Sánchez and Rosario Hernández-Galán
  • Biomimetic synthesis, antibacterial activity and structure–activity properties of the pyroglutamate core of oxazolomycin
    Plamen Angelov, Yui Kwan Sonia Chau, Paul J. Fryer, Mark G. Moloney, Amber L. Thompson and Paul C. Trippier
  • Ketosulfonyl indoles in the regiodefined synthesis of tryptophols and related indole derivatives
    Alessandro Palmieri and Marino Petrini
  • Also of Interest:

    MedChemComm’s themed issue on Natural Products is growing – have you had a look yet? View all the articles here

    Want to see your natural products article featured on this blog? Submit online here

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    Latest Natural Product Research in OBC

    Organic & Biomolecular Chemistry, our sister journal, publishes many articles that cover natural product chemistry.

    We will try to keep you updated, although the safest bet is for you to sign up to OBC’s e-alert (free service) and receive the table of content directly in your inbox every time an issue is published.

    The latest natural products’ related articles from OBC have been collated here:

    • Also of Interest:
      The first articles from MedChemComm’s themed issue on Natural Products are available, including contributions from Professors Craig Townsend and Margaret Brimble
    • Want to see your natural products article featured on this blog? Submit online here
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    Vibsane-type diterpenoids on the cover of NPR issue 4

    Welcome to NPR issue 4, 2012!

    This month’s cover features the work of Jeffrey Y. W. Mak and Craig M. Williams who highlight the key accomplishments in the total synthesis of visbanins, which are rare, structurally dense diterpenes occuring exclusively in the Viburnum species.

    Key achievements in the total synthesis of vibsane-type diterpenoids
    Jeffrey Y. W. Mak and Craig M. Williams
    Nat. Prod. Rep., 2012, 29, 440-448
    DOI: 10.1039/C2NP00067A

    Also in the issue, read the latest Hot Of The Press article by Robert A. Hill and Andrew Sutherland,

    A Highlight by Jiyong Hong and Hendrik Luesch  on Largazole,  a potent inhibitor of histone deacetylases (HDACs) which has attracted considerable interest from the scientific community. This Highlight summarizes recent advances to date in the characterization of this marine natural product: 

    A review article by Yuan-Chao Li and Ze-Hong Miao et al. focusing on thunder god vine’s (Tripterygium wilfordii Hook F) principal bioactive ingredient triptolide:

    Richard Robins and Guillaume Tcherkez et al. ‘s review discussing biochemical and physiological factors underlying the site-specific, non-random distribution of 13C/12C isotope ratios within plant metabolites, which can be determined by isotopic 13C NMR spectrometry:

    R. Kiss and coworkers present both natural and synthetic phenazines with a critical focus on in vitro, in vivo and available clinical anti-cancer activities of these compounds, covering the literature published since 2000:

    View the issue

     

    Also of Interest:
    The first articles from MedChemComm’s themed issue on Natural Products are available, including contributions from Professors Craig Townsend and Margaret Brimble

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    Natural Products in OBC and MedChemComm

    Organic & Biomolecular Chemistry and MedChemComm, our sister journals, publish many articles that cover natural product chemistry.

    We will try to keep you updated, although the safest bet is for you to sign up to OBC’s and MedChemComm‘s e-alerts (free service), and receive their tables of content directly in your inbox every time an issue is published.

    The latest natural products’ related articles have been collated here:

    The microbial cell factory
    Cormac D. Murphy
    Org. Biomol. Chem., 2012, 10, 1949-1957
    DOI: 10.1039/C2OB06903B, Perspective

    Fungal biofilm inhibitors from a human oral microbiome-derived bacterium
    Xiaoru Wang, Lin Du, Jianlan You, Jarrod B. King and Robert H. Cichewicz
    Org. Biomol. Chem., 2012, 10, 2044-2050
    DOI: 10.1039/C2OB06856G, Paper

    Pyrazine alkaloids via dimerization of amino acid-derived α-amino aldehydes: biomimetic synthesis of 2,5-diisopropylpyrazine, 2,5-bis(3-indolylmethyl)pyrazine and actinopolymorphol C
    Sandhya Badrinarayanan and Jonathan Sperry
    Org. Biomol. Chem., 2012, 10, 2126-2132
    DOI: 10.1039/C2OB06935K, Paper

    Novel, unifying mechanism for amphotericin B and other polyene drugs: electron affinity, radicals, electron transfer, autoxidation, toxicity, and antifungal action
    Peter Kovacic and Andrew Cooksy
    Med. Chem. Commun., 2012, 3, 274-280
    DOI: 10.1039/C2MD00267A, Review

    Intramolecular proton transfer impact on antibacterial properties of ansamycin antibiotic rifampicin and its new amino analogues
    Krystian Pyta, Piotr Przybylski, Barbara Wicher, Maria Gdaniec and Joanna Stefańska
    Org. Biomol. Chem., 2012, 10, 2385-2388
    DOI: 10.1039/C2OB00008C, Communication

    Efficient syntheses of 2,3-disubstituted natural quinazolinones via iridium catalysis
    Jie Fang and Jianguang Zhou
    Org. Biomol. Chem., 2012, 10, 2389-2391
    DOI: 10.1039/C2OB07178A, Communication

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    NPR poster prizes awarded at Zing Natural Products conference

    Congratulations to Ramona Riclea (TU Braunschweig, Germany) and Khomaizon Kadir (University of Bristol, UK) who each won a Natural Product Reports poster prize at the Zing Natural Products conference  held on 10-13 February in Lanzarote.

    Ramona, currently studying for her PhD in the group of Dr. Jeroen S. Dickschat, presented her winning work entitled

    •  ‘Synthesis and biosynthesis of novel bioactive secondary metabolites from Streptomycetes’

    while Khomaizon, PhD student working with Drs Andy Bailey and Colin M Lazarus, was rewarded for her winning poster presenting her research on:

    •  ‘Efficient expression system for production of natural products in Aspergillus orizae’

    Both awardees receive a prize certificate and a one-year subscription to Natural Product Reports. Congratulations!

    From left to right, Dr Jeroen Dickschat and poster prize winners Ramona Riclea and  Khomaizon Kadir receiving their award certificate from Dr Marie Cote, NPR deputy editor.

    The meeting was co-Chaired by NPR Advisory Board member and former NPR Chair David O’Hagan (University of St Andrews, UK) and NPR Advisory Board member Margaret Brimble (University of Auckland, New Zealand) and brilliantly covered the breadth of natural products research: from isolation and structural studies to biosynthesis to synthesis of molecules. Included in the line up of speakers were NPR Editorial Board members Andreas Kirschning (Leibniz University of Hannover, Germany)  Stefan Schulz (TU Braunschweig, Germany), Dirk Trauner (Ludwig-Maximilians-Universität München),  former NPR Chair Tom Simpson (University of Bristol, UK) and former Lecture Award winner Jason Micklefield (University of Manchester, UK).

    The conference was a perfect opportunity to not only see some of the latest cutting edge natural products research but also to meet authors and readers of the journal –  all this in very enjoyable surroundings!

    For critical and though-provoking reviews across a broad range of areas of natural products research, you can turn to Natural Product Reports…   

    But did you know?

    – Our sister journal Organic & Biomolecular Chemistry regularly publishes natural products related works: See them all here.

    – Why not also view the very first articles from MedChemComm’s themed issue on Natural Products?

     

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    Enzymatic cascade reactions in biosynthesis on the cover of NPR issue 3, 2012

    Welcome to NPR issue 3, 2012!

    This month’s cover features the work of Kurt Faber et al. at the University of Graz, Austria, with a review on the enzyme-initiated cascade reactions for the ring formation of cyclic terpenoids and polyethers. The authors provide a mechanistic analysis of enzymatic cascade reactions leading to biomimetic strategies for natural product synthesis. 

    Also in the issue, read Clay C. C. Wang‘s review article on the  impact of whole genome sequencing on Aspergillus secondary metabolite research:

    Pedro N. Leão and coworkers provide insights into the chemical ecology of cyanobacteria, highlighting both evolutionary and chemotaxonomical studies:

    Qingsong Liu et al. review the history of several classes of natural products as kinase inhibitors, analyzing their structural binding information and highlighting their therapeutic development potential:

    Why not also read on the didemnin family of marine depsipeptides in this review article by Madeleine M. Joullié et al..  The authors highlight the long-standing study of didemnins and its critical application towards the understanding of the molecular mechanism of action of tamandarins and their potential use as therapeutic agents:

     We hope that you enjoy this issue!

    View the issue

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    Natural Products in OBC

    Organic & Biomolecular Chemistry, our sister journal, publishes many articles that cover natural product chemistry.

    We will try to keep you updated, although the safest bet is for you to sign up to OBC’s e-alert (free service) and receive the table of content directly in your inbox every time an issue is published.

    The latest natural products’ related articles from OBC issue 9 have been collated here:

    Studies of the H–D exchange mechanism of malonganenone B
    Peter G. K. Clark, Matthias Lein and Robert A. Keyzers

    Unexpected enzyme-catalyzed regioselective acylation of flavonoid aglycones and rapid product screening
    Eleni Kyriakou, Alexandra Primikyri, Pantelis Charisiadis, Maria Katsoura, Ioannis P. Gerothanassis, Haralambos Stamatis and Andreas G. Tzakos

    Total synthesis of a cuticular hydrocarbon from the cane beetle Antitrogus parvulus: confirmation of the relative stereochemistry
    Norazah B. Basar, Hao Liu, Devendra Negi, Hasnah M. Sirat, Gareth A. Morris and Eric J. Thomas

    An iterative Shimizu non-aldol approach for the stereoselective synthesis of C13-C22 fragment of callystatin A
    Sandip A. Pujari and Krishna P. Kaliappan

    Organocatalytic stereoselective synthesis of passifloricin A
    Pradeep Kumar, Menaka Pandey, Priti Gupta and Dilip D. Dhavale

    Stereocontrolled asymmetric synthesis of syn-E-1,4-diol-2-enes using allyl boronates and its application in the total synthesis of solandelactone F
    Anna Robinson and Varinder K. Aggarwal

    Enantioselective synthesis of the carbocyclic nucleoside (−)-abacavir
    Grant A. Boyle, Christopher D. Edlin, Yongfeng Li, Dennis C. Liotta, Garreth L. Morgans and Chitalu C. Musonda


     

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