Themed collection on “Synthesis and chemical biology of macrocycles”

We’re pleased to announce that our first guest-edited themed collection, on the Synthesis and Chemical Biology of Macrocycles, has now been published online! We thank the Guest Editors, Gong Chen (Nankai University), Monika Raj (Emory University), and Andrei Yudin (University of Toronto) for their work editing this collection.

Read the collection

Macrocycles are an important class of compounds with a long-recognised, significant role in chemical biology and drug discovery. This themed collection offers a collection of articles that showcase the ongoing interest in the chemical biology of macrocycles. Recent years have witnessed the development of new synthetic and biological strategies to construct large rings composed of amino acid residues. In addition, significant progress has been made in efforts to understand and predict the properties of macrocycles. We have collected contributions that are representative of the tremendous promise and pace of growth in this area.

The work in this collection covers all areas of the synthesis and chemical biology of macrocycles, including new synthetic and biosynthetic pathways for synthesis of diverse range of macrocycles; peptide and peptidomimetics macrocycles; design and synthesis of macrocycles for biological and medicinal applications; cell permeable macrocycles for targeting intracellular proteins; structural studies of macrocycles to expand the conformational drug space, and much more. Taken together, the papers collected in this themed collection represent the state of the art in macrocycles and highlight work at the interface of chemistry and biology.

Editorial

Introduction to ‘Synthesis and chemical biology of macrocycles’
RSC Chem. Biol., 2022, 3, 993-993. DOI: 10.1039/D2CB90018A

Reviews

Peptide/protein-based macrocycles: from biological synthesis to biomedical applications
Wen-Hao Wu, Jianwen Guo, Longshuai Zhang, Wen-Bin Zhang and Weiping Gao
RSC Chem. Biol., 2022, 3, 815-829. DOI: 10.1039/D1CB00246E

Cyclic peptide drugs approved in the last two decades (2001–2021)
Huiya Zhanga and Shiyu Chen
RSC Chem. Biol., 2022, 3, 18-31. DOI: 10.1039/D1CB00154J

Communication

Targeted disruption of PKC from AKAP signaling complexes
Ameya J. Limaye, George N. Bendzunasa and Eileen J. Kennedy
RSC Chem. Biol., 2021, 2, 1227-1231. DOI: 10.1039/D1CB00106J

Papers

Landscaping macrocyclic peptides: stapling hDM2-binding peptides for helicity, protein affinity, proteolytic stability and cell uptake
Aline D. de Araujo, Junxian Lim, Kai-Chen Wu, Huy N. Hoang, Huy T. Nguyen and David P. Fairlie
RSC Chem. Biol., 2022, 3, 895-904. DOI: 10.1039/D1CB00231G

Navigating complex peptide structures using macrocycle conformational maps
Timothy J. McTiernan, Diego B. Diaz, George J. Saunders, Fiona Spranga and Andrei K. Yudin
RSC Chem. Biol., 2022, 3, 739-747. DOI: 10.1039/D2CB00016D

Structural impact of thioamide incorporation into a β-hairpin
Kristen E. Fiore, Martijn J. Patist, Sam Giannakoulias, Cheng-Hsin Huang, Hitesh Verma, Bhavesh Khatri, Richard P. Cheng, Jayanta Chatterjee and E. James Petersson
RSC Chem. Biol., 2022, 3, 582-591. DOI: 10.1039/D1CB00229E

Synthesis of medium-ring lactams and macrocyclic peptide mimetics via conjugate addition/ring expansion cascade reactions
Kleopas Y. Palate, Zhongzhen Yang, Adrian C. Whitwood and William P. Unsworth
RSC Chem. Biol., 2022, 3, 334-340. DOI: 10.1039/D1CB00245G

Inner residues of macrothiolactone in autoinducer peptides I/IV circumvent spontaneous S-to-O acyl transfer to the upstream serine residue
Masanobu Nagano, Satoshi Ishida and Hiroaki Suga
RSC Chem. Biol., 2022, 3, 295-300. DOI: 10.1039/D1CB00225B

Discovery, X-ray structure and CPP-conjugation enabled uptake of p53/MDM2 macrocyclic peptide inhibitors
Anselm F. L. Schneider, Joerg Kallen, Johannes Ottl, Patrick C. Reid, Sebastien Ripoche, Stephan Ruetz, Therese-Marie Stachyra, Samuel Hintermann, Christoph E. Dumelin, Christian P. R. Hackenberger and Andreas L. Marzinzik
RSC Chem. Biol., 2021, 2, 1661-1668. DOI: 10.1039/D1CB00056J

Entropy of stapled peptide inhibitors in free state is the major contributor to the improvement of binding affinity with the GK domain
Ilona Christy Unarta, Jianchao Xu, Yuan Shang, Carina Hey Pui Cheung, Ruichi Zhu, Xudong Chen, Siqin Cao, Peter Pak-Hang Cheung, Donald Bierer, Mingjie Zhang, Xuhui Huang and Xuechen Li
RSC Chem. Biol., 2021, 2, 1274-1284. DOI: 10.1039/D1CB00087J

The first RSC Chemical Biology Emerging Investigators collection

Photographs of the six corresponding authors on the articles in this collection

We’re pleased to announce that our first Emerging Investigators collection has now been published online!

Read the collection

RSC Chemical Biology is committed to supporting and recognizing the excellent work of early career researchers. We are thus proud to present our first annual Emerging Investigators collection. The collection showcases research carried out by internationally recognised, up-and-coming scientists in the early stage of their independent careers who are making outstanding contributions to their respective fields. Each contributor was recommended by an expert in their field for carrying out work with the potential to influence future directions. The collection encompasses the entire scope of the journal.

Looking forward, we will soon be inviting for an Emerging Investigators Collection that will be published in 2023, and you are encouraged to recommend a colleague at the beginning of their career by contacting the Editorial Office. To be considered, a scientist must be a research group leader with less than 10 years of independent research (although the timescale is flexible in cases of career breaks and personal circumstances).

Congratulations to all the featured researchers on their work. Join us in celebrating their contributions!

Editorial

RSC Chemical Biology Emerging Investigators Collection and Outstanding Paper Award 
RSC. Chem. Biol., 2022, Advance Article, DOI: 10.1039/D2CB90027K

Profile

Contributors to the RSC Chemical Biology Emerging Investigators Collection 2022 
RSC. Chem. Biol., 2022, Advance Article, DOI: 10.1039/D2CB90028A

Communications

The CSY-protecting group in the microwave-assisted synthesis of aggregation-prone peptides 
Truc Lam Pham, Jennifer Zilke, Christine Charlotte Müller and Franziska Thomas
RSC. Chem. Biol., 2022, 3, 426–430, DOI: 10.1039/D1CB00252J

A light-initiated chemical reporter strategy for spatiotemporal labeling of biomolecules 
Feifei Wang, Hao Kong, Xiangfeng Meng, Xiao Tian, Changjiang Wang, Lei Xu, Xiang Zhang, Lei Wang and Ran Xie
RSC. Chem. Biol., 2022, 3, 539–545, DOI: 10.1039/D2CB00072E

A dual-responsive doxorubicin–indoximod conjugate for programmed chemoimmunotherapy 
Zhaoxuan Yang, Jiaqi Huang, Yaying Lin, Xiangjie Luo, Haojin Lin, Hongyu Lin and Jinhao Gao
RSC. Chem. Biol., 2022, 3, 853–858, DOI: 10.1039/D1CB00257K

Papers

Proteomic characterization of phagocytic primary human monocyte-derived macrophages
Regan F. Volk, José L. Montaño, Sara E. Warrington, Katherine L. Hofmann and Balyn W. Zaro
RSC. Chem. Biol., 2022, 3, 783–793, DOI: 10.1039/D2CB00076H

Improved ClickTags enable live-cell barcoding for highly multiplexed single cell sequencing
Xinlu Zhao, Shiming Sun, Wenhao Yu, Wenqi Zhu, Zihan Zhao, Yiqi Zhou, Xiuheng Ding, Nan Fang, Rong Yang and Jie P. Li
RSC. Chem. Biol., 2022, Advance Article, DOI: 10.1039/D2CB00046F

Structural insights into inhibition of the drug target dihydroorotate dehydrogenase by bacterial hydroxyalkylquinolines 
Samantha M. Horwitz, Tamra C. Blue, Joseph A. Ambarian, Shotaro Hoshino, Mohammad R. Seyedsayamdost and Katherine M. Davis
RSC. Chem. Biol., 2022, 3, 420–425, DOI: 10.1039/D1CB00255D

Call for papers – The Epitranscriptome

 

RSC Chemical Biology is delighted to welcome papers for its latest online themed collection on ‘The Epitranscriptome’, guest edited by Ralph Kleiner (Princeton, USA), Claudia Höbartner (University of Würzburg, Germany) and Guifang Jia (Peking University, China).

Scope

Contributions are welcome which investigate structural and functional consequences of native RNA modifications in vitro and in living systems. New chemical and chemoenzymatic methods for detection, validation, and characterization of epitranscriptomic modifications and their functions are welcome for this themed collection on emerging topics in epitranscriptomic research.

The deadline for submissions is 30 November 2022.

Submit to the collection now!

Promotion of the collection is scheduled for spring 2023, with articles published online as soon as they’re accepted.

Authors are welcome to submit original research in the form of a Communication or Full Paper.  Articles can be submitted via our website: rsc.li/rsc-chembio. We would be grateful if upon submission you would be able to mention that your manuscript is intended for this themed collection in the “notes to the editor” box.

If you have any questions about the journal or the collection, I would be happy to answer them in reply to this email.

With kind regards,

Ralph Kleiner

Princeton, USA

Claudia Höbartner

University of Würzburg, Germany

Guifang Jia

Peking University, China

Explore all open calls for papers from RSC journals! 

 

About RSC Chemical Biology

Led by Hiroaki Suga (University of Tokyo), RSC Chemical Biology is dedicated to publishing and disseminating the most exceptionally significant, breakthrough findings of interest to the chemical biology community. All submissions are handled by our experienced and internationally recognised Associate Editors. For more information on the journal, please visit the journal homepage.

As a gold open access journal, there are no barriers to accessing content and your research article will reach an international audience. Please note that the article processing charges are waived until mid-2022, so the journal is currently free to publish in.

 

RSC Chemical Biology is now indexed in the Directory of Open Access Journals (DOAJ), PubMed Central, Scopus and Web of Science: Emerging Sources Citation Index.  Find out more about the journal and submit your work at rsc.li/rsc-chembio

 

RSC Chemical Biology

Royal Society of Chemistry

www.rsc.org

 

 

Cross-journal themed collection on “Multimolecular Crowding in Biosystems”

We’re excited to share with you our new cross-journal themed collection on “Multimolecular Crowding in Biosystems” for RSC Chemical Biology and ChemComm.

Living cells comprise a variety of molecules from small cations/anions, metabolites, lipids, peptides, to biopolymers such as peptides/proteins, polysaccharides, and nucleic acids. These biomolecules are highly condensed inside the live cells and their distribution and concentration are heterogeneously varied (in a controlled manner). Such multimolecular crowding conditions are sharply distinct from those of conventional biochemical study, should be crucial for elucidating structures and functions of biomolecules in live cells, as well as for developing functional artificial molecules useful in chemical biology study, drug discovery, and medical diagnosis.

In this cross-journal themed issue, explore research papers, reviews, and communications in ChemComm and RSC Chemical Biology concerning chemical, physical, theoretical, or biological characterization of various biomolecules under the multimolecular crowding conditions. Also discover the development of chemical tools and devices enabling the detection and imaging of key biomolecules and the relevant events in live cells, methods for the structural modification and functional switching/control of biomolecules, and analytical or physical chemistry approaches applicable to study of multimolecular crowding biosystems.

Explore some of the papers in the collection below, and see the full collection here: Cross-journal themed collection on ‘Multimolecular Crowding in Biosystems’

  

Highlight

Fluorescent probes for targeting endoplasmic reticulum: design strategies and their applications
Deepmala Singh, Deeksha Rajput and Sriram Kanvah
Chem. Commun., 2022, 58, 2413-2429
DOI: 10.1039/D1CC06944F

  

Feature Article

Cancer diagnosis and analysis devices based on multimolecular crowding
Daisuke Onoshima and Yoshinobu Baba
Chem. Commun., 2021, 57, 13655-13661
DOI: 10.1039/D1CC05556A

 

 Review

Chemogenetics of cell surface receptors: beyond genetic and pharmacological approaches
Yuta Miura, Akinobu Senoo, Tomohiro Doura and Shigeki Kiyonaka
RSC Chem. Biol., 2022, 3, 269-287
DOI: 10.1039/D1CB00195G

  

Paper

Versatile naphthalimide tetrazines for fluorogenic bioorthogonal labelling
Marcus E. Graziotto, Liam D. Adair, Amandeep Kaur, Pauline Vérité, Sarah R. Ball, Margaret Sunde, Denis Jacquemin and Elizabeth J. New
RSC Chem. Biol., 2021, 2, 1491-1498
DOI: 10.1039/D1CB00128K

 

We hope you enjoy reading these articles!

 


Contact us:  chembio-rsc@rsc.org

Visit our website – rsc.li/rsc-chembio

 

RSC Chemical Biology is an international gold open access journal, publishing exceptionally significant findings in chemical biology.

Sign up now to get updates on all articles as they are published on Twitter and in our e-alerts.

 

‘Exploring proteins and their interactions’ topical collection

We’re excited to share with you our new topical collection on “Exploring proteins and their interactions” for RSC Chemical Biology, highlighting the excellent work published so far in the journal in this exciting area of research.

The study of proteins, their structure and function, interactions and roles in disease is a vast topic encompassing a range of different approaches, techniques and tools. Work in this collection reflects the variety and scope of this area of chemical biology research, including studies on the mechanisms of aromatases, coronavirus host-cell interactions, the mapping of epitopes, and much more.

Explore some of the papers in the collection below, and see the full collection here:

Exploring proteins and their interactions’ topical collection

 

Review

Segmental and site-specific isotope labelling strategies for structural analysis of posttranslationally modified proteins
Dominik P. Vogl, Anne C. Conibear and Christian F. W. Becker
RSC Chem. Biol., 2021, 2, 1441-1461
DOI: 10.1039/D1CB00045D

 

Communication

Protein–protein interaction based substrate control in the E. coli octanoic acid transferase, LipB
Thomas G. Bartholow, Terra Sztain, Megan A. Young, Tony D. Davis, Ruben Abagyan and Michael D. Burkart
RSC Chem. Biol., 2021, 2, 1466-1473
DOI: 10.1039/D1CB00125F

 

Paper

The identification and characterization of an oxalyl-CoA synthetase from grass pea (Lathyrus sativus L.)
Moshe Goldsmith, Shiri Barad, Yoav Peleg, Shira Albeck, Orly Dym, Alexander Brandis, Tevie Mehlman and Ziv Reich
RSC Chem. Biol., 2022, 3, 320-333
DOI: 10.1039/D1CB00202C

 

We hope you enjoy reading these articles!

 


 

RSC Chemical Biology is an international gold open access journal, publishing exceptionally significant findings in chemical biology.

Sign up now to get updates on all articles as they are published on Twitter and in our e-alerts.

Contact us:  chembio-rsc@rsc.org

Visit our website – rsc.li/rsc-chembio

Call for papers – Molecular Glues

 

RSC Chemical Biology is delighted to welcome papers for its latest online themed collection on ‘Molecular glues’, guest edited by Professor Michelle Arkin (UCSF, USA), Professor Luc Brunsveld (TU Eindhoven, Netherlands) and Dr Eric Fischer (Dana-Farber Cancer Institute & Harvard Medical School, USA).

Scope

welcome broad studies on molecular glues, including studies on but not limited to protein degradation glues, protein binders and stabilizers. We also welcome studies at the intersection of molecular glues and bi-functional molecules for protein degradation and beyond with a particular interest on molecular recognition.

The deadline for submissions is 30 September 2022.

Submit to the collection now!

Promotion of the collection is scheduled for spring 2023, with articles published online as soon as they’re accepted.

Authors are welcome to submit original research in the form of a Communication or Full Paper.  Articles can be submitted via our website: rsc.li/rsc-chembio. We would be grateful if upon submission you would be able to mention that your manuscript is intended for this themed collection in the “notes to the editor” box.

Please note that before a final decision is made, all submissions are subject to an initial assessment to confirm the manuscript’s suitability for full peer review.

If you have any questions about the journal or the collection, I would be happy to answer them in reply to this email.

 

With kind regards,

Professor Michelle Arkin

UCSF, USA

Professor Luc Brunsveld

Tu Eindhoven, Netherlands

Dr Eric Fischer

Dana-Farber Cancer Institute & Harvard Medical School, USA

Explore all open calls for papers from RSC journals! 

 

About RSC Chemical Biology

Led by Hiroaki Suga (University of Tokyo), RSC Chemical Biology is dedicated to publishing and disseminating the most exceptionally significant, breakthrough findings of interest to the chemical biology community. All submissions are handled by our experienced and internationally recognised Associate Editors. For more information on the journal, please visit the journal homepage.

As a gold open access journal, there are no barriers to accessing content and your research article will reach an international audience. Please note that the article processing charges are waived until mid-2022, so the journal is currently free to publish in.

 

RSC Chemical Biology is now indexed in the Directory of Open Access Journals (DOAJ), PubMed Central, Scopus and Web of Science: Emerging Sources Citation Index.  Find out more about the journal and submit your work at rsc.li/rsc-chembio

 

RSC Chemical Biology

Royal Society of Chemistry

www.rsc.org

 

 

 

Celebrating International Women’s Day 2022

Today at the RSC we are celebrating International Women’s Day 2022 and the fantastic women who have recently published in our journals.

We encourage you to explore some of the excellent work published in RSC Chemical Biology by women so far, and don’t forget to browse our whole collection of articles here.

  

Reviews

Professor Anne-Kathrin Duhme-Klair, University of York, UK:

Artificial imine reductases: developments and future directions
Rosalind L. Booth, Gideon Grogan, Keith S. Wilson and Anne-Kathrin Duhme-Klair
RSC Chem. Biol., 2020, 1, 369-378
DOI: 10.1039/D0CB00113A

 

Professor Rosa de Lederkremer, University of Buenos Aires, Argentina:

trans-Sialylation: a strategy used to incorporate sialic acid into oligosaccharides
Rosa M. de Lederkremer, María Eugenia Giorgi and Rosalía Agusti
RSC Chem. Biol., 2022, 3, 121-139
DOI: 10.1039/D1CB00176K

 

Professor Yan Zhang, University of Texas at Austin, USA:

What’s all the phos about? Insights into the phosphorylation state of the RNA polymerase II C-terminal domain via mass spectrometry
Blase M. LeBlanc, R. Yvette Moreno, Edwin E. Escobar, Mukesh Kumar Venkat Ramani, Jennifer S. Brodbelt and Yan Zhang
RSC Chem. Biol., 2021, 2, 1084-1095
DOI: 10.1039/D1CB00083G

 

Communications

Professor Franziska Thomas, University of Heidelberg, Germany:

The CSY-protecting group in the microwave-assisted synthesis of aggregation-prone peptides
Truc Lam Pham, Jennifer Zilke, Christine Charlotte Müller and Franziska Thomas
RSC Chem. Biol., 2022, Advance Article
DOI: 10.1039/D1CB00252J

 

Dr Katherine Davis, Emory University, USA:

Structural insights into inhibition of the drug target dihydroorotate dehydrogenase by bacterial hydroxyalkylquinolines
Samantha M. Horwitz, Tamra C. Blue, Joseph A. Ambarian, Shotaro Hoshino, Mohammad R. Seyedsayamdost and Katherine M. Davis
RSC Chem. Biol., 2022, Advance Article
DOI: 10.1039/D1CB00255D

 

Papers

Professor Andrea Rentmeister, University of Munster, Germany:

Computational design and experimental characterization of a photo-controlled mRNA-cap guanine-N7 methyltransferase
Dennis Reichert, Helena Schepers, Julian Simke, Horst Lechner, Wolfgang Dörner, Birte Höcker, Bart Jan Ravoo and Andrea Rentmeister
RSC Chem. Biol., 2021, 2, 1484-1490
DOI: 10.1039/D1CB00109D

 

Dr Anne Connibear, University of Queensland, Australia:

Site-specific modification and segmental isotope labelling of HMGN1 reveals long-range conformational perturbations caused by posttranslational modifications
Gerhard Niederacher, Debra Urwin, Yasmin Dijkwel, David J. Tremethick, K. Johan Rosengren, Christian F. W. Becker and Anne C. Conibear
RSC Chem. Biol., 2021, 2, 537-550
DOI: 10.1039/D0CB00175A

 

Dr Clarissa Czekster, University of St Andrews, UK:

Bypassing the requirement for aminoacyl-tRNA by a cyclodipeptide synthase enzyme
Christopher J. Harding, Emmajay Sutherland, Jane G. Hanna, Douglas R. Houston and Clarissa M. Czekster
RSC Chem. Biol., 2021, 2, 230-240
DOI: 10.1039/D0CB00142B

 

Professor Tia Keyes, Dublin City University, Ireland:

Ru(II)/BODIPY core co-encapsulated ratiometric nanotools for intracellular O2 sensing in live cancer cells
Karmel Sofia Gkika, Anna Kargaard, Christopher S. Burke, Ciaran Dolan, Andreas Heise and Tia E. Keyes
RSC Chem. Biol., 2021, 2, 1520-1533
DOI: 10.1039/D1CB00102G

 

We hope you enjoy reading these articles!


Contact us:  chembio-rsc@rsc.org

Visit our website – rsc.li/rsc-chembio

 

RSC Chemical Biology is an international gold open access journal, publishing exceptionally significant findings in chemical biology.

Sign up now to get updates on all articles as they are published on Twitter and in our e-alerts.

 

Call for papers – Chemical Proteomics

RSC Chemical Biology is delighted to welcome papers for its latest online themed collection on ‘Chemical Proteomics’, guest edited by Dr Keriann Backus (UCLA, USA) and Dr Stephan Hacker (Leiden University, Netherlands).

Scope

RSC Chemical Biology is delighted to welcome submissions on applications of chemoproteomics to study the targets and off-targets of covalent and non-covalent inhibitors, to study the reactivity of amino acids in the proteome, to develop new reactive groups for photocrosslinkers, covalent inhibitors and protein labeling as well as to study post-translational modifications and cofactor binding proteome-wide.

The deadline for submissions is 30 June 2022.

Submit to the collection now!

Promotion of the collection is scheduled for winter 2022, but articles will be published online as soon as they’re accepted.

Authors are welcome to submit original research in the form of a Communication or Full Paper.  Articles can be submitted via our website: rsc.li/rsc-chembio. We would be grateful if upon submission you would be able to mention that your manuscript is intended for this themed collection in the “notes to the editor” box.

Please note that before a final decision is made, all submissions are subject to an initial assessment to confirm the manuscript’s suitability for full peer review.

 If you have any questions about the journal or the collection, please contact the editorial office via chembio-rsc@rsc.org.

With kind regards,

Dr Keriann Backus

UCLA, USA

Dr Stephan Hacker

Leiden University, Netherlands

 

Explore all open calls for papers from RSC journals! 

 

About RSC Chemical Biology

Led by Hiroaki Suga (University of Tokyo), RSC Chemical Biology is dedicated to publishing and disseminating the most exceptionally significant, breakthrough findings of interest to the chemical biology community. All submissions are handled by our experienced and internationally recognised Associate Editors. For more information on the journal, please visit the journal homepage.

As a gold open access journal, there are no barriers to accessing content and your research article will reach an international audience. Please note that the article processing charges are waived until mid-2022, so the journal is currently free to publish in.

 

RSC Chemical Biology is now indexed in the Directory of Open Access Journals (DOAJ), PubMed Central, Scopus and Web of Science: Emerging Sources Citation Index.  Find out more about the journal and submit your work at rsc.li/rsc-chembio

 

RSC Chemical Biology

Royal Society of Chemistry

www.rsc.org

 

 

 

RSC Chemical Biology Infographics

We have partnered with Editage Infographics and selected authors, to create a series of infographics based on the authors’ work published in RSC Chemical Biology.


Xanthine-based photoaffinity probes allow assessment of ligand engagement by TRPC5 channels

RSC Chem. Biol., 2020,1, 436-448
DOI: 10.1039/D0CB00126K

A self-labeling protein based on the small ultra-red fluorescent protein, smURFP

RSC Chem. Biol., 2021,2, 1221-1226
DOI: 10.1039/D1CB00127B

Versatile naphthalimide tetrazines for fluorogenic bioorthogonal labelling

RSC Chem. Biol., 2021,2, 1491-1498
DOI: 10.1039/D1CB00128K

 


 

‘Analytical methods in Chemical Biology’ topical collection

We’re excited to share with you our new topical collection on “Analytical methods in chemical biology” for RSC Chemical Biology, highlighting the excellent work published so far in the journal in this exciting area of research.

This collection seeks to highlight important advancements in fields such as imaging, spectroscopy, sensing and omics.  Analytical methods developed and utilized by chemical biologists encompass a wide range of techniques, including Raman probes for exploring uptake into plant cells, nanobodies for non-invasive imaging, single-cell multi-omics, single-molecule fluorescent sensors and much more.

Explore some of the papers in the collection below, and see the full collection here:

‘Analytical methods in chemical biology’ Topical Collection

  

Review

Nanobodies as in vivo, non-invasive, imaging agents
Thibault J. Harmand, Ashraful Islam, Novalia Pishesha and Hidde L. Ploegh
RSC Chem. Biol., 2021, 2, 685-701
DOI: 10.1039/D1CB00023C

 

Communication

Squaric acid as a new chemoselective moiety for mass spectrometry-based metabolomics analysis of amines
Weifeng Lin, Zhen Yang, Amanpreet Kaur, Annika Block, Miroslav Vujasinovic, J.-Matthias Löhr and Daniel Globisch
RSC Chem. Biol., 2021, 2, 1479-1483
DOI: 10.1039/D0CB00132A

 

Paper

Versatile naphthalimide tetrazines for fluorogenic bioorthogonal labelling
Marcus E. Graziotto, Liam D. Adair, Amandeep Kaur, Pauline Vérité, Sarah R. Ball, Margaret Sunde, Denis Jacquemin and Elizabeth J. New
RSC Chem. Biol., 2021, 2, 1491-1498
DOI: 10.1039/D1CB00128K

 

We hope you enjoy reading these articles!

 


 

RSC Chemical Biology is an international gold open access journal, publishing exceptionally significant findings in chemical biology.

Sign up now to get updates on all articles as they are published on Twitter and in our e-alerts.

Contact us:  chembio-rsc@rsc.org

Visit our website – rsc.li/rsc-chembio