RSC Chemical Biology Blog

We’re pleased to announce that a new themed collection from RSC Chemical Biology and RSC Medicinal Chemistry has now been published online.

Read the collection

This themed collection, Guest Edited by Professor Thimmaiah Govindaraju (Jawaharlal Nehru Centre for Advanced Scientific Research, India), covers advancements in molecular and nanotheranostics with particular emphasis on the design of theranostic tools and their selective interaction with biomolecular targets to image and ameliorate pathological conditions. The collection is anticipated to catalyze the development of precision theranostics as advanced and personalizable tools in chemical biology and modern medicine.

The articles in the collection are listed below. Articles in RSC Chemical Biology are open access and free to read.

Editorial

Introduction to the themed collection on ‘Molecular and nanotheranostics’
Thimmaiah Govindaraju
RSC. Chem. Biol., 2024, 5, DOI: 10.1039/D3CB90050A

Reviews

Small molecules and conjugates as theranostic agents
Sumon Pratihar, Krithi K. Bhagavath and Thimmaiah Govindaraju
RSC. Chem. Biol., 2023, 4, 826–849, DOI: 10.1039/D3CB00073G

Recent progress of small-molecule-based theranostic agents in Alzheimer’s disease
Furong Gao, Jiefang Chen, Yuancun Zhou, Letong Cheng, Ming Hu and Xiaohui Wang
RSC. Med. Chem., 2023, 14, 2231–2245, DOI: 10.1039/D3MD00330B

Papers and Communications

Single-chain multicolor-reporter templates for subcellular localization of molecular events in mammalian cells
Sung-Bae Kim, Ramasamy Paulmurugan, Nobuo Kitada and Sojiro A. Maki
RSC. Chem. Biol., 2023, 4, 1043–1049, DOI: 10.1039/D3CB00077J

Fluorescent naphthalimide boronates as theranostics: structural investigations, confocal fluorescence and multiphoton fluorescence lifetime imaging microscopy in living cells
Megan J. Green, Haobo Ge, Stephen E. Flower, Charareh Pourzand, Stanley W. Botchway, Hui-Chen Wang, Navaratnarajah Kuganathan, Gabriele Kociok-Köhn, Meng Li, Suying Xu, Tony D. James and Sofia I. Pascu
RSC. Chem. Biol., 2023, 4, 1082–1095, DOI: 10.1039/D3CB00112A

Cationic Dextrin Nanoparticles for Effective Intracellular Delivery of Cytochrome C in Cancer Therapy
Ankita Sarkar, Sanchita Sarkhel, Deepali Bisht and Amit Jaiswal
RSC. Chem. Biol., 2024, 5, DOI: 10.1039/D3CB00090G

We hope you enjoy this new themed collection from RSC Chemical Biology and RSC Medicinal Chemistry.

We’re pleased to announce that a new themed collection from RSC Chemical Biology on Chemical Proteomics has now been published online.

Read the collection

This collection, Guest Edited by Dr Keriann Backus (UCLA, USA) and Dr Stephan Hacker (Leiden University, Netherlands), highlights work on applications of chemoproteomics to study the targets and off-targets of covalent and non-covalent inhibitors, to study the reactivity of amino acids in the proteome, to develop new reactive groups for photocrosslinkers, covalent inhibitors and protein labeling as well as to study post-translational modifications and cofactor binding proteome-wide.

A listing of the articles has been provided below. All articles in RSC Chemical Biology are open access and free to read.

Perspective

Finding a vocation for validation: taking proteomics beyond association and location
Marcus J. C. Long, Jinmin Liu and Yimon Aye
RSC. Chem. Biol., 2023, 3, 110–120, DOI: 10.1039/D2CB00214K

Communications

Quantitative profiling of PTM stoichiometry by resolvable mass tags
Ying Chen, Baiyi Quan, Yuanpei Li, Yuan Liu, Wei Qin and Chu Wang
RSC. Chem. Biol., 2023, 3, 1320–1324, DOI: 10.1039/D2CB00179A

Chemoproteomic mapping of human milk oligosaccharide (HMO) interactions in cells
Abdullah A. Hassan, Jacob M. Wozniak, Zak Vilen, Weichao Li, Appaso Jadhav, Christopher G. Parker and Mia L. Huang
RSC. Chem. Biol., 2023, 3, 1369–1374, DOI: 10.1039/D2CB00176D

Papers

The covalent reactivity of functionalized 5-hydroxy-butyrolactams is the basis for targeting of fatty acid binding protein 5 (FABP5) by the neurotrophic agent MT-21
Esben B. Svenningsen, Rasmus N. Ottosen, Katrine H. Jørgensen, Marija Nisavic, Camilla K. Larsen, Bente K. Hansen, Yong Wang, Kresten Lindorff-Larsen, Thomas Tørring, Stephan M. Hacker, Johan Palmfeldt and Thomas B. Poulsen
RSC. Chem. Biol., 2023, 3, 1216–1229, DOI: 10.1039/D2CB00161F

A peptide-crosslinking approach identifies HSPA8 and PFKL as selective interactors of an actin-derived peptide containing reduced and oxidized methionine
Aaron Maurais and Eranthie Weerapana
RSC. Chem. Biol., 2023, 3, 1282–1289, DOI: 10.1039/D2CB00183G

Chemical proteomic analysis of bile acid-protein targets in Enterococcus faecium
Xinglin Yang, Xiaohui Zhao, Victor Chen and Howard C. Hang
RSC. Chem. Biol., 2023, 3, 1397–1402, DOI: 10.1039/D2CB00178K

Photoreactive bioorthogonal lipid probes and their applications in mammalian biology
Karthik Shanbhag, Kavita Sharma and Siddhesh S. Kamat
RSC. Chem. Biol., 2023, 3, 37–46, DOI: 10.1039/D2CB00174H

Predicting small molecule binding pockets on diacylglycerol kinases using chemoproteomics and AlphaFold
Roberto Mendez, Minhaj Shaikh, Michael C. Lemke, Kun Yuan, Adam H. Libby, Dina L. Bai, Mark M. Ross, Thurl E. Harris and Ku-Lung Hsu
RSC. Chem. Biol., 2023, 3, 422–430, DOI: 10.1039/D3CB00057E

We hope you enjoy this new themed collection from RSC Chemical Biology.

RSC Chemical Biology is delighted to welcome papers for its latest online themed collection on ‘Medicinal Chemistry Small Molecule Probes’, guest edited by John Spencer (University of Sussex, UK), Gemma Nixon (University of Liverpool, UK), and Miraz Rahman (King’s College London, UK).

Contributions are welcome which investigate general medicinal chemistry, chemical probes for imaging, proteomics, protacs, fragment-based drug discovery, covalent binders, chemical tools for protein profiling and activity modulation, and natural product inspired medicinal chemistry and chemical biology.

The deadline for submissions is 1 June 2023. Submit your work to the collection now!

Promotion of the collection is scheduled for late 2023, with articles published online as soon as they’re accepted.

Authors are welcome to submit original research in the form of a Communication or Full Paper. Articles can be submitted via our website: rsc.li/rsc-chembio. When submitting your manuscript, please mention that it is intended for this themed collection in the “notes to the editor” box. The Editorial Office reserves the right to check suitability of submissions for both the journal and the scope of the collection, and inclusion of accepted articles in the final themed collection is not guaranteed.

Explore all open calls for papers from RSC journals!

About RSC Chemical Biology:

Led by Hiroaki Suga (University of Tokyo), RSC Chemical Biology is dedicated to publishing and disseminating the most exceptionally significant, breakthrough findings of interest to the chemical biology community. All submissions are handled by our experienced and internationally recognised Associate Editors. For more information on the journal, please visit the journal homepage.

As a gold open access journal, there are no barriers to accessing content and your research article will reach an international audience. Articles accepted for publication in this themed collection will have their article processing charges waived.

RSC Chemical Biology is now indexed in the Directory of Open Access Journals (DOAJ), PubMed Central, Scopus and Web of Science: Emerging Sources Citation Index. Find out more about the journal and submit your work at rsc.li/rsc-chembio.

We’re pleased to announce that a new themed collection from RSC Chemical Biology has now been published online.

Read the collection

Guest-edited by Chengqi Yi (Peking University, China) and Yan Zhang (Nanjing University, China), this collection highlights work on bio-orthogonal chemistry, reactions and probes in labeling, manipulating, imaging and sequencing of protein, DNA, RNA and bioactive metabolites.

The article line-up is provided below. All articles in RSC Chemical Biology are open access and free to read.

Editorial

Introduction to ‘Development of bio-orthogonal tools’
Yan Zhang and Chengqi Yi
RSC. Chem. Biol., 2022, Advance Article, DOI: 10.1039/D2CB90045A

Reviews

Labeling and sequencing nucleic acid modifications using bio-orthogonal tools
Hui Liu, Yafen Wang and Xiang Zhou
RSC. Chem. Biol., 2022, 3, 994–1007, DOI: 10.1039/D2CB00087C

Imitate to illuminate: labeling of bacterial peptidoglycan with fluorescent and bio-orthogonal stem peptide-mimicking probes
Huibin Lin, Chaoyong Yang and Wei Wang
RSC. Chem. Biol., 2022, 3, 1198–1208, DOI: 10.1039/D2CB00086E

Papers

A library of Rhodamine6G-based pH-sensitive fluorescent probes with versatile in vivo and in vitro applications
Benton Swanson, Margaret Durdan, Miranda Eberle, Seth Woodbury, Ava Mauser, Jason Gregory, Boya Zhang, David Niemann, Jacob Herremans, Peter X. Ma, Joerg Lahann, Megan Weivoda, Yuji Mishina and Colin F. Greineder
RSC. Chem. Biol., 2022, 3, 748–764, DOI: 10.1039/D2CB00030J

Methyltetrazine as a small live-cell compatible bioorthogonal handle for imaging enzyme activities in situ
Diana Torres-García, Merel A. T. van de Plassche, Emma van Boven, Tyrza van Leeuwen, Mirjam G. J. Groenewold, Alexi J. C. Sarris, Luuk Klein, Herman S. Overkleeft and Sander I. van Kasteren
RSC. Chem. Biol., 2022, 3, 1325–1330, DOI: 10.1039/D2CB00120A

We hope you enjoy this new themed collection from RSC Chemical Biology.

RSC Chemical Biology and RSC Medicinal Chemistry are delighted to welcome papers for an online themed collection on ‘Molecular and nanotheranostics’, guest edited by Prof. Thimmaiah Govindaraju (Jawaharlal Nehru Centre for Advanced Scientific Research, India).

 Over a decade of intense research has positioned theranostics as a promising and integrated approach to advance biomedical research and medicine. The term theranostics essentially conveys the idea of combining therapeutic and diagnostic modalities to provide a holistic solution for disease management. Theranostics is also referred to as diagnostic therapy, wherein molecular and/or material tools for non-invasive treatment and diagnostic imaging are strategically embedded into a single system. For instance, multifunctional diagnostic platforms carrying therapeutic and target tracking agents offer remedial effects and imaging of markers in tissue or organs, which is used to assess disease staging, treatment planning and therapeutic efficacy.

Theranostics has the potential to revolutionize the practice and adaptation of personalized medicine to tackle chronic disease conditions like cancer and neuronal disorders. Generally, radiopharmaceutical, nano and macromolecular systems armed with tools to detect, treat, track, and image biomolecular targets in real-time have been employed as theranostics to effectively manage disease progression and cure.

In recent years, the field has witnessed the emergence of small molecules or small molecular conjugates as theranostic tools. This special collection in RSC Chemical Biology and RSC Medicinal Chemistry intends to cover and highlight advancements in molecular theranostics with particular emphasis on chemical biology of molecular design of theranostic tools and their selective interaction with the biomolecular targets to image and ameliorate the pathological conditions. This themed collection is anticipated to catalyze the development of precision theranostics as advanced and personalizable tools in chemical biology and modern medicine.

 The deadline for submissions has been extended to 30 June 2023.

 Articles can be submitted via  the appropriate journal’s website, where you can find details on their scopes and focus. RSC Chemical Biology accepts exceptionally significant and breakthrough findings of interest to the chemical biology community, while RSC Medicinal Chemistry publishes significant research in medicinal chemistry and related drug discovery science.

RSC Chemical Biology: rsc.li/rsc-chembio
RSC Medicinal Chemistry: rsc.li/rsc-medchem

Authors are welcome to submit original research in the form of a Communication or Full Paper. Note that RSC Chemical Biology is a gold open access, journal, however submissions for this collection will have their article processing charges (APCs) waived.

When submitting your manuscript, please mention that it is intended for this themed collection in the “notes to the editor” box. The Editorial Office reserves the right to check suitability of submissions for both the journal and the scope of the collection, and inclusion of accepted articles in the final themed collection is not guaranteed. Promotion of the collection is scheduled for late-2023, with articles published online as soon as they’re accepted.

Explore all open calls for papers from RSC journals!