Selection of quadruplex-binding ligand based on the structure switching of GDNA
Yan Jin and colleagues from Shaanxi Normal University have designed a G-quadruplex-binding ligand screening strategy that utilises an electrochemical method to select natural G-quadruplex-binding ligands based on structure-switching of telomeric DNA.
Ligands that bind and stabilize G-quadruplex DNA structures are of significant interest because of their potential to inhibit telomerase and halt tumour cell proliferation.
The results demonstrated that daidzein, berberine, emodin, aloe-emodin, rhein and chrysophanol could induce the human telomeric DNA G-quadruplex architecture.
The paper will be free to access to until 3rd May.
Electrochemical selection of G-quadruplex-binding ligands based on structure-switching of telomeric DNA
Xiao-Qin Liu, Yan Jin, Yuexia Wang and Yunxia Qiao
Anal. Methods
DOI: 10.1039/C1AY05046J
