Analytical Methods Blog

Selection of quadruplex-binding ligand based on the structure switching of GDNA

Yan Jin and colleagues from Shaanxi Normal University have designed a G-quadruplex-binding ligand screening strategy that utilises an electrochemical method to select natural G-quadruplex-binding ligands based on structure-switching of telomeric DNA.

Ligands that bind and stabilize G-quadruplex DNA structures are of significant interest because of their potential to inhibit telomerase and halt tumour cell proliferation.

The results demonstrated that daidzein, berberine, emodin, aloe-emodin, rhein and chrysophanol could induce the human telomeric DNA G-quadruplex architecture.

The paper will be free to access to until 3rd May.

Electrochemical selection of G-quadruplex-binding ligands based on structure-switching of telomeric DNA
Xiao-Qin Liu, Yan Jin, Yuexia Wang and Yunxia Qiao
Anal. Methods
DOI: 10.1039/C1AY05046J

Malgorzata Grabarczyk and Anna Koper from Maria Curie-Sklodowska University, Poland, report a simple and sensitive stripping voltammertric method to determine trace amounts of uranium in natural water samples in this communication. They used an Amberlite XAD-7 or XAD-16 resin to eliminate interference from the surfactants that are often present in environmental samples.

The procedure is based on the adsorptive accumulation of the U(VI)–cupferron complex onto a hanging mercury drop electrode, followed by a reduction of the adsorbed species by a voltammetric scan using differential pulse modulation.

The paper will be free until 13th May.

Adsorptive stripping voltammetry of uranium: elimination of interferences from surface active substances and application to the determination in natural water samples
Malgorzata Grabarczyk and Anna Koper
Anal. Methods
DOI: 10.1039/C1AY05043E