Slobodan Šašić and colleagues from Pfizer describe the use of microspectroscopic chemical imaging with white light optical microscopic imagery for monitoring the agglomeration of pharmaceutical ingredients during the manufacturing process, in this HOT paper.
In a separate paper, Šašić compares the performance of three chemical mapping and imaging platforms to determine the distribution of the active pharmaceutical ingredient in various pharmaceutical products.
Both Analytical Methods papers are free to access until the 1st March using the links below:
Monitoring of API particle size during solid dosage form manufacturing process by chemical imaging and particle sizing
Slobodan Šašić, Weili Yu and Lin Zhang
Anal. Methods, 2011
DOI: 10.1039/c0ay00562b
Parallel imaging of active pharmaceutical ingredients in some tablets and blends on Raman and near-infrared mapping and imaging platforms
Slobodan Šašić
Anal. Methods, 2011
DOI: 10.1039/c0ay00532k
