One-pot synthesis of heterocycles

Read about two of our latest hot articles on one-pot syntheses of heterocycles…

Yong Huang (Peking University, China) and Hong Shen (Merck Research Laboratories, New Jersey, USA) and colleagues report the synthesis of medicinally useful heterocycles such as pyridazinones and dihydropyrimidinones through a mild and highly efficient one-pot triple cascade procedure.  The cascade involves a Claisen-decarboxylation, an electrophilic reaction and subsequent heterocyclisation.  Indazoles and benzofurans could also be constructed through a double cascade reaction.  Click on the link below to find out more…

One-pot synthesis of useful heterocycles in medicinal chemistry using a cascade strategy, Guiyong Wu, Weiyu Yin, Hong C. Shen and Yong Huang, Green Chem., 2012, DOI: 10.1039/C2GC16457D

Li-Rong Wen, Ming Li and colleagues from Qingdao University of Science and Technology, China, present the efficient, solvent-free synthesis of imidazo[1,2-α]pyridine derivatives via a one-pot three-component reaction.  The reaction involves annualtion of heterocyclic ketene aminals and β-oxodithioesters with aldehydes using ET3N as the catalyst. The procedure is completed quickly with high regioselectivity and allows for easy purification.  Click on the link below to find out more…

Solvent-free and efficient synthesis of imidazo[1,2-a]pyridine derivatives via a one-pot three-component reaction, Li-Rong Wen, Zhao-Rui Li, Ming Li and Han Cao, Green Chem., 2012, DOI: 10.1039/C2GC16388H

These articles are free to access until the 2nd March 2012!  

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