RSC journal lecture awards

While you are thinking about your nominee for the OBC Lecture Award, why not consider making nominations for other journal awards?

ChemComm Emerging Investigator Lectureship

ChemComm is delighted to invite nominations for the very first ChemComm Emerging Investigator Lectureship. The lectureship, which will be awarded annually, will recognise an emerging scientist in the early stages of their independent academic career. Deadline for nominations: 28th February 2011. Visit the ChemComm blog for more information.

Natural Product Reports Award Lecture

The NPR Lecture Award is an annual event which is held at an international meeting of the recipient’s choosing. The recipient will be someone who has made significant research contribution to natural products chemistry in its broadest sense.

Anyone can make a nomination for the award. Simply send the name of the person you would like to nominate, along with a brief justification, to the Editor, Dr Richard Kelly. All nominations should be received by Monday 6th December. Visit to NPR blog for more details.

Chem Soc Rev Emerging Investigators award

Don’t forget to nominate your colleagues for the Chem Soc Rev 2011 Emerging Investigator Award before the end of January. This annual award is given to recognise an emerging scientist who has made a significant contribution to their research field. Those wishing to make a nomination should send details of the nominee, including a brief C.V. together with a letter supporting the nomination, to the Chem Soc Rev  Editorial Office by 31st January 2011. Please note that self nomination is not permissible. More details on the CSR blog.

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Top ten most accessed articles in September

This month sees the following articles in OBC that are in the top ten most accessed:-

Chiral BINOL-derived phosphoric acids: privileged Bronsted acid organocatalysts for C-C bond formation reactions 
Alexandru Zamfir, Sebastian Schenker, Matthias Freund and Svetlana B. Tsogoeva 
Org. Biomol. Chem., 2010, Advance Article, DOI: 10.1039/C0OB00209G , Perspective 

In water, on water, and by water: mimicking nature’s aldolases with organocatalysis and water 
Nobuyuki Mase and Carlos F. Barbas, III 
Org. Biomol. Chem., 2010, 8, 4043-4050, DOI: 10.1039/C004970K , Perspective 

Strain-promoted double-click reaction for chemical modification of azido-biomolecules 
Isao Kii, Akira Shiraishi, Toshiyuki Hiramatsu, Takeshi Matsushita, Hidehiro Uekusa, Suguru Yoshida, Makoto Yamamoto, Akira Kudo, Masatoshi Hagiwara and Takamitsu Hosoya 
Org. Biomol. Chem., 2010, 8, 4051-4055, DOI: 10.1039/C0OB00003E , Communication 

Multicolor fluorescent switches in gel systems controlled by alkoxyl chain and solvent 
Yue Xu, Pengchong Xue, Defang Xu, Xiaofei Zhang, Xingliang Liu, Huipeng Zhou, Junhui Jia, Xinchun Yang, Fengyong Wang and Ran Lu 
Org. Biomol. Chem., 2010, 8, 4289-4296, DOI: 10.1039/C0OB00091D , Paper 

High-throughput synthesis of azide libraries suitable for direct “click” chemistry and in situ screening 
Rajavel Srinivasan, Lay Pheng Tan, Hao Wu, Peng-Yu Yang, Karunakaran A. Kalesh and Shao Q. Yao 
Org. Biomol. Chem., 2009, 7, 1821-1828, DOI: 10.1039/B902338K , Paper 

Stereoselective synthesis of the bicyclic guanidine alkaloid (+)-monanchorin 
Ahmed M. Zaed and Andrew Sutherland 
Org. Biomol. Chem., 2010, 8, 4394-4399, DOI: 10.1039/C0OB00219D , Paper 

Selectivity enhancement in functionalization of C-H bonds: A review 
Georgiy B. Shul’pin 
Org. Biomol. Chem., 2010, 8, 4217-4228, DOI: 10.1039/C004223D , Perspective 

Picolylamine as an organocatalyst template for highly diastereo- and enantioselective aqueous aldol reactions 
Thomas C. Nugent, M. Naveed Umar and Ahtaram Bibi 
Org. Biomol. Chem., 2010, 8, 4085-4089, DOI: 10.1039/C0OB00049C , Paper 

Four-fold click reactions: Generation of tetrahedral methane- and adamantane-based building blocks for higher-order molecular assemblies 
Oliver Plietzsch, Christine Inge Schilling, Mariyan Tolev, Martin Nieger, Clemens Richert, Thierry Muller and Stefan Bräse 
Org. Biomol. Chem., 2009, 7, 4734-4743, DOI: 10.1039/B912189G , Paper 

Recent advances in transition metal-catalyzed N-atom transfer reactions of azides 
Tom G. Driver 
Org. Biomol. Chem., 2010, 8, 3831-3846, DOI: 10.1039/C005219C , Perspective 

Why not take a look at the articles today and blog your thoughts and comments below.

Fancy submitting an article to OBC? Then why not submit to us today or alternatively email us your suggestions.
  

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HOT: How reliable are DFT transition structures?

Luis Simón and Jonathan Goodman calculate the geometries of covalent-bond forming transition states by using computational methods.

The manuscript reports an analysis of the performance of different density functionals in computational organic chemistry. The paper is based on a very large number of calculations and provides significant conclusions that have immediate application. The referees said that the manuscript stands out and that is why it is a HOT article.

Find out more on the original paper which is free to access until 25th November.

How reliable are DFT transition structures? Comparison of GGA, hybrid-meta-GGA and meta-GGA functionals
Luis Simón and Jonathan M. Goodman
Org. Biomol. Chem., 2011, Advance Article
DOI: 10.1039/C0OB00477D, Paper

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HOT: Understanding the mechanism of non polar Diels Alder reactions

Luis Domingo and colleagues at Universidad de Valencia study the electronic reorganization associated with the non-polar Diels-Alder reaction between cyclopentadiene and ethylene.

To know more about their findings read this HOT (as recommended by the referees) article which is free to access until the 25th November.

Understanding the mechanism of non-polar Diels–Alder reactions. A comparative ELF analysis of concerted and stepwise diradical mechanisms
Luis R. Domingo, Eduardo Chamorro and Patricia Pérez
Org. Biomol. Chem., 2010, Advance Article
DOI: 10.1039/C0OB00563K, Paper

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An ‘unexpected’ synthesis – cover of OBC Issue 22

Xianzhang Bu and colleagues at Sun Yat-Sen University in China have ‘unexpectedly’ discovered new fluorescent trans-dihydrofluoren-3-ones from one pot reactions of benzaldehydes and acetylacetone.

Find out more on the article which is free to access until the 7th December
Have you ever experienced an ‘unexpected’ synthesis in your lab? You can now tell us by commenting on this blog.

New fluorescent trans-dihydrofluoren-3-ones from aldol–Robinson annulation–regioselective addition involved one-pot reaction
Yingpeng Huo, Xu Qiu, Weiyan Shao, Jianing Huang, Yanjun Yu, Yinglin Zuo, Linkun An, Jun Du and Xianzhang Bu
Org. Biomol. Chem., 2010, 8, 5048-5052
DOI: 10.1039/C0OB00401D

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OBC Lecture Award 2011 – nominations now open!

Nominations are now invited for the 2011 Organic & Biomolecular Chemistry Lecture Award, to be given at the 16th IUPAC International Symposium on Organometallic Chemistry Directed Towards Organic Synthesis (OMCOS 16), held from 24-28 July 2011 in Shanghai, China.

Anyone can make a nomination for the award. All you need to do is send the name of your nominee and a brief justification to the Editor, Dr Richard Kelly. All nominations should take account of the award criteria (below) and the topic of the conference and should be received by Monday 6th December 2010.

This annual award is open to scientists who have made a significant contribution within the scope of OBC and ideally will have an independent academic career of between 8 and 15 years.

The winner, who must be available to give the sponsored lecture, will also be invited to submit a related article for publication in OBC (which will be subject to the usual peer review process). The award, open to anyone fitting these criteria, will cover various expenses incurred at the meeting.

The winner will be selected from the nominees by a panel of judges, who will announce the result in early 2011.

We look forward to receiving your nominations.

Previous winners of the award include Professor Wilfred van der Donk, from University of Illinois, USA and Dr Akimitsu Okamoto, from RIKEN, Japan.

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Chemistry Nobel Prize 2010 Web Collection

Chemistry Nobel Prize 2010

Richard Heck, Ei-ichi Negishi and Akira Suzuki

To commemorate the 2010 Nobel Prize, Organic & Biomolecular Chemistry has collated some of the OBC articles published on cross-coupling reactions in organic chemistry in the last years.

You can take a look at them on this special 2010 Chemistry Nobel Prize web collection.

We hope you enjoy reading them and once again, congratulations to the recipients of this prestigious award.

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HOT: New methodology to screen thousands of drug-like molecules

David Spring and colleagues at University of Cambridge have developed a new methodology to rapidly screen large arrays of drug-like small molecules.

By using this new 3D microarray platform, they discover small molecules (novel pharmacores) that bind to quorum sensing receptors.
The platform has the potential to display and examine 10000 different small molecules in a miniaturised, low-cost format.

The authors say that ‘this new methodology is likely to find important application within the fields of medicinal chemistry, chemical biology, molecular recognition and chemical genetics, where the aim is to discover small molecules that bind to macromolecular complexes’

As a HOT article, it will be free to access until the 10th November.

Read more and tell us about it.

Discovery of a quorum sensing modulator pharmacophore by 3D small-molecule microarray screening
David M. Marsden, Rebecca L. Nicholson, Mette E. Skindersoe, Warren R. J. D. Galloway, Hannah F. Sore, Michael Givskov, George P. C. Salmond, Mark Ladlow, Martin Welch and David R. Spring
Org. Biomol. Chem., 2010, Advance Article
DOI: 10.1039/C0OB00300J, Paper

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OBC Inside Cover Issue 21

Toshihiro Ihara and colleagues at Kumamoto University demonstrate a quick reversible photocircularization of an anthracene-modified oligodeoxyribonucleotide conjugate and provide an example of its analytical application.

‘ The oligonucleotide conjugate was reversibly circularized through photodimerization of the antracenes attached on both ends. This process would be potentially useful as a probe reaction with high specificity and sensitivity’ say the authors on the description of their cover.

Read the article free to access until the end of November

Reversible circularization of an anthracene-modified DNA conjugate through bimolecular triplex formation and its analytical application
Pelin Arslan, Akinori Jyo and Toshihiro Ihara
Org. Biomol. Chem., 2010, 8, 4843-4848
DOI: 10.1039/C0OB00282H

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OBC Issue 21 Outside Cover

Tanabe, Nishimoto and co-workers at Kyoto University, propose a mechanism for the intramolecular cyclization of modified oligodeoxynucleotides bearing a pair of disulfides.

This colourful cover represents how X-Ray irradiation of an aqueous solution of modified oligodeoxynucleotides with a pair of disulfides at both ends causes efficient cyclization via an
intramolecular exchange reaction.

The article is free to access until the end of November.

Radiolytic cyclization of stem-and-loop structured oligodeoxynucleotide with neighboring arrangement of α,ω-bis-disulfides
Kazuhito Tanabe, Eiji Matsumoto, Takeo Ito and Sei-ichi Nishimoto
Org. Biomol. Chem., 2010, 8, 4837-4842
DOI: 10.1039/C0OB00275E

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