Welcome to OBC Issue 2, 2012
On the cover this week is the work of Tamas Martinek et al. at the University of Szeged (Hungary), reporting a tunable H12 helix –> H18 helix transition not previously observed for foldamers.
Combining traditional methods for peptide folding (ECD, DOSY-NMR) and molecular modeling to investigate the folding and self-assembly of peptide mimics, the authors show that foldamer sequences constructed using trans-ABHC and β3-hSer residues produce β-H18 helix in a solvent- and concentration-dependent way.
‘These observations strongly support the view that foldameric helix refolding is promoted by higher-order packing of the helices in protic solvent’, say the authors.
Self-association-driven transition of the β-peptidic H12 helix to the H18 helix
Éva Szolnoki, Anasztázia Hetényi, Tamás A. Martinek, Zsolt Szakonyi and Ferenc Fülöp
Org. Biomol. Chem., 2012, 10, 255-259
DOI: 10.1039/C1OB06627G
View the rest of Issue 2 here
