In this ‘Hot’ OBC Perspective, Alethea Tabor (University College London, UK) provides an excellent overview of the recent advances in the chemical synthesis of lantibiotics, a field which has considerably moved on since the last review in the area in 2005 by W. A. van der Donk.
The approaches covered include:
- solution-phase and solid-phase synthesis
- biomimetic approaches
- biotransformation strategies
Keep up-to date with the synthesis of these structurally complex peptides possessing unique antibacterial properties and read this review article, FREE to access for the next 4 weeks*
The challenge of the lantibiotics: synthetic approaches to thioether-bridged peptides
Alethea B. Tabor
Org. Biomol. Chem., 2011, 9, 7606-7628
DOI: 10.1039/C1OB05946G
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