On the outside front cover of this issue we have a hot communication from José L. Mascareñas and M. Eugenio Vázquez on the design of a peptide fluorescent sensor for cyclin A, a key protein in cycle cycle regulation.
Rational design of a cyclin A fluorescent peptide sensor
Elena Pazos, Miguel Pérez, Hugo Gutiérrez-de-Terán, Mar Orzáez, Tatiana Guevara, José L. Mascareñas and M. Eugenio Vázquez
Org. Biomol. Chem., 2011, Advance Article
DOI: 10.1039/C1OB06009K
The image on the inside front cover depicts work from Julio Casado et al. on minoxidil – a treatment for hair loss and high blood pressure. They have investigated C-nitrosation at the C-5 position of the pyrimidine ring, which is 7 times more likely to occur than in phenol, and conclude that the resultant N-nitrosominoxidil could be harmful to minoxidil users.
Aromatic C-nitrosation of a bioactive molecule. Nitrosation of minoxidil
Mario González-Jiménez, Jorge Arenas-Valgañón, Emilio Calle and Julio Casado
Org. Biomol. Chem., 2011, Advance Article
DOI: 10.1039/C1OB05686G
View the rest of the issue, including reviews on the photo-dehydro-Diels–Alder reaction and synthetic approaches to lantibiotics
