Archive for December, 2014

What are your colleagues reading in Organic & Biomolecular Chemistry?

The articles below are the most read Organic & Biomolecular Chemistry articles in July, August and September 2014.

Marine natural products-inspired phenylmethylene hydantoins with potent in vitro and in vivo antitumor activities via suppression of Brk and FAK signaling
Asmaa A. Sallam, Mohamed M. Mohyeldin, Ahmed I. Foudah, Mohamed R. Akl, Sami Nazzal, Sharon A. Meyer, Yong-Yu Liu and Khalid A. El Sayed 
DOI: 10.1039/C4OB00553H

Watsonianone A–C, anti-plasmodial β-triketones from the Australian tree, Corymbia watsoniana
Anthony R. Carroll, Vicky M. Avery, Sandra Duffy, Paul I. Forster and Gordon P. Guymer 
DOI: 10.1039/C2OB26931G

Pyridostatin analogues promote telomere dysfunction and long-term growth inhibition in human cancer cells
Sebastian Müller, Deborah A. Sanders, Marco Di Antonio, Stephanos Matsis, Jean-François Riou, Raphaël Rodriguez and Shankar Balasubramanian 
DOI: 10.1039/C2OB25830G

Synthesis, characterization and biological evaluation of carboranylmethylbenzo[b]acridones as novel agents for boron neutron capture therapy
A. Filipa F. da Silva, Raquel S. G. R. Seixas, Artur M. S. Silva, Joana Coimbra, Ana C. Fernandes, Joana P. Santos, António Matos, José Rino, Isabel Santos and Fernanda Marques 
DOI: 10.1039/C4OB00644E

Organic synthetic transformations using organic dyes as photoredox catalysts
Shunichi Fukuzumi and Kei Ohkubo 
DOI: 10.1039/C4OB00843J

Copper-catalysed direct radical alkenylation of alkyl bromides
Xu Zhang, Hong Yi, Zhixiong Liao, Guoting Zhang, Chao Fan, Chu Qin, Jie Liu and Aiwen Lei 
DOI: 10.1039/C4OB00813H

Metal-free oxidative olefination of primary amines with benzylic C–H bonds through direct deamination and C–H bond activation
Liang Gong, Li-Juan Xing, Tong Xu, Xue-Ping Zhu, Wen Zhou, Ning Kang and Bin Wang 
DOI: 10.1039/C4OB01025F

Recent advances in trifluoromethylation of organic compounds using Umemoto’s reagents
Cai Zhang 
DOI: 10.1039/C4OB00671B

An efficient route to synthesize isatins by metal-free, iodine-catalyzed sequential C(sp3)–H oxidation and intramolecular C–N bond formation of 2′-aminoacetophenones
Venkatachalam Rajeshkumar, Selvaraj Chandrasekar and Govindasamy Sekar 
DOI: 10.1039/C4OB01564A

Amino acid chirons: a tool for asymmetric synthesis of heterocycles
Priyanka Singh, Krishnananda Samanta, Sanjit Kumar Das and Gautam Panda 
DOI: 10.1039/C4OB00943F

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HOT Organic & Biomolecular Chemistry articles

The following Organic & Biomolecular Chemistry articles have all been recommened by the reviewers of the articles as being particularly interesting or particularly significant research. These have all been made free to access until 31st December 2014. The order they appear in the list holds no special meaning or ranking.

Catalytic asymmetric desymmetrization approaches to enantioenriched cyclopentanes
Madhu Sudan Manna and Santanu Mukherjee  
DOI: 10.1039/C4OB01649A, Perspective

C4OB01649A GA


Corrin-based chemosensors for the ASSURED detection of endogenous cyanide
Felix Zelder and Lucas Tivana  
DOI: 10.1039/C4OB01889C, Perspective


An efficient synthetic route to 1,3-bis(arylethynyl)isobenzofuran using alkoxybenzocyclobutenone as a reactive platform
Kenta Asahina, Suguru Matsuoka, Ryosuke Nakayama and Toshiyuki Hamura  
DOI: 10.1039/C4OB02012J, Communication

C4OB02012J GA


Cationic azacryptands as selective three-way DNA junction binding agents
Jana Novotna, Aurelien Laguerre, Anton Granzhan, Marc Pirrotta, Marie-Paule Teulade-Fichou and David Monchaud  
DOI: 10.1039/C4OB01846J, Paper

C4OB01846J GA


An efficient reagent for covalent introduction of alkynes into proteins
Jie Zhang, Dejun Ma, Dawei Du, Zhen Xi and Long Yi  
DOI: 10.1039/C4OB01873G, Communication

C4OB01873G GA


Efficient merging of copper and photoredox catalysis for the asymmetric cross-dehydrogenative-coupling of alkynes and tetrahydroisoquinolines
Inna Perepichka, Soumen Kundu, Zoë Hearne and Chao-Jun Li  
DOI: 10.1039/C4OB02138J, Paper

C4OB02138J GA


Naphthalene diimides as red fluorescent pH sensors for functional cell imaging
Filippo Doria, Marco Folini, Vincenzo Grande, Graziella Cimino-Reale, Nadia Zaffaroni and Mauro Freccero  
DOI: 10.1039/C4OB02054E, Paper

C4OB02054E GA

A peptide topological template for the dispersion of [60]fullerene in water
S. Bartocci, D. Mazzier, A. Moretto and M. Mba  
DOI: 10.1039/C4OB02102A, Communication
C4OB02102A GA

6-Substituted 1,2-benzoxathiine-2,2-dioxides are isoform-selective inhibitors of human carbonic anhydrases IX, XII and VA
Muhammet Tanc, Fabrizio Carta, Andrea Scozzafava and Claudiu T. Supuran  
DOI: 10.1039/C4OB02155J, Communication
C4OB02155J GA

The rapid synthesis of oxazolines and their heterogeneous oxidation to oxazoles under flow conditions
Steffen Glöckner, Duc N. Tran, Richard J. Ingham, Sabine Fenner, Zoe E. Wilson, Claudio Battilocchio and Steven V. Ley  
DOI: 10.1039/C4OB02105C, Paper
From themed collection Recent Advances in Flow Synthesis and Continuous Processing
C4OB02105C GA
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Winners at the 2014 RSC Organic Division Poster Symposium

Congratulations to the winners at the 2014 RSC Organic Division Poster Symposium, held on 01 December 2014 at the Royal Society of Chemistry, Burlington House, London.

The symposium, supported by headline sponsor F. Hoffmann-La Roche Ltd, provided a fantastic opportunity for final year organic chemistry PhD students to showcase their research and network with their peers, leading academics, and industrial chemists.

Organic & Biomolecular Chemistry was delighted to offer a front cover artwork opportunity to the winner of the First Prize, as well as a 1-year personal subscription to the journal to the winner of the Industry Prize.

First Prize

Sonja Kuschel, University of Manchester (Supervisor: Professor David Leigh). Poster title: Towards man-made ribosomes: Nanomachines for sequential peptide synthesis

Runners Up Prizes

Antony Burton, University of Bristol (Supervisor: Professor Derek Woolfson). Poster title: Installing Catalytic Activity into a de novo Designed Protein Structure

Sarah Walker, Heriot-Watt University (Supervisor: Dr Ai-Lan Lee). Poster title: Development of Pd(II)-catalysed oxidative Heck reactions and CH functionalisations

Industry Prize (selected by the industrial delegates)

Antoine Maruani, University College London (Supervisors: Professor Stephen Caddick and Dr Vijay Chudasama). Poster title: A Novel Class of Tuneable reagents for Selective Dual Modification of Proteins

Participants’ Prize (selected by the students)

Owen Davis, Imperial College London (Supervisor: Dr James Bull). Poster title: Synthesis and Functionalisation of Highly Substituted Oxetanes: Molecular Scaffolds for Drug Discovery

The event was also supported by: AstraZeneca, Evotec, Johnson Matthey Catalysis and Chiral Technologies, Pfizer Neusentis, Takeda, UCB and Vertex Pharmaceuticals.

Winners (left to right): Sonja Kuschel, Owen Davis, Sarah Walker, Antony Burton, Antoine Maruani (© MPP Image Creation / Royal Society of Chemistry)

With the judges and organising committee (left to right): Dr Andrew Thomas, Dr Anne Horan, Professor Jonathan Clayden, Mr Owen Davis, Professor Rob Field, Mrs Sonja Kuschel, Professor Julian Blagg, Miss Sarah Walker, Professor Stuart Conway, Mr Antony Burton, Mr Antoine Maruani, Dr David Rees, Dr Sarah Rook, Professor Sue Gibson, Miss Charlotte Still (© MPP Image Creation / Royal Society of Chemistry)

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Take 1…minute for chemistry in health

Can you explain the importance of chemistry to human health in just 1 minute? If you’re an early-career researcher who is up to the challenge, making a 1 minute video could win you £500.

The chemical sciences will be fundamental in helping us meet the healthcare challenges of the future, and we are committed to ensuring that they contribute to their full potential. As part of our work in this area, we are inviting undergraduate and PhD students, post-docs and those starting out their career in industry to produce an original video that demonstrates the importance of chemistry in health.

We are looking for imaginative ways of showcasing how chemistry helps us address healthcare challenges. Your video should be no longer than 1 minute, and you can use any approach you like.

The winner will receive a £500 cash prize, with a £250 prize for second place and £150 prize for third place up for grabs too.

Stuck for inspiration? Last year’s winning video is a good place to start. John Gleeson’s video was selected based on the effective use of language, dynamic style, creativity and its accurate content.

The closing date for entries to be submitted is 30 January 2015. Our judging panel will select the top five videos. We will then publish the shortlisted videos online and open the judging to the public to determine the winner and the runners up.

For more details on how to enter the competition and who is eligible, join us at the Take 1… page.

Good luck!

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