Organic & Biomolecular Chemistry Blog

In this HOT paper Didier Boturyn, Jean-Luc Coll and colleagues have designed a probe containing arginine-glycine-aspartic acid (RGD) that can be used for the dual-targeting of αVβ3 integrin and matrix metallopeptidase -9 extracellular proteases in tumours.

Boturyn et al. synthesise the probe via iterative oxime ligations of peptide fragments and use in vitro and in vivo experiments to evaluate it.

To find out more about this dual-targeting probe download the paper for free today!

Integrin and matrix metalloprotease dual-targeting with an MMP substrate–RGD conjugate
Christiane H. F. Wenk, Véronique Josserand, Pascal Dumy, Jean-Luc Coll and Didier Boturyn
DOI: 10.1039/C2OB26926K