In this HOT communication Jian Wang and colleagues at National University of Singapore report an efficient method to construct enantiomeric 2-amino-3-nitrile-chromenes through 2-iminochromenes and malonates. Using a thiourea catalyst Wang et al. rapidly construct the 2-amino-3-nitrile-chromene complexes via a multi-hydrogen-bond cooperative activation model.
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Organocatalytic conjugate addition promoted by multi-hydrogen-bond cooperation: access to chiral 2-amino-3-nitrile-chromenes
Wenjun Li, Jiayao Huang and Jian Wang
DOI: 10.1039/C2OB27102H
