Organic & Biomolecular Chemistry Blog

In this HOT Communication Patrick J. Hrdlicka and colleagues at University of Idaho study the hybridization properties of oligonucleotides, which are modified with 5-(1-aryl-1,2,3-triazol-4-yl)-2′-deoxyuridine monomers featuring three differentially sized aromatic moieties at the 1-position of the triazole ring.

These modified oligonucleotides modified with consecutive show a strong thermal affinity and binding specificity toward RNA targets, due to the formation of stabilizing chromophore arrays in the major groove.

This Communication can be downloaded for free for 4 weeks.

This work is also part of the OBC collection on ‘Nucleic acids: new life, new materials‘, so for related articles have a browse through the collection.

Synthesis and hybridization properties of oligonucleotides modified with 5-(1-aryl-1,2,3-triazol-4-yl)-2′-deoxyuridines
Mamta Kaura, Pawan Kumar and Patrick J. Hrdlicka
DOI: 10.1039/C2OB26717A