This HOT review from Christian Melander and colleagues at North Carolina State University presents a comprehensive overview of development of small molecules targeting bacterial biofilms through non-microbicidal mechanisms. Melander et al. discuss the varied approaches that are applied to the discovery of lead small molecules that mediate the development of biofilms. These are grouped as:
- Compounds that modulate biofilms by targeting bacterial signalling pathways
- Chemical library screening
- Natural products and natural product analogues that possess anti-biofilm activity
This review is very timely and covers an important topic in addressing bacterial infections, as antibiotic resistance is an issue of ever increasing concern, and has been described as a must read.
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Small molecule control of bacterial biofilms
Roberta J. Worthington, Justin J. Richards and Christian Melander