Featuring on this week’s front cover is a review from Margaret A. Brimble summarising the application of the Kulinkovich cyclopropanation in the transformation of esters with diisopropoxytitanacyclopropane derivatives into cyclopropanols in the total synthesis of natural biologically active compounds.
The Kulinkovich hydroxycyclopropanation reaction in natural product synthesis
Isabell Haym and Margaret A. Brimble
On the inside cover is a HOT communication from Ying Fu et al. presenting a general procedure for the nucleophilic addition of organozinc halides to nitrones using trimethylsilyl chloride as a promoter and as a good protection reagent for the sensitive N-hydroxylamine group.
Trimethylsilyl chloride promoted synthesis of α-branched amines by nucleophilic addition of organozinc halides to nitrones
Ying Fu, Yanhua Liu, Yaojuan Chen, Helmut M. Hügel, Minzhu Wang, Danfeng Huang and Yulai Hu
Both articles are free to access for 6 weeks
| Also in this issue:
3 more HOT articles: Catalytic asymmetric synthesis of butane diacetal-protected (4S,5S)-dihydroxycyclohexen-1-one and use in natural product synthesis An alternative one-pot gold-catalyzed approach to the assembly of 11H-indolo[3,2-c]quinolines Steric effects on the catalytic activities of zinc(II) complexes containing [12]aneN3 ligating units in the cleavage of the RNA and DNA model phosphates |
