Arindam Banerjee and collaborators at the Indian Institute of Chemical Biology and Indian Association for the Cultivation of Science in Jadavpur (India) demonstrate the spontaneous formation of hierarchical vesicle-in-vesicle systems from remarkably simple peptides.
These multivesicular structures are stable over a wide pH range (2 to 12) and can encapsulate anticancer drugs and fluorescent dyes, while the release is triggered by biocompatible Ca2+ ions. Combined with a negligible cytotoxicity, these peptide based functional vesicles hold future promise as biocompatible delivery vehicles.
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Self-assembling dipeptide-based nontoxic vesicles as carriers for drugs and other biologically important molecules Jishu Naskar, Subhasish Roy, Anindita Joardar, Sumantra Das and Arindam Banerjee
Org. Biomol. Chem., 2011, 9, 6610-6615
DOI: 10.1039/C1OB05757J, Paper
