On the cover of Issue 19 is an article from Ference Fülöp and colleagues from the University of Szeged and the University of Valencia.
They have developed a synthetic route to fluorinated β-aminocyclohexene or cyclohexane esters from a bicyclic β-lactam via selective hydroxylation and hydroxy–fluorine exchange. Despite the potential of fluorinated cyclic amino acids for medicinal chemistry applications, only a handle of other fluorinated derivatives have been reported so far.
This article is part of a forthcoming Organic & Biomolecular Chemistry web theme issue on Foldamer Chemistry – check back soon for related articles.
Regio- and diastereoselective fluorination of alicyclic β-amino acids
Loránd Kiss, Enikő Forró, Santos Fustero and Ferenc Fülöp
Org. Biomol. Chem., 2011, 9, 6528-6534, Advance Article
DOI: 10.1039/C1OB05648D
