Archive for August, 2010

Top ten most accessed articles in July

This month sees the following articles in Organic & Biomolecular Chemistry that are in the top ten most accessed:-

Heterocycles in organic synthesis: thiazoles and triazoles as exemplar cases of synthetic auxiliaries
Alessandro Dondoni
Org. Biomol. Chem., 2010, 8, 3366-3385, DOI: 10.1039/C002586K

In water, on water, and by water: mimicking nature’s aldolases with organocatalysis and water
Nobuyuki Mase and Carlos F. Barbas, III
Org. Biomol. Chem., 2010, 8, 4043-4050, DOI: 10.1039/C004970K

Folding and self-assembly of aromatic and aliphatic urea oligomers: Towards connecting structure and function
Lucile Fischer and Gilles Guichard
Org. Biomol. Chem., 2010, 8, 3101-3117, DOI: 10.1039/C001090A

Nitrone protecting groups for enantiopure N-hydroxyamino acids: synthesis of N-terminal peptide hydroxylamines for chemoselective ligations
S. Irene Medina, Jian Wu and Jeffrey W. Bode
Org. Biomol. Chem., 2010, 8, 3405-3417, DOI: 10.1039/C004490C

Intramolecular Michael addition reaction for the synthesis of benzylbutyrolactones
Hu He, Li-Xin Dai and Shu-Li You
Org. Biomol. Chem., 2010, 8, 3207-3210, DOI: 10.1039/B924770J

Expedient, one-pot preparation of fused indoles via CAN-catalyzed three-component domino sequences and their transformation into polyheterocyclic compounds containing pyrrolo[1,2-a]azepine fragments
Padmakar A. Suryavanshi, Vellaisamy Sridharan and J. Carlos Menéndez
Org. Biomol. Chem., 2010, 8, 3426-3436, DOI: 10.1039/C004703A

Ultrafast Grignard addition reactions in the presence of water
Gyorgyi Osztrovszky, Torkil Holm and Robert Madsen
Org. Biomol. Chem., 2010, 8, 3402-3404, DOI: 10.1039/C0OB00170H

A three-step tandem process for the synthesis of bicyclic γ-lactams
Fiona I. McGonagle, Lindsay Brown, Andrew Cooke and Andrew Sutherland
Org. Biomol. Chem., 2010, 8, 3418-3425, DOI: 10.1039/C004695G

Total synthesis of decarestrictine I and botryolide B via RCM protocol
Palakodety Radha Krishna and T. Jagannadha Rao
Org. Biomol. Chem., 2010, 8, 3130-3132, DOI: 10.1039/C004556J

Picolylamine as an organocatalyst template for highly diastereo- and enantioselective aqueous aldol reactions
Thomas C. Nugent, M. Naveed Umar and Ahtaram Bibi
Org. Biomol. Chem., 2010, 8, 4085-4089, DOI: 10.1039/C0OB00049C

Why not take a look at the articles today and blog your thoughts and comments below.

Fancy submitting an article to Organic & Biomolecular Chemistry? Then why not submit to us today or alternatively email us your suggestions.

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HOT: Deuterium as a protecting group

Can Deuterium act as a protecting group to prevent unwanted hydrogen atom transfers?

Mark Wood and colleagues have the answer here.

Reviewers were very impressed with it and we made it a HOT article.

Curious? Find out more! Free to access until the end of September.

Synthetic use of the primary kinetic isotope effect in hydrogen atom transfer: generation of α-aminoalkyl radicals
Mark E. Wood, Sabine Bissiriou, Christopher Lowe, Andrew M. Norrish, Katell Sénéchal, Kim M. Windeatt, Simon J. Coles and Michael B. Hursthouse
Org. Biomol. Chem., 2010, Advance Article
DOI: 10.1039/C0OB00205D , Paper

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HOT: Chemistry of a hydrazone-disulfide macrocycle

David Leigh and co-workers talk about a macrocycle that contains both a hydrazone and a disulfide linkage.
Find out more about the synthesis, the structure and the different chemistry they perform on it in this very interesting paper.

Excellent reviews from the referees and thumbs up from the editorial office make it a HOT paper.

Free to access until the end of September.

Synthesis and solid state structure of a hydrazone-disulfide macrocycle and its dynamic covalent ring-opening under acidic and basic conditions
Max von Delius, Edzard M. Geertsema, David A. Leigh and Alexandra M. Z. Slawin
Org. Biomol. Chem., 2010, Advance Article
DOI: 10.1039/C0OB00214C, Paper

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HOT: Nitroalkenes and nitrodienes reactions

Namboothiri and colleagues describe Rauhut-Curier (RC) reactions of aliphatic nitroalkenes and nitrodienes with enones and acrylates.

It has received very positive comments from the referees and the Editorial Office. What do you think?

As a HOT article, it will be free to access until September 26th.

Rauhut–Currier type homo- and heterocouplings involving nitroalkenes and nitrodienes
Pramod Shanbhag, Pradeep R. Nareddy, Mamta Dadwal, Shaikh M. Mobin and Irishi N. N. Namboothiri
Org. Biomol. Chem., 2010, Advance Article
DOI: 10.1039/C0OB00062K , Paper

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OBC Issue 18 Cover: Organocatalysis and aqueous aldol reactions

Thomas Nugent and co-workers talk about the top organocatalysts for cyclic ketones and discover a 2-picolylamine template which is a promising new organocatalyst for aqueous aldol reactions.

Do you want to read more? You can do it for free until early October here!

Picolylamine as an organocatalyst template for highly diastereo- and enantioselective aqueous aldol reactions
Thomas C. Nugent, M. Naveed Umar and Ahtaram Bibi
Org. Biomol. Chem., 2010, 8, 4085-4089
DOI: 10.1039/C0OB00049C

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OBC Inside Cover Issue 18: “Double-click” chemistry

Isao Kii, Takamitsu Hosoya and colleagues modify an azido-biomolecule by a new method that conjugates three molecules spontaneously in a catalyst-free strain-promoted “double-click” (SPDC) reaction.

If you find “click chemistry” interesting, this will double your enjoyment!

Discover this facile method to prepare various functional biomolecules by “clicking” here.

Strain-promoted double-click reaction for chemical modification of azido-biomolecules
Isao Kii, Akira Shiraishi, Toshiyuki Hiramatsu, Takeshi Matsushita, Hidehiro Uekusa, Suguru Yoshida, Makoto Yamamoto, Akira Kudo, Masatoshi Hagiwara and Takamitsu Hosoya
Org. Biomol. Chem., 2010, 8, 4051-4055
DOI: 10.1039/C0OB00003E , Communication

Free to access until early October!

What do you think?

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Tom Driver-OBC cover Issue 17-Free to access now

Tom Driver, from University of Illinois at Chicago, tells us about efficient ways to  construct new C-N and S-N bonds from azides using Transition metal-catalyzed N-atom transfer reactions.

This is the inside cover article of OBC Issue 17 and therefore is free to access for 6 weeks!

A simple, colourful and direct cover for a comprehensible, didactic and clear perspective.

Read it here and feel free to comment on it.

Recent advances in transition metal-catalyzed N-atom transfer reactions of azides
Tom G. Driver
Org. Biomol. Chem., 2010, 8, 3831-3846

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Synthesis of oxindole-OBC Issue 17 cover

Jian Zhou and colleagues at East China Normal University in Shanghai find a very straightforward method for the synthesis of oxindole, a very important subunit in many bioactive natural products and drugs.

OBC cover of Issue 17 shows the direct road that leads to the synthesis of this very useful product. It is free to access for 6 weeks from publication of the issue.

Do you want to know more? Read it here and let us know what you think!

A facile method for the synthesis of oxindole based quaternary α-aminonitriles via the Strecker reaction
Yun-Lin Liu, Feng Zhou, Jun-Jie Cao, Cong-Bin Ji, Miao Ding and Jian Zhou
Org. Biomol. Chem., 2010, 8, 3847-3850

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OBC Accepted Manuscripts

In a fast moving subject field, you need your research results to be available to the community as soon as possible.

At Organic & Biomolecular Chemistry (OBC), you can now have the unedited and unformatted version of your article published shortly after acceptance as an Accepted Manuscript. This new, free service from RSC Publishing allows you to make your results available to the community, in citable form, before publication of the edited article.

Of course, each OBC article will continue to receive the current high quality editing and formatting service from a professional technical editor, and the Accepted Manuscript version of an article will become unavailable when the fully edited and formatted Advance Article version is published.
 
More information about Accepted Manuscripts can be found below.

What are Accepted Manuscripts?
Accepted Manuscripts are articles which have been published prior to technical editing, formatting and proof reading. All Accepted Manuscripts have been through the RSC Publishing peer review process and have been accepted for publication.

In what format does my Accepted Manuscript appear?
Accepted Manuscripts appear online as a PDF file. An Accepted Manuscript is published in the format in which it is received from you. Any supplementary material will be available as a separate file(s).

How does my Accepted Manuscript appear in the online article listing?
Accepted Manuscripts are listed in the Advance Article tab on the RSC Publishing Platform. The authors’ names in this listing will appear in the form and the order that they were entered into OBC’s online submission system by the corresponding author. Once the Advance Article version is published, the names in the listing will appear as given in the manuscript.

What files do I need to supply before acceptance?
Information about the required file formats will be supplied to you at the same time as you receive the referees’ comments on your manuscript. Submission using the RSC’s article template is encouraged but not required. Where text and image files are received separately they will be collated for publication by an RSC Publishing Editor.

What happens to my article once it has been published as an Accepted Manuscript?
Once an article has been published as an Accepted Manuscript it will be edited and formatted by a professional team of Technical Editors. The proof will then be sent to you for checking. The Accepted Manuscript will be replaced by the fully edited, formatted and proof-read Advance Article as soon as this is available.

Are Accepted Manuscripts the final scientific article of record?
No. The articles published as Accepted Manuscripts are not the final scientific version of record. The Advance Article version of the article represents the final scientific article of record.

How do I cite an Accepted Manuscript?
Accepted Manuscripts can be cited using the Digital Object Identifier (DOI®), which is printed in the left-hand margin of each page of the manuscript. The DOI for each manuscript will be retained once the fully edited Advance Article is published, so that any citations to the Accepted Manuscript will link to the final version.

Does my article have to be published as an Accepted Manuscript?
No. You have the opportunity to opt out of having your manuscript published as an Accepted Manuscript before it is accepted. Therefore not all OBC articles will be published as an Accepted Manuscript version.

When is the official publication date of my manuscript?
The official publication date of your article will be the date when the Accepted Manuscript version is published.

Can my Accepted Manuscript be published before the RSC’s “Licence to Publish” is completed?
No. A completed “Licence to Publish” must be received before your article can be published.

For further information about Accepted Manuscripts please contact the Editorial office.

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OBC HOT article- Hans Joachim Knolker

Knölker and co-workers  describe an efficient total synthesis of the sesquiterpenes (±)-β-isocomene and (±)-isocomene using a Lewis acid-promoted [3 + 2] cycloaddition of allyl-tert-butyldiphenylsilane as the key-step.

This is an OBC HOT article (as rated by the referees and the Editorial Office) and it will be free to access for 4 weeks.

You can download it here and comment on this blog.

Organosilicon-mediated total synthesis of the triquinane sesquiterpenes (±)-β-isocomene and (±)-isocomene
Arndt W. Schmidt, Thomas Olpp, Elke Baum, Tina Stiffel and Hans-Joachim Knölker
Org. Biomol. Chem., 2010, Advance Article

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