Natural Products Blog

Organic & Biomolecular Chemistry, our sister journal, publishes many articles that cover a variety of natural product chemistry.

We try to keep you updated here, although signing up to OBC’s e-alert (free service) means you will receive the tables of content directly in your inbox every time an issue is published.

Hand-picked for you from the latest issues are:

Bioinspired total syntheses of terpenoids
Cedric L. Hugelshofer and Thomas Magauer
DOI: 10.1039/C6OB02488B, Perspective

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Total synthesis and confirmation of the revised structures of jiangrines A, C and D
Zhijiang Zhang and Bo Liu
DOI: 10.1039/C6OB02379G, Paper

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Fluorometabolite biosynthesis: isotopically labelled glycerol incorporations into the antibiotic nucleocidin in Streptomyces calvus
Axel Bartholomé, Jeffrey E. Janso, Usa Reilly and David O’Hagan
DOI: 10.1039/C6OB02291J, Communication

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Enantiospecific total syntheses of meroterpenoids (−)-F1839-I and (−)-corallidictyals B and D
Dattatraya H. Dethe, Balu D. Dherange, Saghir Ali and Mahesh M. Parsutkar
DOI: 10.1039/C6OB02322C, Communication

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Second-generation total synthesis of aplyronine A featuring Ni/Cr-mediated coupling reactions
Ichiro Hayakawa, Keita Saito, Sachiko Matsumoto, Shinichi Kobayashi, Ayaka Taniguchi, Kenichi Kobayashi, Yusuke Fujii, Takahiro Kaneko and Hideo Kigoshi
DOI: 10.1039/C6OB02241C, Paper

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The first total synthesis of the marine acetylenic alcohol, lembehyne B – a selective inducer of early apoptosis in leukemia cancer cells
Lilya U. Dzhemileva, Vladimir A. D’yakonov, Aleksey A. Makarov, Evgeny N. Andreev, Milyausha M. Yunusbaeva and Usein M. Dzhemilev  
DOI: 10.1039/C6OB02346K, Paper

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An efficient approach to trans-4-hydroxy-5-substituted 2-pyrrolidinones through a stereoselective tandem Barbier process: divergent syntheses of (3R,4S)-statines, (+)-preussin and (−)-hapalosin
Chang-Mei Si, Lu-Ping Shao, Zhuo-Ya Mao, Wen Zhou and Bang-Guo Wei  
DOI: 10.1039/C6OB02523D, Paper

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A protecting-group-free synthesis of (+)-nephrosteranic, (+)-protolichesterinic, (+)-nephrosterinic, (+)-phaseolinic, (+)-rocellaric acids and (+)-methylenolactocin
Jothi L. Nallasivam and Rodney A. Fernandes
DOI: 10.1039/C6OB02398C, Paper

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Stepwise cyclopropanation on the polycyclopropanated polyketide formation in jawsamycin biosynthesis
Tomoshige Hiratsuka, Hideaki Suzuki, Atsushi Minami and Hideaki Oikawa
DOI: 10.1039/C6OB02675C, Communication

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A novel withanolide with an unprecedented carbon skeleton from Physalis angulata
Cheng-Peng Sun, Andrei G. Kutateladze, Feng Zhao, Li-Xia Chen and Feng Qiu  
DOI: 10.1039/C6OB02656G, Communication

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Total synthesis and biological activity of dolastatin 16
Loida O. Casalme, Arisa Yamauchi, Akinori Sato, Julie G. Petitbois, Yasuyuki Nogata, Erina Yoshimura, Tatsufumi Okino, Taiki Umezawa and Fuyuhiko Matsuda  
DOI: 10.1039/C6OB02657E, Paper

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New compounds from a hydrothermal vent crab-associated fungus Aspergillus versicolor XZ-4
Chengqian Pan, Yutong Shi, Xuegang Chen, Chen-Tung Arthur Chen, Xinyi Tao and Bin Wu  
DOI: 10.1039/C6OB02374F, Paper

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Chemoenzymatic synthesis of unmodified heparin oligosaccharides: cleavage of p-nitrophenyl glucuronide by alkaline and Smith degradation
Xing Zhang, Yongmei Xu, Po-Hung Hsieh, Jian Liu, Lei Lin, Eric P. Schmidt and Robert J. Linhardt  
DOI: 10.1039/C6OB02603F, Paper

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Isoafricanol synthase from Streptomyces malaysiensis
Patrick Rabe, Markiyan Samborskyy, Peter F. Leadlay and Jeroen S. Dickschat  
DOI: 10.1039/C7OB00234C, Communication

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An efficient Ugi-3CR/aza Diels–Alder/Pomeranz–Fritsch protocol towards novel aza-analogues of (±)-nuevamine, (±)-lennoxamine and magallanesine: a diversity oriented synthesis approach
Óscar Vázquez-Vera, Jorge S. Sánchez-Badillo, Alejandro Islas-Jácome, Manuel A. Rentería-Gómez, Shrikant G. Pharande, Carlos J. Cortes-García, Mónica A. Rincón-Guevara, Ilich A. Ibarra, Rocío Gámez-Montaño and Eduardo González-Zamora  
DOI: 10.1039/C6OB02572B, Paper

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Intramolecular macrolactonization, photophysical and biological studies of new class of polycyclic pyrrole derivatives
Suresh Kumar Mondal, Arabinda Mandal, Susanta Kumar Manna, Sk Asraf Ali, Maidul Hossain, Vangala Venugopal, Avijit Jana and Shubhankar Samanta  
DOI: 10.1039/C7OB00160F, Paper

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Organic & Biomolecular Chemistry, our sister journal, publishes many articles that cover a variety of natural product chemistry.

We try to keep you updated here, although signing up to OBC’s e-alert (free service) means you will receive the tables of content directly in your inbox every time an issue is published.

Hand-picked for you from the latest issues are:

Gold catalysis: synthesis of spiro, bridged, and fused ketal natural products
Rachelle Quach, Daniel P. Furkert and Margaret A. Brimble  
DOI: 10.1039/C7OB00496F, Review Article

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Application of the aza-Diels–Alder reaction in the synthesis of natural products
Min-Hui Cao, Nicholas J. Green and Sheng-Zhen Xu  
DOI: 10.1039/C6OB02761J, Review Article

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ipso-Cyclization: an emerging tool for multifunctional spirocyclohexadienones
Chada Raji Reddy, Santosh Kumar Prajapti, Kamalkishor Warudikar, Ravi Ranjan and Billa Bhargava Rao  
DOI: 10.1039/C7OB00405B, Review Article

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cis or trans with class II diterpene cyclases
Meirong Jia and Reuben J. Peters  
DOI: 10.1039/C7OB00510E, Communication

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Enantioselective Diels-Alder-lactamization organocascades employing a furan-based diene
Mikail E. Abbasov, Brandi M. Hudson, Weixu Kong, Dean J. Tantillo and Daniel Romo  
DOI: 10.1039/C6OB02738E, Communication

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Synthesis, SAR and biological studies of sugar amino acid-based almiramide analogues: N-methylation leads the way
Dipendu Das, Hina P. A. Khan, Rahul Shivahare, Suman Gupta, Jayanta Sarkar, Mohd. Imran Siddiqui, Ravi Sankar Ampapathi and Tushar Kanti Chakraborty  
DOI: 10.1039/C6OB02610A, Paper

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JA-Ile-macrolactones uncouple growth and defense in wild tobacco
Guillermo H. Jimenez-Aleman, Ricardo A. R. Machado, Ian T. Baldwin and Wilhelm Boland  
DOI: 10.1039/C7OB00249A, Communication

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Enantioselective total synthesis of (+)-arborescidine C and related tetracyclic indole alkaloids using organocatalysis
Vishal M. Sheth, Bor-Cherng Hong and Gene-Hsiang Lee  
DOI: 10.1039/C7OB00473G, Communication

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Synthesis of AHMOD-containing aminolipopeptides, unique bioactive peptaibiotics
Louise A. Stubbing, Iman Kavianinia and Margaret A. Brimble  
DOI: 10.1039/C7OB00541E, Review Article

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Enantioselective total synthesis of colomitides and their absolute configuration determination and structural revision
Hongguang Yang, Xiaoyu Liu, Xiaoyu Li, Xiang Shi, Feilong Yang, Xiaozhen Jiao and Ping Xie  
DOI: 10.1039/C7OB00539C, Paper

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Biochemical studies of inositol N-acetylglucosaminyltransferase involved in mycothiol biosynthesis in Corynebacterium diphtheria
Yuchuan Guo, Lizhen Wang, Jiatong Guo, Guofeng Gu and Zhongwu Guo  
DOI: 10.1039/C7OB00555E, Paper

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Dissection of the neocarazostatin: a C4 alkyl side chain biosynthesis by in vitro reconstitution
Li Su, Rui Zhang, Kwaku Kyeremeh, Zixin Deng, Hai Deng and Yi Yu  
DOI: 10.1039/C7OB00617A, Communication

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Rifamorpholines A–E, potential antibiotics from locust-associated actinobacteria Amycolatopsis sp. Hca4
Yong Sheng Xiao, Bo Zhang, Mei Zhang, Zhi Kai Guo, Xin Zhao Deng, Jing Shi, Wei Li, Rui Hua Jiao, Ren Xiang Tan and Hui Ming Ge  
DOI: 10.1039/C7OB00614D, Paper

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Asymmetric synthesis of ent-fragransin C1
Santikorn Chaimanee, Manat Pohmakotr, Chutima Kuhakarn, Vichai Reutrakul and Darunee Soorukram  
DOI: 10.1039/C7OB00749C, Paper

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Organic & Biomolecular Chemistry, our sister journal, publishes many articles that cover a variety of natural product chemistry.

We try to keep you updated here, although signing up to OBC’s e-alert (free service) means you will receive the tables of content directly in your inbox every time an issue is published.

Hand-picked for you from the latest issues are:

Total synthesis based on the originally claimed structure of mucosin
Harrison C. Gallantree-Smith, Simen G. Antonsen, Carl H. Görbitz, Trond V. Hansen, Jens M. J. Nolsøe and Yngve H. Stenstrøm
DOI: 10.1039/C6OB01511E, Communication

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Synthesis and biological evaluation of palmyrolide A macrocycles as sodium channel blockers towards neuroprotection
Satish Chandra Philkhana, Suneet Mehrotra, Thomas F. Murray and D. Srinivasa Reddy
DOI: 10.1039/C6OB01372D, Paper

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Microwave assisted synthesis of phenanthridinones and dihydrophenanthridines by vasicine/KOtBu promoted intramolecular C–H arylation
Sushila Sharma, Manoranjan Kumar, Shruti Sharma, Onkar S. Nayal, Neeraj Kumar, Bikram Singh and Upendra Sharma
DOI: 10.1039/C6OB01362G, Paper

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Effective one-pot multienzyme (OPME) synthesis of monotreme milk oligosaccharides and other sialosides containing 4-O-acetyl sialic acid
Hai Yu, Jie Zeng, Yanhong Li, Vireak Thon, Baojun Shi and Xi Chen
DOI: 10.1039/C6OB01706A, Paper

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Chemoselective photooxygenations of furans bearing unprotected amines: their use in alkaloid synthesis
T. Montagnon, D. Kalaitzakis, M. Sofiadis and G. Vassilikogiannakis
DOI: 10.1039/C6OB01689H, Perspective

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A protecting group-free synthesis of (−)-hortonones A–C from the Inhoffen–Lythgoe diol
Hovsep Stambulyan and Thomas G. Minehan
DOI: 10.1039/C6OB01738J, Paper

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Total synthesis of cananginone C and structural revision of debilisone A
Tapan Kumar Kuilya and Rajib Kumar Goswami
DOI: 10.1039/C6OB01671E, Paper

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Total synthesis of mangiferin, homomangiferin, and neomangiferin
Xiong Wei, Danlin Liang, Qing Wang, Xiangbao Meng and Zhongjun Li
DOI: 10.1039/C6OB01622G, Paper

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Substitution dependent stereoselective construction of bicyclic lactones and its application to the total synthesis of pyranopyran, tetraketide and polyrhacitide A
B. V. Subba Reddy, Dhanraj O. Biradar, Y. Vikram Reddy, J. S. Yadav, Kiran Kumar Singarapu and B. Sridhar
DOI: 10.1039/C6OB01686C, Paper

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4,4′-Bismoschamine: biomimetic synthesis and evidence to support structural equivalency to montamine
Kaitlin G. Henry, Lachlan M. Blair, Jonathan Sperry and Elizabeth A. Colby Davie
DOI: 10.1039/C6OB01685E, Paper

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Total synthesis of diptoindonesin G and its analogues as selective modulators of estrogen receptors
Ji-tian Liu, Truman J. Do, Christopher J. Simmons, John C. Lynch, Wen Gu, Zhi-Xiong Ma, Wei Xu and Weiping Tang
DOI: 10.1039/C6OB01657J, Communication

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Phosphorylated cyclopropanes in the synthesis of α-alkylidene-γ-butyrolactones: total synthesis of (±)-savinin, (±)-gadain and (±)-peperomin E
Matthew G. Lloyd, Richard J. K. Taylor and William P. Unsworth
DOI: 10.1039/C6OB01527A, Paper

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De novo protecting-group-free total synthesis of (+)-muricadienin, (+)-ancepsenolide and (+)-3-hexadecyl-5-methylfuran-2(5H)-one
Rupesh A. Kunkalkar, Debasish Laha and Rodney A. Fernandes
DOI: 10.1039/C6OB01721E, Paper

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An expeditious synthesis of the ascomycete metabolite rigidiusculamide B
Anja Wunder and Rainer Schobert
DOI: 10.1039/C6OB01836J, Paper

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Total synthesis of haliclamide
Suraksha Gahalawat and Satyendra Kumar Pandey
DOI: 10.1039/C6OB01775D, Paper

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Organic & Biomolecular Chemistry, our sister journal, publishes many articles that cover a variety of natural product chemistry.

We try to keep you updated here, although signing up to OBC’s e-alert (free service) means you will receive the tables of content directly in your inbox every time an issue is published.

Hand-picked for you from the latest issues are:

Asymmetric synthesis and absolute stereochemistry of a labdane-type diterpenoid isolated from the rhizomes of Isodan yuennanensis
Heping Deng, Wei Cao, Zhijiang Zhang and Bo Liu
DOI: 10.1039/C6OB00750C, Paper

Biosynthesis of isoxazolin-5-one and 3-nitropropanoic acid containing glucosides in juvenile Chrysomelina
Tobias Becker, Kerstin Ploss and Wilhelm Boland
DOI: 10.1039/C6OB00899B, Paper

Overproduction and identification of butyrolactones SCB1–8 in the antibiotic production superhost Streptomyces M1152
John D. Sidda, Vincent Poon, Lijiang Song, Weishan Wang, Keqian Yang and Christophe Corre
DOI: 10.1039/C6OB00840B, Communication

Synthesis and biological evaluation of acylated oligorhamnoside derivatives structurally related to mezzettiaside-6 with cytotoxic activity
Gaopeng Song, Sumei Li, Zhiwei Lei, Yibin Li, Junhua Li, Yixian Liao and Zi-Ning Cui
DOI: 10.1039/C6OB00862C, Paper

Asymmetric synthesis of (+)-17-epi-methoxy-kauran-3-one through tandem oxidative polycyclization-pinacol process
Gaëtan Maertens, Samuel Desjardins and Sylvain Canesi
DOI: 10.1039/C6OB01142J, Paper

Enantioselective synthesis of (+)-brevipolide H
Ching-Nung Chen and Duen-Ren Hou
DOI: 10.1039/C6OB01071G, Paper

Synthetic studies of callyspongiolide: synthesis of the macrolactone core of the molecule
Sudhakar Athe, Ashish Sharma, Kanakaraju Marumudi and Subhash Ghosh
DOI: 10.1039/C6OB01007E, Paper

Synthesis of L-indospicine, [5,5,6-²H₃]-L-indospicine and L-norindospicine
Cheng-Shan Lang, Siew-Hoon Wong, Sharon Chow, Victoria L. Challinor, Ken W. L. Yong, Mary T. Fletcher, Dionne M. Arthur, Jack C. Ng and James J. De Voss
DOI: 10.1039/C6OB01187J, Paper

Synthesis of 2,6-trans– and 3,3,6-trisubstituted tetrahydropyran-4-ones from Maitland–Japp derived 2H-dihydropyran-4-ones: a total synthesis of diospongin B
Paul A. Clarke, Nadiah Mad Nasir, Philip B. Sellars, Alejandra M. Peter, Connor A. Lawson and James L. Burroughs
DOI: 10.1039/C6OB01182A, Paper

Catalytic asymmetric reactions and synthesis of quinones
Basavaprabhu Hosamani, Matheus F. Ribeiro, Eufrânio N. da Silva Júnior and Irishi N. N. Namboothiri
DOI: 10.1039/C6OB01119E, Review Article

Platinum-catalyzed cycloisomerizations of a common enyne: a divergent entry to cyclopropane sesquiterpenoids. Formal synthesis of sarcandralactone A
Vera P. Demertzidou and Alexandros L. Zografos
DOI: 10.1039/C6OB011226D, Communication

Synthesis of the 2-formylpyrrole spiroketal pollenopyrroside A and structural elucidation of xylapyrroside A, shensongine A and capparisine BA
James M. Wood, Daniel P. Furkert and Margaret A. Brimble
DOI: 10.1039/C6OB01361A, Paper

Biosynthesis-driven structure–activity relationship study of premonensin-derivatives A
A. Ismail-Ali, E. K. Fansa, N. Pryk, S. Yahiaoui, S. Kushnir, M. Pflieger, A. Wittinghofer and F. Schulz
DOI: 10.1039/C6OB01201A, Paper

Horner–Wadsworth–Emmons approach to piperlongumine analogues with potent anti-cancer activity
Li-Chen Han, Paul A. Stanley, Paul J. Wood, Pallavi Sharma, Anchala I. Kuruppu, Tracey D. Bradshaw and John E. Moses
DOI: 10.1039/C6OB01160H, Paper

We hope you enjoy this selection!
Why not submit your latest natural product research to OBC today?