Archive for the ‘News’ Category

New additions to the macrocyclic bisbibenzyl family on the cover of NPR issue 2

Issue 2 of NPR is now online, including our regular Hot off the Press feature from Robert A. Hill and Andrew Sutherland and the latest marine natural products review from John Blunt et al.

The interesting cover article is from David Harrowven and Sarah Kostiuk, highlighting their review on the synthesis and stereochemistry of newly discovered macrocyclic bisbenzyl natural products, a group commonly, but not exclusively, found in the bryophyte plant family. The review provides at timely update to that by G. M. Keserű and M. Nógrádi in 1995.

The issue also includes a Highlight article from Paris Hamilton and Dev Arya on natural product DNA major groove binders, and reviews on the biosynthesis of 3-amino-5-hydroxybenzoic acid-derived NPs and angucyclines.

View the issue

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Influenza Neuroaminidase on the cover of NPR Issue 1, 2012

Welcome to NPR Issue 1, 2012

Looking back on 2011, we’d like to thank all our authors, readers and referees for what has been another very successful year for Natural Product Reports. A big thanks also goes to the NPR Editorial Board for their great support and enthusiasm.

Read the 2012 Editorial by NPR Chair Professor Bradley Moore and Editor Dr Richard Kelly reflecting on this year’s many highlights and catch a glimpse of what to look ahead to for a bright 2012!



On the cover of this first Issue is the work of Judith M. Rollinger et al., reviewing the increasing research efforts of the past decade on neuroaminidase (NA) for lead discovery strategies from nature, focusing on the structure, function and druggability of influenza NA, and its inhibition by natural products. This review will be free to access for the next 6 weeks.

Influenza neuraminidase: A druggable target for natural products
Ulrike Grienke, Michaela Schmidtke, Susanne von Grafenstein, Johannes Kirchmair, Klaus R. Liedl and Judith M. Rollinger
DOI: 10.1039/C1NP00053E

Also in this Issue, read:

     

    We hope you enjoy reading our first issue for this new volume of NPR and we wish you all the warmest Season’s Greetings.

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    Nominations for the 2012 RSC Prizes and Awards now open

    Nominations for the 2012 RSC Prizes and Awards close on the 15 January 2012

    Our Prizes and Awards represent the dedication and outstanding achievements and are a platform to showcase inspiring science to gain the recognition deserved. Don’t forget to nominate colleagues who have made a significant contribution to advancing the chemical sciences.

    View our full list of Prizes and Awards and use the online system to nominate a colleague.

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    New Editorial Board members for NPR

    We are delighted to announce the appointment of two new members to the Editorial Board of Natural Products Reports, Professors Ikuro Abe and Dirk Trauner who will be joining the Board in January 2012.

    Ikuro Abe received his PhD degree in 1989 from The University of Tokyo under the direction of Professor Yutaka Ebizuka, where he studied chemistry and biochemistry of natural products biosynthesis.  After two years postdoctoral research with Professor Guy Ourisson at the CNRS Institut de Chimie des Substances Naturelles, and mostly with Professor Michel Rohmer at the Ecole Nationale Supérieure de Chimie de Mulhouse, in France (1989-1991), he went to the USA to work with Professor Glenn D. Prestwich at the State University of New York at Stony Brook (1991-1996) and then at The University of Utah (1996-1998) as a Research Assistant Professor.  In 1998, he returned to Japan to the University of Shizuoka, School of Pharmaceutical Sciences (1998-2009).  In 2009, he moved back to The University of Tokyo, Graduate School of Pharmaceutical Sciences as Professor of Natural Products Chemistry.

    His main research interests focus on exploring and engineering natural products biosynthesis, see below for some examples of his work:

    Enzymatic synthesis of cyclic triterpenes
    Ikuro Abe
    DOI: 10.1039/B616857B

    Structure and function of the chalcone synthase superfamily of plant type III polyketide synthases
    Ikuro Abe and Hiroyuki Morita
    DOI: 10.1039/B909988N


    Dirk Trauner was born and grew up in Linz, Austria. After studying biology and then biochemistry at the University of Vienna, he joined Professor Johann Mulzerʼs group at the Free University of Berlin to pursue natural products synthesis. In the late 1990s, he was a postdoctoral fellow with Professor Samuel J. Danishefsky at the Memorial Sloan-Kettering Cancer Center in New York City. In 2000, Dirk joined the University of California, Berkeley, where he rose through the ranks to become an Associate Professor of Chemistry. In summer of 2008, he moved to the University of Munich, where he currently resides as a Professor for Chemical Biology and Genetics.

    His research interests range from organic synthesis and natural products to chemical neurobiology and optochemical genetics. View his contribution to our Synthesis themed issue below:

    The chemistry of marine furanocembranoids, pseudopteranes, gersolanes, and related natural products
    Paul A. Roethle and Dirk Trauner
    DOI: 10.1039/B705660P

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    New Advisory Board members for NPR

    The Editorial Office is pleased to announce the recent appointment of two new Advisory Board members for Natural Product Reports, Yeo Joon Yoon and Vanderlan da Silva Bolzani.

    Yeo Joon Yoon received his PhD in chemical and biological engineering from Seoul National University in 2000. He has worked with Prof Charles R. Hutchinson at the University of Wisconsin at Madison as a predoctoral researcher and also with Prof David H. Sherman at the University of Minnesota as a postdoctoral researcher. In 2002 he returned to Korea as Assistant Professor of Chemical Engineering and Bioengineering at the University of Ulsan and then moved to Ewha Womans University in 2004, where he is Associate Professor of Chemistry.

    His major scientific interests are the characterization of biosynthetic pathways for secondary metabolites, focusing on polyketides and aminoglycosides in actinomycetes, combinatorial biosynthesis of novel natural products, and the application of metabolic engineering and synthetic biology to the production of secondary metabolites.


    Vanderlan da Silva Bolzani is full professor at Sao Paulo State University (UNESP), and has published over 186 research publications, 5 patents and 4 book chapters. A Fellow of the Royal Society of Chemistry (UK) and a Science Productivity CNPq Fellow, she has received several awards, the most recent is the Distinguished Woman in Science Chemistry and Chemical Engineering award conceived by the ACS & IUPAC. Her PhD degree in Organic Chemistry was obtained under the guidance of Professor Otto Richard Gottlieb, University of São Paulo and after a post-doctorate at Virginia Polytechnic Institute (VPISU-USA) she joined the São Paulo State University (UNESP). Dr. Bolzani is currently is Vice-Director of the UNESP Innovation Agency (AUIN), was President of the Brazilian Chemical Society from 2008-2010, and is currently Counsellor. 

    Her field of interest is plant science, and she has been involved in the isolation, bioactivity and function of secondary metabolites and peptides from plants. Also she has studied biosynthesis of piperidine alkaloids, and recently has been involved in metabolomic studies of medicinal plants and sugar cane. She has strong work collaborations with national pharmaceutical and cosmetic industries looking for new drugs from plants species. 

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    Degradation of lignin in bacteria and fungi on the cover of NPR issue 12


    Natural Product Reports’ last issue of the year is now published on line.

    On the cover of this December issue is an article by Timothy Bugg et al. at the University of Warwick (UK), which highlights recent progress in the understanding of the microbial breakdown of lignin, and catabolic pathways for the breakdown of lignin components.

    Also check out our latest Hot of the Press article by Robert A. Hill and Andrew Sutherland, discover the potential of combinatorial biosynthesis in plants, read all about the stereochemical aspects of the biosynthetic pathways to terpenes, and learn on curcumin’s multitargeting powers.

    All of this in a very successful 2011 last issue. We hope you enjoy it!

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    2012 NPR Lectureship – nominations now open!

    Nominations are now open for the 2012 NPR Lectureship.

    Anyone can make a nomination for the award. Simply send the name of the person you would like to nominate, along with a brief justification, to the Editor, Dr Richard Kelly. All nominations should be received by Wednesday 30th November.

    The NPR Lectureship is an annual event which is held at an international meeting of the recipient’s choosing. The recipient will be someone who has made significant research contribution to natural products chemistry in its broadest sense. The winner will be selected by a panel of judges, who will announce the result in early 2012.

    Previous winners of the award include John Blunt of the University of Canterbury, New Zealand and Jason Micklefield of the University of Manchester, UK.

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    NPR Issue 11 now available online


    The latest issue of Natural Product Reports is now available online and features a review by Andrew M. Harned and Kelly A. Volp (University of Minnesota) on the cover. Their article highlights the sorbicillinoid family of natural products and examines their isolation, biosynthesis, and synthetic studies.

    Also in this issue, a Highlight Article by Guy Carter on Natural products and Pharma 2011: Strategic changes spur new opportunities, and reviews examining glyco(randomization/diversification) strategies, by Richard Gantt et al., and shedding light on the syrbactins’ chemistry and biology, by Daniel Krah et al.

    Why not take a look now! Access the full issue here, or follow the links to the individual articles:

    Natural products and Pharma 2011: Strategic changes spur new opportunities
    Guy T. Carter, Nat. Prod. Rep., 2011, 28, 1783-1789

    The sorbicillinoid family of natural products: Isolation, biosynthesis, and synthetic studies
    Andrew M. Harned and Kelly A. Volp, Nat. Prod. Rep., 2011, 28, 1790-1810

    Enzymatic methods for glyco(diversification/randomization) of drugs and small molecules
    Richard W. Gantt, Pauline Peltier-Pain and Jon S. Thorson, Nat. Prod. Rep., 2011, 28, 1811-1853

    The chemistry and biology of syringolins, glidobactins and cepafungins (syrbactins)
    Daniel Krahn, Christian Ottmann and Markus Kaiser, Nat. Prod. Rep., 2011, 28, 1854-1867

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    Latest issue online – flavonoids, SAM enzymes, hypervalent iodine regants and diterpenoids

    Issue 10 is now available online, featuring some of our regular reviews from Peter Roach, Nigel Veitch and Jim Hanson.  Also in the issue, the latest Hot off the Press article from Robert Hill and Andrew Sutherland and an interesting review from Berit Olofsson on hypervalent iodine reagents in NP synthesis:

    Flavonoids and their glycosides, including anthocyanins
    Nigel C. Veitch and Renée J. Grayer, Nat. Prod. Rep., 2011, 28, 1626

    Radical S-adenosylmethionine enzymes: Mechanism, control and function
    Martin R. Challand, Rebecca C. Driesener and Peter L. Roach, Nat. Prod. Rep., 2011, 28, 1696

    Hypervalent iodine reagents in the total synthesis of natural products
    Luiz F. Silva, Jr., Berit Olofsson, Nat. Prod. Rep., 2011, 28, 1722

    Diterpenoids of terrestrial origin
    James R. Hanson, Nat. Prod. Rep., 2011, 28, 1755

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    RSC e-membership now launched

    This week, the RSC launched a new product, RSC e-membership, allowing anyone to access an electronic version of Chemistry World through a MyRSC account and to enjoy the benefits of electronic networking via this professional online community for £20/year.

    Subscribers to this do not benefit from the professional recognition or any of the other many services and discounts available to RSC Members, but it allows chemists from around the world, many already members of another chemical society in their own country, to benefit from the highly-esteemed content in Chemistry World and the networking opportunities offered from MyRSC, which now stands at over 11,000 members. The RSC e-membership also allows subscribers to join a virtual specialist interest group on MyRSC. If you are interested in joining, please visit www.rsc.org/emembership.

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