Archive for the ‘News’ Category

2011 Impact Factor for OBC, MedChemComm & NPR

The 2011 Journal Citation Reports ® (Thomson Reuters, 2012) have just been released, which showed:

Organic & Biomolecular Chemistry: 3.696

MedChemComm: 2.8         (Partial IF only, based on five issues)

Natural Product Reports: 9.79

The Cambridge Editorial Office would like to thank everyone involved for their hard work and dedication to all three journals over the years. In particular, we would like to thank all of our Associate Editors, Editorial and Advisory Board members, authors and referees, without whom none of this would have been possible.

With another successful year in the bag, we hope you will join us in making this year even better…

Read more about the 2011 Impact Factors from across RSC Publishing on the RSC Publishing Blog.

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Rare glycosylation of peptides and proteins on the cover of this month’s issue of NPR

Welcome to NPR issue 7, 2012


Richard Daniellou and Pierre Lafite (ICOA, Orleans, France) have designed this issue’s cover, illustrating their review article on rare and unusual glycosylation of peptides and proteins.
Glycosylation represents the most complex co- and post-translational modification of proteins, and the article focuses on the source and nature of rare glycosidic linkages, rare carbohydrates, and the mechanism of glycosyltransferases, providing the reader with a complete overview of this very relevant topic.

Rare and unusual glycosylation of peptides and proteins
Pierre Lafite and Richard Daniellou
DOI: 10.1039/C2NP20030A

Also in this issue, we trust you will enjoy:

The isoprenoid-precursor dependence of Plasmodium spp.
Jan-Ytzen van der Meer and Anna K. H. Hirsch
Nat. Prod. Rep., 2012, 29, 721-728

Assessing calcareous sponges and their associated bacteria for the discovery of new bioactive natural products
Mélanie Roué, Elodie Quévrain, Isabelle Domart-Coulon and Marie-Lise Bourguet-Kondracki
Nat. Prod. Rep., 2012, 29, 739-751

Synthetic approaches toward sesterterpenoids
Daniel T. Hog, Robert Webster and Dirk Trauner
Nat. Prod. Rep., 2012, 29, 752-779

Authored by NPR Board Member Dirk Trauner and members of his team, why not view Dirk’s profile on our blog… Read.

Also containing the all time favourite:

Triterpenoids
Robert A. Hill and Joseph D. Connolly
Nat. Prod. Rep., 2012, 29, 780-818

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The fungal Pestalotiopsis genus on the cover of NPR issue 6

NPR issue 6, 2012, is here!

The cover of this month’s NPR features a review by Du-Qiang Luo et al. which discusses the taxonomy, biology and chemistry of the Pestalotiopsis genus as well as covering biosynthetic relationships and synthesis of metabolites of this genus. Take a look, it will be free to access for 6 weeks!

The taxonomy, biology and chemistry of the fungal Pestalotiopsis genus
Xiao-Long Yang, Jing-Ze Zhang and Du-Qiang Luo
DOI: 10.1039/C2NP00073C

Also in the issue; read the latest Hot Off The Press article by Robert A. Hill and Andrew Sutherland, as well as these reviews:

Pheromones, attractants and other chemical cues of aquatic organisms and amphibians
Scott F. Cummins and John H. Bowie
DOI: 10.1039/C2NP00102K

Electrophilic natural products and their biological targets
Malte Gersch, Johannes Kreuzer and Stephan A. Sieber
DOI: 10.1039/C2NP20012K

The early stages of taxol biosynthesis: An interim report on the synthesis and identification of early pathway metabolites
Jennifer Guerra-Bubb, Rodney Croteau and Robert M. Williams
DOI: 10.1039/C2NP20021J

Glycosynthases as tools for the production of glycan analogs of natural products
Beatrice Cobucci-Ponzano and Marco Moracci
DOI: 10.1039/C2NP20032E

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RSC US Roadshow 2012 – Week 4: North East

Natural Product Reports Editor Richard Kelly will be visiting several North East universities next week as part of the RSC US Roadshows 2012.

Week 4 sees the Royal Society of Chemistry visiting four universities in Pennsylvania and New York:

May 7th – University of Pittsburgh
May 8th – Pennsylvania State University
May 10th – University of Pennsylvania
May 11th – Columbia University

Read more about the US roadshows 2012:

Starting in mid April 2012, RSC Publishing has been touring the United States of America to share more than 170 years experience of publishing in the chemical sciences. Sixteen universities across the country are hosting these one-day events, which are open to all members of the hosting institute.

Attendees have the opportunity to explore RSC’s apps on mobile devices and meet informally with RSC editors. Lunchtime discussion groups explore reading habits and opportunities in the 21st century and an afternoon seminar give an insight into the world of scholarly publishing, with tips on how to get published in high impact journals. A demonstration of ChemSpider, and a guest lecture from an RSC associate editor or board member are available at many of the roadshows.

Follow the RSC Roadshows on Twitter – just look for #RSC2012.

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Cytotoxic and antioxidant marine natural products on the cover of NPR issue 5

Welcome to NPR issue 5, 2012

This month’s striking subaquatic cover features the work of Suthananda N. Sunassee and Michael T. Davies-Coleman at Rhodes University, Grahamstown, South Africa,  with a review on Cytotoxic and antioxidant marine prenylated quinones and hydroquinones.
Focusing on 159 prenylated quinones, hydroquinones and naphthoquinones with reported cytotoxic and/or antioxidant properties isolated from various marine organisms over the past 40 years, the authors highlight trends in the structural distribution of these cytotoxic compounds within the different marine phyla.

Cytotoxic and antioxidant marine prenylated quinones and hydroquinones
Suthananda N. Sunassee and Michael T. Davies-Coleman
Nat. Prod. Rep., 2012, 29, 513-535
DOI: 10.1039/C2NP00086E

Also in this May issue, why not read:

NMR in natural products: understanding conformation, configuration and receptor interactions
Teresa Carlomagno
Nat. Prod. Rep., 2012, 29, 536-554

Cytisine: a natural product lead for the development of drugs acting at nicotinic acetylcholine receptors
Edwin G. Pérez, Carolina Méndez-Gálvez and Bruce K. Cassels
Nat. Prod. Rep., 2012, 29, 555-567

Peptidoglycan as Nod1 ligand; fragment structures in the environment, chemical synthesis, and their innate immunostimulation
Yukari Fujimoto, Ambara Rachmat Pradipta, Naohiro Inohara and Koichi Fukase
Nat. Prod. Rep., 2012, 29, 568-579

Recent discovery of plant-derived anti-diabetic natural products
Hsin-Yi Hung, Keduo Qian, Susan L. Morris-Natschke, Chau-Shin Hsu and Kuo-Hsiung Lee
Nat. Prod. Rep., 2012, 29, 580-606

Access the full issue

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There is still time to join ICPOC21!

Good news!

There’s still a chance to submit your oral abstract to ICPOC21: 21st IUPAC International Conference on Physical Organic Chemistry organised by the Organic Division of the RSC on behalf of IUPAC, to be held 9 – 13 September 2012 at Durham University.

The Scientific Committee is currently reviewing all submissions, and has agreed to accept contributions up to Friday 13 April to allow for the Easter holiday break.

Why join ICPOC21?

 
Professor Dean Tantillo, University of California, Davis (USA) is the winner of the 2011 NPR Lecture Award. and will be delivering his lecture at ICPOC 21.

The NPR Lecture Award is awarded to a researcher who has made a significant contribution to the field of natural products and who has been involved with the journal. Professor Tantillo was selected for his work in the field of enzymology.

In addition to the outstanding plenary sessions, there will be three parallel sessions over the five days comprising invited lectures and contributed talks, as well as poster sessions.

A broad range of scientists from across the whole community who share a quantitative perspective on chemistry will be there, providing an opportunity to discuss and celebrate the current status, development, and the future of physical organic chemistry.

Make sure you are one of them! Don’t miss the oral abstract submission deadline – 13 April.

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Vibsane-type diterpenoids on the cover of NPR issue 4

Welcome to NPR issue 4, 2012!

This month’s cover features the work of Jeffrey Y. W. Mak and Craig M. Williams who highlight the key accomplishments in the total synthesis of visbanins, which are rare, structurally dense diterpenes occuring exclusively in the Viburnum species.

Key achievements in the total synthesis of vibsane-type diterpenoids
Jeffrey Y. W. Mak and Craig M. Williams
Nat. Prod. Rep., 2012, 29, 440-448
DOI: 10.1039/C2NP00067A

Also in the issue, read the latest Hot Of The Press article by Robert A. Hill and Andrew Sutherland,

A Highlight by Jiyong Hong and Hendrik Luesch  on Largazole,  a potent inhibitor of histone deacetylases (HDACs) which has attracted considerable interest from the scientific community. This Highlight summarizes recent advances to date in the characterization of this marine natural product: 

A review article by Yuan-Chao Li and Ze-Hong Miao et al. focusing on thunder god vine’s (Tripterygium wilfordii Hook F) principal bioactive ingredient triptolide:

Richard Robins and Guillaume Tcherkez et al. ‘s review discussing biochemical and physiological factors underlying the site-specific, non-random distribution of 13C/12C isotope ratios within plant metabolites, which can be determined by isotopic 13C NMR spectrometry:

R. Kiss and coworkers present both natural and synthetic phenazines with a critical focus on in vitro, in vivo and available clinical anti-cancer activities of these compounds, covering the literature published since 2000:

View the issue

 

Also of Interest:
The first articles from MedChemComm’s themed issue on Natural Products are available, including contributions from Professors Craig Townsend and Margaret Brimble

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NPR poster prizes awarded at Zing Natural Products conference

Congratulations to Ramona Riclea (TU Braunschweig, Germany) and Khomaizon Kadir (University of Bristol, UK) who each won a Natural Product Reports poster prize at the Zing Natural Products conference  held on 10-13 February in Lanzarote.

Ramona, currently studying for her PhD in the group of Dr. Jeroen S. Dickschat, presented her winning work entitled

  •  ‘Synthesis and biosynthesis of novel bioactive secondary metabolites from Streptomycetes’

while Khomaizon, PhD student working with Drs Andy Bailey and Colin M Lazarus, was rewarded for her winning poster presenting her research on:

  •  ‘Efficient expression system for production of natural products in Aspergillus orizae’

Both awardees receive a prize certificate and a one-year subscription to Natural Product Reports. Congratulations!

From left to right, Dr Jeroen Dickschat and poster prize winners Ramona Riclea and  Khomaizon Kadir receiving their award certificate from Dr Marie Cote, NPR deputy editor.

The meeting was co-Chaired by NPR Advisory Board member and former NPR Chair David O’Hagan (University of St Andrews, UK) and NPR Advisory Board member Margaret Brimble (University of Auckland, New Zealand) and brilliantly covered the breadth of natural products research: from isolation and structural studies to biosynthesis to synthesis of molecules. Included in the line up of speakers were NPR Editorial Board members Andreas Kirschning (Leibniz University of Hannover, Germany)  Stefan Schulz (TU Braunschweig, Germany), Dirk Trauner (Ludwig-Maximilians-Universität München),  former NPR Chair Tom Simpson (University of Bristol, UK) and former Lecture Award winner Jason Micklefield (University of Manchester, UK).

The conference was a perfect opportunity to not only see some of the latest cutting edge natural products research but also to meet authors and readers of the journal –  all this in very enjoyable surroundings!

For critical and though-provoking reviews across a broad range of areas of natural products research, you can turn to Natural Product Reports…   

But did you know?

– Our sister journal Organic & Biomolecular Chemistry regularly publishes natural products related works: See them all here.

– Why not also view the very first articles from MedChemComm’s themed issue on Natural Products?

 

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Building a nation of scientists

Goverdhan MehtaGoverdhan Mehta talks to Sheena Elliott and Elinor Richards about the progress of science in India and the challenges scientists face

Goverdhan Mehta is a researcher, specialising in organic synthesis. He has helped to build institutions in India – the Indian Institute of Technology, Kanpur, the University of Hyderabad, and the Indian Institute of Science, Bangalore. He was director of the Indian Institute of Science (1998-2005) and vice chancellor of the University of Hyderabad (1994-1998).

Your research is focused on organic chemistry. What attracted you to that field?

There is something intrinsically fascinating about organic chemistry. In my early high school years, when I was exposed to interesting chemical structures, I was attracted to them. I had a sense of appreciation for art and organic molecules to me provided a wonderful expression of art at a molecular level.

What are your main achievements in the field?

I have worked in many areas of organic chemistry, but it’s synthesis that’s given me the greatest pleasure. As organic chemistry advanced, different contemporary challenges came to my attention. The main driver for me to pursue those challenges was the intricacy of the target structure synthesis. There was also an element of expectation that perhaps our research might become useful to society. We continue to need new drugs for a variety of disorders, so we synthesised a large number of natural products; many of them are biologically active and it is quite possible that some of them can provide leads for new drug discovery.

Over the last few years, I have become interested in how to address a problem that the ageing population is facing – neurodegeneration. It has been shown that some natural products can slow down neurodegeneration. In some cases, there is also an indication that they can help restore lost cognitive function. So I have been working on the synthesis of such lead molecules. As I’m getting older, I recognise the need for doing something in that area!

You’ve won numerous awards. Which achievements are you most proud of?

I don’t think that awards and recognition have necessarily brought me a great sense of joy. They do bring a sense of satisfaction because your peers have recognised your work. But I don’t think any serious researcher works for awards. It is the sheer joy of research that keeps people going. Recognition has come my way, but don’t think that I can equate that with the joy of doing research.

What are the challenges facing scientists in India and how could these be overcome?

Scientists all over the world are facing challenges on two fronts. The first problem is that scientists are not being supported by society as much as they should and some governments are not always forthcoming in terms of providing budgetary support. The second problem is that scientists, and science in general, have become isolated both in terms of discipline and, to some extent, in terms of geographical location. This is being redressed now with increasing international collaborations, so in the geographical sense, the isolation is being reduced. But I think disciplinary isolation vis a vis other knowledge streams and fragmentation of science is still a serious challenge.

It is a good time for scientists in India because the government is very supportive of science. Funding is no longer as serious a problem as it is in other parts of the world. Recently, our prime minister said that the budget for science will be almost doubled over the next few years. But I’m not too sure that we as a scientific community are steering science in India in the direction that it ought to be heading. I believe that the government and the scientific community must set a goal that in the next 10 years, India will be among the world’s leading scientific countries.

What is your opinion on the perception that Indian science and research is falling behind the rest of the world, following recent comments by Prime Minister Manmohan Singh?

Prime Minister Singh’s statement referred mainly to China. China has made more progress in science and technology than India. Scientific productivity in India has increased, but not as much as in China. Since we are behind, to simply say that we are walking and walking well is not enough. We should be galloping to catch up. My judgement is that our progress is not commensurate with the support that the government is providing, and not commensurate with the capacity, capability, enthusiasm and the vibrancy that our youth have. We can achieve much more.

How do the different industries compare (the pharmaceutical industry in particular or the more general chemical industry)?

It is only over the last 10 or 12 years, since the economic reforms, that industry in India has grown at such a rate so as to be in a position to invest in research and development. I expect that investment by industry is going to rise; however, the current level of investment is not in an acceptable range. There are certain sectors – pharma, for example – and some other chemical industries, where I think India’s potential is immense, but there are some challenges with the policies that are being pursued. We have to devise a well thought out strategy.

The prime minister’s Science Advisory Council reported that there is an absence of any Indian universities among the world’s best. What is your opinion on the quality of universities in India?

I’m not a great believer in the ranking systems being followed, but the fact is that no Indian university features among the top few hundred universities. However, if we were to look at undergraduate teaching, India has institutions that produce graduates through excellent teaching and training. The graduates are probably as good as they are anywhere else in the world. If you were to grade an institution on the quality of undergraduates, I would say that the Indian Institutes of Technology rank among the top 10 institutions in the world. But, if you bring in research and other elements, they will not feature anywhere near the top. So the quality of research is a serious problem. I think it is high time that the scientific community and scientific leadership in our country sort out an effective, implementable strategy to make a major shift.

You experienced difficulty obtaining a visa to travel to the US in 2006, when you were invited to give a lecture at the University of Florida. At the time, a report from the National Academy of Sciences in the US said that at least 3000 scientists had faced a similar problem. Have things improved since then or do you believe that the visa problem is hampering scientific progress and career development for scientists?

It was ironic that I and a leading scientist from the US, Jane Lubchenco (who at that time was president of the International Council for Science before I succeeded her), wrote an editorial about the principle of universatility of science and the visa regime in Science a few months before this happened. We wrote that it was important for the international growth of science that scientists were able to travel. Little did I realise that soon I would be a victim of this! I think the situation has improved, but a lot more needs to be done. While the US National Academy of Sciences is playing a very positive role towards this end, the academies can only do the advocacy. Eventually, it is the government and the state department of security staff that makes the final judgement.

If you have any spare time, how do you fill it?

For most scientists, and I’m no exception, your research is a hobby. What other profession can give you that pleasure and privilege? In a previous interview, I was asked what I would wish for. I said we Indians believe in rebirth and so the only wish I have is that if I were to be born again, I would be a scientist. I would like to be a chemist, hopefully a better one.

Read the original article and see Professor Mehta’s recent RSC published papers at Chemistry World

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Dean Tantillo wins 2012 NPR Lecture Award

Dean TantilloWe are delighted to announce that Professor Dean Tantillo from the University of California, Davis (USA) is the winner of the 2011 NPR Lecture Award. Professor Tantillo was selected for his work in the field of enzymology.

“It is an honor to be chosen as the 2012 NPR lecturer,” Professor Tantillo commented on receiving the award. “My students at UC Davis have worked hard to show how theoretical chemistry can contribute to natural products research and I am delighted that a fantastic journal like NPR supports this growing part of the natural products community. Thanks!”

The conference at which the lecture will be delivered will be announced in due course.

The NPR Lecture Award is awarded to a researcher who has made a significant contribution to the field of natural products and who has also had some involvement with the journal. You can view Professor Tantillo’s recent article for NPR below:

Biosynthesis via carbocations: Theoretical studies on terpene formation
Dean J. Tantillo
Nat. Prod. Rep., 2011, 28, 1035-1053
DOI: 10.1039/C1NP00006C

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