Archive for the ‘Board News’ Category

New Editorial Board Members – Natural Product Reports

We are delighted to warmly welcome three new Editorial Board Members to our Natural Product ReportsProfessor Dong-Chan Oh (Seoul National University, South Korea), and Professor Eriko Takano (University of Manchester, UK), and Professor Changsheng Zhang (South China Sea Institute of Oceanology, China Academy of Sciences, China).

Dong-Chan Oh studied oceanography and chemistry at Seoul National University, Republic of Korea. He obtained Ph. D. in marine natural products chemistry at Scripps Institution of Oceanography in 2006. After graduation, he joined Harvard Medical School as a postdoctoral research fellow and later worked as an instructor. In 2009, he started his independent academic career at Natural Products Research Institute, College of Pharmacy, Seoul National University in Korea. He conducted his research as a Howard Hughes Medical Institute International Early Career Scientist from 2012 to 2017. Dong-Chan Oh is currently a full professor of College of Pharmacy and the director of Natural Products Research Institute at Seoul National University.

His research focuses on the discovery, the structure elucidation, and the stereochemical determination of new bioactive natural products from microbes.

Eriko Takano is the Professor of Synthetic Biology in the Manchester Institute of Biotechnology, Department of Chemistry, School of Natural Sciences, Faculty of Science and Engineering, at the University of Manchester since 2012. In 2014, she was appointed as one of the three directors for the EPSRC/BBSRC-funded Manchester Synthetic Biology Research Centre, SYNBIOCHEM and in 2018, she was appointed as the deputy head of department of Chemistry. Eriko graduated from Kitasato University in Japan and did her undergraduate project with Prof Satoshi Omura (2015 Nobel Prize in Physiology and Medicine), before working at a R&D facility for a company, Meiji Seika Kaisha, for several years. After leaving industry, she obtained her PhD at the John Innes Institute, Norwich, UK, in 1994 on the regulation of antibiotic production in Streptomyces coelicolor. Before her arrival in Manchester, she had been Associate Professor at the University of Groningen, The Netherlands, and Assistant Professor (C1) at the Department of Microbiology / Biotechnology, University of Tübingen, in Germany.

Eriko is internationally recognized as a pioneer in the synthetic biology of microbes for antibiotic production. Her interests are in bioinformatics software development for designing natural products producers; untargeted metabolomics for chassis engineering in Streptomyces; secondary metabolite biosynthesis pathway assembly; and regulatory circuit engineering through signalling molecules and non-coding RNAs. Eriko has published 103 peer-reviewed papers and 4 book chapters and holds 5 patents. She is the Fellow of the Royal Society of Biology and has served as an expert advisor for the European Commission Scientific Committee on Emerging and Newly Identified Health Risks on synthetic biology, where she contributed to a series of three official Opinions with major impact on the development of the field.

Changsheng Zhang obtained a BSc. in Biology (Shanghai Jiaotong University, China, 1994) and an MSc. in Biotechnolgy (East China University of Science and Technology, 1997). In 2002, he obtained his Ph.D in Chemical Microbiology (Bergische University of Wuppertal, Germany) with Prof. Dr. W. Piepersberg. He carried out postdoctoral research on natural product glycosylation studies with J. S. Thorson at University of Wisconsin, Madison (2003-2008). In 2008, he joined the South China Sea Institute of Oceanology, China Academy of Sciences.

His research interest focuses on marine polycyclic natural product discovery and biosynthesis

You can find some of their most recent RSC publications below:


Bioinformatics for the synthetic biology of natural products: integrating across the Design–Build–Test cycle
Pablo Carbonell, Andrew Currin, Adrian J. Jervis, Nicholas J. W. Rattray, Neil Swainston, Cunyu Yan, Eriko Takano and Rainer Breitling
Nat. Prod. Rep., 2016, 33, 925-932, DOI: 10.1039/C6NP00018E, Highlight

Switchable foldamer ion channels with antibacterial activity
Anna D. Peters, Stefan Borsley, Flavio della Sala, Dominic F. Cairns-Gibson, Marios Leonidou, Jonathan Clayden, George F. S. Whitehead, Iñigo J. Vitórica-Yrezábal, Eriko Takano, John Burthem, Scott L. Cockroft and Simon J. Webb
Chem. Sci., 2020, Advance Article, DOI: 10.1039/D0SC02393K, Edge Article

Functional characterization of the halogenase SpmH and discovery of new deschloro-tryptophan dimers
Zhiwen Liu, Liang Ma, Liping Zhang, Wenjun Zhang, Yiguang Zhu, Yuchan Chen, Weimin Zhang and Changsheng Zhang
Org. Biomol. Chem., 2019, 17, 1053-1057, DOI: 10.1039/C8OB02775G, Communication

Heterologous expression of the trichostatin gene cluster and functional characterization of N-methyltransferase TsnB8
Wei Liu, Vinay Gopal Jannu, Zhiwen Liu, Qingbo Zhang, Xiaodong Jiang, Liang Ma, Wenjun Zhang, Changsheng Zhang and Yiguang Zhu
Org. Biomol. Chem., 2020, 18, 3649-3653, DOI: 10.1039/D0OB00617C, Communication

Activation and characterization of a cryptic gene cluster reveals a cyclization cascade for polycyclic tetramate macrolactams
Subhasish Saha, Wenjun Zhang, Guangtao Zhang, Yiguang Zhu, Yuchan Chen, Wei Liu, Chengshan Yuan, Qingbo Zhang, Haibo Zhang, Liping Zhang, Weimin Zhang and Changsheng Zhang
Chem. Sci., 2017, 8, 1607-1612, DOI: 10.1039/C6SC03875A, Edge Article

Identification and bioactivity evaluation of secondary metabolites from Antarctic-derived Penicillium chrysogenum CCTCC M 2020019
Imran Khan, Haibo Zhang, Wei Liu, Liping Zhang, Fang Peng, Yuchan Chen, Qingbo Zhang, Guangtao Zhang, Weimin Zhang and Changsheng Zhang
RSC Adv., 2020, 10, 20738-20744, DOI: 10.1039/D0RA03529G, Paper

Characterization of the flavoenzyme XiaK as an N-hydroxylase and implications in indolosesquiterpene diversification
Qingbo Zhang, Huixian Li, Lu Yu, Yu Sun, Yiguang Zhu, Hanning Zhu, Liping Zhang, Shu-Ming Li, Yuemao Shen, Changlin Tian, Ang Li, Hung-wen Liu and Changsheng Zhang
Chem. Sci., 2017, 8, 5067-5077, DOI: 10.1039/C7SC01182B

Flavoenzyme CrmK-mediated substrate recycling in caerulomycin biosynthesis
Yiguang Zhu, Marie-Ève Picard, Qingbo Zhang, Julie Barma, Xavier Murphy Després, Xiangui Mei, Liping Zhang, Jean-Baptiste Duvignaud, Manon Couture, Weiming Zhu, Rong Shi and Changsheng Zhang
Chem. Sci., 2016, 7, 4867-4874, DOI: 10.1039/C6SC00771F, Edge Article

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Tobias Gulder – NPR’s new Chair of the Editorial Board

We are delighted to announce that Professor Tobias A. M. Gulder is the new Chair of the Natural Product Reports Editorial Board.

“Natural Product Reports has been my favorite journal for critical reviews in natural product chemistry since entering the field as a graduate student. I became a member of the Editorial Board of NPR in 2017 and have since enjoyed working with the Royal Society of Chemistry Editorial Team and the Board Members to further develop the journal. I feel honored to succeed Brad Moore as the Chair of the journal and look forward to continue his successful work for the natural product community.”

We are very grateful to Professor Bradley Moore for all of his contributions to the journal during his years with us as an Editorial Board member and then as Chair.

As we wish Professor Moore well with his future endeavours we warmly welcome Professor Gulder to his new position, leading the journal to continued success.

About Tobias

Tobias A. M. Gulder holds degrees in Chemistry from the University of Würzburg (Diploma 2004, PhD 2008). After postdoctoral training at the Scripps Institution of Oceanography with Bradley Moore (2008-2010) he started his independent work as a Liebig and Emmy Noether fellow at the University of Bonn (2011-2014). In 2014 he accepted to offer to join the Technical University of Munich as Professor of Biosystems Chemistry at the Department of Chemistry and the Center for Integrated Protein Science Munich (CIPSM). In 2019 he became the Chair of Technical Biochemistry at the Technical University of Dresden.

Professor Gulder’s research interests focus on the structure, biosynthesis and synthesis of bacterial natural products. This includes the elucidation of new biosynthetic transformations and their application to the biocatalytic synthesis of natural products as well as the manipulation of biosynthetic pathways to generate new molecular structures.

 

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New Editorial Board Members

We are delighted to welcome two new Editorial Board Members to Natural Product Reports. Professor Hendrik Luesch (University of Florida, USA) and Dr Marnix Medema (Wageningen University, Netherlands).

Professor Hendrik Luesch leads a multidisciplinary marine natural products research program that integrates isolation, synthesis, pharmacology, mechanism of action and early development studies. Find out more on his lab’s webpage.

Hendrik obtained his PhD at University of Hawaii with Richard E. Moore in 2002. He undertook three years of postdoctoral studies  as an Irving S. Sigal Fellow at The Scripps Research Institute with Peter G. Schultz. Since 2005 he has been faculty at the University of Florida (UF) and is currently Professor and Chair of the Department of Medicinal Chemistry.

 

 

 


Dr Marnix Medema’s group currently develops and applies computational tools to understand bacterial, fungal and plant natural product biosynthesis from a genomic perspective. Find out more on his webpage.

Marnix completed his PhD in 2013 in the groups of Eriko Takano and Rainer Breitling at the University of Groningen. In 2015, following a postdoctoral fellowship in the group of Frank Oliver Glöckner (Max Planck Institute for Marine Microbiology in Bremen, Germany), he joined Wageningen University.

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New Editorial Board Members

We are very pleased to welcome two new members to our Natural Product Reports Editorial Board. Professor Janet Smith (University of Michigan, USA) and Dr Olga Genilloud (Fundación MEDINA, Spain).

Professor Janet Smith obtained her PhD in Biochemistry from the University of Wisconsin-Madison in 1978. After postdoctoral studies at the Naval Research Laboratory, she was an associate research scientist at Columbia University.  Professor Smith moved to Purdue University and established a research program in structural biology in 1987, where she remained as Professor of Biological Sciences until moving to the Life Science Institute, University of Michigan, in 2005. She is currently Margaret J. Hunter Collegiate Professor in the Life Sciences, Professor of Biological Chemistry and Director of the Centre for Structural Biology at University of Michigan.

Her research focuses on:

  • Understanding protein structure and function using X-ray crystallography as a structural tool
  • Examining the structures of proteins from infectious pathogens including the RNA viruses that cause West Nile disease, yellow fever, and dengue hemorrhagic fever
  • Understanding the operation of biosynthetic assembly lines for natural products and the activity and selectivity of enzymes that catalyse unusual reactions in natural product biosynthesis

Dr Olga Genilloud obtained her PhD in Biochemistry and Molecular Genetics from the Universidad Complutense de Madrid in 1988. Following this she joined the Drug Discovery Research Center at Merck Sharp and Dohme in Spain were she led the bacterial natural products program. In 2009 she was appointed Scientific Director at Fundación MEDINA and Head of the Microbiology department.

Her main research interests are focused on:

  • The production of novel microbial natural products
  • The exploration of novel microbial diversity to deliver novel chemistry
  • The development of molecular and chemical tools to support natural products drug discovery and the identification of potential new therapeutics

Find out more about the other members of our Editorial and Advisory Boards here.

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Editorial Board Changes

As the new year gets underway we would like to share some changes to our Editorial Board.

Editorial Board Retirements

After 6 years with Natural Product Reports we are very sorry to see Professors David L. Jakeman and Stefan Schulz step down from their roles on the Editorial Board. We would like to take this opportunity to thank both David and Stefan for all of their time and effort over the past 6 years, helping to make the journal the success it is today. Thank you!

However, we are pleased to say that although David and Stefan may be leaving the Editorial Board they will not be leaving us entirely. Both are now members of the Advisory Board for the journal and we look forward to continue working with them in the future in this new role.

Prof. David L. Jakeman

Prof. Stefan Schulz


New Editorial Board Members

We would also like to take this opportunity to welcome some new faces to the Natural Product Reports family.

Prof. Giovanni Appendino

Professor Giovanni Appendino, Universita del Piemonte Orientale, Italy.

Professor Giovanni Appendino did his Laurea Degree at the University of Torino (Italy) in 1979. He did Post-Laurea work at the Laboratory of Organic Synthesis, University of Gent (Belgium) with Prof. Pierre De Clercq. He has been a Full Professor of Organic Chemistry at the Università del Piemonte Orientale, Department of Pharmaceutical Sciences, Novara (Italy), since 2000.

Research activity in his laboratories takes inspiration from plant natural products to address problems in various realms of biomedical investigation, from pharmacology and nutrition (new drug leads and health-promoting dietary ingredients) to organic/medicinal chemistry (new synthetic methodologies and optimization of natural product drug leads) and cell biology (novel mechanisms of activity).



Prof. Mark Brönstrup

Professor Mark Brönstrup, Helmholtz Centre for Infection Research, Germany

Mark Brönstrup studied Chemistry at the Philipps-Universität Marburg and at the Imperial College in London. In 1999 he received his doctorate from the Technical University Berlin in Organic Chemistry. After his graduation, he worked from 2000 to 2004 as a laboratory head for Mass Spectrometry at Aventis, complemented by a research sabbatical in 2003 at Harvard Medical School. From 2005 to 2010 he led the Natural Product Sciences section at Sanofi-Aventis in Frankfurt with the goal of discovering leads from natural sources and optimising them to clinical candidates. He dealt with translational research projects from 2010 to 2013 as a section head for Biomarkers & Diagnostics in the Diabetes Division, and a domain head for Biomarkers, Bioimaging & Biological Assays at Sanofi. Since December 2013, he heads the department Chemical Biology at the Helmholtz Centre for Infection Research; additionally, he holds a Professorship (W3) at the Leibniz Universität Hannover.

Mark Brönstrup’s research uses chemical biology tools to understand mechanisms for the treatment of infectious diseases.



Professors Appendino and Brönstrup began their roles as Editorial Board members from January 2015, and we look forward to working closely with them over the coming months and years.

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New Editorial Board Members for Natural Product Reports

We are very pleased to welcome two new members to our Editorial Board this month: Professor Julia Kubanek (Georgia Institute of Technology, USA) and Professor Wen Liu (Shanghai Institute of Organic Chemistry, China).


Professor Julia Kubanek

Prof. Kubanek received her Ph.D. in Organic Chemistry in 1998 from the University of British Columbia. Following this she held postdoctoral positions at the Scripps Institution of Oceanography, University California San Diego (1998–2000) and the University of North Carolina at Wilmington (2000–2001). In 2001 she joined the Georgia Institute of Technology becoming a Professor in 2011.

Her current areas of interest include:

Aquatic chemical ecology; Chemical signaling; Chemical communication; Marine natural products chemistry; Chemical biology; Secondary metabolism; Drug discovery; Plankton ecology; Metabolomics

I’ve been reading Natural Product Reports since I was a graduate student in the early 1990’s. I’m pleased to join the NPR family as a member of the Editorial Board and looking forward to working with authors to bring important research to the attention of the natural products chemistry community.” Prof. Julia Kubanek



Professor Wen Liu

Prof. Wen Liu obtained his Ph.D. degree from the Chinese Academy of Medical Sciences (Peking Union Medical School) in 2000. After postdoctoral studies at the Department of Chemistry, University of California, Davis (2000-2001), and the School of Pharmacy, University of Wisconsin-Madison (2001-2003), he joined the Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences in 2003.

His research interests focus on:
1) natural product biosynthesis (genetics, biochemistry and chemistry)
2) combinatorial biosynthesis for production improvement and structural diversity
3) genome and/or transcriptome mining for discovery of novel microbial natural products

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NPR welcomes Professor Greg Challis to its Editorial Board

Natural Product Reports is delighted to announce Professor Greg Challis (University of Warwick, UK) as a new Editorial Board member. 

Greg Challis graduated with a BSc in Chemistry (1994) from Imperial College London and a DPhil in Organic Chemistry (1998) from the University of Oxford. He was a postdoctoral research fellow in the Department of Chemistry at Johns Hopkins University, USA (1998-2000) and in the Department of Genetics at the John Innes Centre, UK (2000-2001). In 2001 he was appointed to a lectureship in Chemical Biology in the Department of Chemistry at the University of Warwick and in 2006 he was promoted to his present position of Professor of Chemical Biology.

Challis’s research interests encompass diverse aspects of the chemistry and biology of natural products, including genomics-driven discovery of new bioactive metabolites, elucidation of novel pathways for natural product biosynthesis, mechanistic enzymology of unusual biosynthetic enzymes, biosynthetic engineering approaches to the production of novel natural product derivatives, elucidation of the biological functions of natural products, and natural product total synthesis. His research achievements have been recognised by numerous honours and awards, most recently the Gabor Medal (2009).

Why not read some of Greg Challis’s latest NPR contributions to NPR:

New natural product biosynthetic chemistry discovered by genome mining
Nat. Prod. Rep., 2009,26, 977-986

Ribosomally synthesized and post-translationally modified peptide natural products: overview and recommendations for a universal nomenclature
Nat. Prod. Rep., 2013,30, 108-160 (bottromycins section)

NPR benefits from the expertise of exceptional scientists guiding the development of the journal.
 Find out more on our Editorial and Advisory Board members!

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Welcome to Professor Daniel Romo who joins the NPR Editorial Board

We are delighted to announce the appointment of Professor Daniel Romo to the Editorial Board of Natural Products Reports, as of January 2013. 

Daniel Romo received his B.A. in chemistry/biology from Texas A&M and a PhD in Chemistry from Colorado State University as a NSF Minority Graduate Fellow under the tutelage of the late Prof. Albert I. Meyers. Following postdoctoral studies at Harvard as an American Cancer Society Fellow, with Prof. Stuart L. Schreiber, he began his independent career at TexasA&M in 1993 and is currently Professor of Chemistry and Director of the Natural Products LINCPHIN Laboratory (TAMU).

Research interests in the Romo Group are at the interface of chemistry and biology focused on total synthesis and biomechanistic studies of natural products and the asymmetric synthesis and application of beta-lactones in organic synthesis and as potential drug candidates. This search led Romo to examine marine specimens –  many recent bioactive molecules have been discovered in marine species that are now making their way to the clinic.
Romo sees natural products as playgrounds for developing new synthetic strategies and making related compounds with potentially important therapeutic applications. Natural products are keys to cell biology, and he is working to build the bridge between synthesis and biology.

‘If I couldn’t be dreaming up ways to make natural products, I would want to be diving to isolate those natural products and fishing from the deck on my off time!’ says Daniel.

Why not read Daniel Romo’s latest NPR review article:

Biosynthesis, asymmetric synthesis, and pharmacology, including cellular targets, of the pyrrole-2-aminoimidazole marine alkaloids
Ali Al-Mourabit, Manuel A. Zancanella, Supriya Tilvi and Daniel Romo
DOI: 10.1039/C0NP00013B

 
NPR benefits from the expertise of exceptional scientists guiding the development of the journal. Do you know who they are? Find out more on our Editorial and Advisory Board members.
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New Editorial Board members for NPR

We are delighted to announce the appointment of two new members to the Editorial Board of Natural Products Reports, Professors Ikuro Abe and Dirk Trauner who will be joining the Board in January 2012.

Ikuro Abe received his PhD degree in 1989 from The University of Tokyo under the direction of Professor Yutaka Ebizuka, where he studied chemistry and biochemistry of natural products biosynthesis.  After two years postdoctoral research with Professor Guy Ourisson at the CNRS Institut de Chimie des Substances Naturelles, and mostly with Professor Michel Rohmer at the Ecole Nationale Supérieure de Chimie de Mulhouse, in France (1989-1991), he went to the USA to work with Professor Glenn D. Prestwich at the State University of New York at Stony Brook (1991-1996) and then at The University of Utah (1996-1998) as a Research Assistant Professor.  In 1998, he returned to Japan to the University of Shizuoka, School of Pharmaceutical Sciences (1998-2009).  In 2009, he moved back to The University of Tokyo, Graduate School of Pharmaceutical Sciences as Professor of Natural Products Chemistry.

His main research interests focus on exploring and engineering natural products biosynthesis, see below for some examples of his work:

Enzymatic synthesis of cyclic triterpenes
Ikuro Abe
DOI: 10.1039/B616857B

Structure and function of the chalcone synthase superfamily of plant type III polyketide synthases
Ikuro Abe and Hiroyuki Morita
DOI: 10.1039/B909988N


Dirk Trauner was born and grew up in Linz, Austria. After studying biology and then biochemistry at the University of Vienna, he joined Professor Johann Mulzerʼs group at the Free University of Berlin to pursue natural products synthesis. In the late 1990s, he was a postdoctoral fellow with Professor Samuel J. Danishefsky at the Memorial Sloan-Kettering Cancer Center in New York City. In 2000, Dirk joined the University of California, Berkeley, where he rose through the ranks to become an Associate Professor of Chemistry. In summer of 2008, he moved to the University of Munich, where he currently resides as a Professor for Chemical Biology and Genetics.

His research interests range from organic synthesis and natural products to chemical neurobiology and optochemical genetics. View his contribution to our Synthesis themed issue below:

The chemistry of marine furanocembranoids, pseudopteranes, gersolanes, and related natural products
Paul A. Roethle and Dirk Trauner
DOI: 10.1039/B705660P

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New Advisory Board members for NPR

The Editorial Office is pleased to announce the recent appointment of two new Advisory Board members for Natural Product Reports, Yeo Joon Yoon and Vanderlan da Silva Bolzani.

Yeo Joon Yoon received his PhD in chemical and biological engineering from Seoul National University in 2000. He has worked with Prof Charles R. Hutchinson at the University of Wisconsin at Madison as a predoctoral researcher and also with Prof David H. Sherman at the University of Minnesota as a postdoctoral researcher. In 2002 he returned to Korea as Assistant Professor of Chemical Engineering and Bioengineering at the University of Ulsan and then moved to Ewha Womans University in 2004, where he is Associate Professor of Chemistry.

His major scientific interests are the characterization of biosynthetic pathways for secondary metabolites, focusing on polyketides and aminoglycosides in actinomycetes, combinatorial biosynthesis of novel natural products, and the application of metabolic engineering and synthetic biology to the production of secondary metabolites.


Vanderlan da Silva Bolzani is full professor at Sao Paulo State University (UNESP), and has published over 186 research publications, 5 patents and 4 book chapters. A Fellow of the Royal Society of Chemistry (UK) and a Science Productivity CNPq Fellow, she has received several awards, the most recent is the Distinguished Woman in Science Chemistry and Chemical Engineering award conceived by the ACS & IUPAC. Her PhD degree in Organic Chemistry was obtained under the guidance of Professor Otto Richard Gottlieb, University of São Paulo and after a post-doctorate at Virginia Polytechnic Institute (VPISU-USA) she joined the São Paulo State University (UNESP). Dr. Bolzani is currently is Vice-Director of the UNESP Innovation Agency (AUIN), was President of the Brazilian Chemical Society from 2008-2010, and is currently Counsellor. 

Her field of interest is plant science, and she has been involved in the isolation, bioactivity and function of secondary metabolites and peptides from plants. Also she has studied biosynthesis of piperidine alkaloids, and recently has been involved in metabolomic studies of medicinal plants and sugar cane. She has strong work collaborations with national pharmaceutical and cosmetic industries looking for new drugs from plants species. 

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