Georgian Bay Day at Killbear Park

After 3 days of intensive science at CanBIC-4, time for some fun—though not relaxation!

After 3 full days, Martin Stillman offered participants in CanBIC-4 a day of R&R in Killbear Provincial Park. Boarding a big yellow school bus (it’s been over 40 years since I last rode one in high school!) we were taken to the park, where we split into 2 groups. I’d opted for the “kayak in the afternoon” group (we’ll see later how that worked out) so my group started the morning with a talk on snakes.

An Eastern Foxsnake found in Ontario

Jimmy, a domesticated Eastern Foxsnake

The star of this “show-and-tell” presentation was undoubtedly Jimmy, an Eastern Foxsnake, which is an endangered species. Jimmy was illegally taken from his natural home to live in an apartment, during which time he became thoroughly domesticated. Jimmy has now lived in the park’s visitor centre for 11 years and he loves to be handled by visitors.

 

Jimmy, an Eastern Foxsnake

Jimmy enjoying a snuggle!

View along Georgian Bay at Killbear park.

Our group then headed out for a walk along the Georgian Bay shore to learn all about lichens. Our guide Jessica had done extensive research to prepare for our learned group. While Jessica pointed out various species of lichens, she told us many interesting facts about them: the symbiotic relationship (or not?) between a fungus and a photosynthetic parter (green algae or cyanobacterium); their classification and distribution; modes of reproduction; their chemistry and finally applications, such as dyes.

For me the most provocative fact was that 3 species of lichens are able to degrade the toxic form of prions, which normally are very resistant to degradation. Yes, lichens have prions, though since they have no central nervous system they are not subject to the diseases that prions can cause. So why would some specific lichens be able to degrade toxic prions?

Some leafy lichens

 

Very bright green lichens!

 

Strange black lichens

Kayaking on Georgian Bay

The morning group kayaking on Georgian Bay.

After a picnic on the beach, it was my group’s turn to go out kayaking on the bay, in tandem boats (excuse me, kayaks!). After a quick tutorial on how to put on the “skirt” that seals you into the kayak (our first challenge), how to paddle, and the responsibilities of each team member (brawn in the front, brains in the back—of course I was in the back for lack of the former), we set off for some exercise.

And exercise it was! Many of us had opted to kayak in the afternoon, thinking it would be warmer and indeed it was. However, the wind had come up in the early afternoon, leading to choppy water and a much harder row for those of us out there. We didn’t make it as far as the morning group, and on our way back, against the wind, the shore seemed to remain out of reach, until we finally arrived. And that is when it happened—trying to get out of the kayak I didn’t coordinate very well with my partner and ended up “sitting down” in the water. Yikes!

Finally, some relaxation: time for a BBQ and convivial talk to end the day, before returning to Parry Sound.

If there’s one word that characterises Martin, it has to be energy—boundless energy—and one needs plenty of it to keep up with him, even in fun!

A view of Georgian Bay at Killbear Park Myself on the rocky shore of Georgian Bay Killbear Park shore

All photos copyright Denise Parent

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NJC at CanBIC-4 in Ontario

Read NJC Editor Denise Parent’s account of this bioinorganic chemistry conference, held in the small town of Parry Sound.

Stockey Centre for the Performing Arts in Parry Sound

Stockey Centre for the Performing Arts in Parry Sound, location for the CanBIC conferences

I arrived in Parry Sound on Georgian Bay, after flying into Toronto and taking a long bus ride up north, to promote NJC at the 4th Georgian Bay International Conference on Bioinorganic Chemistry. NJC was a major sponsor this year, providing support for the student volunteers who are “on call” to ensure that the conference runs smoothly.

This year’s event brought together about 140 scientists: about two-thirds from North America with the other participants being mainly from Europe and Japan.

This is not a conference for the weak-of-heart: the conference organisers (Martin Stillman, Nagao Kobayashi, C Frank Shaw III) put together a very full and challenging program combining science and fun in a beautiful natural setting.

Conference organizers Frank, Martin and Nagao, windblown on the Island Queen cruise boat.

Sunset behind the Stockey Centre Lilacs in bloom in Parry Sound Georgian Bay shore behind Stockey Centre

The science consisted of 90 talks (3 parallel sessions over 3 days), which ranged from the physical techniques, synthesis and properties, to medical applications. Ed Solomon‘s plenary lecture on copper–dioxygen reactivity closed the conference, while over 30 posters completed the program.

My favourite talks were those given by Wojciech Bal (U Warsaw) on nickel toxicity, Kyung-Bin Cho (Ewha Womans U) on rebound reactions in non-heme systems, Andrew Cammidge (U East Anglia) on Pcs-Por hybrids, Peter Caravan (Harvard Medical School) on MRI probes, Tim Storr (Simon Fraser U) on treating Alzheimer’s disease, Danny Leznoff (also at SFU) on metallo-Pcs, Jennifer Wytko (U Strasbourg) on porphyrin wires and Ian Butler (McGill U) on analysing artists’ pigments.
The fun included a boat cruise on the bay (a welcome and relaxing break), two music recitals in the evening, and an after-conference all-day outing to Killbear Provincial Park for hiking, kayaking and a BBQ. (More on the outing in an upcoming post, with photos.)

Island Queen cruise ship in Parry Sound Hole in the Wall passage in Georgian Bay Lighthouse on Georgian Bay

The cruise on the Island Queen was a welcome and relaxing break—staying warm inside the boat with occasional forays outside for photo ops.

The CanBIC conferences also feature music, provided by Katie Stillman on violin and Miaomiao Yu on piano. These two young talented musicians have played together for many years, which was evident from their perfect harmony in pieces ranging from Mozart to 20th century composers.

After this informal and small conference out in the woods, next week will be a complete change of scenery as I’m off to the 96th Canadian Society of Chemistry conference in Quebec City. Check back for my comments on this event.

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Meet Our Authors – May 2013

Explore and find out a little bit more about the people behind the research article! We have profiled some of our authors so you can learn more about them, their work and check out their latest entries.

The first of author is Brigida BOCHICCHO who is the assistant professor at the Department of Science, Università del la Basilicata, Potenza, Italy. Brigida‘s research interests are in the area of Protein-inspired (bio)materials.

Her NJC paper deals with the self-assembly behavior of some elastin-derived polypeptides rich in proline and proline-modified residues in order to investigate the role of proline in the self- assembly of elastin. This work constitutes the basis for the proper design of elastin-inspired drugs with tailored conformational properties.

If she could solve any scientific problem in any field, it would be: “The early recognition of Alzheimer disease onset in humans through chemical tools.” says Brigida.

Effect of proline analogues on the conformation of elastin peptides by Antonietta Pepe, Maria Antonietta Crudele and Brigida Bochicchio; New J. Chem., 2013,37, 1326-1335, DOI: 10.1039/C3NJ41001C; From themed collection Prolines.

The next author who accepted to answer some questions for us was Samuel COUVE-BONNAIRE, assistant professor at the University of Rouen, France. His current research interests concern Organometallic chemistry, Fluorine chemistry, Asymmetric synthesis and Peptidomimetics. The article by Samuel and his co-authors looks into the new efficient asymmetric synthesis that has been developed to obtain the relevant fluorinated pseudodipeptide Ala-Ψ[(Z)CFCH]-Pro. Outside the laboratory, Samuel likes to spend time with his family and to play badminton (leisure and competition).

Straightforward asymmetric synthesis of Ala-Ψ[CFCH]-Pro, a proline-containing pseudodipeptide bearing a fluoroolefin as a peptide bond mimic by Guillaume Dutheuil, Camille Pierry, Emilie Villiers, Samuel Couve-Bonnaire and Xavier Pannecoucke  , New J. Chem., 2013,37, 1320-1325; DOI: 10.1039/C2NJ40891K, From themed collection Prolines

Professor Roberto CAO from the University of Havana, Cuba is our last interviewed author. He research interests focus on Nanosciences, especially self-assembled monolayers on metal surfaces including supramolecular interactions.

“The NJC is a “fresh” journal, very dynamic, that includes all topics of Chemistry. The last few years it has been increased in papers devoted to Nanosciences” commented Roberto on choosing the NJC journal.

When asked which scientific problem he would like to solve, Robert replied: ”Cancer. We are now working on gold nanoparticles linked to monoclonal antibodies that can target different types of cancer.”

Besides his research activity, Roberto enjoys reading historic novels and swiming in the Caribbean sea, next to his house.

An unusual self-assembly of a deuteroporphyrin 4-aminothiophenol derivative on Au(111) surfaces by Rudy Martin, Roberto Cao, Franz-Peter Montforts and Paul-Ludwig M. Noeske , New J. Chem., 2013, 37, 1610-1615

DOI: 10.1039/C3NJ00118K

This month’s issue of NJC includes an online collection of articles on the exciting topic of prolines and derivatives, from synthesis to biological activities.  Look out the online themed collection here.

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Antifungal activity of phosphonium ionic liquids

Due to their toxic nature the ionic liquids became an interesting subject of development for new applications.

In this NJC paper quaternary phosphonium ionic liquids are discussed in light of their potential use as an antifungal compounds. The authors Diego O. Hartmann and Cristina Silva Pereira (University  of Lisbon, Portugal) aimed this paper at investigating toxicity of several alkylphosphonium chlrorides versus a fungus, Aspergillus nidulans at a molecular level. They describe the use of qRT-PCR to analyse the expression of Aspergillus nidulans genes after exposure to alkyltributylphosphonium chlorides. The results indicate cell wall damage as the common mechanism of toxicity amongst these ionic liquids, while plasma membrane permeabilisation is dependent on the alkyl substituent length. The work provides an important basic insight to apply phosphonium type ionic liquids as an antifungal medicine.

A molecular analysis of the toxicity of alkyltributylphosphonium chlorides in Aspergillus nidulans by Diego O. Hartmann and Cristina Silva Pereira , New J. Chem., 2013, 37, 1569-1577, DOI: 10.1039/C3NJ00167A

Interested in reading further? Why not download the full article now, FREE to access for a period of 4 weeks!

 

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We invite you to visit the May issue of NJC

A focus article by Ernest Giralt and co-workers opens the May issue on the uses of ion mobility coupled to mass spectrometry (IMMS) to gain structural and dynamic information for a wide variety of biomacromolecules.

Applications and future of ion mobility mass spectrometry in structural biology by Abraham López, Teresa Tarragó, Marta Vilaseca and Ernest Giralt New J. Chem., 2013, 37, 1283-1289 DOI: 10.1039/C3NJ41051J.

The outside front cover was produced by Qin Wei and co-workers on honeycomb-structured macroporous films of graphene nanocomposites prepared by the breath figure method at both an air/solid interface and an air/water interface.

Assembly of graphene nanocomposites into honeycomb-structured macroporous films with enhanced hydrophobicity by Hongmin Ma, Picheng Gao, Dawei Fan, Bin Du, Jingcheng Hao and Qin Wei New J. Chem., 2013, 37, 1307-1311 DOI: 10.1039/C2NJ41031A.

On the inside front cover, Philippe Karoyan and colleagues illustrate their research on the synthesis and study using CD and NMR in water and alcohols on homooligomers of substituted prolines and -prolines.

Homooligomers of substituted prolines and β-prolines: syntheses and secondary structure investigation by Cécile Caumes, Nicolas Delsuc, Redouane Beni Azza, Isabelle Correia, Fabrice Chemla, Franck Ferreira, Ludovic Carlier, Alejandro Perez Luna, Roba Moumné, Olivier Lequin and Philippe Karoyan New J. Chem., 2013, 37, 1312-1319 DOI: 10.1039/C3NJ00127J.

Take you pick amongst the 4 letters and 42 full papers that composed this issue of May here.

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NJC Poster prize winners at Paris 2013 Symposium on Foldamers

Two NJC poster prizes were awarded during the Paris 2013 Symposium on Foldamers, which was held at the “Les Cordeliers” Conference Centre.

The two laureates received a one-year subscription to the journal and a RSC book. Our thanks go to the organizers of the conference for their help in organizing these awards, and our deep gratitude to all of the senior scientists who served on the jury to select the two following winners:

Elisabeth K. Nyakatura, who received her BSc in chemistry from the Freie Universität Berlin, Germany, in 2007. She then joined the London School of Hygiene and Tropical Medicine and successfully completed a MSc programme in Molecular Biology of Infectious Diseases. After graduating from London in 2008, Elisabeth returned to the Freie Universität to pursue her PhD in the group of Prof. Koksch.Her research is now focused on the application of phage display to identify preferred interaction partners of chemically modified amino acids in helical protein environments. She also implements the unique properties of these nonnatural building blocks in the development of biological active peptides. It is this interface of chemistry and molecular biology that accounts for Elisabeth’s interest in using chemical means to address pathogen-host interactions.

Liam Byrne was born in Wegberg, Germany in 1984. He received his undergraduate and postgraduate education at the University of Leeds; the latter with Prof. Steve Marsden, working on the development of new synthetic applications of the catalytic aza-Wittig reaction. Liam is currently employed as a post-doctoral research associate with Prof. Jonathan Clayden at the University of Manchester. His research has sought to maximise conformational control in a class of helical foldamers and exploit this to achieve stereoselective transformations over long (nanometre) distances.

NJC wishes them continuing success in their research!
A list of all previous NJC Poster Prize winners can be found here.

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Hot article: Green Giant

Heterocyclic N-oxides are ubiquitous protecting groups, auxiliary agents, oxidants, catalysts, surrogates for heterocyclic boronic acids or ligands in metal complexes. In addition, pyridine N-oxide derivatives have been recently reported to represent a new class of anti-HIV compounds. In this NJC letter, Wei Zhao and Chunxia Yang (Nanyang Normal University, China) report an effective and green procedure for pyridine oxidation using the large Δ-Na8HPW9O34 polyoxometalate as catalyst. In this system, reactions were carried out in water at room temperature with hydrogen peroxide as oxidant. The catalyst could be recovered and reused several times without obvious loss of activity.

“A green catalytic procedure for oxidation of pyridines catalyzed by a lacunary polyoxometalate in water at room temperature” Wei Zhao and Chunxia Yang, New J. Chem., 2013, Advance Article. DOI: 10.1039/C3NJ00149K (Letter).

 

Interested in reading further? These “Hot articles” will be FREE to access for a period of 4 weeks.

 

To stay up-to-date with the latest NJC developments, sign up to its table-of-contents email alert.
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Meet our Authors – April 2013

Two authors of NJC’s April Issue are interviewed for this month’s Meet our Authors feature.

 

Our first author is Kathleen Mullen, who is an Australian Postdoctoral Fellow and a Lecturer at the Queensland University of Technology. Kathleen’s research is in the broad field of supramolecular chemistry, but she is particularly interested in incorporating porphyrins into interlocked architectures, anion sensors and molecular machines.

 

The article by Kathleen and her co-authors looks into he construction of interlocked architectures that will have interesting photo-and electrochemical properties. Porphyrins and bipyidinium moieties are perfect targets for such purposes, however the range of chemical reactions that are compatible with both species is relatively limited. The work in this paper set out to gain a better understanding of the size/structure of strapped porphyrin macrocycles and broaden the synthetic tools available for he construction of rotaxanes incorporating these motifs.

 

On choosing NJC to publish this work, Kathleen commented: “Because our work appeals to a general chemistry audience, which NJC caters for.”

 

When not working, Kathleen loves to travel: “Its even better that our work enables us to travel so much. Last year my visit to the University of Cambridge also coincided with the Olympics which was an amazing experience.” (see photo).
If she could not be a scientist, Kathleen would be a food critic. She thinks that it would be a great way to travel the world, tasting gourmet food along the way.

 

The second author is Ian Fairlamb, who is a Professor of Chemistry at the University of York (UK). His research group is currently working on catalysis, synthetic chemistry, mechanistic examination and carbon monoxide therapeutics.

 

For several years Ian has been intrigued by macrocyclic aryl ketone natural products, and their derivatives. He and co-workers noted that efficient synthetic routes to these types of structures were limited. Therefore they developed and exploited a Pd-catalysed protocol for aryl ketone synthesis. Silyl deprotection of the resultant products and a subsequent Mitsunobu reaction gave access to both 16-membered and 17-membered macrocyclic compounds.

 

On the main motivation for submitting his work to NJC, Ian commented: “The NJC experience, from paper subimission and revision, through to publication, is an efficient process. We wanted to submit our paper to a more general-focused journal, where it would be visible to different research fields. NJC occupies a unique position in this respect.”

 

Outside the laboratory, Ian has several favourite activities, including playing the guitar and being outdoors for gardening, walking in the hills, running and cycling. His favourite books include ‘Comfrey’, by Lawrence D. Hills and ‘Memoirs of a Fellwanderer’ by Alfred Wainwright.
When asked for an alternative career path if not a scientist, Ian answered running shoe designer (just do it…yourself !)

 

We would like to thank to our authors for making time in their busy schedules to answer these questions for us.

 

Why not submit your high impact research to us today!
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Top ten most accessed articles in March

This month sees the following articles in New Journal of Chemistry that are in the top ten most accessed:-

Facile and controllable fabrication of three-dimensionally quasi-ordered macroporous TiO2 for high performance lithium-ion battery applications 
Hongliang Jiang, Xiaoling Yang, Cheng Chen, Yihua Zhu and Chunzhong Li   
New J. Chem., 2013,37, 1578-1583 
DOI: 10.1039/C3NJ00024A   

Photonic crystal pH and metal cation sensors based on poly(vinyl alcohol) hydrogel 
Hongliang Jiang, Yihua Zhu, Cheng Chen, Jianhua Shen, Hua Bao, Liming Peng, Xiaoling Yang and Chunzhong Li   
New J. Chem., 2012,36, 1051-1056 
DOI: 10.1039/C2NJ20989F   

One-pot hydrothermal synthesis of graphene quantum dots surface-passivated by polyethylene glycol and their photoelectric conversion under near-infrared light 
Jianhua Shen, Yihua Zhu, Xiaoling Yang, Jie Zong, Jianmei Zhang and Chunzhong Li   
New J. Chem., 2012,36, 97-101 
DOI: 10.1039/C1NJ20658C   

Preparation of graphene–TiO2 composites with enhanced photocatalytic activity 
Kangfu Zhou, Yihua Zhu, Xiaoling Yang, Xin Jiang and Chunzhong Li  
New J. Chem., 2011,35, 353-359 
DOI: 10.1039/C0NJ00623H   

MOFs, MILs and more: concepts, properties and applications for porous coordination networks (PCNs) 
Christoph Janiak  and Jana K. Vieth   
New J. Chem., 2010,34, 2366-2388 
DOI: 10.1039/C0NJ00275E   

Donor–acceptor–donor (D–A–D) molecules based on isoindigo as active material for organic solar cells 
Ali Yassin, Philippe Leriche, Magali Allain and Jean Roncali   
New J. Chem., 2013,37, 502-507 
DOI: 10.1039/C2NJ40879A   

Morphology-controllable synthesis of MnO2 hollow nanospheres and their supercapacitive performance 
Jingping Ma, Qilin Cheng, Vladimir Pavlinek, Petr Saha and Chunzhong Li  
New J. Chem., 2013,37, 722-728 
DOI: 10.1039/C2NJ40880E   

Synthesis and efficient solid-state emission of conjugated donor–acceptor–donor triphenylamine chromophores 
Binbin Wang and Ying Qian 
New J. Chem., 2013,37, 1402-1407 
DOI: 10.1039/C3NJ41115J   

Metal–organic coordination polymers with a new 3,5-(4-carboxybenzyloxy) benzoic acid linker 
Ranjan Patra, Hatem M. Titi and Israel Goldberg 
New J. Chem., 2013,37, 1494-1500 
DOI: 10.1039/C3NJ00054K   

Synthesis of donor-substituted meso-phenyl and meso-ethynylphenyl BODIPYs with broad absorption 
Katja Gräf, Thomas Körzdörfer, Stephan Kümmel and Mukundan Thelakkat   
New J. Chem., 2013,37, 1417-1426 
DOI: 10.1039/C3NJ00157A   

Why not take a look at the articles today and blog your thoughts and comments below.

Fancy submitting an article to New Journal of Chemistry? Then why not submit to us today or alternatively email us your suggestions.

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Top ten most accessed articles in February

 This month sees the following articles in New Journal of Chemistry that are in the top ten most accessed:-

Preparation of graphene–TiO2 composites with enhanced photocatalytic activity 
Kangfu Zhou, Yihua Zhu, Xiaoling Yang, Xin Jianga and Chunzhong Li 
New J. Chem., 2011,35, 353-359 
DOI: 10.1039/C0NJ00623H    

MOFs, MILs and more: concepts, properties and applications for porous coordination networks (PCNs) 
Christoph Janiak and Jana K. Vieth 
New J. Chem., 2010,34, 2366-2388 
DOI: 10.1039/C0NJ00275E    

Design and synthesis of sulfobetainic diketopyrrolopyrrole (DPP) laser dyes Soumyaditya
Mula, Delphine Hablot, Krishna K. Jagtap, Elodie Heyerb and Raymond Ziessel 
New J. Chem., 2013,37, 303-308 
DOI: 10.1039/C2NJ40569E    

Donor–acceptor–donor (D–A–D) molecules based on isoindigo as active material for organic solar cells 
Ali Yassin, Philippe Leriche, Magali Allaina and Jean Roncali 
New J. Chem., 2013,37, 502-507 
DOI: 10.1039/C2NJ40879A   

Synthesis, crystal structure, and polymerization of butterfly-shaped thieno[3,2-b]thiophene oligomers 
Ying Liu, Qida Liu, Xingye Zhang, Ling Ai, Yang Wang, Ruixiang Penga and Ziyi Ge 
New J. Chem., 2013,37, 1189-1194 
DOI: 10.1039/C3NJ40909K   

Synthesis and characterization of simple trans-AB-porphyrins for dye-sensitized solar cells 
Nuo-nuo Zhang, Ya-qing Feng, Yuan-chao Li, Xiao Peng, Cheng-zhi Gu, Xiao-dong Xue, Jia-ying Yan, Qing-long Chen, Xiang-gao Lia and Bao Zhang 
New J. Chem., 2013,37, 1134-1141 
DOI: 10.1039/C3NJ41073K    

The synthesis and photovoltaic properties of A–D–A-type small molecules containing diketopyrrolopyrrole terminal units 
Ling Zhang, Shaohang Zeng, Lunxiang Yin, Changyan Ji, Kechang Li, Yanqin Li and Yue Wang 
New J. Chem., 2013,37, 632-639 
DOI: 10.1039/C2NJ40963A    

From a BODIPY–rhodamine scaffold to a ratiometric fluorescent probe for nitric oxide 
Haibo Yu, Liji Jin, Yong Dai, Huaqiang Lib and Yi Xiao 
New J. Chem., 2013, Advance Article 
DOI: 10.1039/C3NJ41127C   

Outer sphere hydrogenation catalysis 
Odile Eisenstein and Robert H. Crabtree 
New J. Chem., 2013,37, 21-27 
DOI: 10.1039/C2NJ40659D    

Linearly p-extended squaraine dyes enable the spectral response of dye-sensitized solar cells in the NIR region over 800 nm 
Takeshi Maeda, Shigeki Arikawa, Hidekazu Nakao, Shigeyuki Yagia and Hiroyuki Nakazumi 
New J. Chem., 2013,37, 701-708 
DOI: 10.1039/C2NJ40991G    

Why not take a look at the articles today and blog your thoughts and comments below.

Fancy submitting an article to New Journal of Chemistry? Then why not submit to us today or alternatively email us your suggestions.

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